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The map label for this gene is fes [H]

Identifier: 116620894

GI number: 116620894

Start: 2206294

End: 2208411

Strand: Reverse

Name: fes [H]

Synonym: Acid_1775

Alternate gene names: 116620894

Gene position: 2208411-2206294 (Counterclockwise)

Preceding gene: 116620896

Following gene: 116620893

Centisome position: 22.16

GC content: 62.42

Gene sequence:

>2118_bases
ATGAGATTTGGAAACGTTTGCGGGAACGCGAATACCGAAAAGTGGAGAACGGGCTACTTTGTGGGATTGGTATATTCTAC
GAACCGGAGGATCGGGATGCGTCTTGCCGTCGTACTCGTCGGAATTTTCGCGGCTAACAGCGGCTGGGCGGCCGACCCAT
TGGCCGGCGACTGGAGATTAAACCCCGCGAAATCCGAATTTAAGGATAAGGTGAAGGCCGGCCGTGTCCTGGTCGAGGCC
GATAACGCCGGCGGTTACCGGGAGCTTTACGAAATCATCTTCGAGACCGCGGCCCCGCTCCGCCTCACCGCCCGCAGCCA
ATTCGACGGCCCACCGGAAGAGACCAGCCTCGATGGCCAGGATGTCCGCTACACGTCCACGCGCATTGACGCGAACGCCT
TCGAGATCACCTATCGCGACCGGGGTACAGAGCGCGTCAGCCGGACCATGCGGTTTACCGCGGAGCCTCGCGACCGGATG
CTCACGGTTCTCACGACGGGCTCCAAGGCGGTGTTCGAGAAACTCAGCGAAGGGCCGCTGCTCGAGGCTGGGAAGAGCGT
AGAACAGACGTTCGGCGCCGGAGCGGTCTACGAATATCGCATCCGCCTGAAGGCCGGTGAGTATTGCGCGGGCCGAATCG
AGCCGAAGGAAGGAGGCGTCAACGGCGCGTTTTATGGTCCCGATGGCGAACGGCTCTATAACCTCGGCGGACCCGCCGCA
GAGAACCGGCCCTTCGGGTTGGAGGCGCCGGTCGCCGGAATCTACAAGCTCGCCCTCCGGTCCGCGACGCCGGCGGCGAA
GAGTTTCACCTTAAAGGTGGACTCCATCGTTCCTGCCGAGAAGCGGGTGCCCGCGGCGCCGGCGAATGCGCCCAAGGAGA
AGTTCCCCAGCCCGCGTATCGCGGCTCTGCGGAAGGCAGTGGAAGCTGGAAATCGCGAGGCGGTGGCGGCCTTTTGGCGC
GCCATCGAGAGGGAAGGCGCGCCAATTTTCGAGCGTCCCGAAGGCAACGATCACGATACGCTGGTGACGTTCCTGTGGCG
CGGCACGCCGGCAACGCGCAATGTGATGATCCTTTGGTACCCGTACGCGCCGGCGAAGCCCGCCGATTATCAGATGGTGA
ACATCGCGGGCACCGACGTCTGGTATCGGACGCGGGCGATCCGCCGCGGCGCGCGCTTCGCCTATCAACTCTCTCCCAAC
GATCCGCTGGAATTCAACCAGGACTCCGGAATTCAACGCGCGCTCACCGCGCAGGCCGATCCGCTGAATCCCCGCAAGTG
GCGCAATGGCCCGTTCAACACGAAATTCGAATATCAGTCCGCATTGGAGATGCCCGATGCGCGGCCCCAGCCCTACAGCA
CGAAGCGCGCCGGAGTGCCTGAGGGCAAGGTCGAGAAGAGCCGGATCCAGAGCGCGCTCCTAAAAAACGAGCATGCGCTC
TCGATCTACACGCCGCCGGGGTATCGCAAGGACGGGCCGCCCAACGGCCTGTTGGTGGTCTTCGACGAAAGCGCGTACCT
GATCCTGGTCCCGACGCCGGTGATCCTGGACAATCTGCTCTCGGAGAAGAAAATTGCGCCGATGGTGGCGGTGCTGATCG
CCAATCCGAACCAGGAAACGCGAACTCGCGAGCTCCCGCCGAATCCGGCGTTCGCCGAGTTTCTAAATAACGAGCTGATC
CCCTGGGTGCGCCAGCATTACAACGTAACCACCGATCCGGCGAAGGTGGTGGTAGCGGGTTCGAGCTTCGGTGGGATCGC
CTCCGTGTACGCGGGCCTGCGGCACCCGGAGACGTTCGGCAATATCCTCTGTCAATCCGGCTCGTTCTGGTGGAGCGCCG
CCAAGCCGGAACCGTACACGGAGCCTAACTTCCTGGCAAAGGAGTTCCTGAAGAGCTCGAAGCTGCCGCTGCGCTTCTAT
ATGGACGCCGGCTCATTCGAGGTCGATATTGAGGGCGAAGGCGGAGCCATTCTGGAACCGAGCCGTCACATGCGCGACGT
GCTGCTGGCTAAGGGCTACGAAGTCCATTATCAGGAAAACGTGGGAGGACACGATTACCTGAGCTGGCGCGGCTCCCTCG
CCGATGGCCTGCTGGCGCTGGTCGGATTATCAAAGTAG

Upstream 100 bases:

>100_bases
CGAAGGACCTCCTAAAACGATGCAAACGTTTCCGAGAATATCACCGGCCCTACAGTGTGTCAACCATTTCACTACGCAGT
ACGAAGGAGATCGGACCAAT

Downstream 100 bases:

>100_bases
GCTTGCTGCAAGCGGGAATTCCCGGAGATGTTACGTGTAAGTTAGCACCGTCCCCGGATAACTGCCGCCACTATTATTTG
TAAGTGGATCTTTCGGGTGA

Product: putative esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MRFGNVCGNANTEKWRTGYFVGLVYSTNRRIGMRLAVVLVGIFAANSGWAADPLAGDWRLNPAKSEFKDKVKAGRVLVEA
DNAGGYRELYEIIFETAAPLRLTARSQFDGPPEETSLDGQDVRYTSTRIDANAFEITYRDRGTERVSRTMRFTAEPRDRM
LTVLTTGSKAVFEKLSEGPLLEAGKSVEQTFGAGAVYEYRIRLKAGEYCAGRIEPKEGGVNGAFYGPDGERLYNLGGPAA
ENRPFGLEAPVAGIYKLALRSATPAAKSFTLKVDSIVPAEKRVPAAPANAPKEKFPSPRIAALRKAVEAGNREAVAAFWR
AIEREGAPIFERPEGNDHDTLVTFLWRGTPATRNVMILWYPYAPAKPADYQMVNIAGTDVWYRTRAIRRGARFAYQLSPN
DPLEFNQDSGIQRALTAQADPLNPRKWRNGPFNTKFEYQSALEMPDARPQPYSTKRAGVPEGKVEKSRIQSALLKNEHAL
SIYTPPGYRKDGPPNGLLVVFDESAYLILVPTPVILDNLLSEKKIAPMVAVLIANPNQETRTRELPPNPAFAEFLNNELI
PWVRQHYNVTTDPAKVVVAGSSFGGIASVYAGLRHPETFGNILCQSGSFWWSAAKPEPYTEPNFLAKEFLKSSKLPLRFY
MDAGSFEVDIEGEGGAILEPSRHMRDVLLAKGYEVHYQENVGGHDYLSWRGSLADGLLALVGLSK

Sequences:

>Translated_705_residues
MRFGNVCGNANTEKWRTGYFVGLVYSTNRRIGMRLAVVLVGIFAANSGWAADPLAGDWRLNPAKSEFKDKVKAGRVLVEA
DNAGGYRELYEIIFETAAPLRLTARSQFDGPPEETSLDGQDVRYTSTRIDANAFEITYRDRGTERVSRTMRFTAEPRDRM
LTVLTTGSKAVFEKLSEGPLLEAGKSVEQTFGAGAVYEYRIRLKAGEYCAGRIEPKEGGVNGAFYGPDGERLYNLGGPAA
ENRPFGLEAPVAGIYKLALRSATPAAKSFTLKVDSIVPAEKRVPAAPANAPKEKFPSPRIAALRKAVEAGNREAVAAFWR
AIEREGAPIFERPEGNDHDTLVTFLWRGTPATRNVMILWYPYAPAKPADYQMVNIAGTDVWYRTRAIRRGARFAYQLSPN
DPLEFNQDSGIQRALTAQADPLNPRKWRNGPFNTKFEYQSALEMPDARPQPYSTKRAGVPEGKVEKSRIQSALLKNEHAL
SIYTPPGYRKDGPPNGLLVVFDESAYLILVPTPVILDNLLSEKKIAPMVAVLIANPNQETRTRELPPNPAFAEFLNNELI
PWVRQHYNVTTDPAKVVVAGSSFGGIASVYAGLRHPETFGNILCQSGSFWWSAAKPEPYTEPNFLAKEFLKSSKLPLRFY
MDAGSFEVDIEGEGGAILEPSRHMRDVLLAKGYEVHYQENVGGHDYLSWRGSLADGLLALVGLSK
>Mature_705_residues
MRFGNVCGNANTEKWRTGYFVGLVYSTNRRIGMRLAVVLVGIFAANSGWAADPLAGDWRLNPAKSEFKDKVKAGRVLVEA
DNAGGYRELYEIIFETAAPLRLTARSQFDGPPEETSLDGQDVRYTSTRIDANAFEITYRDRGTERVSRTMRFTAEPRDRM
LTVLTTGSKAVFEKLSEGPLLEAGKSVEQTFGAGAVYEYRIRLKAGEYCAGRIEPKEGGVNGAFYGPDGERLYNLGGPAA
ENRPFGLEAPVAGIYKLALRSATPAAKSFTLKVDSIVPAEKRVPAAPANAPKEKFPSPRIAALRKAVEAGNREAVAAFWR
AIEREGAPIFERPEGNDHDTLVTFLWRGTPATRNVMILWYPYAPAKPADYQMVNIAGTDVWYRTRAIRRGARFAYQLSPN
DPLEFNQDSGIQRALTAQADPLNPRKWRNGPFNTKFEYQSALEMPDARPQPYSTKRAGVPEGKVEKSRIQSALLKNEHAL
SIYTPPGYRKDGPPNGLLVVFDESAYLILVPTPVILDNLLSEKKIAPMVAVLIANPNQETRTRELPPNPAFAEFLNNELI
PWVRQHYNVTTDPAKVVVAGSSFGGIASVYAGLRHPETFGNILCQSGSFWWSAAKPEPYTEPNFLAKEFLKSSKLPLRFY
MDAGSFEVDIEGEGGAILEPSRHMRDVLLAKGYEVHYQENVGGHDYLSWRGSLADGLLALVGLSK

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=382, Percent_Identity=30.3664921465969, Blast_Score=129, Evalue=8e-31,
Organism=Escherichia coli, GI145693201, Length=180, Percent_Identity=29.4444444444444, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 77952; Mature: 77952

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFGNVCGNANTEKWRTGYFVGLVYSTNRRIGMRLAVVLVGIFAANSGWAADPLAGDWRL
CCCCCCCCCCCCCCEECEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NPAKSEFKDKVKAGRVLVEADNAGGYRELYEIIFETAAPLRLTARSQFDGPPEETSLDGQ
CCCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC
DVRYTSTRIDANAFEITYRDRGTERVSRTMRFTAEPRDRMLTVLTTGSKAVFEKLSEGPL
CEEEEEEEECCCEEEEEECCCCHHHHHHHHEECCCCCCCEEEEEECCCHHHHHHHCCCCC
LEAGKSVEQTFGAGAVYEYRIRLKAGEYCAGRIEPKEGGVNGAFYGPDGERLYNLGGPAA
HHCCCHHHHHCCCCCEEEEEEEEECCCEECCCCCCCCCCCCCEEECCCCCEEEECCCCCC
ENRPFGLEAPVAGIYKLALRSATPAAKSFTLKVDSIVPAEKRVPAAPANAPKEKFPSPRI
CCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHCCCCCCCCCCHHHCCCHHH
AALRKAVEAGNREAVAAFWRAIEREGAPIFERPEGNDHDTLVTFLWRGTPATRNVMILWY
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEECCCCCCCEEEEEEE
PYAPAKPADYQMVNIAGTDVWYRTRAIRRGARFAYQLSPNDPLEFNQDSGIQRALTAQAD
CCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCC
PLNPRKWRNGPFNTKFEYQSALEMPDARPQPYSTKRAGVPEGKVEKSRIQSALLKNEHAL
CCCCHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
SIYTPPGYRKDGPPNGLLVVFDESAYLILVPTPVILDNLLSEKKIAPMVAVLIANPNQET
EEECCCCCCCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEECCCCCC
RTRELPPNPAFAEFLNNELIPWVRQHYNVTTDPAKVVVAGSSFGGIASVYAGLRHPETFG
CCCCCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHCCCCHHHH
NILCQSGSFWWSAAKPEPYTEPNFLAKEFLKSSKLPLRFYMDAGSFEVDIEGEGGAILEP
HHEECCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCEEECC
SRHMRDVLLAKGYEVHYQENVGGHDYLSWRGSLADGLLALVGLSK
HHHHHHHHHHCCEEEEEECCCCCCCEEEECCCHHHHHHHHHCCCC
>Mature Secondary Structure
MRFGNVCGNANTEKWRTGYFVGLVYSTNRRIGMRLAVVLVGIFAANSGWAADPLAGDWRL
CCCCCCCCCCCCCCEECEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NPAKSEFKDKVKAGRVLVEADNAGGYRELYEIIFETAAPLRLTARSQFDGPPEETSLDGQ
CCCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC
DVRYTSTRIDANAFEITYRDRGTERVSRTMRFTAEPRDRMLTVLTTGSKAVFEKLSEGPL
CEEEEEEEECCCEEEEEECCCCHHHHHHHHEECCCCCCCEEEEEECCCHHHHHHHCCCCC
LEAGKSVEQTFGAGAVYEYRIRLKAGEYCAGRIEPKEGGVNGAFYGPDGERLYNLGGPAA
HHCCCHHHHHCCCCCEEEEEEEEECCCEECCCCCCCCCCCCCEEECCCCCEEEECCCCCC
ENRPFGLEAPVAGIYKLALRSATPAAKSFTLKVDSIVPAEKRVPAAPANAPKEKFPSPRI
CCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHCCCCCCCCCCHHHCCCHHH
AALRKAVEAGNREAVAAFWRAIEREGAPIFERPEGNDHDTLVTFLWRGTPATRNVMILWY
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEECCCCCCCEEEEEEE
PYAPAKPADYQMVNIAGTDVWYRTRAIRRGARFAYQLSPNDPLEFNQDSGIQRALTAQAD
CCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCC
PLNPRKWRNGPFNTKFEYQSALEMPDARPQPYSTKRAGVPEGKVEKSRIQSALLKNEHAL
CCCCHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
SIYTPPGYRKDGPPNGLLVVFDESAYLILVPTPVILDNLLSEKKIAPMVAVLIANPNQET
EEECCCCCCCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEECCCCCC
RTRELPPNPAFAEFLNNELIPWVRQHYNVTTDPAKVVVAGSSFGGIASVYAGLRHPETFG
CCCCCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHCCCCHHHH
NILCQSGSFWWSAAKPEPYTEPNFLAKEFLKSSKLPLRFYMDAGSFEVDIEGEGGAILEP
HHEECCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCEEECC
SRHMRDVLLAKGYEVHYQENVGGHDYLSWRGSLADGLLALVGLSK
HHHHHHHHHHCCEEEEEECCCCCCCEEEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA