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The map label for this gene is selB [H]

Identifier: 116620611

GI number: 116620611

Start: 1826806

End: 1828665

Strand: Reverse

Name: selB [H]

Synonym: Acid_1490

Alternate gene names: 116620611

Gene position: 1828665-1826806 (Counterclockwise)

Preceding gene: 116620615

Following gene: 116620597

Centisome position: 18.35

GC content: 66.67

Gene sequence:

>1860_bases
GTGAAGCACATCATCGTCGGCACCGCCGGACACATCGACCACGGCAAAACCGCGCTCGTCAAAGCCCTCACCGGTATCGA
CGCCGACCGCCTCGAGGAAGAGAAGCGCCGCGGCATCACCATCGATCTCGGCTTTGCCCACCTCGATCTCACGCCCGCCC
TTCGTCTCGGCTTCGTCGACGTTCCCGGCCACGAGCGCTTCGTCAAGAACATGCTCGCCGGCGTCGGCGGCATCGATCTC
GTCCTCTTCGTCATCGCCGCCGACGAATCCATCAAGCCCCAGACTCGCGAGCACTTCGACATCTGCCGCCTCCTCGGCAT
CCCTCGCGGCATCGTCGCGCTCACCAAGAGCGACCTCGTCGATGCCGATATCCTCGGCCTCGTCCGCATGGAGGTCGAAG
AGCTGGTCGCCGGATCCTTCCTCGAATCCGCCCCCATCGTCCCCGTCAGTTCCACCACCGGTGCCGGCCTCGACGATCTC
CGCCGCGAGCTCGCCCGCGTCGCCGCCGCCGTCCCCGAAAAGAACGCCTCCGGGCACTTCCGGCTCCCCATCGATCGCGT
TTTCACCGTTAAGGGCTTCGGCACCGTGGTCACCGGGACCCTCGTCTCAGGCTCGGTCGCGAAGGATTCCGAGGTCGAAC
TCTTCCCCGCCGGACGCCGCCTCCGCGTTCGCGGCATACAGGTCCACGGCGCTAAATCCGAGCGCGCCGTCGCCGGCCAA
CGCACCGCCCTCAATCTCGCTGACATCGAACCCGCCGAACTACAGCGCGGCTACGTCCTCAGTGACCCGAACCGCTTCCG
CGGGAGCTACCAGATCGATTGCCGCCTGAACCTGCTCCCCTCCGCGAAGCCTCTGAAGCACCGCGCCCCTGTTCACTTCC
ACGCCGGCACCGCCGAAATCGAGGCCCAGGTCCGCCTCCTCGAAGGCACCGCCGCCCTGCGCCCCGGCGCCTCCGCCTAC
GCGCGCATCATACTCCGCGACGGCACGCTACTTCTCCCAGGCGACCGCTTCATCATTCGCATGTTCTCACCGGTGATCAC
GATCGGCGGCGGCATCGTGATCGATACTGCCGGGCGCCGCTACCGCAAGTCCGACAATGTCAAGGCTCGCCTTGACACGC
TCTCTGGCGATGACCCCGCCGCGCGCATCGCCCTTCTCGTCCGCGAAGCCGAATTCGGCATGGATCTTATCCAACTTATC
GCCCGTACCGGCATGAGCGAGCCCGCGATCGTCGGCGCTGCGGCCAAGGCGCCCGTCGTCGCCATCGGCCAGCCGCGCTC
CTGGTACGTCGATCGCGCCTGGATGCAGTCCGCCCGCGAGCGCATTGTCCGCACCGTCCGCGAGTTTCACCAGAACCACC
CGCTCCTGCCCGGCATCGCCCGTCAGGAGCTGCGCGCCGGAGCTCCGCCCTGGGTGCTGGACGCCCTTCTCGCCGATTCC
AAAGAGGTGGTCGCCGATGCCGAGATCGTGCGCTCCCGCAGCCACAAACTCGTGCTCAAAGAGGACGAAGCGCAAGCCCG
CGCAAAAATCGAGAGCGCCTTCCAGGAGGCCGGACTGGCCGTCCCCGCCCTTCCGGAGGTACTCGCAAAATCCGGTGTGG
AGCCCGCCCGCGCCCGCTCGCTGCTCCAGATCCTGCTCCGCGAAAAGGTTCTGGTGCGTGTCAGCGAAGACCTCGTCTTC
CACGCGTCCGCGATCGATCAGCTGCGCACCCTGCTCGCTGCTCACAAAGGCGAACGCTTCGCCGTCCCCGCCTTCAAAGA
ATGGACCGGCATCTCTCGCAAGTACGCCATCCCCCTCCTCGAATTCCTCGACCGCGAAAAGGTAACCCGCCGCGACGCCG
ACCACCGCGTGATCCTCTAG

Upstream 100 bases:

>100_bases
TTATCGTGAGAACGCAGTAGACCAGCGAGCCCGTGACCAGGGCCAGCAGCAGCCAGGCAAGCACACTCCTAATCTAACCC
ACGCACCCTACAATGAATCT

Downstream 100 bases:

>100_bases
CCGGCTTTATTCCCCGCCGAGCTGTGTATTGGTCTGCTCGCAGCCCGCGACTTCCCCGAGCCAACGAGCCACCACCGTAA
GGGAGCGCAACGTGCCCTCG

Product: selenocysteine-specific translation elongation factor SelB

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MKHIIVGTAGHIDHGKTALVKALTGIDADRLEEEKRRGITIDLGFAHLDLTPALRLGFVDVPGHERFVKNMLAGVGGIDL
VLFVIAADESIKPQTREHFDICRLLGIPRGIVALTKSDLVDADILGLVRMEVEELVAGSFLESAPIVPVSSTTGAGLDDL
RRELARVAAAVPEKNASGHFRLPIDRVFTVKGFGTVVTGTLVSGSVAKDSEVELFPAGRRLRVRGIQVHGAKSERAVAGQ
RTALNLADIEPAELQRGYVLSDPNRFRGSYQIDCRLNLLPSAKPLKHRAPVHFHAGTAEIEAQVRLLEGTAALRPGASAY
ARIILRDGTLLLPGDRFIIRMFSPVITIGGGIVIDTAGRRYRKSDNVKARLDTLSGDDPAARIALLVREAEFGMDLIQLI
ARTGMSEPAIVGAAAKAPVVAIGQPRSWYVDRAWMQSARERIVRTVREFHQNHPLLPGIARQELRAGAPPWVLDALLADS
KEVVADAEIVRSRSHKLVLKEDEAQARAKIESAFQEAGLAVPALPEVLAKSGVEPARARSLLQILLREKVLVRVSEDLVF
HASAIDQLRTLLAAHKGERFAVPAFKEWTGISRKYAIPLLEFLDREKVTRRDADHRVIL

Sequences:

>Translated_619_residues
MKHIIVGTAGHIDHGKTALVKALTGIDADRLEEEKRRGITIDLGFAHLDLTPALRLGFVDVPGHERFVKNMLAGVGGIDL
VLFVIAADESIKPQTREHFDICRLLGIPRGIVALTKSDLVDADILGLVRMEVEELVAGSFLESAPIVPVSSTTGAGLDDL
RRELARVAAAVPEKNASGHFRLPIDRVFTVKGFGTVVTGTLVSGSVAKDSEVELFPAGRRLRVRGIQVHGAKSERAVAGQ
RTALNLADIEPAELQRGYVLSDPNRFRGSYQIDCRLNLLPSAKPLKHRAPVHFHAGTAEIEAQVRLLEGTAALRPGASAY
ARIILRDGTLLLPGDRFIIRMFSPVITIGGGIVIDTAGRRYRKSDNVKARLDTLSGDDPAARIALLVREAEFGMDLIQLI
ARTGMSEPAIVGAAAKAPVVAIGQPRSWYVDRAWMQSARERIVRTVREFHQNHPLLPGIARQELRAGAPPWVLDALLADS
KEVVADAEIVRSRSHKLVLKEDEAQARAKIESAFQEAGLAVPALPEVLAKSGVEPARARSLLQILLREKVLVRVSEDLVF
HASAIDQLRTLLAAHKGERFAVPAFKEWTGISRKYAIPLLEFLDREKVTRRDADHRVIL
>Mature_619_residues
MKHIIVGTAGHIDHGKTALVKALTGIDADRLEEEKRRGITIDLGFAHLDLTPALRLGFVDVPGHERFVKNMLAGVGGIDL
VLFVIAADESIKPQTREHFDICRLLGIPRGIVALTKSDLVDADILGLVRMEVEELVAGSFLESAPIVPVSSTTGAGLDDL
RRELARVAAAVPEKNASGHFRLPIDRVFTVKGFGTVVTGTLVSGSVAKDSEVELFPAGRRLRVRGIQVHGAKSERAVAGQ
RTALNLADIEPAELQRGYVLSDPNRFRGSYQIDCRLNLLPSAKPLKHRAPVHFHAGTAEIEAQVRLLEGTAALRPGASAY
ARIILRDGTLLLPGDRFIIRMFSPVITIGGGIVIDTAGRRYRKSDNVKARLDTLSGDDPAARIALLVREAEFGMDLIQLI
ARTGMSEPAIVGAAAKAPVVAIGQPRSWYVDRAWMQSARERIVRTVREFHQNHPLLPGIARQELRAGAPPWVLDALLADS
KEVVADAEIVRSRSHKLVLKEDEAQARAKIESAFQEAGLAVPALPEVLAKSGVEPARARSLLQILLREKVLVRVSEDLVF
HASAIDQLRTLLAAHKGERFAVPAFKEWTGISRKYAIPLLEFLDREKVTRRDADHRVIL

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=388, Percent_Identity=32.4742268041237, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI54607086, Length=342, Percent_Identity=27.7777777777778, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI194018520, Length=357, Percent_Identity=26.0504201680672, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI194097354, Length=357, Percent_Identity=26.0504201680672, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI194018522, Length=357, Percent_Identity=26.0504201680672, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI4503475, Length=325, Percent_Identity=24.3076923076923, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI223555963, Length=309, Percent_Identity=24.2718446601942, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI46094014, Length=359, Percent_Identity=26.4623955431755, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI5729864, Length=309, Percent_Identity=24.2718446601942, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI4503471, Length=325, Percent_Identity=23.6923076923077, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI53729339, Length=209, Percent_Identity=30.1435406698565, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI53729337, Length=209, Percent_Identity=30.1435406698565, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI45593140, Length=334, Percent_Identity=25.4491017964072, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367247, Length=643, Percent_Identity=32.348367029549, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1790412, Length=382, Percent_Identity=29.8429319371728, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789737, Length=387, Percent_Identity=29.7157622739018, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1789108, Length=256, Percent_Identity=29.296875, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25141371, Length=378, Percent_Identity=29.8941798941799, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17556456, Length=394, Percent_Identity=27.9187817258883, Blast_Score=128, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17552884, Length=324, Percent_Identity=25.9259259259259, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17569207, Length=324, Percent_Identity=25.9259259259259, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506081, Length=256, Percent_Identity=29.296875, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI115532067, Length=343, Percent_Identity=27.6967930029155, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI115532065, Length=343, Percent_Identity=27.6967930029155, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI32566303, Length=310, Percent_Identity=23.5483870967742, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565438, Length=313, Percent_Identity=25.2396166134185, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994658, Length=209, Percent_Identity=30.622009569378, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324761, Length=392, Percent_Identity=30.1020408163265, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6325337, Length=321, Percent_Identity=27.4143302180685, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319594, Length=321, Percent_Identity=27.4143302180685, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320863, Length=259, Percent_Identity=25.8687258687259, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19921738, Length=383, Percent_Identity=30.0261096605744, Blast_Score=167, Evalue=3e-41,
Organism=Drosophila melanogaster, GI281363316, Length=388, Percent_Identity=29.639175257732, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI17864358, Length=388, Percent_Identity=29.639175257732, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI19922690, Length=323, Percent_Identity=31.5789473684211, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24647046, Length=259, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24647048, Length=259, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45553807, Length=324, Percent_Identity=24.6913580246914, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45553816, Length=324, Percent_Identity=24.6913580246914, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24651721, Length=324, Percent_Identity=24.6913580246914, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI17864154, Length=324, Percent_Identity=24.6913580246914, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45550900, Length=319, Percent_Identity=23.1974921630094, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28572034, Length=158, Percent_Identity=32.9113924050633, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 67528; Mature: 67528

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHIIVGTAGHIDHGKTALVKALTGIDADRLEEEKRRGITIDLGFAHLDLTPALRLGFVD
CCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCEEEEEEEEEECCCHHHHEEEEE
VPGHERFVKNMLAGVGGIDLVLFVIAADESIKPQTREHFDICRLLGIPRGIVALTKSDLV
CCCHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCC
DADILGLVRMEVEELVAGSFLESAPIVPVSSTTGAGLDDLRRELARVAAAVPEKNASGHF
CHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEE
RLPIDRVFTVKGFGTVVTGTLVSGSVAKDSEVELFPAGRRLRVRGIQVHGAKSERAVAGQ
ECCHHHEEEEECCCCEEEEHEEECCCCCCCCEEEECCCCEEEEEEEEEECCCCCHHHCCC
RTALNLADIEPAELQRGYVLSDPNRFRGSYQIDCRLNLLPSAKPLKHRAPVHFHAGTAEI
CCEEEECCCCHHHHCCCEEECCCHHCCCCEEEEEEEEECCCCCCCCCCCCEEEECCCCEE
EAQVRLLEGTAALRPGASAYARIILRDGTLLLPGDRFIIRMFSPVITIGGGIVIDTAGRR
EEEEEEEECCCCCCCCHHHEEEEEEECCCEEECCCHHHHHHHHHHHEECCCEEEECCCCC
YRKSDNVKARLDTLSGDDPAARIALLVREAEFGMDLIQLIARTGMSEPAIVGAAAKAPVV
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEECCCCCCEE
AIGQPRSWYVDRAWMQSARERIVRTVREFHQNHPLLPGIARQELRAGAPPWVLDALLADS
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHCCC
KEVVADAEIVRSRSHKLVLKEDEAQARAKIESAFQEAGLAVPALPEVLAKSGVEPARARS
HHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHH
LLQILLREKVLVRVSEDLVFHASAIDQLRTLLAAHKGERFAVPAFKEWTGISRKYAIPLL
HHHHHHHHHHHEEEHHHHEEHHHHHHHHHHHHHHCCCCEEECCCHHHHCCCCHHHHHHHH
EFLDREKVTRRDADHRVIL
HHHCHHHHHHCCCCCEECC
>Mature Secondary Structure
MKHIIVGTAGHIDHGKTALVKALTGIDADRLEEEKRRGITIDLGFAHLDLTPALRLGFVD
CCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCEEEEEEEEEECCCHHHHEEEEE
VPGHERFVKNMLAGVGGIDLVLFVIAADESIKPQTREHFDICRLLGIPRGIVALTKSDLV
CCCHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCC
DADILGLVRMEVEELVAGSFLESAPIVPVSSTTGAGLDDLRRELARVAAAVPEKNASGHF
CHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEE
RLPIDRVFTVKGFGTVVTGTLVSGSVAKDSEVELFPAGRRLRVRGIQVHGAKSERAVAGQ
ECCHHHEEEEECCCCEEEEHEEECCCCCCCCEEEECCCCEEEEEEEEEECCCCCHHHCCC
RTALNLADIEPAELQRGYVLSDPNRFRGSYQIDCRLNLLPSAKPLKHRAPVHFHAGTAEI
CCEEEECCCCHHHHCCCEEECCCHHCCCCEEEEEEEEECCCCCCCCCCCCEEEECCCCEE
EAQVRLLEGTAALRPGASAYARIILRDGTLLLPGDRFIIRMFSPVITIGGGIVIDTAGRR
EEEEEEEECCCCCCCCHHHEEEEEEECCCEEECCCHHHHHHHHHHHEECCCEEEECCCCC
YRKSDNVKARLDTLSGDDPAARIALLVREAEFGMDLIQLIARTGMSEPAIVGAAAKAPVV
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEECCCCCCEE
AIGQPRSWYVDRAWMQSARERIVRTVREFHQNHPLLPGIARQELRAGAPPWVLDALLADS
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHCCC
KEVVADAEIVRSRSHKLVLKEDEAQARAKIESAFQEAGLAVPALPEVLAKSGVEPARARS
HHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHH
LLQILLREKVLVRVSEDLVFHASAIDQLRTLLAAHKGERFAVPAFKEWTGISRKYAIPLL
HHHHHHHHHHHEEEHHHHEEHHHHHHHHHHHHHHCCCCEEECCCHHHHCCCCHHHHHHHH
EFLDREKVTRRDADHRVIL
HHHCHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8893853 [H]