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The map label for this gene is phoP [H]

Identifier: 116620224

GI number: 116620224

Start: 1353481

End: 1354176

Strand: Reverse

Name: phoP [H]

Synonym: Acid_1101

Alternate gene names: 116620224

Gene position: 1354176-1353481 (Counterclockwise)

Preceding gene: 116620225

Following gene: 116620217

Centisome position: 13.59

GC content: 59.77

Gene sequence:

>696_bases
ATGACGCCGCGCATTTTGCTGGCGGAAGACGATCCCGGGTTGGTTCTGACGCTAACCGACCGGTTGCAGAATGAGGGCTA
CGCGGTGGAATCTCGACAGGATGGCGACAGTGCGCTGGCGGAGGCGATGGGCCAGTCGTACGACCTGATTCTGCTGGACG
TGATGCTGCCGCGGCGGAGTGGGTTCGACGTGTGCAAAAAGCTCCGCGAGAGCGAGATCGGCGTGCCGATTTTGATGCTG
ACGGCGCGGGGTGAAGTGGTGGATAAGGTAGTCGGGTTGAAATCGGGGGCCGACGACTACCTGACAAAGCCATTCGAGAT
GATGGAGCTGCTGGCGCGGATCGAGGCACTGCTGCGGCGGGCTCCGGTGCGGCGGAGTTTGAATGCGGGCACGTTTCAAC
TGGGCGGAATCGCGGTGGATTTCCGCCGTGCGGAGGTGACACGCGCGGGAAAACCCGTAACACTTTCGGCAAGGGAGTAC
CGGCTGCTCGGATACCTGATCGATCACTGCGGCGAAACCGTTACCCGCGAAGATTTGTTGACACAGGTTTGGGGCTATTC
CGCCACGACGGATACACGAACGGTGGACGTCCATGTGGCGTGGCTACGGCAGAAGCTCGAAGAAAATCCCAAATATCCTC
GCTATCTGCAGACGGTGCGCGGTCTGGGTTACAAGTTGTCGGACGAAGAATTGTAA

Upstream 100 bases:

>100_bases
TCGTGGAGGCGCATGACGGAACAGTGAACGTGGAGAGCACGGCTGGTATGGGAAGCTGTTTCACGCTGCGGCTGCCGGTT
GCGGCCGGGGAGGTTACCTG

Downstream 100 bases:

>100_bases
CGGCCCCTGAGTTGCTCATCGATTGATGAACGGGGGTATGGTTATGATCGTCGCAACAGGACTCGCAGTTTTCGTGGTGG
TTTGCCTGCTGCTGTCCATG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MTPRILLAEDDPGLVLTLTDRLQNEGYAVESRQDGDSALAEAMGQSYDLILLDVMLPRRSGFDVCKKLRESEIGVPILML
TARGEVVDKVVGLKSGADDYLTKPFEMMELLARIEALLRRAPVRRSLNAGTFQLGGIAVDFRRAEVTRAGKPVTLSAREY
RLLGYLIDHCGETVTREDLLTQVWGYSATTDTRTVDVHVAWLRQKLEENPKYPRYLQTVRGLGYKLSDEEL

Sequences:

>Translated_231_residues
MTPRILLAEDDPGLVLTLTDRLQNEGYAVESRQDGDSALAEAMGQSYDLILLDVMLPRRSGFDVCKKLRESEIGVPILML
TARGEVVDKVVGLKSGADDYLTKPFEMMELLARIEALLRRAPVRRSLNAGTFQLGGIAVDFRRAEVTRAGKPVTLSAREY
RLLGYLIDHCGETVTREDLLTQVWGYSATTDTRTVDVHVAWLRQKLEENPKYPRYLQTVRGLGYKLSDEEL
>Mature_230_residues
TPRILLAEDDPGLVLTLTDRLQNEGYAVESRQDGDSALAEAMGQSYDLILLDVMLPRRSGFDVCKKLRESEIGVPILMLT
ARGEVVDKVVGLKSGADDYLTKPFEMMELLARIEALLRRAPVRRSLNAGTFQLGGIAVDFRRAEVTRAGKPVTLSAREYR
LLGYLIDHCGETVTREDLLTQVWGYSATTDTRTVDVHVAWLRQKLEENPKYPRYLQTVRGLGYKLSDEEL

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=40.8071748878924, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=37.3333333333333, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=38.4279475982533, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=37.6681614349776, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=38.5650224215247, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=37.3333333333333, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=34.6846846846847, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=37.6106194690265, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=36.6812227074236, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=33.6283185840708, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=36.0515021459227, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=32.7659574468085, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=29.6943231441048, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788713, Length=127, Percent_Identity=35.4330708661417, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=34.2105263157895, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25946; Mature: 25815

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRILLAEDDPGLVLTLTDRLQNEGYAVESRQDGDSALAEAMGQSYDLILLDVMLPRRS
CCCCEEEECCCCCEEEEEEHHHCCCCEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCC
GFDVCKKLRESEIGVPILMLTARGEVVDKVVGLKSGADDYLTKPFEMMELLARIEALLRR
CHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHH
APVRRSLNAGTFQLGGIAVDFRRAEVTRAGKPVTLSAREYRLLGYLIDHCGETVTREDLL
CCHHHCCCCCEEEECCEEEEEHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCHHHHHHHH
TQVWGYSATTDTRTVDVHVAWLRQKLEENPKYPRYLQTVRGLGYKLSDEEL
HHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TPRILLAEDDPGLVLTLTDRLQNEGYAVESRQDGDSALAEAMGQSYDLILLDVMLPRRS
CCCEEEECCCCCEEEEEEHHHCCCCEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCC
GFDVCKKLRESEIGVPILMLTARGEVVDKVVGLKSGADDYLTKPFEMMELLARIEALLRR
CHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHH
APVRRSLNAGTFQLGGIAVDFRRAEVTRAGKPVTLSAREYRLLGYLIDHCGETVTREDLL
CCHHHCCCCCEEEECCEEEEEHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCHHHHHHHH
TQVWGYSATTDTRTVDVHVAWLRQKLEENPKYPRYLQTVRGLGYKLSDEEL
HHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]