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The map label for this gene is tynA [C]

Identifier: 116620044

GI number: 116620044

Start: 1144825

End: 1146729

Strand: Direct

Name: tynA [C]

Synonym: Acid_0916

Alternate gene names: 116620044

Gene position: 1144825-1146729 (Clockwise)

Preceding gene: 116620043

Following gene: 116620046

Centisome position: 11.49

GC content: 65.88

Gene sequence:

>1905_bases
GTGCGTCCCGTCCTGTTTATTCTGATTGCTGCGCTCGCCGCCTGTCGCACCGCGGCGCCGCCGCCGCACCCGCTCGCGCC
GCTGAGCGCAGCGGAGATCCGTGCGGCCACGGCTCTCCTGAAGCCGCGTGCAGCGCCCTCAGCCCGCTTCGTCCTGATCA
CGCTCGATGAGCCGCCCAAGGAGATTGTCCTGCGCGCCATGCCAACGCCGCGGCGCGCCTTCGCCGTGCTCTACGATCCG
GATTCCAACGCTACGTGGGAAGCGGTCGCCAGTCTTTCAGAGGGCCGCATTGACCGCCTGCAGCAGGTCCGCGGCGCGCA
ACCCATCGTCACCGGCGAGGACTCCGCCCGCGCCGACCAGATCGTCCGCTCCGACCCGCGCTGGCGCGCCGCCATCGAGG
CGCGCGGCATCCACGATTTCAACAACGTGACCATCGTTGCCTGGACCGCCGGGTACTTCGCACTTCCCGGCACCGAACAG
GGTCGCGTGGTCCGCGCCATCCCGTATTACTCCGCCGGGAATACGCGCAACTATTTCGCCCACCCGATCGAAGGCGTCGT
GGCTCACGTCAATCTCACTACCGGCGCGATCCTCGATCTGCTCGATACCGGGCGAAACGTTCCGGTGCCCCGCCAGCCCG
CGGAACTCGGGCCGCTCTTCAACACCCCTCTCCGCCTGTTGCCGGCTCCTCTCTCGATCACCCAATCCTCCGGACCCGGC
TTCCGCATGGAAGATGGCGAGGTGCGCTGGCAGAAGTGGCGCTTTCGCTTTGCGCTCCATCCCCGCGAAGGGCTGGTGCT
CTACACGGTGGGCTACGAGGATGGCGGCCGCGTGCGCCCGATTCTCTATCGCGGGTCTCTCTCGGAAATGGTGGTCCCTT
ACGGCGATCCCTCCGGCGGCTGGTTCTTCCGCAACAGCTTCGATGCCGGGGAACTCGGGCTCGGCCTGAACGCGACCCCA
TTGCGTGCCGGGGTCGACTGTCCCCAGAACTGTACGCTCTACGATGCCGTCCTGTCCGATGCCGAGGGCCGTCCCGCGGA
GTTCCCGCGCGCCATCGCTCTCTATGAGCGCGATGGAGGGATCGCGTGGAAACACGAGGAGGAAGCGCGCCGTGCCCGCG
ACCTGGTGCTCGGTTTCGTCTCCACCGTCGGTAACTATGATTACGGCTTCGACTGGATCTTTCACCAGGATGGCTCGCTC
GAAATGCGCGTGGCCCTGACGGGCGTAATGGCCGCCAAAGCCATTGCCACCGGCGAGCACGATCCTTACAGCCACGTGGT
CGGACCCAACCTTGCGGCGCCCCACCACCAGCATTTCTTCACCTTCCGGCTGGATCTCGACGTGGATGGACCCTCACCCA
ATCGGGTAATCGAGATCAACACGGTGCCCGTGCCCACCGGTCCGGGGAATCCCTACGGCGGCGCCTTCCAGATGGTCGAG
ACTCCCTTGAGCACCGAATCGGACGCACAGCGCAACCTGGATCTTTCCTCCAGCCGCAAGTGGATCGTCACCAATCCGCA
CGAGCGCAATGCGCTTGGCCACGCTACCGGATACGCCCTGCTCCCCGGTGAAAATGCCGTGCCATTCGCGCAACCCGATA
GCTGGGTCCGCCGCCGCGCCGCCTTCCTGGACTCGCACATCTGGGTCACACCGTACCGGGCCAGTGAAATGTACGCCGGT
GGCGACTATCCCAACCAGAGCCGTGGCGGCGATGGGCTCCGGCAGTGGACAGCCGCCAATCGTGACATCCACAATCACGA
CGTCGTCCTCTGGTACACCCTCGGCATCACCCACAATCCTCGCCCGGAGGATTGGCCGGTCATGCCCGTGCATGCGGCCG
GCTTCAGGCTTGTCCCCTGGGGCTTCTTTGCCCGAAACCCGGCGATGGATTTGCCGAGGGAGTGA

Upstream 100 bases:

>100_bases
CACCCGAGAAACCCTGCGAACACGCCGTCTGCTTCAAAATCGTGGGCGCCTGATTCAACCGGGATACTGCGACAGGGTTC
ACTGCGATACCCTGAGAACG

Downstream 100 bases:

>100_bases
TTTGCCGAGGGAGTGATTTGCCGAAAGCGTAGACAAAACTGGAGCACGCACGCACAGATTCGTGTGATCGTGCCTACAAA
TGAAAAGAGGCGCTGCCCGC

Product: tyramine oxidase

Products: NA

Alternate protein names: Copper amine oxidase [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MRPVLFILIAALAACRTAAPPPHPLAPLSAAEIRAATALLKPRAAPSARFVLITLDEPPKEIVLRAMPTPRRAFAVLYDP
DSNATWEAVASLSEGRIDRLQQVRGAQPIVTGEDSARADQIVRSDPRWRAAIEARGIHDFNNVTIVAWTAGYFALPGTEQ
GRVVRAIPYYSAGNTRNYFAHPIEGVVAHVNLTTGAILDLLDTGRNVPVPRQPAELGPLFNTPLRLLPAPLSITQSSGPG
FRMEDGEVRWQKWRFRFALHPREGLVLYTVGYEDGGRVRPILYRGSLSEMVVPYGDPSGGWFFRNSFDAGELGLGLNATP
LRAGVDCPQNCTLYDAVLSDAEGRPAEFPRAIALYERDGGIAWKHEEEARRARDLVLGFVSTVGNYDYGFDWIFHQDGSL
EMRVALTGVMAAKAIATGEHDPYSHVVGPNLAAPHHQHFFTFRLDLDVDGPSPNRVIEINTVPVPTGPGNPYGGAFQMVE
TPLSTESDAQRNLDLSSSRKWIVTNPHERNALGHATGYALLPGENAVPFAQPDSWVRRRAAFLDSHIWVTPYRASEMYAG
GDYPNQSRGGDGLRQWTAANRDIHNHDVVLWYTLGITHNPRPEDWPVMPVHAAGFRLVPWGFFARNPAMDLPRE

Sequences:

>Translated_634_residues
MRPVLFILIAALAACRTAAPPPHPLAPLSAAEIRAATALLKPRAAPSARFVLITLDEPPKEIVLRAMPTPRRAFAVLYDP
DSNATWEAVASLSEGRIDRLQQVRGAQPIVTGEDSARADQIVRSDPRWRAAIEARGIHDFNNVTIVAWTAGYFALPGTEQ
GRVVRAIPYYSAGNTRNYFAHPIEGVVAHVNLTTGAILDLLDTGRNVPVPRQPAELGPLFNTPLRLLPAPLSITQSSGPG
FRMEDGEVRWQKWRFRFALHPREGLVLYTVGYEDGGRVRPILYRGSLSEMVVPYGDPSGGWFFRNSFDAGELGLGLNATP
LRAGVDCPQNCTLYDAVLSDAEGRPAEFPRAIALYERDGGIAWKHEEEARRARDLVLGFVSTVGNYDYGFDWIFHQDGSL
EMRVALTGVMAAKAIATGEHDPYSHVVGPNLAAPHHQHFFTFRLDLDVDGPSPNRVIEINTVPVPTGPGNPYGGAFQMVE
TPLSTESDAQRNLDLSSSRKWIVTNPHERNALGHATGYALLPGENAVPFAQPDSWVRRRAAFLDSHIWVTPYRASEMYAG
GDYPNQSRGGDGLRQWTAANRDIHNHDVVLWYTLGITHNPRPEDWPVMPVHAAGFRLVPWGFFARNPAMDLPRE
>Mature_634_residues
MRPVLFILIAALAACRTAAPPPHPLAPLSAAEIRAATALLKPRAAPSARFVLITLDEPPKEIVLRAMPTPRRAFAVLYDP
DSNATWEAVASLSEGRIDRLQQVRGAQPIVTGEDSARADQIVRSDPRWRAAIEARGIHDFNNVTIVAWTAGYFALPGTEQ
GRVVRAIPYYSAGNTRNYFAHPIEGVVAHVNLTTGAILDLLDTGRNVPVPRQPAELGPLFNTPLRLLPAPLSITQSSGPG
FRMEDGEVRWQKWRFRFALHPREGLVLYTVGYEDGGRVRPILYRGSLSEMVVPYGDPSGGWFFRNSFDAGELGLGLNATP
LRAGVDCPQNCTLYDAVLSDAEGRPAEFPRAIALYERDGGIAWKHEEEARRARDLVLGFVSTVGNYDYGFDWIFHQDGSL
EMRVALTGVMAAKAIATGEHDPYSHVVGPNLAAPHHQHFFTFRLDLDVDGPSPNRVIEINTVPVPTGPGNPYGGAFQMVE
TPLSTESDAQRNLDLSSSRKWIVTNPHERNALGHATGYALLPGENAVPFAQPDSWVRRRAAFLDSHIWVTPYRASEMYAG
GDYPNQSRGGDGLRQWTAANRDIHNHDVVLWYTLGITHNPRPEDWPVMPVHAAGFRLVPWGFFARNPAMDLPRE

Specific function: Oxidizes histamine. Other amines including phenethylamine, tyramine, tryptamine, putrescine, and benzylamine also serve as substrate [H]

COG id: COG3733

COG function: function code Q; Cu2+-containing amine oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the copper/topaquinone oxidase family [H]

Homologues:

Organism=Homo sapiens, GI73486661, Length=437, Percent_Identity=28.8329519450801, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI60498982, Length=421, Percent_Identity=28.5035629453682, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI60498984, Length=432, Percent_Identity=28.0092592592593, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4502119, Length=421, Percent_Identity=27.3159144893112, Blast_Score=103, Evalue=7e-22,
Organism=Escherichia coli, GI1787651, Length=639, Percent_Identity=35.2112676056338, Blast_Score=382, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000269
- InterPro:   IPR015798
- InterPro:   IPR016182
- InterPro:   IPR015800
- InterPro:   IPR015801
- InterPro:   IPR015802 [H]

Pfam domain/function: PF01179 Cu_amine_oxid; PF02727 Cu_amine_oxidN2; PF02728 Cu_amine_oxidN3 [H]

EC number: =1.4.3.22 [H]

Molecular weight: Translated: 69901; Mature: 69901

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01164 COPPER_AMINE_OXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPVLFILIAALAACRTAAPPPHPLAPLSAAEIRAATALLKPRAAPSARFVLITLDEPPK
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCH
EIVLRAMPTPRRAFAVLYDPDSNATWEAVASLSEGRIDRLQQVRGAQPIVTGEDSARADQ
HHHEECCCCCCEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCHHHHH
IVRSDPRWRAAIEARGIHDFNNVTIVAWTAGYFALPGTEQGRVVRAIPYYSAGNTRNYFA
HHHCCCCCEEEEEECCCCCCCCEEEEEEECCEEECCCCCCCCEEEEEEEECCCCCCCCCC
HPIEGVVAHVNLTTGAILDLLDTGRNVPVPRQPAELGPLFNTPLRLLPAPLSITQSSGPG
CCCCCEEEEEEECHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCHHHCCCCCEEECCCCCC
FRMEDGEVRWQKWRFRFALHPREGLVLYTVGYEDGGRVRPILYRGSLSEMVVPYGDPSGG
CEECCCCEEEEEEEEEEEECCCCCEEEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCC
WFFRNSFDAGELGLGLNATPLRAGVDCPQNCTLYDAVLSDAEGRPAEFPRAIALYERDGG
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCEEEEEECCCC
IAWKHEEEARRARDLVLGFVSTVGNYDYGFDWIFHQDGSLEMRVALTGVMAAKAIATGEH
EEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEHHHHHHHHHHCCCC
DPYSHVVGPNLAAPHHQHFFTFRLDLDVDGPSPNRVIEINTVPVPTGPGNPYGGAFQMVE
CCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCEEEEEE
TPLSTESDAQRNLDLSSSRKWIVTNPHERNALGHATGYALLPGENAVPFAQPDSWVRRRA
CCCCCCCCHHHCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHH
AFLDSHIWVTPYRASEMYAGGDYPNQSRGGDGLRQWTAANRDIHNHDVVLWYTLGITHNP
HHHCCCEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCC
RPEDWPVMPVHAAGFRLVPWGFFARNPAMDLPRE
CCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRPVLFILIAALAACRTAAPPPHPLAPLSAAEIRAATALLKPRAAPSARFVLITLDEPPK
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCH
EIVLRAMPTPRRAFAVLYDPDSNATWEAVASLSEGRIDRLQQVRGAQPIVTGEDSARADQ
HHHEECCCCCCEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCHHHHH
IVRSDPRWRAAIEARGIHDFNNVTIVAWTAGYFALPGTEQGRVVRAIPYYSAGNTRNYFA
HHHCCCCCEEEEEECCCCCCCCEEEEEEECCEEECCCCCCCCEEEEEEEECCCCCCCCCC
HPIEGVVAHVNLTTGAILDLLDTGRNVPVPRQPAELGPLFNTPLRLLPAPLSITQSSGPG
CCCCCEEEEEEECHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCHHHCCCCCEEECCCCCC
FRMEDGEVRWQKWRFRFALHPREGLVLYTVGYEDGGRVRPILYRGSLSEMVVPYGDPSGG
CEECCCCEEEEEEEEEEEECCCCCEEEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCC
WFFRNSFDAGELGLGLNATPLRAGVDCPQNCTLYDAVLSDAEGRPAEFPRAIALYERDGG
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCEEEEEECCCC
IAWKHEEEARRARDLVLGFVSTVGNYDYGFDWIFHQDGSLEMRVALTGVMAAKAIATGEH
EEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEHHHHHHHHHHCCCC
DPYSHVVGPNLAAPHHQHFFTFRLDLDVDGPSPNRVIEINTVPVPTGPGNPYGGAFQMVE
CCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCEEEEEE
TPLSTESDAQRNLDLSSSRKWIVTNPHERNALGHATGYALLPGENAVPFAQPDSWVRRRA
CCCCCCCCHHHCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHH
AFLDSHIWVTPYRASEMYAGGDYPNQSRGGDGLRQWTAANRDIHNHDVVLWYTLGITHNP
HHHCCCEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCC
RPEDWPVMPVHAAGFRLVPWGFFARNPAMDLPRE
CCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7876243 [H]