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The map label for this gene is 116620956

Identifier: 116620956

GI number: 116620956

Start: 2290475

End: 2291386

Strand: Reverse

Name: 116620956

Synonym: Acid_1837

Alternate gene names: NA

Gene position: 2291386-2290475 (Counterclockwise)

Preceding gene: 116620957

Following gene: 116620955

Centisome position: 22.99

GC content: 65.9

Gene sequence:

>912_bases
ATGCGCATCCTCCAACTGCCGGAGATCCGGGCGGTGCTTGAATATCCGGCGATCATCGAACGCATGCGCGATGCGCTGAT
TGCCTATTCACACGGCGAGTGCGATACGCCGATGCCGATGCACCTCGCGATTGCGCCGGCGAACGCCGAGGTTCACATGA
AATCCAGCTACCGCCGTGGAGGCCGGTACTTCGCGCTCAAGATCGCCGCCACTTTCCCGGGTAAAGGGAGCAGCGGCATG
ATGCTCCTCTCCTCGGCCGACAACGGCGAGCCCGTCGCGTTCCTGGCGGACAGCGGGCACCTGACGGATGTACGCACCGC
CGCGGTGGCCGCGCTGGTGGCCCGCGAACTCGGGCGGCGCGATCGCGTCCTTGGAATCCTTGGCACCGGCATTCAGGCGC
GGCTGCTGGCCGCCATCCATGCCGAGATCATGGAACTGGCCGGGATCGTAATCTGGGGCCGCACGCCGGAGCGCGCCGAG
GACTGCCGTCGCGATCTTCAGGAGCTTTTGCCCGATACCGAAATTTCCGTAGTGGCGGACCCGGCGGAGGTGGCGCGGCG
CACGCGCCTGATTGCGACCGCGACCGCCGCGCGCCAACCTATGCTTCGCGCCGGAGACCTTCAACCTGGCACGCACATCT
CCGCGGTGGGTTCGGATTCCCCGGGCAAGCAGGAACTCGACGCCGATATCCTGCGCCGCGCGTCGCAGTTGCTGGCCGAT
TCGCGGCGGCAGTGTGAGAAGCTGGGTGAACTGCAACATGCCCCGGATCAAATGGGGCGCGTGGTCGAGATCGGCGAGTT
CTGCCTCGCGCCCACGCTGGAGGACTCGGCCGGCATCACGGTCTGCGATTTCACCGGGCTGGGCGTGGAAGACTTGTATA
TCGCCGAATACTGCTACGAGAGGGCACAGTGA

Upstream 100 bases:

>100_bases
GTACACCACGTGGCCGTAACGCTCCCTCACGGTCGCGGCTCGGAATGGAGCCGCGACGGTAAGCGTCAAGGGAGAGGAAG
GCAGTGCTAGGCTGTCGTTA

Downstream 100 bases:

>100_bases
AAATAGAACCATTCGAAATGGAGCGCATGCAATCGACCTGGGAGAACCTTGTCGAGTTCGACATGAGCGAGAGCGGCGTG
CGCCCGGTGAGTTTGCGCGA

Product: ornithine cyclodeaminase

Products: L-proline; NH3

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MRILQLPEIRAVLEYPAIIERMRDALIAYSHGECDTPMPMHLAIAPANAEVHMKSSYRRGGRYFALKIAATFPGKGSSGM
MLLSSADNGEPVAFLADSGHLTDVRTAAVAALVARELGRRDRVLGILGTGIQARLLAAIHAEIMELAGIVIWGRTPERAE
DCRRDLQELLPDTEISVVADPAEVARRTRLIATATAARQPMLRAGDLQPGTHISAVGSDSPGKQELDADILRRASQLLAD
SRRQCEKLGELQHAPDQMGRVVEIGEFCLAPTLEDSAGITVCDFTGLGVEDLYIAEYCYERAQ

Sequences:

>Translated_303_residues
MRILQLPEIRAVLEYPAIIERMRDALIAYSHGECDTPMPMHLAIAPANAEVHMKSSYRRGGRYFALKIAATFPGKGSSGM
MLLSSADNGEPVAFLADSGHLTDVRTAAVAALVARELGRRDRVLGILGTGIQARLLAAIHAEIMELAGIVIWGRTPERAE
DCRRDLQELLPDTEISVVADPAEVARRTRLIATATAARQPMLRAGDLQPGTHISAVGSDSPGKQELDADILRRASQLLAD
SRRQCEKLGELQHAPDQMGRVVEIGEFCLAPTLEDSAGITVCDFTGLGVEDLYIAEYCYERAQ
>Mature_303_residues
MRILQLPEIRAVLEYPAIIERMRDALIAYSHGECDTPMPMHLAIAPANAEVHMKSSYRRGGRYFALKIAATFPGKGSSGM
MLLSSADNGEPVAFLADSGHLTDVRTAAVAALVARELGRRDRVLGILGTGIQARLLAAIHAEIMELAGIVIWGRTPERAE
DCRRDLQELLPDTEISVVADPAEVARRTRLIATATAARQPMLRAGDLQPGTHISAVGSDSPGKQELDADILRRASQLLAD
SRRQCEKLGELQHAPDQMGRVVEIGEFCLAPTLEDSAGITVCDFTGLGVEDLYIAEYCYERAQ

Specific function: Unknown

COG id: COG2423

COG function: function code E; Predicted ornithine cyclodeaminase, mu-crystallin homolog

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ornithine cyclodeaminase family [H]

Homologues:

Organism=Homo sapiens, GI4503065, Length=221, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI62241008, Length=221, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014334
- InterPro:   IPR016040
- InterPro:   IPR003462 [H]

Pfam domain/function: PF02423 OCD_Mu_crystall [H]

EC number: 4.3.1.12

Molecular weight: Translated: 32898; Mature: 32898

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILQLPEIRAVLEYPAIIERMRDALIAYSHGECDTPMPMHLAIAPANAEVHMKSSYRRG
CCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCEEEECHHHCCC
GRYFALKIAATFPGKGSSGMMLLSSADNGEPVAFLADSGHLTDVRTAAVAALVARELGRR
CEEEEEEEEEECCCCCCCCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
DRVLGILGTGIQARLLAAIHAEIMELAGIVIWGRTPERAEDCRRDLQELLPDTEISVVAD
CCEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEC
PAEVARRTRLIATATAARQPMLRAGDLQPGTHISAVGSDSPGKQELDADILRRASQLLAD
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
SRRQCEKLGELQHAPDQMGRVVEIGEFCLAPTLEDSAGITVCDFTGLGVEDLYIAEYCYE
HHHHHHHHHHHCCCHHHHCCHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
RAQ
HCC
>Mature Secondary Structure
MRILQLPEIRAVLEYPAIIERMRDALIAYSHGECDTPMPMHLAIAPANAEVHMKSSYRRG
CCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCEEEECHHHCCC
GRYFALKIAATFPGKGSSGMMLLSSADNGEPVAFLADSGHLTDVRTAAVAALVARELGRR
CEEEEEEEEEECCCCCCCCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
DRVLGILGTGIQARLLAAIHAEIMELAGIVIWGRTPERAEDCRRDLQELLPDTEISVVAD
CCEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEC
PAEVARRTRLIATATAARQPMLRAGDLQPGTHISAVGSDSPGKQELDADILRRASQLLAD
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
SRRQCEKLGELQHAPDQMGRVVEIGEFCLAPTLEDSAGITVCDFTGLGVEDLYIAEYCYE
HHHHHHHHHHHCCCHHHHCCHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
RAQ
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-ornithine

Specific reaction: L-ornithine = L-proline + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]