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The map label for this gene is trxA [H]

Identifier: 116619824

GI number: 116619824

Start: 868799

End: 869245

Strand: Direct

Name: trxA [H]

Synonym: Acid_0694

Alternate gene names: 116619824

Gene position: 868799-869245 (Clockwise)

Preceding gene: 116619819

Following gene: 116619827

Centisome position: 8.72

GC content: 64.43

Gene sequence:

>447_bases
ATGGCTGAAGCGGATCTGATTCGTTGTCCCGCGTGCGGCGCTACCAACCGGGTACCGCGCGAAAAAATCGCACAGGGGTT
ACAGCCGGTCTGCGGACAATGCAAGGCGGGGCTGCCGGTTGACAGCAGTCCAATAGTGGTCACGGACAAGACGTTTGCGG
CGGTGGTGGAGCAGTCCGCGGTGCCTGTGCTGGTGGACTTGTGGGCGCCGTGGTGCGGTCCCTGCCGCATGGTGGCGCCG
GCGGTGGAAGCGCTCGCCGCGGAGATGGCCGGACGGCTGCGCGTGGCCAAGATCAATGTCGATGACAACCCCGGCGTCTC
TTCGCGCTTTAATGTGCAAAGCATTCCGACGCTGCTGCTGATTCGCGGCGGCCGTGAAGTGAACCGGTTGGTTGGCGCGC
AGCCAAAGCAGGATATTGCACGCTGGCTGGCGCGCTCGCTGGGGTAA

Upstream 100 bases:

>100_bases
CTGCATCTGTACCTGGCAATGCGCTGCTTTTCACGATTCACCTCCTACCGGGAGTGATGAGCAGTCCTCTTGCCAAGATT
CGTCATGTCACACTTAGAGC

Downstream 100 bases:

>100_bases
TCGAATTACCGGCCGCTTGCTGACGGGTCTGGCTAGTTCGCGCGATAGGAAATGCGCCAGACCTTTTTGCCGCCATCGTC
GGAGAGCAGCAGGCTGCCAT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MAEADLIRCPACGATNRVPREKIAQGLQPVCGQCKAGLPVDSSPIVVTDKTFAAVVEQSAVPVLVDLWAPWCGPCRMVAP
AVEALAAEMAGRLRVAKINVDDNPGVSSRFNVQSIPTLLLIRGGREVNRLVGAQPKQDIARWLARSLG

Sequences:

>Translated_148_residues
MAEADLIRCPACGATNRVPREKIAQGLQPVCGQCKAGLPVDSSPIVVTDKTFAAVVEQSAVPVLVDLWAPWCGPCRMVAP
AVEALAAEMAGRLRVAKINVDDNPGVSSRFNVQSIPTLLLIRGGREVNRLVGAQPKQDIARWLARSLG
>Mature_147_residues
AEADLIRCPACGATNRVPREKIAQGLQPVCGQCKAGLPVDSSPIVVTDKTFAAVVEQSAVPVLVDLWAPWCGPCRMVAPA
VEALAAEMAGRLRVAKINVDDNPGVSSRFNVQSIPTLLLIRGGREVNRLVGAQPKQDIARWLARSLG

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=31.9587628865979, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI21361657, Length=109, Percent_Identity=31.1926605504587, Blast_Score=63, Evalue=8e-11,
Organism=Escherichia coli, GI1788936, Length=139, Percent_Identity=39.568345323741, Blast_Score=111, Evalue=2e-26,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=41.747572815534, Blast_Score=97, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=41.8604651162791, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115532380, Length=111, Percent_Identity=32.4324324324324, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=81, Percent_Identity=38.2716049382716, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=29.5918367346939, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=111, Percent_Identity=32.4324324324324, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=104, Percent_Identity=30.7692307692308, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=81, Percent_Identity=45.679012345679, Blast_Score=79, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=96, Percent_Identity=39.5833333333333, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573567, Length=102, Percent_Identity=38.2352941176471, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24639826, Length=86, Percent_Identity=36.046511627907, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21358065, Length=99, Percent_Identity=34.3434343434343, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24664269, Length=72, Percent_Identity=41.6666666666667, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17648013, Length=75, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583090, Length=75, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 15723; Mature: 15591

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEADLIRCPACGATNRVPREKIAQGLQPVCGQCKAGLPVDSSPIVVTDKTFAAVVEQSA
CCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHCC
VPVLVDLWAPWCGPCRMVAPAVEALAAEMAGRLRVAKINVDDNPGVSSRFNVQSIPTLLL
CCCCEEHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHCCEEEE
IRGGREVNRLVGAQPKQDIARWLARSLG
EECCCHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AEADLIRCPACGATNRVPREKIAQGLQPVCGQCKAGLPVDSSPIVVTDKTFAAVVEQSA
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHCC
VPVLVDLWAPWCGPCRMVAPAVEALAAEMAGRLRVAKINVDDNPGVSSRFNVQSIPTLLL
CCCCEEHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHCCEEEE
IRGGREVNRLVGAQPKQDIARWLARSLG
EECCCHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]