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The map label for this gene is barA [H]

Identifier: 116620185

GI number: 116620185

Start: 1308411

End: 1310303

Strand: Direct

Name: barA [H]

Synonym: Acid_1058

Alternate gene names: 116620185

Gene position: 1308411-1310303 (Clockwise)

Preceding gene: 116620184

Following gene: 116620187

Centisome position: 13.13

GC content: 64.13

Gene sequence:

>1893_bases
ATGAAGGGCTATGCGTCGTTGCGCCGCAAGCTGGCCACCCTGATCGCGGGAGGCGGAGTAGTCACGGCGCTGATCGCGGC
CGCGGGCTTCTCCTGGCTGGACCTGCAGCGCTTCCAGCAGCAGGCGAATGCGCAAGTGACCGCGATCGCGAACATTGTCG
CCGGGCAGGTGGAGCCGTCGATCGCGCTGGGCGACCGCAGGGTGGCGGCAGAGATTCTGCAATCCCTGCGCGGCGACCGG
ATGATCCGGGACGCCATTCTGTACGACGGCGAGGGTGAATGTTTCGCGGTCGCGCGGGCGTTGCTGGCGGCCTGTCCACC
GCGTCCGCGCGATGGCTTGAAGCGTGAGCGCGAGGCGATCGTGTTAGTGCGGCCGGTGCTTTCCGGGGGCGAGCGGGTGG
GGACGCTGGTTCTGGCCGCCAGCGTGCCGTCCATAAGAGAAGTGCTGGGCCAGTACCTGGGGGGAGCCGCGTTGATTATG
GCGCTCACCCTGCTCGTGGCGGGGGTGCTCGCGATGGTGCTGCAGGCGCGGGTGTCAGCGCCGATCCTGGCAATCGCCCG
TGTGGCCGAGCGGATCACGCAGACGCATCAGTTCGACGACCGGGTGGCGGTGGACTCCTCGGACGAGCTGGGAGTGCTGG
CGAGATCGTTCAACACCATGCTGGAAGAAATCGCGAGGAGCGGGGCCGAGCTCGAGCAGCAGATCATGGAGCGCAACCGT
GTGAACGCGGAGCTGCTGGCCGCCAAGGAACGGGCCGAGGACGCGGCGCGTCAGAAAACGCAATTCCTGGCGAACATGAG
CCACGAGATTCGGACGCCCATGAACGGTGTGATGGGCATGATCAGCCTGGTGCTGGACCATGAACTTGACTCGCAGGACC
GTGAGCACCTGCTGATGGCGCAGAGCGCCGCGCAATCGCTGATCATTATCCTCAACGACATTCTCGATCTTTCCAAGATC
GAGGCGGGCAAGATGACCTTCGAAACCGTGGATTTCGATCTGCACCGGCTGATCGGGGATGCCATGGGGATTTTCAGCTC
GGCGGCGATTGCCAAAGGGCTCGATCTGGGCATCGATCTGGCGCCAGATAGTCCTCGCTGGGTGCGCGGAGATCCGGTGC
GGCTGCGGCAGATTCTGATCAACCTGGTGGGCAACGCTGTCAAATTCACCGCGGCCGGATCGGTGCGGCTGACGCTGGCG
CCGCATCTGGATAACCTGGTGCGTTTCGCGGTGCGAGATACCGGGATCGGCGTTCCGAAAGACCAAATGGAGGCAATCTT
CGAGGCCTTTGTTCAGGCCGATGGCTCGCACACTCGCCAGTTCGGCGGCACCGGACTGGGCCTGGCGATCACGCGGCGAC
TGGTTGCGCTGATGGAGGGAACGCTGTGGGCCGAGAGCCAGTCAGGCTGCGGGAGCACGTTCTTCGTGGAACTGCCGGTA
CAGCCGGGCTCGGCGGTGCAGAGCCTGGTGGCAATGGCGGAATCGGCGCCGGGCGAACTTCCGCCGGTGCTGCGTGTGTT
GGTGGCGGAAGACAACGTGATCAATCAGAAGGTGATCTGCTCCATGCTGCGCCGCCAAGGTTGGACGGTTACGCTAGCGC
TGAACGGTGAAGAGGCCTACCGCCGTTTCCTGGAGAGCCGCTTCGACCTGATTCTGATGGACGTGCAAATGCCGGAGGTG
GATGGGTTGGAATCGTCGCGGCGCATCCGGCAGGCGGAGCGGAATCACAAGCTGGGACGGATCCCGATTCTGGCACTGAC
GGCGCATGCGGCTACGGCACAGCATAAGCAGTGCCTTGCCGCAGGAATGGACGCAGTGATCACTAAGCCGGTTAACTTTC
CGGCGATGCTGGCTCAAATTGCCGCCGTTTTGCCGGAGGGGCAAACCGCGTGA

Upstream 100 bases:

>100_bases
GTTTCGAGGTTAGCCTGGACGCGCTCGATCGGGCGGGCGTCGCGATCAGTTCGACGCTCCTGCGGTACGGACAGGTGGCG
CGGCAGGCGAGGCCTCGAGT

Downstream 100 bases:

>100_bases
AGCGAGAAGAGATGGGCGCGGAGGGCTGACTTACGCCCGGCGGCGCATTTCGGCGCGGGCTTCATCGTCGGCGGTGCGGG
CCTTGTCGGCGGCGCGCTTG

Product: integral membrane sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MKGYASLRRKLATLIAGGGVVTALIAAAGFSWLDLQRFQQQANAQVTAIANIVAGQVEPSIALGDRRVAAEILQSLRGDR
MIRDAILYDGEGECFAVARALLAACPPRPRDGLKREREAIVLVRPVLSGGERVGTLVLAASVPSIREVLGQYLGGAALIM
ALTLLVAGVLAMVLQARVSAPILAIARVAERITQTHQFDDRVAVDSSDELGVLARSFNTMLEEIARSGAELEQQIMERNR
VNAELLAAKERAEDAARQKTQFLANMSHEIRTPMNGVMGMISLVLDHELDSQDREHLLMAQSAAQSLIIILNDILDLSKI
EAGKMTFETVDFDLHRLIGDAMGIFSSAAIAKGLDLGIDLAPDSPRWVRGDPVRLRQILINLVGNAVKFTAAGSVRLTLA
PHLDNLVRFAVRDTGIGVPKDQMEAIFEAFVQADGSHTRQFGGTGLGLAITRRLVALMEGTLWAESQSGCGSTFFVELPV
QPGSAVQSLVAMAESAPGELPPVLRVLVAEDNVINQKVICSMLRRQGWTVTLALNGEEAYRRFLESRFDLILMDVQMPEV
DGLESSRRIRQAERNHKLGRIPILALTAHAATAQHKQCLAAGMDAVITKPVNFPAMLAQIAAVLPEGQTA

Sequences:

>Translated_630_residues
MKGYASLRRKLATLIAGGGVVTALIAAAGFSWLDLQRFQQQANAQVTAIANIVAGQVEPSIALGDRRVAAEILQSLRGDR
MIRDAILYDGEGECFAVARALLAACPPRPRDGLKREREAIVLVRPVLSGGERVGTLVLAASVPSIREVLGQYLGGAALIM
ALTLLVAGVLAMVLQARVSAPILAIARVAERITQTHQFDDRVAVDSSDELGVLARSFNTMLEEIARSGAELEQQIMERNR
VNAELLAAKERAEDAARQKTQFLANMSHEIRTPMNGVMGMISLVLDHELDSQDREHLLMAQSAAQSLIIILNDILDLSKI
EAGKMTFETVDFDLHRLIGDAMGIFSSAAIAKGLDLGIDLAPDSPRWVRGDPVRLRQILINLVGNAVKFTAAGSVRLTLA
PHLDNLVRFAVRDTGIGVPKDQMEAIFEAFVQADGSHTRQFGGTGLGLAITRRLVALMEGTLWAESQSGCGSTFFVELPV
QPGSAVQSLVAMAESAPGELPPVLRVLVAEDNVINQKVICSMLRRQGWTVTLALNGEEAYRRFLESRFDLILMDVQMPEV
DGLESSRRIRQAERNHKLGRIPILALTAHAATAQHKQCLAAGMDAVITKPVNFPAMLAQIAAVLPEGQTA
>Mature_630_residues
MKGYASLRRKLATLIAGGGVVTALIAAAGFSWLDLQRFQQQANAQVTAIANIVAGQVEPSIALGDRRVAAEILQSLRGDR
MIRDAILYDGEGECFAVARALLAACPPRPRDGLKREREAIVLVRPVLSGGERVGTLVLAASVPSIREVLGQYLGGAALIM
ALTLLVAGVLAMVLQARVSAPILAIARVAERITQTHQFDDRVAVDSSDELGVLARSFNTMLEEIARSGAELEQQIMERNR
VNAELLAAKERAEDAARQKTQFLANMSHEIRTPMNGVMGMISLVLDHELDSQDREHLLMAQSAAQSLIIILNDILDLSKI
EAGKMTFETVDFDLHRLIGDAMGIFSSAAIAKGLDLGIDLAPDSPRWVRGDPVRLRQILINLVGNAVKFTAAGSVRLTLA
PHLDNLVRFAVRDTGIGVPKDQMEAIFEAFVQADGSHTRQFGGTGLGLAITRRLVALMEGTLWAESQSGCGSTFFVELPV
QPGSAVQSLVAMAESAPGELPPVLRVLVAEDNVINQKVICSMLRRQGWTVTLALNGEEAYRRFLESRFDLILMDVQMPEV
DGLESSRRIRQAERNHKLGRIPILALTAHAATAQHKQCLAAGMDAVITKPVNFPAMLAQIAAVLPEGQTA

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=534, Percent_Identity=32.5842696629214, Blast_Score=243, Evalue=4e-65,
Organism=Escherichia coli, GI48994928, Length=388, Percent_Identity=35.8247422680412, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1788713, Length=406, Percent_Identity=33.2512315270936, Blast_Score=209, Evalue=6e-55,
Organism=Escherichia coli, GI87081816, Length=475, Percent_Identity=30.3157894736842, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=35.6275303643725, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1788393, Length=302, Percent_Identity=30.1324503311258, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1786783, Length=359, Percent_Identity=25.3481894150418, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI87082128, Length=336, Percent_Identity=26.7857142857143, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1786600, Length=277, Percent_Identity=29.6028880866426, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=30.0813008130081, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=28.8065843621399, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788549, Length=247, Percent_Identity=25.5060728744939, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=27.3542600896861, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786784, Length=124, Percent_Identity=29.8387096774194, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1790437, Length=119, Percent_Identity=29.4117647058824, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=120, Percent_Identity=40.8333333333333, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323034, Length=143, Percent_Identity=31.4685314685315, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67985; Mature: 67985

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50885 HAMP ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGYASLRRKLATLIAGGGVVTALIAAAGFSWLDLQRFQQQANAQVTAIANIVAGQVEPS
CCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
IALGDRRVAAEILQSLRGDRMIRDAILYDGEGECFAVARALLAACPPRPRDGLKREREAI
CCCCCHHHHHHHHHHHCCCHHHHHHHEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHCEE
VLVRPVLSGGERVGTLVLAASVPSIREVLGQYLGGAALIMALTLLVAGVLAMVLQARVSA
EEEEHHHCCCCHHHHEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCC
PILAIARVAERITQTHQFDDRVAVDSSDELGVLARSFNTMLEEIARSGAELEQQIMERNR
HHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
VNAELLAAKERAEDAARQKTQFLANMSHEIRTPMNGVMGMISLVLDHELDSQDREHLLMA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
QSAAQSLIIILNDILDLSKIEAGKMTFETVDFDLHRLIGDAMGIFSSAAIAKGLDLGIDL
HHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
APDSPRWVRGDPVRLRQILINLVGNAVKFTAAGSVRLTLAPHLDNLVRFAVRDTGIGVPK
CCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCH
DQMEAIFEAFVQADGSHTRQFGGTGLGLAITRRLVALMEGTLWAESQSGCGSTFFVELPV
HHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEECC
QPGSAVQSLVAMAESAPGELPPVLRVLVAEDNVINQKVICSMLRRQGWTVTLALNGEEAY
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCHHHH
RRFLESRFDLILMDVQMPEVDGLESSRRIRQAERNHKLGRIPILALTAHAATAQHKQCLA
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHH
AGMDAVITKPVNFPAMLAQIAAVLPEGQTA
HCCHHHHCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKGYASLRRKLATLIAGGGVVTALIAAAGFSWLDLQRFQQQANAQVTAIANIVAGQVEPS
CCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
IALGDRRVAAEILQSLRGDRMIRDAILYDGEGECFAVARALLAACPPRPRDGLKREREAI
CCCCCHHHHHHHHHHHCCCHHHHHHHEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHCEE
VLVRPVLSGGERVGTLVLAASVPSIREVLGQYLGGAALIMALTLLVAGVLAMVLQARVSA
EEEEHHHCCCCHHHHEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCC
PILAIARVAERITQTHQFDDRVAVDSSDELGVLARSFNTMLEEIARSGAELEQQIMERNR
HHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
VNAELLAAKERAEDAARQKTQFLANMSHEIRTPMNGVMGMISLVLDHELDSQDREHLLMA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
QSAAQSLIIILNDILDLSKIEAGKMTFETVDFDLHRLIGDAMGIFSSAAIAKGLDLGIDL
HHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
APDSPRWVRGDPVRLRQILINLVGNAVKFTAAGSVRLTLAPHLDNLVRFAVRDTGIGVPK
CCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCH
DQMEAIFEAFVQADGSHTRQFGGTGLGLAITRRLVALMEGTLWAESQSGCGSTFFVELPV
HHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEECC
QPGSAVQSLVAMAESAPGELPPVLRVLVAEDNVINQKVICSMLRRQGWTVTLALNGEEAY
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCHHHH
RRFLESRFDLILMDVQMPEVDGLESSRRIRQAERNHKLGRIPILALTAHAATAQHKQCLA
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHH
AGMDAVITKPVNFPAMLAQIAAVLPEGQTA
HCCHHHHCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]