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The map label for this gene is exbB [H]

Identifier: 116620404

GI number: 116620404

Start: 1579791

End: 1580525

Strand: Direct

Name: exbB [H]

Synonym: Acid_1281

Alternate gene names: 116620404

Gene position: 1579791-1580525 (Clockwise)

Preceding gene: 116620403

Following gene: 116620405

Centisome position: 15.85

GC content: 60.27

Gene sequence:

>735_bases
ATGCTTTTGCAATTGCAAGTGTGGTCGCTGTATTTGCTTCAGGAAGGCAGCACCGTTAGTTGGGATCCAGCATCCCTTTG
GAAGCAGATGGGCCCCCTGGCGAAGGCAGTCGTCGTCGGCCTGTTCATTATGTCCGCGTACTCCATCGGCGTCATGATCG
ATCGCCTGATGGCGTACAGCGCAGCCCGCAAGCAGTCGCGGCAGTTTGCTCCGGCGGTTGCCGGCGCGCTGCGCGAAGGC
AAGCTGGATGAAGCCGTGAAGATTGCGGATCGCTACAAGAAGAGCCACCTGGCGAAGGTCGTTGTCGCAGGGTTGCAGGA
ATTCCAGGCGCACCAGATCAGCTCGGAGATTCCGGGTGAGGAGATCGAAGCGTCCAAGCGTGCTCTCGAGCGCGCCGAAG
CCATCGTCCACGCGGAACTGAAGCGCGGCGTCAGCGGCCTGGCCACGATCGGTTCGACGGCTCCGTTCGTCGGACTGTTC
GGCACGGTCGTCGGCATCATCAACGCGTTCAAGGGTATTTCGAACGAGAAGTCGACCGGTCTGGGCGCGGTCGCCGGCGG
TATTTCGGAAGCGCTGGTGACCACCGCTATCGGTCTGTTCGTGGCTATTCCCGCCGTCTGGATGTTCAACTATTTCACGG
GGAAGATCGAAAGCTTCGACGTGGAAATGGGGAACTCCAGCAGCGAATTGATCGACTACTTCCTGAAGCGGTCGCAGCGC
GGCGTCCGCAAGTAG

Upstream 100 bases:

>100_bases
GACGTGAACTTCACGTTGAGCCAGTAGTAAAAAAGAAGCCCCGGTACGTTCAACACCGGGCAGATAGCAGAAAAATCAAC
TCGCAGGAGAGAGAAAACCT

Downstream 100 bases:

>100_bases
CTCCAGCGGGTAACCGCTGGTATTTGGGTTCCGGTGAGTTGATTGAGGGGAGTTCCGCGAGGCGCTCCCCTGCTTCTACC
CCGCACCTCTGGAGAGAACG

Product: MotA/TolQ/ExbB proton channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MLLQLQVWSLYLLQEGSTVSWDPASLWKQMGPLAKAVVVGLFIMSAYSIGVMIDRLMAYSAARKQSRQFAPAVAGALREG
KLDEAVKIADRYKKSHLAKVVVAGLQEFQAHQISSEIPGEEIEASKRALERAEAIVHAELKRGVSGLATIGSTAPFVGLF
GTVVGIINAFKGISNEKSTGLGAVAGGISEALVTTAIGLFVAIPAVWMFNYFTGKIESFDVEMGNSSSELIDYFLKRSQR
GVRK

Sequences:

>Translated_244_residues
MLLQLQVWSLYLLQEGSTVSWDPASLWKQMGPLAKAVVVGLFIMSAYSIGVMIDRLMAYSAARKQSRQFAPAVAGALREG
KLDEAVKIADRYKKSHLAKVVVAGLQEFQAHQISSEIPGEEIEASKRALERAEAIVHAELKRGVSGLATIGSTAPFVGLF
GTVVGIINAFKGISNEKSTGLGAVAGGISEALVTTAIGLFVAIPAVWMFNYFTGKIESFDVEMGNSSSELIDYFLKRSQR
GVRK
>Mature_244_residues
MLLQLQVWSLYLLQEGSTVSWDPASLWKQMGPLAKAVVVGLFIMSAYSIGVMIDRLMAYSAARKQSRQFAPAVAGALREG
KLDEAVKIADRYKKSHLAKVVVAGLQEFQAHQISSEIPGEEIEASKRALERAEAIVHAELKRGVSGLATIGSTAPFVGLF
GTVVGIINAFKGISNEKSTGLGAVAGGISEALVTTAIGLFVAIPAVWMFNYFTGKIESFDVEMGNSSSELIDYFLKRSQR
GVRK

Specific function: Involved in the tonB-dependent energy-dependent transport of various receptor-bound substrates. Protects exbD from proteolytic degradation and functionally stabilizes tonB [H]

COG id: COG0811

COG function: function code U; Biopolymer transport proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the exbB/tolQ family [H]

Homologues:

Organism=Escherichia coli, GI1789381, Length=207, Percent_Identity=33.3333333333333, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1786958, Length=133, Percent_Identity=36.0902255639098, Blast_Score=87, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002898
- InterPro:   IPR014164 [H]

Pfam domain/function: PF01618 MotA_ExbB [H]

EC number: NA

Molecular weight: Translated: 26285; Mature: 26285

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLQLQVWSLYLLQEGSTVSWDPASLWKQMGPLAKAVVVGLFIMSAYSIGVMIDRLMAYS
CEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARKQSRQFAPAVAGALREGKLDEAVKIADRYKKSHLAKVVVAGLQEFQAHQISSEIPGE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EIEASKRALERAEAIVHAELKRGVSGLATIGSTAPFVGLFGTVVGIINAFKGISNEKSTG
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
LGAVAGGISEALVTTAIGLFVAIPAVWMFNYFTGKIESFDVEMGNSSSELIDYFLKRSQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHHC
GVRK
CCCC
>Mature Secondary Structure
MLLQLQVWSLYLLQEGSTVSWDPASLWKQMGPLAKAVVVGLFIMSAYSIGVMIDRLMAYS
CEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARKQSRQFAPAVAGALREGKLDEAVKIADRYKKSHLAKVVVAGLQEFQAHQISSEIPGE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EIEASKRALERAEAIVHAELKRGVSGLATIGSTAPFVGLFGTVVGIINAFKGISNEKSTG
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
LGAVAGGISEALVTTAIGLFVAIPAVWMFNYFTGKIESFDVEMGNSSSELIDYFLKRSQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHHC
GVRK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]