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The map label for this gene is xdhB [H]

Identifier: 116619496

GI number: 116619496

Start: 453927

End: 455315

Strand: Direct

Name: xdhB [H]

Synonym: Acid_0355

Alternate gene names: 116619496

Gene position: 453927-455315 (Clockwise)

Preceding gene: 116619495

Following gene: 116619497

Centisome position: 4.55

GC content: 67.03

Gene sequence:

>1389_bases
ATGGCGTCGCCACTCTCTGATTTTTCATTCCATCTCAACGGCGAAGCTGTGTTCGTCGAGCACGCCCCCAACTCCCAGAC
CACCCTGCTCGATTTCCTCCGTTCCCGCGGACTCACCGGCGCCAAGGAAGGTTGCGCCGAAGGGGAATGCGGAGCGTGCA
CTGTCGCCTTCGTGAGAGCCCACGACCACGGGTCCGTCTATTGCCCTGTGAACAGTTGCCTGATCTTCCTCCCCATGGTT
GCTGGTCAAGAGATTTACACAGTCGAGGCCCTCGCCGCCTCAGGGGAACTCAACCCCGTGCAGCAATCTATCGGTGAGCG
CGGCGGTTCGCAGTGCGGCTACTGCACCCCCGGCTTCGTCATGAGTCTTTTCGCGGAACATTACCGTCCCGGCCGGGACA
CCGCCTGCGACCCTCACGCGATGGATGGCAATCTCTGCCGTTGCACCGGCTATCGCCCCTTGCGCGATGCCGCACTCGCT
CTCGCCCCCGCGCCCGGCGACACCTTTCGGCGCCGCCTCGACCTGCCCGCTCCCTCCATACCTGCGTTCACCTCTCCCCA
CTTCTCGCGTCCCGCCACGGTTGACGCCTGCCTCGAACTCCTCTCCCGCCACCCCGACGCGCGACTCGTCTCCGGTGGCA
CCGATCTCGCCGTCGAGTCCAACCTCCTCGGCCGCGTCTTCCCGCACCTCGTCAGCCTGGAAGCCCTCGAGGAGCTCCGC
GTGTTCCGCCGCACCGGCGATCACATCGAAATCGGCGCCGGACATACCCTCTCCGAAATTGCCGCCCTCTGGCACGATGC
ACCGCCGGCATTTTTCGAATGGATCGAACTCTTCGCCTCGCCGCTCATCCGCAACCGCGCGACCCTCGGCGGCAATCTCG
CGACGGCCTCGCCGATCGGTGACGCCGCCCCCCTCTTGCTCGCGCTCGATGCCTCCGTCTTGATCGCTGCCGAGTCCGGC
ACGCGCACCGTCCCGCTTCACGAGTTCTACCTCGACTACCGCAAGACCGCGCTCGCCCCCGGCGAAATCCTGGTCTCCGT
CCTCATCCCCACGCCGCTCCCCGACGAGCTCCGTTTCTATAAGGCCGCCAAACGCCGCCTCGATGACATCAGCACTGTCG
CCGCCGCCTTCTCGCTCACCTTCGATGCCGCCTCCCGCATACATACCGCCCGCCTCGCCTATGGAGGCGTCGCCGCCGTC
CCCCTGCGCTGTACCGAAGCCGAGGCCGCTCTCACCGGCCGCTCCTGGAACCAGTCCGCCGTCGCCGCCGCCACATCCGC
CATCGCCGCCACCATCCACCCCCTCTCCGACCACCGCGGCTCCGCCGCCTACCGCCTCGCCCTGGCCCAGTCCCTCCTGG
CCAAGTTCCACCACGAGGTCCCCGCATGA

Upstream 100 bases:

>100_bases
CTGTAACTCTTTTATTATCAATAAATCAATTCCAGAAAGTGGGCACCCTGGCCCGTTTTCGCATTTCTGCTGTACACTTG
TCCGAATAGGCCTCAGAGCC

Downstream 100 bases:

>100_bases
CCTTCCCATCAGGGCCGCGACCGCCAGGGACCGATCACCCGTCTTGTACTACTGTGCATATGTTTGCTCGCACGCCTCGA
AGATTCGCATCAGAGCCGCG

Product: molybdopterin dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MASPLSDFSFHLNGEAVFVEHAPNSQTTLLDFLRSRGLTGAKEGCAEGECGACTVAFVRAHDHGSVYCPVNSCLIFLPMV
AGQEIYTVEALAASGELNPVQQSIGERGGSQCGYCTPGFVMSLFAEHYRPGRDTACDPHAMDGNLCRCTGYRPLRDAALA
LAPAPGDTFRRRLDLPAPSIPAFTSPHFSRPATVDACLELLSRHPDARLVSGGTDLAVESNLLGRVFPHLVSLEALEELR
VFRRTGDHIEIGAGHTLSEIAALWHDAPPAFFEWIELFASPLIRNRATLGGNLATASPIGDAAPLLLALDASVLIAAESG
TRTVPLHEFYLDYRKTALAPGEILVSVLIPTPLPDELRFYKAAKRRLDDISTVAAAFSLTFDAASRIHTARLAYGGVAAV
PLRCTEAEAALTGRSWNQSAVAAATSAIAATIHPLSDHRGSAAYRLALAQSLLAKFHHEVPA

Sequences:

>Translated_462_residues
MASPLSDFSFHLNGEAVFVEHAPNSQTTLLDFLRSRGLTGAKEGCAEGECGACTVAFVRAHDHGSVYCPVNSCLIFLPMV
AGQEIYTVEALAASGELNPVQQSIGERGGSQCGYCTPGFVMSLFAEHYRPGRDTACDPHAMDGNLCRCTGYRPLRDAALA
LAPAPGDTFRRRLDLPAPSIPAFTSPHFSRPATVDACLELLSRHPDARLVSGGTDLAVESNLLGRVFPHLVSLEALEELR
VFRRTGDHIEIGAGHTLSEIAALWHDAPPAFFEWIELFASPLIRNRATLGGNLATASPIGDAAPLLLALDASVLIAAESG
TRTVPLHEFYLDYRKTALAPGEILVSVLIPTPLPDELRFYKAAKRRLDDISTVAAAFSLTFDAASRIHTARLAYGGVAAV
PLRCTEAEAALTGRSWNQSAVAAATSAIAATIHPLSDHRGSAAYRLALAQSLLAKFHHEVPA
>Mature_461_residues
ASPLSDFSFHLNGEAVFVEHAPNSQTTLLDFLRSRGLTGAKEGCAEGECGACTVAFVRAHDHGSVYCPVNSCLIFLPMVA
GQEIYTVEALAASGELNPVQQSIGERGGSQCGYCTPGFVMSLFAEHYRPGRDTACDPHAMDGNLCRCTGYRPLRDAALAL
APAPGDTFRRRLDLPAPSIPAFTSPHFSRPATVDACLELLSRHPDARLVSGGTDLAVESNLLGRVFPHLVSLEALEELRV
FRRTGDHIEIGAGHTLSEIAALWHDAPPAFFEWIELFASPLIRNRATLGGNLATASPIGDAAPLLLALDASVLIAAESGT
RTVPLHEFYLDYRKTALAPGEILVSVLIPTPLPDELRFYKAAKRRLDDISTVAAAFSLTFDAASRIHTARLAYGGVAAVP
LRCTEAEAALTGRSWNQSAVAAATSAIAATIHPLSDHRGSAAYRLALAQSLLAKFHHEVPA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=523, Percent_Identity=29.8279158699809, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI71773480, Length=529, Percent_Identity=26.4650283553875, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1789231, Length=274, Percent_Identity=31.021897810219, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789232, Length=151, Percent_Identity=38.4105960264901, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786480, Length=161, Percent_Identity=34.7826086956522, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17540638, Length=285, Percent_Identity=30.8771929824561, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32566215, Length=385, Percent_Identity=26.7532467532467, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=465, Percent_Identity=24.9462365591398, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17737937, Length=515, Percent_Identity=31.4563106796116, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24647201, Length=499, Percent_Identity=27.0541082164329, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24647197, Length=508, Percent_Identity=28.5433070866142, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24647199, Length=496, Percent_Identity=28.2258064516129, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24647195, Length=503, Percent_Identity=26.6401590457256, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24647193, Length=496, Percent_Identity=26.8145161290323, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 49264; Mature: 49133

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPLSDFSFHLNGEAVFVEHAPNSQTTLLDFLRSRGLTGAKEGCAEGECGACTVAFVRA
CCCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEE
HDHGSVYCPVNSCLIFLPMVAGQEIYTVEALAASGELNPVQQSIGERGGSQCGYCTPGFV
CCCCCEEECHHHHHHHHHHHCCCEEEEEEHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHH
MSLFAEHYRPGRDTACDPHAMDGNLCRCTGYRPLRDAALALAPAPGDTFRRRLDLPAPSI
HHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHEEEECCCCHHHHHHCCCCCCCC
PAFTSPHFSRPATVDACLELLSRHPDARLVSGGTDLAVESNLLGRVFPHLVSLEALEELR
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHH
VFRRTGDHIEIGAGHTLSEIAALWHDAPPAFFEWIELFASPLIRNRATLGGNLATASPIG
HHHHCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCC
DAAPLLLALDASVLIAAESGTRTVPLHEFYLDYRKTALAPGEILVSVLIPTPLPDELRFY
CCCHHHEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHEEEEECCCCCCHHHHHH
KAAKRRLDDISTVAAAFSLTFDAASRIHTARLAYGGVAAVPLRCTEAEAALTGRSWNQSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHCCCCCCCHH
VAAATSAIAATIHPLSDHRGSAAYRLALAQSLLAKFHHEVPA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASPLSDFSFHLNGEAVFVEHAPNSQTTLLDFLRSRGLTGAKEGCAEGECGACTVAFVRA
CCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEE
HDHGSVYCPVNSCLIFLPMVAGQEIYTVEALAASGELNPVQQSIGERGGSQCGYCTPGFV
CCCCCEEECHHHHHHHHHHHCCCEEEEEEHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHH
MSLFAEHYRPGRDTACDPHAMDGNLCRCTGYRPLRDAALALAPAPGDTFRRRLDLPAPSI
HHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHEEEECCCCHHHHHHCCCCCCCC
PAFTSPHFSRPATVDACLELLSRHPDARLVSGGTDLAVESNLLGRVFPHLVSLEALEELR
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHH
VFRRTGDHIEIGAGHTLSEIAALWHDAPPAFFEWIELFASPLIRNRATLGGNLATASPIG
HHHHCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCC
DAAPLLLALDASVLIAAESGTRTVPLHEFYLDYRKTALAPGEILVSVLIPTPLPDELRFY
CCCHHHEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHEEEEECCCCCCHHHHHH
KAAKRRLDDISTVAAAFSLTFDAASRIHTARLAYGGVAAVPLRCTEAEAALTGRSWNQSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHCCCCCCCHH
VAAATSAIAATIHPLSDHRGSAAYRLALAQSLLAKFHHEVPA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]