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The map label for this gene is hbd [H]

Identifier: 116620227

GI number: 116620227

Start: 1356539

End: 1357468

Strand: Reverse

Name: hbd [H]

Synonym: Acid_1104

Alternate gene names: 116620227

Gene position: 1357468-1356539 (Counterclockwise)

Preceding gene: 116620230

Following gene: 116620225

Centisome position: 13.62

GC content: 67.31

Gene sequence:

>930_bases
ATGAGATTCGGCAAAGGTTGTGTGATCGGAACCGGGATGATGGGGCCGGGGATCGCGTTGACGCTGGCGCTGGGCGGAGT
GCAGACGACTTTGCTGAGCCGCACCCCGGCGGGGGCGGAGCGTGGGGTGGCGGAGGCGCGGCGACTGGGGCGCGTGCTGG
TGGAGCAGGAACTGGCGGCCGCATTGGATCTCGACATCGCCGGATCCACCGATTTCGAATATTCGATCGGGCAAGCAGAC
ATCGTGATCGAGTCGGGGCCGGAGGAGATGGGATGGAAGCAGGAGCTCTTCGCTCGCATGGATCGGGTCGCGCGGGCGGA
TGCGGTGCTGGCGTCGAACACGTCGGGGCTGAGCGTCACGGCGATCGCGGCGGAGTGCGCGCGGCCGGAGCAGGTGTTGG
CGACGCACTTCTGGAATCCACCGCACCTGGTTCCCCTGGTAGAGATTATTCAGGGCCGGGCGACGTCGCCGGCGGCGGCG
GCGGCGGTGCGGGAGTTGCTGACGGCGTGCGGGAAGACGCCGGTGGTGGTGAAGCTCGACCGGCCGGGACAACTCGGCAA
CCGGTTGCAGATGGCCCTGGTGCGGGAGGCGGCCAACATCGTGGCGGAGGGAATCGCGGATGCGGAGGCGGTGGACAGCG
TGGTGAAGAATGGTCTGGGGATTCGCATGCCGGCGTATGGCATCTTCGAACACATGGATGTGGCGGGACTCGACCTGGCG
CTGCGGGTGATGGAACACGTGACGCCGGATTTGTACAACGAAGGGCGCGCCCCGGAGTTTCTGCGCGAGCTGGTGCGCGA
GGGGAAGCTCGGCGCGAAGACAGGTCGCGGGTTTTACGATTGGGGGATCAAGAGCGCCGACGCGGTGCGAGCGGAACGCG
ACGCGTTCCTGGTGGAGGTGCTGCGCTACCGGCGTCGGCGCTCGGAGTAA

Upstream 100 bases:

>100_bases
GGATCCGCATAAGTTTTCAGGCCCATTGTTTCAGGGCGCGCGAGGTTCTGGCAAGGGGAAAGTGTGAGTTTCGGAGGGGA
GCGCTCATTACGATGTAGAG

Downstream 100 bases:

>100_bases
AGTCTACTGGTCGATGCCGCCGCCGGAGCGGCGCATCATCATGCCCATGCTGGGCGGGCCGCCGCGGCCGGCGGGTCCGC
GCATTCCGGGGGCGCCGCCC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MRFGKGCVIGTGMMGPGIALTLALGGVQTTLLSRTPAGAERGVAEARRLGRVLVEQELAAALDLDIAGSTDFEYSIGQAD
IVIESGPEEMGWKQELFARMDRVARADAVLASNTSGLSVTAIAAECARPEQVLATHFWNPPHLVPLVEIIQGRATSPAAA
AAVRELLTACGKTPVVVKLDRPGQLGNRLQMALVREAANIVAEGIADAEAVDSVVKNGLGIRMPAYGIFEHMDVAGLDLA
LRVMEHVTPDLYNEGRAPEFLRELVREGKLGAKTGRGFYDWGIKSADAVRAERDAFLVEVLRYRRRRSE

Sequences:

>Translated_309_residues
MRFGKGCVIGTGMMGPGIALTLALGGVQTTLLSRTPAGAERGVAEARRLGRVLVEQELAAALDLDIAGSTDFEYSIGQAD
IVIESGPEEMGWKQELFARMDRVARADAVLASNTSGLSVTAIAAECARPEQVLATHFWNPPHLVPLVEIIQGRATSPAAA
AAVRELLTACGKTPVVVKLDRPGQLGNRLQMALVREAANIVAEGIADAEAVDSVVKNGLGIRMPAYGIFEHMDVAGLDLA
LRVMEHVTPDLYNEGRAPEFLRELVREGKLGAKTGRGFYDWGIKSADAVRAERDAFLVEVLRYRRRRSE
>Mature_309_residues
MRFGKGCVIGTGMMGPGIALTLALGGVQTTLLSRTPAGAERGVAEARRLGRVLVEQELAAALDLDIAGSTDFEYSIGQAD
IVIESGPEEMGWKQELFARMDRVARADAVLASNTSGLSVTAIAAECARPEQVLATHFWNPPHLVPLVEIIQGRATSPAAA
AAVRELLTACGKTPVVVKLDRPGQLGNRLQMALVREAANIVAEGIADAEAVDSVVKNGLGIRMPAYGIFEHMDVAGLDLA
LRVMEHVTPDLYNEGRAPEFLRELVREGKLGAKTGRGFYDWGIKSADAVRAERDAFLVEVLRYRRRRSE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=293, Percent_Identity=34.8122866894198, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI296179427, Length=310, Percent_Identity=32.9032258064516, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI20127408, Length=303, Percent_Identity=30.3630363036304, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI115430219, Length=269, Percent_Identity=29.7397769516729, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI261878539, Length=319, Percent_Identity=30.0940438871473, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI68989263, Length=319, Percent_Identity=30.0940438871473, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1787661, Length=297, Percent_Identity=34.3434343434343, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1788682, Length=221, Percent_Identity=32.579185520362, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790281, Length=254, Percent_Identity=33.0708661417323, Blast_Score=104, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71985923, Length=305, Percent_Identity=28.8524590163934, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71985930, Length=298, Percent_Identity=27.1812080536913, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17508953, Length=294, Percent_Identity=30.6122448979592, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25144276, Length=294, Percent_Identity=30.6122448979592, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17508951, Length=294, Percent_Identity=30.6122448979592, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17558304, Length=306, Percent_Identity=31.0457516339869, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=29.1666666666667, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=29.9651567944251, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17563036, Length=294, Percent_Identity=28.2312925170068, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI115533614, Length=245, Percent_Identity=27.7551020408163, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193203623, Length=245, Percent_Identity=27.7551020408163, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45549573, Length=243, Percent_Identity=29.2181069958848, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129993, Length=325, Percent_Identity=26.7692307692308, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19921000, Length=297, Percent_Identity=29.2929292929293, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24583077, Length=297, Percent_Identity=29.2929292929293, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24583079, Length=297, Percent_Identity=29.2929292929293, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33185; Mature: 33185

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFGKGCVIGTGMMGPGIALTLALGGVQTTLLSRTPAGAERGVAEARRLGRVLVEQELAA
CCCCCCCEEECCCCCCCCEEHEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALDLDIAGSTDFEYSIGQADIVIESGPEEMGWKQELFARMDRVARADAVLASNTSGLSVT
HHCCCCCCCCCCCEECCCEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEH
AIAAECARPEQVLATHFWNPPHLVPLVEIIQGRATSPAAAAAVRELLTACGKTPVVVKLD
HHHHHHCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEC
RPGQLGNRLQMALVREAANIVAEGIADAEAVDSVVKNGLGIRMPAYGIFEHMDVAGLDLA
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHH
LRVMEHVTPDLYNEGRAPEFLRELVREGKLGAKTGRGFYDWGIKSADAVRAERDAFLVEV
HHHHHHCCHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHH
LRYRRRRSE
HHHHHHCCC
>Mature Secondary Structure
MRFGKGCVIGTGMMGPGIALTLALGGVQTTLLSRTPAGAERGVAEARRLGRVLVEQELAA
CCCCCCCEEECCCCCCCCEEHEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALDLDIAGSTDFEYSIGQADIVIESGPEEMGWKQELFARMDRVARADAVLASNTSGLSVT
HHCCCCCCCCCCCEECCCEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEH
AIAAECARPEQVLATHFWNPPHLVPLVEIIQGRATSPAAAAAVRELLTACGKTPVVVKLD
HHHHHHCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEC
RPGQLGNRLQMALVREAANIVAEGIADAEAVDSVVKNGLGIRMPAYGIFEHMDVAGLDLA
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHH
LRVMEHVTPDLYNEGRAPEFLRELVREGKLGAKTGRGFYDWGIKSADAVRAERDAFLVEV
HHHHHHCCHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHH
LRYRRRRSE
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]