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The map label for this gene is patA [H]

Identifier: 116620479

GI number: 116620479

Start: 1672621

End: 1674000

Strand: Reverse

Name: patA [H]

Synonym: Acid_1357

Alternate gene names: 116620479

Gene position: 1674000-1672621 (Counterclockwise)

Preceding gene: 116620480

Following gene: 116620478

Centisome position: 16.8

GC content: 62.03

Gene sequence:

>1380_bases
ATGCAGGCTCCCAAATCCTCCCTAATGGCAACCACTGTACCCTCGCTTGACCGCCTTTATTCCGACCACGTCAACCCGCA
GTGGGTCAGGCTTCTCGACCTGCTGCAGATGAATGTGCAGTACGAGCGTTGCTCTGGCAGCGAATTGTTCACCACCGAAG
GTCGTCGGATTCTCGACTTTCTCTCCGGCTATTGCGTCCACAATGCCGGCCACAATCATCCTGCGATCGTCGCCGCCCTC
AAGGACGAGTTGGATCGCTCCGGGCCCGCCATGCTGCAAAGCCACGTCCCCCAGTTGGCCGCCGAATTGGCGCAGCGCCT
CTTACAGCGCGCCGGAGGGAACCTGCAGCGCGTCTATTTCACCAATTCCGGCAGCGAGGGCGTCGAAACGGCCATCAAAT
TCGCCCGCGCCCACACCGGCCGCACTGGTCTCCTCTATGCCGCCGGTGGATTTCATGGACTCACCTGTGGCGCGCTGTCA
CTGATGAGCGACCCTTTCTGGAGCGATGGCTTCGGGCCCATGCTGCCCGGCACCCAATCCGTGCACTTCGGCGATATCGC
CGCGCTCGAGTCCCATCTGGCCACGCGAAAGTTCGCCGCGTACATCCTCGAGCCCGTGCAGTCTGAAGGCGGCATTCAGG
TACCCGACGCTTCTTACCTGCACGCGGCGCAGGAACTCTGCCGCCGCTACGGCACCCTGCTCGTGCTCGATGAAGTGCAG
ACCGGCATGTACCGCACCGGCTCCTTTCTGGCCGCGCATCGCTTTCAGGTCGAGCCCGACATGGTGATTCTGGCCAAGGC
GCTCTCCGGCGGCCTGATCCCCGTGGGTGCCGTGCTCATGACCGAGGCCGTCTCCAATTCTGTATTCAGTTCCCTGAAAC
GCGCCTTTGTCCACGCCTCCACCTTTGGCGAGAACGCCCTCGCCATGCGTGCCGGACTCGCCACCCTCGATGTGCTGGAA
CACGATGACCTCGGCGAACGCAGCGCCGCAACCGGTGCGCGCCTCCGCTTGCATCTCGCCGAGGCTCTGGCGCCTTATGA
AATGGTCGGTGCCATCCGCGGACTCGGAATGCTCAATGGCATCCAGTTCACCGCCCCCCGGCAGTTGCGCCTGCGCGTTG
CTTTCGAAGGCTTCCAGCGCATTCATCCCGCGATGTTCGGGCAGGTCGTAGTAATGCGACTCTTCCGCGATAAGGGCATC
CTCACACAGATCTGCGGCAACAATTTCATGGTGCTCAAAGTCGCACCGCCCCTGGTGGCCACCGACGTGCAACTCGAGGA
ATTCGTGGATTGCGTCCGCGATGTAGTCCATCTGATTCACAATTCGGGCGCTTTCTGGACAGACGCTTTGGGTCTGGCGC
GCCGGGCGGTAGGTATTTAA

Upstream 100 bases:

>100_bases
ACACCTAACCTTCTTCGTCCCCTAACTCCAGTCATTCCAATACTTGCCCCGGTTCGTGCGGAACCTCGCGAAACGGCAGC
GGGATTGCACCCGTCTCTGT

Downstream 100 bases:

>100_bases
TTCGAATGAATATACGTAACCTGGTCCCTTTCGCTCTCCTCGGCGTCCTCCCCGCTGTAGCCGCGCCCACGGTCGATCTG
CTCGACCGTGGCTACCGCGA

Product: aminotransferase

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MQAPKSSLMATTVPSLDRLYSDHVNPQWVRLLDLLQMNVQYERCSGSELFTTEGRRILDFLSGYCVHNAGHNHPAIVAAL
KDELDRSGPAMLQSHVPQLAAELAQRLLQRAGGNLQRVYFTNSGSEGVETAIKFARAHTGRTGLLYAAGGFHGLTCGALS
LMSDPFWSDGFGPMLPGTQSVHFGDIAALESHLATRKFAAYILEPVQSEGGIQVPDASYLHAAQELCRRYGTLLVLDEVQ
TGMYRTGSFLAAHRFQVEPDMVILAKALSGGLIPVGAVLMTEAVSNSVFSSLKRAFVHASTFGENALAMRAGLATLDVLE
HDDLGERSAATGARLRLHLAEALAPYEMVGAIRGLGMLNGIQFTAPRQLRLRVAFEGFQRIHPAMFGQVVVMRLFRDKGI
LTQICGNNFMVLKVAPPLVATDVQLEEFVDCVRDVVHLIHNSGAFWTDALGLARRAVGI

Sequences:

>Translated_459_residues
MQAPKSSLMATTVPSLDRLYSDHVNPQWVRLLDLLQMNVQYERCSGSELFTTEGRRILDFLSGYCVHNAGHNHPAIVAAL
KDELDRSGPAMLQSHVPQLAAELAQRLLQRAGGNLQRVYFTNSGSEGVETAIKFARAHTGRTGLLYAAGGFHGLTCGALS
LMSDPFWSDGFGPMLPGTQSVHFGDIAALESHLATRKFAAYILEPVQSEGGIQVPDASYLHAAQELCRRYGTLLVLDEVQ
TGMYRTGSFLAAHRFQVEPDMVILAKALSGGLIPVGAVLMTEAVSNSVFSSLKRAFVHASTFGENALAMRAGLATLDVLE
HDDLGERSAATGARLRLHLAEALAPYEMVGAIRGLGMLNGIQFTAPRQLRLRVAFEGFQRIHPAMFGQVVVMRLFRDKGI
LTQICGNNFMVLKVAPPLVATDVQLEEFVDCVRDVVHLIHNSGAFWTDALGLARRAVGI
>Mature_459_residues
MQAPKSSLMATTVPSLDRLYSDHVNPQWVRLLDLLQMNVQYERCSGSELFTTEGRRILDFLSGYCVHNAGHNHPAIVAAL
KDELDRSGPAMLQSHVPQLAAELAQRLLQRAGGNLQRVYFTNSGSEGVETAIKFARAHTGRTGLLYAAGGFHGLTCGALS
LMSDPFWSDGFGPMLPGTQSVHFGDIAALESHLATRKFAAYILEPVQSEGGIQVPDASYLHAAQELCRRYGTLLVLDEVQ
TGMYRTGSFLAAHRFQVEPDMVILAKALSGGLIPVGAVLMTEAVSNSVFSSLKRAFVHASTFGENALAMRAGLATLDVLE
HDDLGERSAATGARLRLHLAEALAPYEMVGAIRGLGMLNGIQFTAPRQLRLRVAFEGFQRIHPAMFGQVVVMRLFRDKGI
LTQICGNNFMVLKVAPPLVATDVQLEEFVDCVRDVVHLIHNSGAFWTDALGLARRAVGI

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=35.3658536585366, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI284507298, Length=323, Percent_Identity=35.9133126934984, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI13994255, Length=373, Percent_Identity=28.686327077748, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI37574042, Length=428, Percent_Identity=25.9345794392523, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI226442705, Length=427, Percent_Identity=25.2927400468384, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI226442709, Length=407, Percent_Identity=26.2899262899263, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24119277, Length=408, Percent_Identity=25.2450980392157, Blast_Score=115, Evalue=9e-26,
Organism=Escherichia coli, GI145693181, Length=431, Percent_Identity=33.8747099767981, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI1789016, Length=409, Percent_Identity=28.361858190709, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1787560, Length=412, Percent_Identity=30.0970873786408, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789759, Length=391, Percent_Identity=30.1790281329923, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1786991, Length=376, Percent_Identity=31.9148936170213, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788044, Length=343, Percent_Identity=31.7784256559767, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786349, Length=345, Percent_Identity=27.8260869565217, Blast_Score=105, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=409, Percent_Identity=28.6063569682152, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25144274, Length=293, Percent_Identity=31.0580204778157, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=28.3372365339578, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71992977, Length=432, Percent_Identity=26.6203703703704, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323470, Length=426, Percent_Identity=31.924882629108, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324432, Length=403, Percent_Identity=26.0545905707196, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6324386, Length=436, Percent_Identity=24.5412844036697, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357415, Length=399, Percent_Identity=33.3333333333333, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI28574759, Length=417, Percent_Identity=29.2565947242206, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI161085790, Length=423, Percent_Identity=29.5508274231678, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21356575, Length=416, Percent_Identity=27.1634615384615, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 49864; Mature: 49864

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAPKSSLMATTVPSLDRLYSDHVNPQWVRLLDLLQMNVQYERCSGSELFTTEGRRILDF
CCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCCEECCCCHHHHHH
LSGYCVHNAGHNHPAIVAALKDELDRSGPAMLQSHVPQLAAELAQRLLQRAGGNLQRVYF
HHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
TNSGSEGVETAIKFARAHTGRTGLLYAAGGFHGLTCGALSLMSDPFWSDGFGPMLPGTQS
ECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
VHFGDIAALESHLATRKFAAYILEPVQSEGGIQVPDASYLHAAQELCRRYGTLLVLDEVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHCCEEEEECHH
TGMYRTGSFLAAHRFQVEPDMVILAKALSGGLIPVGAVLMTEAVSNSVFSSLKRAFVHAS
CCHHHCCCHHHHHEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFGENALAMRAGLATLDVLEHDDLGERSAATGARLRLHLAEALAPYEMVGAIRGLGMLNG
HCCCCHHHHHHCCHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCC
IQFTAPRQLRLRVAFEGFQRIHPAMFGQVVVMRLFRDKGILTQICGNNFMVLKVAPPLVA
CEECCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCEE
TDVQLEEFVDCVRDVVHLIHNSGAFWTDALGLARRAVGI
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQAPKSSLMATTVPSLDRLYSDHVNPQWVRLLDLLQMNVQYERCSGSELFTTEGRRILDF
CCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCCEECCCCHHHHHH
LSGYCVHNAGHNHPAIVAALKDELDRSGPAMLQSHVPQLAAELAQRLLQRAGGNLQRVYF
HHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
TNSGSEGVETAIKFARAHTGRTGLLYAAGGFHGLTCGALSLMSDPFWSDGFGPMLPGTQS
ECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
VHFGDIAALESHLATRKFAAYILEPVQSEGGIQVPDASYLHAAQELCRRYGTLLVLDEVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHCCEEEEECHH
TGMYRTGSFLAAHRFQVEPDMVILAKALSGGLIPVGAVLMTEAVSNSVFSSLKRAFVHAS
CCHHHCCCHHHHHEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFGENALAMRAGLATLDVLEHDDLGERSAATGARLRLHLAEALAPYEMVGAIRGLGMLNG
HCCCCHHHHHHCCHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCC
IQFTAPRQLRLRVAFEGFQRIHPAMFGQVVVMRLFRDKGILTQICGNNFMVLKVAPPLVA
CEECCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCEE
TDVQLEEFVDCVRDVVHLIHNSGAFWTDALGLARRAVGI
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA