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The map label for this gene is acoA [H]

Identifier: 116619493

GI number: 116619493

Start: 451072

End: 452094

Strand: Direct

Name: acoA [H]

Synonym: Acid_0352

Alternate gene names: 116619493

Gene position: 451072-452094 (Clockwise)

Preceding gene: 116619489

Following gene: 116619494

Centisome position: 4.53

GC content: 63.83

Gene sequence:

>1023_bases
ATGAGCGCTGTCGAAGCTACGGGTGCGGCAACACATAACGCGTCCTCGGCGGCCGGCAGTCTACAGGCCGAACTCGCCCA
CAAGTGTCTCTACTACATGCTGCTCATGCGCGAAGTCGAAGATCGCATCGAGCGCAAGCTCTATCGCCAGGGAAAAATCC
TCGGCGGCGTTTACGTCGGCCGCGGCCAGGAAGCCATCCCGGTCGGTAGCGCCCTCGTCGCCGTCCCCGAGGACGTCATG
TTCCCCTCCCACCGCGACATGGCCGTCTTCTTCATCCGCGGAGTCTCCGCCCGCCGCGTCCTCGCTCAATATATGGGACG
CCTCGGTGGACTCACCCGCGGACGCGACGGCAACATGCACATGGGCGATATGAGCGTCAACGTCGTGTCCATCATCAGCG
CCCTCGCAGCCACCGTCCCGGTCGCCACCGGCGCCGCCCTCGCCATGCGCTACAAGGGAATCCCCGGCGTCGCCTTCAGC
TACTTCGGCGATGGCTCCACCAGCCGCGGCGATTGGCACGAAGGCGTCAATTTCGCCAGCGTCCAGAAGCTCCCCGTCGT
CTTCATCTGCAACAACAACCAGTACGCGTATTCCACGCCCCTCCATCTCCAAATGGCCTGCGCCAACGTCGCCGATCGCG
GCCCCGCCTACAACATGCCCGCCGAAATCGTCGATGGAAATGACGTGCTCGCCGTTTACGAAGCCACTCAGCGCGCTGTC
ACCCACGCCCGCGGCGGCCTCGGCCCCTACCTGCTCGAGTGCAAGACTTTTCGCATGACAGGACACTCCGCACACGACGC
CGCCACCTACGTTCCCAAGGGCCTCTTTGAGGAATGGGGCAAGCTCGACCCCATCGTCCGCCTCGAAAAACGCATGCTCG
AGGAACGCTGGTCGCTCCAGGAAGAAATCGACGAGCTTCACGCCGCCGTCATCCGCGAAGTGGATGACGCTGTCGCCTGG
GCCGAGCAGAGTCCCTACCCCGACGCCGCCAGCCTGCTTGACGACGTTTACGAGAACCAATAG

Upstream 100 bases:

>100_bases
AGCGATCTCTCCATCGTTCTTTTGCGCGTAAGCATCCGCACCCCTTGCGCCTGCACCGCTGGTATACTACCCGTTGAACC
CCAAGTTAGAGGTAATCCCC

Downstream 100 bases:

>100_bases
CCCATGTCCACCACGTACCTCGAAGCAATCCGCGAAGGCCTCTGGGAAGAGATGGAGCGCGATCCCAACGTCTTCTGCAT
CGGTGAGGACATCGGCGAAT

Product: pyruvate dehydrogenase

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit alpha [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSAVEATGAATHNASSAAGSLQAELAHKCLYYMLLMREVEDRIERKLYRQGKILGGVYVGRGQEAIPVGSALVAVPEDVM
FPSHRDMAVFFIRGVSARRVLAQYMGRLGGLTRGRDGNMHMGDMSVNVVSIISALAATVPVATGAALAMRYKGIPGVAFS
YFGDGSTSRGDWHEGVNFASVQKLPVVFICNNNQYAYSTPLHLQMACANVADRGPAYNMPAEIVDGNDVLAVYEATQRAV
THARGGLGPYLLECKTFRMTGHSAHDAATYVPKGLFEEWGKLDPIVRLEKRMLEERWSLQEEIDELHAAVIREVDDAVAW
AEQSPYPDAASLLDDVYENQ

Sequences:

>Translated_340_residues
MSAVEATGAATHNASSAAGSLQAELAHKCLYYMLLMREVEDRIERKLYRQGKILGGVYVGRGQEAIPVGSALVAVPEDVM
FPSHRDMAVFFIRGVSARRVLAQYMGRLGGLTRGRDGNMHMGDMSVNVVSIISALAATVPVATGAALAMRYKGIPGVAFS
YFGDGSTSRGDWHEGVNFASVQKLPVVFICNNNQYAYSTPLHLQMACANVADRGPAYNMPAEIVDGNDVLAVYEATQRAV
THARGGLGPYLLECKTFRMTGHSAHDAATYVPKGLFEEWGKLDPIVRLEKRMLEERWSLQEEIDELHAAVIREVDDAVAW
AEQSPYPDAASLLDDVYENQ
>Mature_339_residues
SAVEATGAATHNASSAAGSLQAELAHKCLYYMLLMREVEDRIERKLYRQGKILGGVYVGRGQEAIPVGSALVAVPEDVMF
PSHRDMAVFFIRGVSARRVLAQYMGRLGGLTRGRDGNMHMGDMSVNVVSIISALAATVPVATGAALAMRYKGIPGVAFSY
FGDGSTSRGDWHEGVNFASVQKLPVVFICNNNQYAYSTPLHLQMACANVADRGPAYNMPAEIVDGNDVLAVYEATQRAVT
HARGGLGPYLLECKTFRMTGHSAHDAATYVPKGLFEEWGKLDPIVRLEKRMLEERWSLQEEIDELHAAVIREVDDAVAWA
EQSPYPDAASLLDDVYENQ

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde. The alpha subunit is probably the catalytic subunit of the enzyme [H]

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=313, Percent_Identity=36.741214057508, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI11386135, Length=311, Percent_Identity=35.6913183279743, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI258645172, Length=311, Percent_Identity=35.6913183279743, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4505685, Length=315, Percent_Identity=35.5555555555556, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI291084742, Length=315, Percent_Identity=35.5555555555556, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI291084744, Length=322, Percent_Identity=34.1614906832298, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI291084757, Length=315, Percent_Identity=32.0634920634921, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI86563355, Length=312, Percent_Identity=35.8974358974359, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI86563357, Length=312, Percent_Identity=35.8974358974359, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17536047, Length=329, Percent_Identity=31.306990881459, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI32564172, Length=329, Percent_Identity=31.306990881459, Blast_Score=150, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6321026, Length=312, Percent_Identity=33.3333333333333, Blast_Score=153, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24639746, Length=297, Percent_Identity=33.6700336700337, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24639740, Length=297, Percent_Identity=33.6700336700337, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24639744, Length=318, Percent_Identity=33.0188679245283, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28571106, Length=318, Percent_Identity=33.0188679245283, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21355903, Length=322, Percent_Identity=31.3664596273292, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24639748, Length=307, Percent_Identity=31.9218241042345, Blast_Score=131, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: 1.2.4.1

Molecular weight: Translated: 37088; Mature: 36956

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVEATGAATHNASSAAGSLQAELAHKCLYYMLLMREVEDRIERKLYRQGKILGGVYVG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
RGQEAIPVGSALVAVPEDVMFPSHRDMAVFFIRGVSARRVLAQYMGRLGGLTRGRDGNMH
CCCCCCCCCCCCEECCHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCEE
MGDMSVNVVSIISALAATVPVATGAALAMRYKGIPGVAFSYFGDGSTSRGDWHEGVNFAS
ECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEECCCCCCCCCCHHHCCCHHE
VQKLPVVFICNNNQYAYSTPLHLQMACANVADRGPAYNMPAEIVDGNDVLAVYEATQRAV
ECCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCCCEEECCCCEEEEHHHHHHHH
THARGGLGPYLLECKTFRMTGHSAHDAATYVPKGLFEEWGKLDPIVRLEKRMLEERWSLQ
HHHCCCCCCHHHEEEEEEECCCCCCHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EEIDELHAAVIREVDDAVAWAEQSPYPDAASLLDDVYENQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SAVEATGAATHNASSAAGSLQAELAHKCLYYMLLMREVEDRIERKLYRQGKILGGVYVG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
RGQEAIPVGSALVAVPEDVMFPSHRDMAVFFIRGVSARRVLAQYMGRLGGLTRGRDGNMH
CCCCCCCCCCCCEECCHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCEE
MGDMSVNVVSIISALAATVPVATGAALAMRYKGIPGVAFSYFGDGSTSRGDWHEGVNFAS
ECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEECCCCCCCCCCHHHCCCHHE
VQKLPVVFICNNNQYAYSTPLHLQMACANVADRGPAYNMPAEIVDGNDVLAVYEATQRAV
ECCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCCCEEECCCCEEEEHHHHHHHH
THARGGLGPYLLECKTFRMTGHSAHDAATYVPKGLFEEWGKLDPIVRLEKRMLEERWSLQ
HHHCCCCCCHHHEEEEEEECCCCCCHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EEIDELHAAVIREVDDAVAWAEQSPYPDAASLLDDVYENQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 10368162; 9384377 [H]