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The map label for this gene is yqeC [H]

Identifier: 116620329

GI number: 116620329

Start: 1488494

End: 1489507

Strand: Direct

Name: yqeC [H]

Synonym: Acid_1206

Alternate gene names: 116620329

Gene position: 1488494-1489507 (Clockwise)

Preceding gene: 116620325

Following gene: 116620330

Centisome position: 14.94

GC content: 66.17

Gene sequence:

>1014_bases
ATGCAACTGGGAATGATCGGTCTGGGCCGCATGGGCTCGAATATGGTACGCCGCCTCATGCGCGGTGGACATAATTGCGT
GGTCTATGACCGCGACCCGGCAGGAGTCGCAAGCCTGGCCGCCGAAGGCGCCACCGGCGCCAAATCCCTCGACGATCTGA
TCGCCGGACTCCAGCCGCCCCGCGCCATCTGGCTGATGGTTCCCGCCGCCGTCGTCGATTCCGCCCTTCACGACCTCGTC
CCCAAGCTCCAGCCCGGCGACACCGTCATCGATGGCGGCAACTCCTACTATGTCGATGATATCCGCCGCGCCTCCGAGCT
TTCCGCTAAGTCCATTCATTACATGGACGTAGGTACCAGCGGCGGGGTTTTCGGACTGGAGCGGGGCTTTTGCCTTATGG
CTGGCGGCGAGCGGCCGGTCTTCGATCGCCTCGCCCCCGTCCTCCGCACCCTCGCTCCCGGCCCCGGCAACGCCGAACGG
ACTCCCGGGCGCGACAAAGCTCACAGCGCTGCCGAGGAGGGCTATCTCTACTGCGGCCCCGCCGGCGCCGGGCACTTCGT
CAAAATGGTCCACAACGGCATCGAGTACGGCATGATGGCCTCCTTCGCCGAAGGCCTCAACATCCTCAAGCACGCCAACG
CCGGTGAGTCCGCCCGTGCTGCCGACGCCGAAACCACGCCGCTCCGCCACCCTGAGCTCTACCGCTACCGGCTCGATCTC
GCCGAAATCACCGAGGTCTGGCGCCGCGGCAGCGTCATCGCCTCCTGGCTGCTCGATCTCACCGCCGCCGCCTTGCTCGC
CAGCCCCGAACTCGACCACTTCACCGGCAGCGTAGCCGATTCCGGCGAGGGCCGCTGGACGCTGACCGCCGCCATCGACG
AGTCCGTCCCCGCTCCCGTTCTCGCCGCCGCTCTATTCCAGCGCTTTAGCTCACGTGGCGAGAGTGGGTTTGCCAACAAA
CTCCTTTCCGCCATGCGCGCTGAGTTTGGCGGCCATCATGAGCCCCCTCATTAA

Upstream 100 bases:

>100_bases
CAACCAGGAAACGGGACAAATTTGTCCTACTTCGCCGGACTGTGCGGCATCTAACCCCGCTTCTCGCCGCTGACCGCCGA
AAATATCTACAGGAGGGTCG

Downstream 100 bases:

>100_bases
ACTGAAAATTTGCAACCGTTCCAGGGGGTTTTCGAGTCTACTATAGTGTTAAGGGAAGCGTTTTCGCCGCCCCGGGGGTA
ATTCATGAAAATTCGGACTT

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQLGMIGLGRMGSNMVRRLMRGGHNCVVYDRDPAGVASLAAEGATGAKSLDDLIAGLQPPRAIWLMVPAAVVDSALHDLV
PKLQPGDTVIDGGNSYYVDDIRRASELSAKSIHYMDVGTSGGVFGLERGFCLMAGGERPVFDRLAPVLRTLAPGPGNAER
TPGRDKAHSAAEEGYLYCGPAGAGHFVKMVHNGIEYGMMASFAEGLNILKHANAGESARAADAETTPLRHPELYRYRLDL
AEITEVWRRGSVIASWLLDLTAAALLASPELDHFTGSVADSGEGRWTLTAAIDESVPAPVLAAALFQRFSSRGESGFANK
LLSAMRAEFGGHHEPPH

Sequences:

>Translated_337_residues
MQLGMIGLGRMGSNMVRRLMRGGHNCVVYDRDPAGVASLAAEGATGAKSLDDLIAGLQPPRAIWLMVPAAVVDSALHDLV
PKLQPGDTVIDGGNSYYVDDIRRASELSAKSIHYMDVGTSGGVFGLERGFCLMAGGERPVFDRLAPVLRTLAPGPGNAER
TPGRDKAHSAAEEGYLYCGPAGAGHFVKMVHNGIEYGMMASFAEGLNILKHANAGESARAADAETTPLRHPELYRYRLDL
AEITEVWRRGSVIASWLLDLTAAALLASPELDHFTGSVADSGEGRWTLTAAIDESVPAPVLAAALFQRFSSRGESGFANK
LLSAMRAEFGGHHEPPH
>Mature_337_residues
MQLGMIGLGRMGSNMVRRLMRGGHNCVVYDRDPAGVASLAAEGATGAKSLDDLIAGLQPPRAIWLMVPAAVVDSALHDLV
PKLQPGDTVIDGGNSYYVDDIRRASELSAKSIHYMDVGTSGGVFGLERGFCLMAGGERPVFDRLAPVLRTLAPGPGNAER
TPGRDKAHSAAEEGYLYCGPAGAGHFVKMVHNGIEYGMMASFAEGLNILKHANAGESARAADAETTPLRHPELYRYRLDL
AEITEVWRRGSVIASWLLDLTAAALLASPELDHFTGSVADSGEGRWTLTAAIDESVPAPVLAAALFQRFSSRGESGFANK
LLSAMRAEFGGHHEPPH

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=317, Percent_Identity=31.8611987381703, Blast_Score=131, Evalue=9e-31,
Organism=Escherichia coli, GI1788341, Length=347, Percent_Identity=30.835734870317, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI145693186, Length=217, Percent_Identity=25.8064516129032, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17542558, Length=317, Percent_Identity=31.2302839116719, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321695, Length=334, Percent_Identity=32.9341317365269, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6321977, Length=333, Percent_Identity=31.5315315315315, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24639279, Length=312, Percent_Identity=30.7692307692308, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24655230, Length=209, Percent_Identity=25.3588516746411, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI19922568, Length=209, Percent_Identity=25.3588516746411, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 35829; Mature: 35829

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLGMIGLGRMGSNMVRRLMRGGHNCVVYDRDPAGVASLAAEGATGAKSLDDLIAGLQPP
CCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHCCCCC
RAIWLMVPAAVVDSALHDLVPKLQPGDTVIDGGNSYYVDDIRRASELSAKSIHYMDVGTS
CEEEEEHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEHHHHHHHHHHHHCCEEEEECCCC
GGVFGLERGFCLMAGGERPVFDRLAPVLRTLAPGPGNAERTPGRDKAHSAAEEGYLYCGP
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCEEEECC
AGAGHFVKMVHNGIEYGMMASFAEGLNILKHANAGESARAADAETTPLRHPELYRYRLDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCH
AEITEVWRRGSVIASWLLDLTAAALLASPELDHFTGSVADSGEGRWTLTAAIDESVPAPV
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCHHH
LAAALFQRFSSRGESGFANKLLSAMRAEFGGHHEPPH
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQLGMIGLGRMGSNMVRRLMRGGHNCVVYDRDPAGVASLAAEGATGAKSLDDLIAGLQPP
CCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHCCCCC
RAIWLMVPAAVVDSALHDLVPKLQPGDTVIDGGNSYYVDDIRRASELSAKSIHYMDVGTS
CEEEEEHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEHHHHHHHHHHHHCCEEEEECCCC
GGVFGLERGFCLMAGGERPVFDRLAPVLRTLAPGPGNAERTPGRDKAHSAAEEGYLYCGP
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCEEEECC
AGAGHFVKMVHNGIEYGMMASFAEGLNILKHANAGESARAADAETTPLRHPELYRYRLDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCH
AEITEVWRRGSVIASWLLDLTAAALLASPELDHFTGSVADSGEGRWTLTAAIDESVPAPV
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCHHH
LAAALFQRFSSRGESGFANKLLSAMRAEFGGHHEPPH
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]