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The map label for this gene is glmS [H]

Identifier: 116620718

GI number: 116620718

Start: 1963037

End: 1964080

Strand: Reverse

Name: glmS [H]

Synonym: Acid_1598

Alternate gene names: 116620718

Gene position: 1964080-1963037 (Counterclockwise)

Preceding gene: 116620720

Following gene: 116620713

Centisome position: 19.71

GC content: 63.98

Gene sequence:

>1044_bases
ATGTCCCGAATGCTCGAAGAAATCCGGCAGCAGCCGGAGGCGCTGGAGCGGACGCTATCCGCCGAGTTAAAGCGCGTGGA
GAAGTTCAAGCGCCTGGTGGAGAAGCGACGCCCGCGCATGGTGGTGCTGGTGGCCCGTGGCACCAGCGACAACGCCGCGC
TGTTCGGCCGCTACCTGCTCGAAATCACCACCGGGATTCCGGTCTCGCTGGCCGCGCCCTCCATCGCCACCCTATACCAG
GCCAAGGTGGATTATCGCGATGCGCTGGTGGTGGCCATCTCCCAATCGGGCGAATCCACCGACACCAATCTCGTGCTGGA
GCGTGCACGGGAACAGGGTGCGCTCACGCTCGGCATCACCAACGAGAGCGGCAGCACGCTGGCCAACCTGGCTGAGCATG
TCATCCTGGTGCGCGCGGGCCGCGAGAAAAGCGTCGCCGCCACCAAGACCTACACCGGGCAGATGCTCGCCATGTACCTG
TTGGCCTACGCACTGGGCGGCCGCGCCGTGCGCACAGAGGACTTGGAGCGCATTCCCGAGCTCGTCAATGCAGCTCTCAC
CCTGGAACCGGAAATCGACGCGCTCAGCGAACGCTACCGCTTCATGCGCCACGCAGTCGTCGTCGGCCGCGGCTTGAACT
ACGCCAACGCGTTCGAAATGGCACTCAAACTGATGGAGACCTGCTACGTTGTGGCCGAGCGCTTCTCATCGGCCGATTTT
CTGCACGGCCCCATCGCGCTGGTGGAACAGAGCTTCCCGGTCTTCGCCTTCGCCCCGCCCGGAGTGACGTGGCCTTCCAT
TGGCGAGACCATTGTCAAACTCAAAGGGCTGCAGGCCGAAATCGTCGCCATCACCGATTCCGGAAATCGCGAGGTCGAAA
CTACGGCAACCAGGCTCATCCGCCTGCCGCGCCGCGTTAAGGAAATCCTGACGCCGATTCCGTATGTGGTCCCGGCGCAG
ATCTTCGCCGCCTGCCTTGCCGCGCAAAAGGGCCTCGACCCCGACAAGCCCCGCACCCTCACCAAGGTGACCCTGACCCT
GTAA

Upstream 100 bases:

>100_bases
GTATTCTGAGCGCGGCAAAGAGCCGCAAGAACCAGGGCCAGAAGAAAGCGTGACATGGCTTAGATCATACTCCCGCCAGT
GGGCTGCTATCGTGGAAGCG

Downstream 100 bases:

>100_bases
TCGTGAAAGCCAGCCTGGCGCTATTTGCCCTGGCGCGGCGAGTACTTATTTAATCCCGCGATCAACTTCGATGCCGCCTG
CGGCATGGTTGCTCCGCTGC

Product: glutamine--fructose-6-phosphate transaminase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSRMLEEIRQQPEALERTLSAELKRVEKFKRLVEKRRPRMVVLVARGTSDNAALFGRYLLEITTGIPVSLAAPSIATLYQ
AKVDYRDALVVAISQSGESTDTNLVLERAREQGALTLGITNESGSTLANLAEHVILVRAGREKSVAATKTYTGQMLAMYL
LAYALGGRAVRTEDLERIPELVNAALTLEPEIDALSERYRFMRHAVVVGRGLNYANAFEMALKLMETCYVVAERFSSADF
LHGPIALVEQSFPVFAFAPPGVTWPSIGETIVKLKGLQAEIVAITDSGNREVETTATRLIRLPRRVKEILTPIPYVVPAQ
IFAACLAAQKGLDPDKPRTLTKVTLTL

Sequences:

>Translated_347_residues
MSRMLEEIRQQPEALERTLSAELKRVEKFKRLVEKRRPRMVVLVARGTSDNAALFGRYLLEITTGIPVSLAAPSIATLYQ
AKVDYRDALVVAISQSGESTDTNLVLERAREQGALTLGITNESGSTLANLAEHVILVRAGREKSVAATKTYTGQMLAMYL
LAYALGGRAVRTEDLERIPELVNAALTLEPEIDALSERYRFMRHAVVVGRGLNYANAFEMALKLMETCYVVAERFSSADF
LHGPIALVEQSFPVFAFAPPGVTWPSIGETIVKLKGLQAEIVAITDSGNREVETTATRLIRLPRRVKEILTPIPYVVPAQ
IFAACLAAQKGLDPDKPRTLTKVTLTL
>Mature_346_residues
SRMLEEIRQQPEALERTLSAELKRVEKFKRLVEKRRPRMVVLVARGTSDNAALFGRYLLEITTGIPVSLAAPSIATLYQA
KVDYRDALVVAISQSGESTDTNLVLERAREQGALTLGITNESGSTLANLAEHVILVRAGREKSVAATKTYTGQMLAMYLL
AYALGGRAVRTEDLERIPELVNAALTLEPEIDALSERYRFMRHAVVVGRGLNYANAFEMALKLMETCYVVAERFSSADFL
HGPIALVEQSFPVFAFAPPGVTWPSIGETIVKLKGLQAEIVAITDSGNREVETTATRLIRLPRRVKEILTPIPYVVPAQI
FAACLAAQKGLDPDKPRTLTKVTLTL

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=357, Percent_Identity=30.812324929972, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI4826742, Length=354, Percent_Identity=30.5084745762712, Blast_Score=158, Evalue=8e-39,
Organism=Escherichia coli, GI1790167, Length=358, Percent_Identity=32.4022346368715, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17532899, Length=356, Percent_Identity=28.6516853932584, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17532897, Length=356, Percent_Identity=28.6516853932584, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17539970, Length=356, Percent_Identity=28.3707865168539, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322745, Length=361, Percent_Identity=31.5789473684211, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323731, Length=359, Percent_Identity=25.9052924791086, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357745, Length=354, Percent_Identity=29.6610169491525, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 38196; Mature: 38065

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRMLEEIRQQPEALERTLSAELKRVEKFKRLVEKRRPRMVVLVARGTSDNAALFGRYLL
CHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHH
EITTGIPVSLAAPSIATLYQAKVDYRDALVVAISQSGESTDTNLVLERAREQGALTLGIT
HHHCCCCEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEE
NESGSTLANLAEHVILVRAGREKSVAATKTYTGQMLAMYLLAYALGGRAVRTEDLERIPE
CCCCCHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LVNAALTLEPEIDALSERYRFMRHAVVVGRGLNYANAFEMALKLMETCYVVAERFSSADF
HHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
LHGPIALVEQSFPVFAFAPPGVTWPSIGETIVKLKGLQAEIVAITDSGNREVETTATRLI
CCCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHH
RLPRRVKEILTPIPYVVPAQIFAACLAAQKGLDPDKPRTLTKVTLTL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEC
>Mature Secondary Structure 
SRMLEEIRQQPEALERTLSAELKRVEKFKRLVEKRRPRMVVLVARGTSDNAALFGRYLL
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHH
EITTGIPVSLAAPSIATLYQAKVDYRDALVVAISQSGESTDTNLVLERAREQGALTLGIT
HHHCCCCEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEE
NESGSTLANLAEHVILVRAGREKSVAATKTYTGQMLAMYLLAYALGGRAVRTEDLERIPE
CCCCCHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LVNAALTLEPEIDALSERYRFMRHAVVVGRGLNYANAFEMALKLMETCYVVAERFSSADF
HHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
LHGPIALVEQSFPVFAFAPPGVTWPSIGETIVKLKGLQAEIVAITDSGNREVETTATRLI
CCCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHH
RLPRRVKEILTPIPYVVPAQIFAACLAAQKGLDPDKPRTLTKVTLTL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]