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The map label for this gene is pucD [H]

Identifier: 116619497

GI number: 116619497

Start: 455530

End: 457773

Strand: Direct

Name: pucD [H]

Synonym: Acid_0356

Alternate gene names: 116619497

Gene position: 455530-457773 (Clockwise)

Preceding gene: 116619496

Following gene: 116619498

Centisome position: 4.57

GC content: 67.6

Gene sequence:

>2244_bases
ATGAAGTACGTCGCCCAGCCCGTCTCCCACGAAAGCGCGCGCGGACATGTCACCGGCGACGCCCTCTACACCGCCGATCT
CGAGTCCCGCTTCCCCAATCTCCTGCACGCATACCCGGTCCTCGCGCCCCACGCGCACGCGCAGTTGCTCGGGCTCGACG
CAGCCGGGGCCACTATTCTCACCGCGGCCGACGTCCCCGGCGAAGGCAACACCGGAGTCAATCGCCACGACGAACCGCTC
TTCCCCTCCACCGTGATGTTCCATCGCCAGCCGGTCGCCTGGGTCCTCGCCGACACCCTCGCAGACTCGCGTGCCGGCGC
CGCCAAGGTCCGCGCGGACTACCAGGCCCTACCGGCCATCGTTCACCTCGAAGACGCGATCGCCGCCCAATCCTTCCTCT
GCGGCCCCGCCACTCTCCAGCGCGGCGATGCCCGCGCCGCCATTGATGGGAGCGCTCACCGCCTGGATGGCGAACTCACT
ATGGGCGGCCAGGAGCACTTCTATCTGGAAACTCACTGCGCCATCGCCTGGCTCGATGAATCCGGCGGCGTCTCGCTCCA
TTCCTCCACCCAGCACCCCGCCGAAACCCAGGCCATCGTGGCTCGCGTCCTCGGTATCCCCGACCACCGGGTCACCGTGG
AGTGCCTCCGCATGGGCGGCGCCTTCGGCGGTAAGGAAGTGCAGTCGAATGCCTTCGCCGCTATCGCCGCGCTCGGCGCC
TGGAAGACCCGCCGCCCCGTGATGGTCCGCCTCCCCCGCGCGGTCGATATGGCGATCACCGGCAAGCGCCATCCCTTCCT
CGCCCGCTTCGAAGCCGGCTACGACGATACCGGCCGCATCCTCGGCCTCCTCGTCAACCTGTTCGCCGATGGCGGTTGGA
GCCTTGATCTTTCCGAGCCCATCATGGGCCGCGCCCTCTTCCACATCGACAACGCCTACCTGCTCCCCAACGTCACCGCC
ACCGGCTTCGTCTGCCGCACGCACAAGACTTCGCAGACCGCCTTCCGCGGTTTCGGCGGTCCGCAGGGGATGCTCGTCAT
TGAAGATGTGCTCGATCGCATCGCGCGCTCCCTTTCCCTCGCGCCGGAAATCGTCCGCCGCCGCAACTTCTATCGCGAGG
GCGATACCACCCACTACGGCATGCCGGTCAAGGACGCCGCGCGCATTGAGCGCATCTGGGACGAGCTCACCGCCACCAGC
GATTTCGCCGTGCGCCGCACCGGGATCGATCGCCACAATCTCACCCATCCTCACACCAAGCGCGGTCTGGCCATCACGCC
CGTGAAATTCGGCATCTCGTTCACCGCCACCTGGTACAACCAGGCCGGAGCGCTCGTGCTCATCTACCGCGATGGCAGCG
TGCAGGTGAACCACGGCGGCACCGAGATGGGCCAGGGTCTCCACACCAAGATCCGCCAGATCGCCGCCGATGCTTTGGAT
ATCGATATTGAGTCGGTGCGCATCATGCCCACCCGCACCGACAAAGTGCCGAACACCTCCGCCACCGCCGCCTCTGCCAG
CACCGACCTCAACGGTGCTGCCGTGCTCGATGCCTGCCGCCAACTGAAGGAACGCCTCGCGCCCATCGCCGCCGAACTCG
GCGACGCTCCCTTTTCGCAGGTCGTCGAGGCCGCCTACCGCCGCCGCACGCCGCTCTTCGCGCAGGGCTACTACCGCACT
CCCGAGATCAACTGGGACGCCGCCGCCGGACGCGGTAGGCCATTCTACTATTTCGCGTACGGAGCGGCCGTCTCCGAAGT
CGAGGTCGATGGTTTCACCGGCGCCTACACCGTGCTCCGCACCGATATCCTCCAGGACGTCGGCGATTCCAGTTCTCCGC
TGATCGATCGCGGCCAGGTGGAGGGCGGCTTCCTCCAGGGCCTCGGCTGGCTCACGTTGGAGGAGCTCCTCTGGAATGAT
GAGGGCCGCCTGACCACCGCCGGAGCGTCTACTTACAAGCTGCCCTCCTGGTCCGAGGTCCCCGCCGATTTCCGCGTCGA
TTTCCTCACGCGCGCCGCCGAGGCCGGCGTCGTCTGCGGCAGTAAAGCCGTCGGCGAGCCGCCGCTTATGCTCGCCATCT
CCGTGCGGGAAGCCCTGCGCGATGCCATCGCCGCCTTCGGCAGCGGCGGCTTGGTCCTGCTCGATAGCCCCGCCACTCCC
GAGCGCGTCTTTTGGGCCATCCAGCGCGCACGCGGGGCCGCCACCGAGCCCGTGTCTTCCGCGGTCGGAGCCGCGCAAGC
GTGA

Upstream 100 bases:

>100_bases
ATCGCCTGTTCGTGGTTTGTGGGGCAGGCAATCCTGCCTGCAGCCGGCTTTCAGCCGGCTCGCCCCGCTGCAATGCGGCC
GCCCCCATCCAGGTGCCCGC

Downstream 100 bases:

>100_bases
GCGAAATCCTGCGTGCCACCATTTTCCACGCGCCGCGCAATCCCTTCCGAACTCCGGGCTCGCTCGTCTTCCATGAGGAT
GGCGCGCTGCTGCTCGCCGA

Product: xanthine oxidase

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MKYVAQPVSHESARGHVTGDALYTADLESRFPNLLHAYPVLAPHAHAQLLGLDAAGATILTAADVPGEGNTGVNRHDEPL
FPSTVMFHRQPVAWVLADTLADSRAGAAKVRADYQALPAIVHLEDAIAAQSFLCGPATLQRGDARAAIDGSAHRLDGELT
MGGQEHFYLETHCAIAWLDESGGVSLHSSTQHPAETQAIVARVLGIPDHRVTVECLRMGGAFGGKEVQSNAFAAIAALGA
WKTRRPVMVRLPRAVDMAITGKRHPFLARFEAGYDDTGRILGLLVNLFADGGWSLDLSEPIMGRALFHIDNAYLLPNVTA
TGFVCRTHKTSQTAFRGFGGPQGMLVIEDVLDRIARSLSLAPEIVRRRNFYREGDTTHYGMPVKDAARIERIWDELTATS
DFAVRRTGIDRHNLTHPHTKRGLAITPVKFGISFTATWYNQAGALVLIYRDGSVQVNHGGTEMGQGLHTKIRQIAADALD
IDIESVRIMPTRTDKVPNTSATAASASTDLNGAAVLDACRQLKERLAPIAAELGDAPFSQVVEAAYRRRTPLFAQGYYRT
PEINWDAAAGRGRPFYYFAYGAAVSEVEVDGFTGAYTVLRTDILQDVGDSSSPLIDRGQVEGGFLQGLGWLTLEELLWND
EGRLTTAGASTYKLPSWSEVPADFRVDFLTRAAEAGVVCGSKAVGEPPLMLAISVREALRDAIAAFGSGGLVLLDSPATP
ERVFWAIQRARGAATEPVSSAVGAAQA

Sequences:

>Translated_747_residues
MKYVAQPVSHESARGHVTGDALYTADLESRFPNLLHAYPVLAPHAHAQLLGLDAAGATILTAADVPGEGNTGVNRHDEPL
FPSTVMFHRQPVAWVLADTLADSRAGAAKVRADYQALPAIVHLEDAIAAQSFLCGPATLQRGDARAAIDGSAHRLDGELT
MGGQEHFYLETHCAIAWLDESGGVSLHSSTQHPAETQAIVARVLGIPDHRVTVECLRMGGAFGGKEVQSNAFAAIAALGA
WKTRRPVMVRLPRAVDMAITGKRHPFLARFEAGYDDTGRILGLLVNLFADGGWSLDLSEPIMGRALFHIDNAYLLPNVTA
TGFVCRTHKTSQTAFRGFGGPQGMLVIEDVLDRIARSLSLAPEIVRRRNFYREGDTTHYGMPVKDAARIERIWDELTATS
DFAVRRTGIDRHNLTHPHTKRGLAITPVKFGISFTATWYNQAGALVLIYRDGSVQVNHGGTEMGQGLHTKIRQIAADALD
IDIESVRIMPTRTDKVPNTSATAASASTDLNGAAVLDACRQLKERLAPIAAELGDAPFSQVVEAAYRRRTPLFAQGYYRT
PEINWDAAAGRGRPFYYFAYGAAVSEVEVDGFTGAYTVLRTDILQDVGDSSSPLIDRGQVEGGFLQGLGWLTLEELLWND
EGRLTTAGASTYKLPSWSEVPADFRVDFLTRAAEAGVVCGSKAVGEPPLMLAISVREALRDAIAAFGSGGLVLLDSPATP
ERVFWAIQRARGAATEPVSSAVGAAQA
>Mature_747_residues
MKYVAQPVSHESARGHVTGDALYTADLESRFPNLLHAYPVLAPHAHAQLLGLDAAGATILTAADVPGEGNTGVNRHDEPL
FPSTVMFHRQPVAWVLADTLADSRAGAAKVRADYQALPAIVHLEDAIAAQSFLCGPATLQRGDARAAIDGSAHRLDGELT
MGGQEHFYLETHCAIAWLDESGGVSLHSSTQHPAETQAIVARVLGIPDHRVTVECLRMGGAFGGKEVQSNAFAAIAALGA
WKTRRPVMVRLPRAVDMAITGKRHPFLARFEAGYDDTGRILGLLVNLFADGGWSLDLSEPIMGRALFHIDNAYLLPNVTA
TGFVCRTHKTSQTAFRGFGGPQGMLVIEDVLDRIARSLSLAPEIVRRRNFYREGDTTHYGMPVKDAARIERIWDELTATS
DFAVRRTGIDRHNLTHPHTKRGLAITPVKFGISFTATWYNQAGALVLIYRDGSVQVNHGGTEMGQGLHTKIRQIAADALD
IDIESVRIMPTRTDKVPNTSATAASASTDLNGAAVLDACRQLKERLAPIAAELGDAPFSQVVEAAYRRRTPLFAQGYYRT
PEINWDAAAGRGRPFYYFAYGAAVSEVEVDGFTGAYTVLRTDILQDVGDSSSPLIDRGQVEGGFLQGLGWLTLEELLWND
EGRLTTAGASTYKLPSWSEVPADFRVDFLTRAAEAGVVCGSKAVGEPPLMLAISVREALRDAIAAFGSGGLVLLDSPATP
ERVFWAIQRARGAATEPVSSAVGAAQA

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=736, Percent_Identity=44.9728260869565, Blast_Score=619, Evalue=1e-177,
Organism=Homo sapiens, GI71773480, Length=739, Percent_Identity=37.0771312584574, Blast_Score=474, Evalue=1e-133,
Organism=Escherichia coli, GI1789230, Length=757, Percent_Identity=25.891677675033, Blast_Score=175, Evalue=1e-44,
Organism=Escherichia coli, GI1789246, Length=698, Percent_Identity=24.3553008595989, Blast_Score=143, Evalue=5e-35,
Organism=Escherichia coli, GI1786478, Length=756, Percent_Identity=24.0740740740741, Blast_Score=99, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17540638, Length=744, Percent_Identity=39.9193548387097, Blast_Score=517, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17539860, Length=721, Percent_Identity=33.8418862690707, Blast_Score=373, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI32566215, Length=710, Percent_Identity=32.9577464788732, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI17737937, Length=741, Percent_Identity=41.2955465587045, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24647199, Length=751, Percent_Identity=30.7589880159787, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24647193, Length=746, Percent_Identity=29.3565683646113, Blast_Score=277, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24647201, Length=751, Percent_Identity=30.0932090545939, Blast_Score=265, Evalue=8e-71,
Organism=Drosophila melanogaster, GI24647195, Length=766, Percent_Identity=29.6344647519582, Blast_Score=251, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24647197, Length=582, Percent_Identity=31.4432989690722, Blast_Score=247, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 80373; Mature: 80373

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYVAQPVSHESARGHVTGDALYTADLESRFPNLLHAYPVLAPHAHAQLLGLDAAGATIL
CCCCCCCCCCCCCCCCCCCCEEEEECHHHHCCHHHHHHCCCCCCCCCEEEEECCCCCEEE
TAADVPGEGNTGVNRHDEPLFPSTVMFHRQPVAWVLADTLADSRAGAAKVRADYQALPAI
EEECCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCEE
VHLEDAIAAQSFLCGPATLQRGDARAAIDGSAHRLDGELTMGGQEHFYLETHCAIAWLDE
EEHHHHHHHHHHCCCCHHHCCCCCCEEECCCCEEECCEEEECCCCEEEEEEEEEEEEEEC
SGGVSLHSSTQHPAETQAIVARVLGIPDHRVTVECLRMGGAFGGKEVQSNAFAAIAALGA
CCCEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHC
WKTRRPVMVRLPRAVDMAITGKRHPFLARFEAGYDDTGRILGLLVNLFADGGWSLDLSEP
CCCCCCEEEECCCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCC
IMGRALFHIDNAYLLPNVTATGFVCRTHKTSQTAFRGFGGPQGMLVIEDVLDRIARSLSL
HHCEEEEEECCEEECCCCCCCCEEEECCCCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHH
APEIVRRRNFYREGDTTHYGMPVKDAARIERIWDELTATSDFAVRRTGIDRHNLTHPHTK
HHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
RGLAITPVKFGISFTATWYNQAGALVLIYRDGSVQVNHGGTEMGQGLHTKIRQIAADALD
CCEEEEEEEECCEEEEEEECCCCEEEEEEECCEEEECCCCHHHCCHHHHHHHHHHHHHHC
IDIESVRIMPTRTDKVPNTSATAASASTDLNGAAVLDACRQLKERLAPIAAELGDAPFSQ
CEECEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VVEAAYRRRTPLFAQGYYRTPEINWDAAAGRGRPFYYFAYGAAVSEVEVDGFTGAYTVLR
HHHHHHHHCCCCEECCCEECCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCHHHHHHH
TDILQDVGDSSSPLIDRGQVEGGFLQGLGWLTLEELLWNDEGRLTTAGASTYKLPSWSEV
HHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCEEECCCCEECCCCCCCC
PADFRVDFLTRAAEAGVVCGSKAVGEPPLMLAISVREALRDAIAAFGSGGLVLLDSPATP
CCCHHHHHHHHHHHCCCEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEECCCCCH
ERVFWAIQRARGAATEPVSSAVGAAQA
HHHHHHHHHHCCCCCCCHHHHHCCCCC
>Mature Secondary Structure
MKYVAQPVSHESARGHVTGDALYTADLESRFPNLLHAYPVLAPHAHAQLLGLDAAGATIL
CCCCCCCCCCCCCCCCCCCCEEEEECHHHHCCHHHHHHCCCCCCCCCEEEEECCCCCEEE
TAADVPGEGNTGVNRHDEPLFPSTVMFHRQPVAWVLADTLADSRAGAAKVRADYQALPAI
EEECCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCEE
VHLEDAIAAQSFLCGPATLQRGDARAAIDGSAHRLDGELTMGGQEHFYLETHCAIAWLDE
EEHHHHHHHHHHCCCCHHHCCCCCCEEECCCCEEECCEEEECCCCEEEEEEEEEEEEEEC
SGGVSLHSSTQHPAETQAIVARVLGIPDHRVTVECLRMGGAFGGKEVQSNAFAAIAALGA
CCCEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHC
WKTRRPVMVRLPRAVDMAITGKRHPFLARFEAGYDDTGRILGLLVNLFADGGWSLDLSEP
CCCCCCEEEECCCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCC
IMGRALFHIDNAYLLPNVTATGFVCRTHKTSQTAFRGFGGPQGMLVIEDVLDRIARSLSL
HHCEEEEEECCEEECCCCCCCCEEEECCCCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHH
APEIVRRRNFYREGDTTHYGMPVKDAARIERIWDELTATSDFAVRRTGIDRHNLTHPHTK
HHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
RGLAITPVKFGISFTATWYNQAGALVLIYRDGSVQVNHGGTEMGQGLHTKIRQIAADALD
CCEEEEEEEECCEEEEEEECCCCEEEEEEECCEEEECCCCHHHCCHHHHHHHHHHHHHHC
IDIESVRIMPTRTDKVPNTSATAASASTDLNGAAVLDACRQLKERLAPIAAELGDAPFSQ
CEECEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VVEAAYRRRTPLFAQGYYRTPEINWDAAAGRGRPFYYFAYGAAVSEVEVDGFTGAYTVLR
HHHHHHHHCCCCEECCCEECCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCHHHHHHH
TDILQDVGDSSSPLIDRGQVEGGFLQGLGWLTLEELLWNDEGRLTTAGASTYKLPSWSEV
HHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCEEECCCCEECCCCCCCC
PADFRVDFLTRAAEAGVVCGSKAVGEPPLMLAISVREALRDAIAAFGSGGLVLLDSPATP
CCCHHHHHHHHHHHCCCEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEECCCCCH
ERVFWAIQRARGAATEPVSSAVGAAQA
HHHHHHHHHHCCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]