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The map label for this gene is pyrG [H]

Identifier: 116620310

GI number: 116620310

Start: 1462344

End: 1463051

Strand: Direct

Name: pyrG [H]

Synonym: Acid_1187

Alternate gene names: 116620310

Gene position: 1462344-1463051 (Clockwise)

Preceding gene: 116620309

Following gene: 116620313

Centisome position: 14.67

GC content: 63.28

Gene sequence:

>708_bases
ATGCACTCAGCCATTCGAGTCGCCCTCGTCGGCGATTTCAACGAGCTCCAACGAGCTCACCAAGCCATCCCCAGGGCCCT
GTCCGCTGCCATGGAAGGCGGAGTGGAAACTGTGTGGATCTCAACAGATTCGGTCGCCAGGGGTGATTCGCTGGCTGGTT
TCGACGGTCTCTGGTGTGTTCCCGGGATGCCCTATCGTAGCGCCGACGGCGCAATTTCCGCTATCCGCTTTGCGCGGACC
AGCAACATGCCTTTCCTCGGCACCTCCGCCGGGTTCCAATACGCTCTGATCGAGTATGCCCGCAACGCCATGGGCTTCAC
TGATGCGGACCATCAGAAAAGCAATCCGCGTGCTTCCATGCCGCTGATCACACCCCTCGACACCGGCCTCGCGGGCGTCA
AGTCCCGTGTTCGCTTTACCCGCGGATCTCACCTCCACAACGCCTATCGCGCCCCCGAGTCCGTCGAAGAGTATCACTGC
AGCTTCGGCCTCAACGGCCGGTACCGCCGCCTCATCGAAAGCGGTCCCCTCACCGTCACCGCGATCGATGACCAGCACGA
CGTCCGCGCCGTGGAACTCGATGGCCACCCCTTCTTCGTGGCCACTCTCTTCCAGCCCGAAATGCGCACGCCCGCAAGCC
CCTTGGTCGGCGCCTTCGTGACTGCCTGCCAGCGCCGCCACGACCGCCTCACCAAAGCCGCCAGCTAA

Upstream 100 bases:

>100_bases
GATTATTTCCCCCTTTTGGCGCTATCTCAGGTGTGACATCATCCAAATATTTACGATTTTGCGGGTACGCTCGTCCGAAT
TTTGTGACATAATCCCGCGC

Downstream 100 bases:

>100_bases
AGGACAGGCCTCCGGGCCTGTCCACTCACCAGTTTTTTCCTCTTGTGGGACACGTACTTCCGCGTTTCGTCTCCGCTGGT
TCTTAATCGGTGGCACTATC

Product: hypothetical protein

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MHSAIRVALVGDFNELQRAHQAIPRALSAAMEGGVETVWISTDSVARGDSLAGFDGLWCVPGMPYRSADGAISAIRFART
SNMPFLGTSAGFQYALIEYARNAMGFTDADHQKSNPRASMPLITPLDTGLAGVKSRVRFTRGSHLHNAYRAPESVEEYHC
SFGLNGRYRRLIESGPLTVTAIDDQHDVRAVELDGHPFFVATLFQPEMRTPASPLVGAFVTACQRRHDRLTKAAS

Sequences:

>Translated_235_residues
MHSAIRVALVGDFNELQRAHQAIPRALSAAMEGGVETVWISTDSVARGDSLAGFDGLWCVPGMPYRSADGAISAIRFART
SNMPFLGTSAGFQYALIEYARNAMGFTDADHQKSNPRASMPLITPLDTGLAGVKSRVRFTRGSHLHNAYRAPESVEEYHC
SFGLNGRYRRLIESGPLTVTAIDDQHDVRAVELDGHPFFVATLFQPEMRTPASPLVGAFVTACQRRHDRLTKAAS
>Mature_235_residues
MHSAIRVALVGDFNELQRAHQAIPRALSAAMEGGVETVWISTDSVARGDSLAGFDGLWCVPGMPYRSADGAISAIRFART
SNMPFLGTSAGFQYALIEYARNAMGFTDADHQKSNPRASMPLITPLDTGLAGVKSRVRFTRGSHLHNAYRAPESVEEYHC
SFGLNGRYRRLIESGPLTVTAIDDQHDVRAVELDGHPFFVATLFQPEMRTPASPLVGAFVTACQRRHDRLTKAAS

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI28559085, Length=253, Percent_Identity=26.8774703557312, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI28559083, Length=253, Percent_Identity=26.8774703557312, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI221316689, Length=253, Percent_Identity=26.8774703557312, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI148491070, Length=259, Percent_Identity=25.8687258687259, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789142, Length=262, Percent_Identity=29.3893129770992, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322563, Length=256, Percent_Identity=25.390625, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319432, Length=253, Percent_Identity=24.1106719367589, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664469, Length=259, Percent_Identity=26.2548262548263, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357815, Length=259, Percent_Identity=26.2548262548263, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 25635; Mature: 25635

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSAIRVALVGDFNELQRAHQAIPRALSAAMEGGVETVWISTDSVARGDSLAGFDGLWCV
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEC
PGMPYRSADGAISAIRFARTSNMPFLGTSAGFQYALIEYARNAMGFTDADHQKSNPRASM
CCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PLITPLDTGLAGVKSRVRFTRGSHLHNAYRAPESVEEYHCSFGLNGRYRRLIESGPLTVT
CEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEE
AIDDQHDVRAVELDGHPFFVATLFQPEMRTPASPLVGAFVTACQRRHDRLTKAAS
EECCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHSAIRVALVGDFNELQRAHQAIPRALSAAMEGGVETVWISTDSVARGDSLAGFDGLWCV
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEC
PGMPYRSADGAISAIRFARTSNMPFLGTSAGFQYALIEYARNAMGFTDADHQKSNPRASM
CCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PLITPLDTGLAGVKSRVRFTRGSHLHNAYRAPESVEEYHCSFGLNGRYRRLIESGPLTVT
CEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEE
AIDDQHDVRAVELDGHPFFVATLFQPEMRTPASPLVGAFVTACQRRHDRLTKAAS
EECCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA