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The map label for this gene is shc [H]

Identifier: 116620383

GI number: 116620383

Start: 1558324

End: 1560249

Strand: Direct

Name: shc [H]

Synonym: Acid_1260

Alternate gene names: 116620383

Gene position: 1558324-1560249 (Clockwise)

Preceding gene: 116620382

Following gene: 116620384

Centisome position: 15.64

GC content: 63.34

Gene sequence:

>1926_bases
ATGAGCGCACCGTCACACGTCGGCAATACGTTGGAGCACGCGGCCGAACTGGCTACCCGCAAGGCGATGGCCTACCTGAC
CTGCCTGCAGGAGCGCGACGGTCACTGGTGCGCGGAGCTGACCGCCGATACCACGCTCGAATCCGATTACATTTTGTTCC
AGTTGTGGCTGTATCCGCCGCAGGATGGGAAGTGGGAACCCGAGACACGGCCGCTGATCCGCAAGGCAGTGAATTCGATT
CTGGAGCGACAGCTTCCGGATGGCGGTTTCAATATCTGCGTCGGCGGACCATCCGAGGTCAGTGCCTCGGTCAAAGCCTA
CGTCGCGATGAAACTGGCCGGCCTGCCACCCGAAGACGATCGGATGGCGCGGTTGCGCGAGCGCATTCTCGCCCTTGGCG
GGATTCAGGCGGCGAACAGCTACGTCAAGGTCAACCTGAGCCTGTTCGACCTGTATCCGCGCGAGTTCAGCCCGAGCATC
CCACCCGAAGTGGCGCTCCTGCCTTTCGACCTGCTGTATCAGATGTCGGCGTGGACGCGCGCGATCGTGATCTCGCTCGG
GATCGTGCATGCCGCCAATCCGCGGCGTCCGGCTCCGGCGGGATTCAATCTGCAGGAATTATGGCTGCCCGGCGTGAGCC
CCGAATTTCGCCGCGACCCTTCGTTCTTCACGTGGCACAACACGTTCCTGACCGTGGACAAGGCGCTCAAGTTGTGGGAG
CGCTATGGCAGTAAAGCGGTGCGGCGCCGCGCGGTCGAGAAGGCTAAGACCTGGATGATCGAGCGCCTGCATCATTCCGA
CGGGCTGGGCGCGATTTACCCGCCCATGATGTACTCGGTGATGGCTCTGGACGTCCTGGGCTATGCGAAGGACGATCCTC
TGCGAGTGGAAGCGCTGCGGCACTTCAACAACCTGATGGTGGATGATGGCGACCGCTTCTTCTTCCAACCGTGCTTCTCG
CCGGTGTGGGATACGGCAATCGGCGCTTACGCGCTGGTGCAGGCCGACCCGTCTCACGAAGCGATCGCTCCGGCGGCCGA
CTGGTTGATCGCCAAGGAAGTCCGGCGCAAGGGCGATTGGAGCGTGAAGCGCCCCAACACCGAACCCTCGGGCTGGGCGT
TTGAGTACTCGAACGAATACTATCCGGACATCGACGACACGGCGATGGTAATGCTGGCCCTCGGCGAAACGCGAGCCAGC
AATACCGAGGCGCAGGCCGCGGCATGCAAGCGCGGGCTGGCGTGGCTCCTGGCAATGCAATCGAGCGATGGCGGGTGGGC
CGCCTTCGACGCCGACAACAACTGGGAGTTCCTCAGCCAGGTGCCGTTTGCGGACCACAATGCGATGCTCGATCCAACCT
GTGCCGATATTACCGGGCGCGTGTTGGAGGCGCTGGCATCGCAGGGGTTGGATCGCAACCACAAGGCGGTGCGGCGTGGC
GCCGAGTGGCTGATCCGGCACCAGGAAAACGACGGAAGCTGGTACGGGCGTTGGGGCGTGGCCTACATTTACGGCACCTG
CTTCGCGCTCCGCGGGCTGGCTGCGTCGGGCGAGAACGATCGTGAAGCGCACATCCTGCGCGCCGGGGAATGGCTGCGGT
CGATCCAGAATGCCGACGGCGGATGGGGCGAGAGTTGCAAGAGTTACGACAACCGCATCTTCACCGGCGGACCGAGCACG
CCGTCGCAGACCGCTTGGGCCATCCTCGGGTTGATTGCGGGCGGCGATGCCAATAGCCTGAGCGTGCAGCACGGCATCGA
GTACCTGCTCGAGACGCAGCGCTCCGACGGCAGCTGGGACGAGCAATTCGCCACCGGCACCGGCTTCCCGCGGGTGTTCT
ACCTCAACTACCACATGTACAAGGATTACTTCCCGCTATTGGCATTGGCTTCGTTTGTGAAGGCTCGCGCCGGCTCGAAC
GGGTAA

Upstream 100 bases:

>100_bases
AGTTTCTGCGCGAATGGGGCTTTGAAGGCCTGGAAGAAATCGAACTGGTGGATGAAGACGTACGATTCTCCCTGCCCGCG
GAGTTGACGATCTCGATCCA

Downstream 100 bases:

>100_bases
GCCTATGGCGGAGATGGCATCCCGCTACTCTCGCAGCACGCTCAATCAGAGCCGCGACCGTCAGGGAGCGATCGCTGTTT
GCTCGCACCCCTCGAAGATT

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MSAPSHVGNTLEHAAELATRKAMAYLTCLQERDGHWCAELTADTTLESDYILFQLWLYPPQDGKWEPETRPLIRKAVNSI
LERQLPDGGFNICVGGPSEVSASVKAYVAMKLAGLPPEDDRMARLRERILALGGIQAANSYVKVNLSLFDLYPREFSPSI
PPEVALLPFDLLYQMSAWTRAIVISLGIVHAANPRRPAPAGFNLQELWLPGVSPEFRRDPSFFTWHNTFLTVDKALKLWE
RYGSKAVRRRAVEKAKTWMIERLHHSDGLGAIYPPMMYSVMALDVLGYAKDDPLRVEALRHFNNLMVDDGDRFFFQPCFS
PVWDTAIGAYALVQADPSHEAIAPAADWLIAKEVRRKGDWSVKRPNTEPSGWAFEYSNEYYPDIDDTAMVMLALGETRAS
NTEAQAAACKRGLAWLLAMQSSDGGWAAFDADNNWEFLSQVPFADHNAMLDPTCADITGRVLEALASQGLDRNHKAVRRG
AEWLIRHQENDGSWYGRWGVAYIYGTCFALRGLAASGENDREAHILRAGEWLRSIQNADGGWGESCKSYDNRIFTGGPST
PSQTAWAILGLIAGGDANSLSVQHGIEYLLETQRSDGSWDEQFATGTGFPRVFYLNYHMYKDYFPLLALASFVKARAGSN
G

Sequences:

>Translated_641_residues
MSAPSHVGNTLEHAAELATRKAMAYLTCLQERDGHWCAELTADTTLESDYILFQLWLYPPQDGKWEPETRPLIRKAVNSI
LERQLPDGGFNICVGGPSEVSASVKAYVAMKLAGLPPEDDRMARLRERILALGGIQAANSYVKVNLSLFDLYPREFSPSI
PPEVALLPFDLLYQMSAWTRAIVISLGIVHAANPRRPAPAGFNLQELWLPGVSPEFRRDPSFFTWHNTFLTVDKALKLWE
RYGSKAVRRRAVEKAKTWMIERLHHSDGLGAIYPPMMYSVMALDVLGYAKDDPLRVEALRHFNNLMVDDGDRFFFQPCFS
PVWDTAIGAYALVQADPSHEAIAPAADWLIAKEVRRKGDWSVKRPNTEPSGWAFEYSNEYYPDIDDTAMVMLALGETRAS
NTEAQAAACKRGLAWLLAMQSSDGGWAAFDADNNWEFLSQVPFADHNAMLDPTCADITGRVLEALASQGLDRNHKAVRRG
AEWLIRHQENDGSWYGRWGVAYIYGTCFALRGLAASGENDREAHILRAGEWLRSIQNADGGWGESCKSYDNRIFTGGPST
PSQTAWAILGLIAGGDANSLSVQHGIEYLLETQRSDGSWDEQFATGTGFPRVFYLNYHMYKDYFPLLALASFVKARAGSN
G
>Mature_640_residues
SAPSHVGNTLEHAAELATRKAMAYLTCLQERDGHWCAELTADTTLESDYILFQLWLYPPQDGKWEPETRPLIRKAVNSIL
ERQLPDGGFNICVGGPSEVSASVKAYVAMKLAGLPPEDDRMARLRERILALGGIQAANSYVKVNLSLFDLYPREFSPSIP
PEVALLPFDLLYQMSAWTRAIVISLGIVHAANPRRPAPAGFNLQELWLPGVSPEFRRDPSFFTWHNTFLTVDKALKLWER
YGSKAVRRRAVEKAKTWMIERLHHSDGLGAIYPPMMYSVMALDVLGYAKDDPLRVEALRHFNNLMVDDGDRFFFQPCFSP
VWDTAIGAYALVQADPSHEAIAPAADWLIAKEVRRKGDWSVKRPNTEPSGWAFEYSNEYYPDIDDTAMVMLALGETRASN
TEAQAAACKRGLAWLLAMQSSDGGWAAFDADNNWEFLSQVPFADHNAMLDPTCADITGRVLEALASQGLDRNHKAVRRGA
EWLIRHQENDGSWYGRWGVAYIYGTCFALRGLAASGENDREAHILRAGEWLRSIQNADGGWGESCKSYDNRIFTGGPSTP
SQTAWAILGLIAGGDANSLSVQHGIEYLLETQRSDGSWDEQFATGTGFPRVFYLNYHMYKDYFPLLALASFVKARAGSNG

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=672, Percent_Identity=26.0416666666667, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI47933397, Length=672, Percent_Identity=26.0416666666667, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI224177558, Length=662, Percent_Identity=26.1329305135952, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI224177556, Length=673, Percent_Identity=25.8543833580981, Blast_Score=139, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6321863, Length=631, Percent_Identity=25.5150554675119, Blast_Score=120, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 71493; Mature: 71362

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS01074 TERPENE_SYNTHASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPSHVGNTLEHAAELATRKAMAYLTCLQERDGHWCAELTADTTLESDYILFQLWLYPP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEECC
QDGKWEPETRPLIRKAVNSILERQLPDGGFNICVGGPSEVSASVKAYVAMKLAGLPPEDD
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCHH
RMARLRERILALGGIQAANSYVKVNLSLFDLYPREFSPSIPPEVALLPFDLLYQMSAWTR
HHHHHHHHHHHHCCHHHCCCEEEEEEEEEEECCHHCCCCCCCCEEECCHHHHHHHHHHHH
AIVISLGIVHAANPRRPAPAGFNLQELWLPGVSPEFRRDPSFFTWHNTFLTVDKALKLWE
HHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCHHHCCCCCEEEEECHHEEHHHHHHHHH
RYGSKAVRRRAVEKAKTWMIERLHHSDGLGAIYPPMMYSVMALDVLGYAKDDPLRVEALR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
HFNNLMVDDGDRFFFQPCFSPVWDTAIGAYALVQADPSHEAIAPAADWLIAKEVRRKGDW
HHCCCEECCCCCEEEHHHCCHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC
SVKRPNTEPSGWAFEYSNEYYPDIDDTAMVMLALGETRASNTEAQAAACKRGLAWLLAMQ
CEECCCCCCCCEEEECCCCCCCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHEEEEEEE
SSDGGWAAFDADNNWEFLSQVPFADHNAMLDPTCADITGRVLEALASQGLDRNHKAVRRG
CCCCCEEEECCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AEWLIRHQENDGSWYGRWGVAYIYGTCFALRGLAASGENDREAHILRAGEWLRSIQNADG
HHHHEEEECCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
GWGESCKSYDNRIFTGGPSTPSQTAWAILGLIAGGDANSLSVQHGIEYLLETQRSDGSWD
CCCHHHHHHCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCH
EQFATGTGFPRVFYLNYHMYKDYFPLLALASFVKARAGSNG
HHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SAPSHVGNTLEHAAELATRKAMAYLTCLQERDGHWCAELTADTTLESDYILFQLWLYPP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEECC
QDGKWEPETRPLIRKAVNSILERQLPDGGFNICVGGPSEVSASVKAYVAMKLAGLPPEDD
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCHH
RMARLRERILALGGIQAANSYVKVNLSLFDLYPREFSPSIPPEVALLPFDLLYQMSAWTR
HHHHHHHHHHHHCCHHHCCCEEEEEEEEEEECCHHCCCCCCCCEEECCHHHHHHHHHHHH
AIVISLGIVHAANPRRPAPAGFNLQELWLPGVSPEFRRDPSFFTWHNTFLTVDKALKLWE
HHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCHHHCCCCCEEEEECHHEEHHHHHHHHH
RYGSKAVRRRAVEKAKTWMIERLHHSDGLGAIYPPMMYSVMALDVLGYAKDDPLRVEALR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
HFNNLMVDDGDRFFFQPCFSPVWDTAIGAYALVQADPSHEAIAPAADWLIAKEVRRKGDW
HHCCCEECCCCCEEEHHHCCHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC
SVKRPNTEPSGWAFEYSNEYYPDIDDTAMVMLALGETRASNTEAQAAACKRGLAWLLAMQ
CEECCCCCCCCEEEECCCCCCCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHEEEEEEE
SSDGGWAAFDADNNWEFLSQVPFADHNAMLDPTCADITGRVLEALASQGLDRNHKAVRRG
CCCCCEEEECCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AEWLIRHQENDGSWYGRWGVAYIYGTCFALRGLAASGENDREAHILRAGEWLRSIQNADG
HHHHEEEECCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
GWGESCKSYDNRIFTGGPSTPSQTAWAILGLIAGGDANSLSVQHGIEYLLETQRSDGSWD
CCCHHHHHHCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCH
EQFATGTGFPRVFYLNYHMYKDYFPLLALASFVKARAGSNG
HHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7894707 [H]