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The map label for this gene is ppnK

Identifier: 116620239

GI number: 116620239

Start: 1373096

End: 1373959

Strand: Direct

Name: ppnK

Synonym: Acid_1116

Alternate gene names: 116620239

Gene position: 1373096-1373959 (Clockwise)

Preceding gene: 116620238

Following gene: 116620240

Centisome position: 13.78

GC content: 62.5

Gene sequence:

>864_bases
ATGCCCATCATTAAAACCGCCGGCATCATCTCCAAACCCAATTCCACCGCGGCCGAAGAGATCGTCCCCAAACTCATCGA
GTGGCTGCGCCGCCGCGGCATCGCCGTGCGCATTGATGAACAGACCTCTTTGTATTCCGGCGGCGTCTCCGGCATGCCGC
GCGAAGAAGTGCCGCAGAGCTGCGATCTCGTCGTCGTTCTCGGCGGCGATGGCACCCTGCTCTCCGCCGCGCGCGCCATC
GGCCGGCGCGAAATTCCGCTCTTCCCCGTCAACCTCGGCGGTCTCGGTTTCCTCACCGCCATCTCCATCGAGGAACTCTA
CCCCGAACTCGAGCGCGCCCTCCGCGGCGAGCACCGCATCGCCAAGCGGAAGCTGATGACCACAGAAGTCATCCGCGAAA
ACAACGTGATCGCCAGCTTCGACGCCCTTAACGACGCCGTCCTCACCAAAAGTTCCATCGCGCGCATGATCGATCTCGAC
ACTTATGTCGATGAGCAGTTCGTCTGCGCCTACAAAGCCGATGGCCTGATCATCGCCACCCCAACCGGCTCCACCGCGTA
CTCCCTCTCCGCTGGCGGCCCCATCATTTTTCCTTCCGTGCCCGCCATCTGCCTCACGCCCATCTGCCCGCACATGCTGA
CCAACCGTCCCGTGCTGGTGCCCGAAACCAGCGTCATCCGCGTGGCCTCGCGCGGCCCCGATGAAAGCGTCTACCTGACG
ATCGATGGGCAGGTCGGCACGCCCATTCGCGAACACGATACCGTAGTCTGCCATAGCTCGCACCATTCGCTGCTGCTGAT
CCGTCCGCCGCGCATGATGTTCTTCGATGTGCTGCGCCAGAAACTCAAGTGGGGAGAACGATGA

Upstream 100 bases:

>100_bases
TGCGAGAAAGTCGAACGGGCCGTGCGCGAAATCGGATTCGAGACCGCCATCATCGAAAGCTCCATCGCCGGCGCCGAAGG
GAACAAGGAGTTTCTCCTCT

Downstream 100 bases:

>100_bases
AAAGAATTTCGCTGACGGCATGGATCTTTATCGGCATGGCCGCCGGTGTGGCCCTCGGTGTCCTTGCGCCCTCATTCGCC
GCGCAACTCGGCCTCCTAAG

Product: NAD(+) kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPIIKTAGIISKPNSTAAEEIVPKLIEWLRRRGIAVRIDEQTSLYSGGVSGMPREEVPQSCDLVVVLGGDGTLLSAARAI
GRREIPLFPVNLGGLGFLTAISIEELYPELERALRGEHRIAKRKLMTTEVIRENNVIASFDALNDAVLTKSSIARMIDLD
TYVDEQFVCAYKADGLIIATPTGSTAYSLSAGGPIIFPSVPAICLTPICPHMLTNRPVLVPETSVIRVASRGPDESVYLT
IDGQVGTPIREHDTVVCHSSHHSLLLIRPPRMMFFDVLRQKLKWGER

Sequences:

>Translated_287_residues
MPIIKTAGIISKPNSTAAEEIVPKLIEWLRRRGIAVRIDEQTSLYSGGVSGMPREEVPQSCDLVVVLGGDGTLLSAARAI
GRREIPLFPVNLGGLGFLTAISIEELYPELERALRGEHRIAKRKLMTTEVIRENNVIASFDALNDAVLTKSSIARMIDLD
TYVDEQFVCAYKADGLIIATPTGSTAYSLSAGGPIIFPSVPAICLTPICPHMLTNRPVLVPETSVIRVASRGPDESVYLT
IDGQVGTPIREHDTVVCHSSHHSLLLIRPPRMMFFDVLRQKLKWGER
>Mature_286_residues
PIIKTAGIISKPNSTAAEEIVPKLIEWLRRRGIAVRIDEQTSLYSGGVSGMPREEVPQSCDLVVVLGGDGTLLSAARAIG
RREIPLFPVNLGGLGFLTAISIEELYPELERALRGEHRIAKRKLMTTEVIRENNVIASFDALNDAVLTKSSIARMIDLDT
YVDEQFVCAYKADGLIIATPTGSTAYSLSAGGPIIFPSVPAICLTPICPHMLTNRPVLVPETSVIRVASRGPDESVYLTI
DGQVGTPIREHDTVVCHSSHHSLLLIRPPRMMFFDVLRQKLKWGER

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=262, Percent_Identity=29.7709923664122, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1788968, Length=286, Percent_Identity=36.3636363636364, Blast_Score=188, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6320794, Length=245, Percent_Identity=34.2857142857143, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6325068, Length=208, Percent_Identity=36.0576923076923, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322509, Length=245, Percent_Identity=31.8367346938775, Blast_Score=125, Evalue=9e-30,
Organism=Drosophila melanogaster, GI28573828, Length=255, Percent_Identity=30.5882352941176, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28573826, Length=210, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28573832, Length=210, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28573830, Length=210, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI161077047, Length=210, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI20129957, Length=281, Percent_Identity=27.7580071174377, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281363323, Length=281, Percent_Identity=27.7580071174377, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24653424, Length=281, Percent_Identity=27.7580071174377, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24653422, Length=281, Percent_Identity=27.7580071174377, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI281363321, Length=281, Percent_Identity=27.7580071174377, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_SOLUE (Q02A16)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_822395.1
- ProteinModelPortal:   Q02A16
- SMR:   Q02A16
- STRING:   Q02A16
- GeneID:   4430731
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_1116
- NMPDR:   fig|234267.9.peg.1054
- eggNOG:   COG0061
- HOGENOM:   HBG713904
- OMA:   FESFMID
- PhylomeDB:   Q02A16
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 31420; Mature: 31289

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIIKTAGIISKPNSTAAEEIVPKLIEWLRRRGIAVRIDEQTSLYSGGVSGMPREEVPQS
CCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEECCCCCCCCHHHCCCC
CDLVVVLGGDGTLLSAARAIGRREIPLFPVNLGGLGFLTAISIEELYPELERALRGEHRI
CCEEEEECCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHH
AKRKLMTTEVIRENNVIASFDALNDAVLTKSSIARMIDLDTYVDEQFVCAYKADGLIIAT
HHHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEC
PTGSTAYSLSAGGPIIFPSVPAICLTPICPHMLTNRPVLVPETSVIRVASRGPDESVYLT
CCCCCEEEECCCCCEEECCCCHHHHHHCCHHHHCCCCEECCCCCEEEEECCCCCCEEEEE
IDGQVGTPIREHDTVVCHSSHHSLLLIRPPRMMFFDVLRQKLKWGER
ECCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PIIKTAGIISKPNSTAAEEIVPKLIEWLRRRGIAVRIDEQTSLYSGGVSGMPREEVPQS
CCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEECCCCCCCCHHHCCCC
CDLVVVLGGDGTLLSAARAIGRREIPLFPVNLGGLGFLTAISIEELYPELERALRGEHRI
CCEEEEECCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHH
AKRKLMTTEVIRENNVIASFDALNDAVLTKSSIARMIDLDTYVDEQFVCAYKADGLIIAT
HHHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEC
PTGSTAYSLSAGGPIIFPSVPAICLTPICPHMLTNRPVLVPETSVIRVASRGPDESVYLT
CCCCCEEEECCCCCEEECCCCHHHHHHCCHHHHCCCCEECCCCCEEEEECCCCCCEEEEE
IDGQVGTPIREHDTVVCHSSHHSLLLIRPPRMMFFDVLRQKLKWGER
ECCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA