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The map label for this gene is norM [H]

Identifier: 116619489

GI number: 116619489

Start: 443578

End: 444915

Strand: Direct

Name: norM [H]

Synonym: Acid_0348

Alternate gene names: 116619489

Gene position: 443578-444915 (Clockwise)

Preceding gene: 116619488

Following gene: 116619493

Centisome position: 4.45

GC content: 66.29

Gene sequence:

>1338_bases
ATGATCCCTGGCTTCCGCAAAGAGATCCGCCCCATGCTGCGCCTCGGCGTGCCTCTCGCCCTCGCCGAACTCGGCTGGAT
GGCGATGGGCTTCGTCGATACCGTCATGGCCGGTCGCCTCGGCGCCGCCGCCATCGGTGCCGGCGCACTCGGAGGCATGC
TGTTCTTCCCCATCGCCGTCTGCGGCACCGGCCTGCTCCTCGGCATGGACACCCTGGTCTCGCAGGCCTTCGGCGCCGGG
GACGACGACGCCTGCCGCCGCACATTCATCAACGGCCTGTGGATCGCCCTCCTGGTCGCCCCCGCCGTCGCCGTGCTGCT
CGCCCTCACCATCCCCGCCCTGCGCGTCACCGGCACGAATCCTGAGGTGTTGAGTCTGCTCGCCCCCTTCGTCCACGCCC
TACTCTGGGGCGTCCTGCCGTTGTTGTTCTACACGGCCTTTCGCCGCTATCTACAGGCGCAGAACATCGTCCGCCCTATT
ACCTTCGCCGTCATCAGCGCCAACCTCGTCAACTTCGCCGGCAACTGGCTGCTCATGTACGGCCACTGGGGCCTGCCTCG
GATGGGCCTCGAAGGCTCCGGGATCTCCACATCCTTCTCGCGCCTCTATATCGCTCTCGTCCTTCTGATCGCCGTGCTCC
GCCACGAGCGCCTCCACCGCAACCGCCTCTTCCACATGGACTGGAGACCCGAGTTCCCCTGCATCCGCGGCCTGCTCGCT
CTCGGTTTCCCGTCCGCCATGCAGATCCTCTTCGAAGGTGCAGTGTTTGCCGTCGTCACGGTGCTCGCGTCCCACCTCGA
CGAGTTCTCGCTCGCTGCCCACGGGATCGCCGTCAACGTCATCTCCATCACTTACATGGTGCCCCTCGGAATCAGCTCCG
CCGCCGCGGTCCGCGTCGGCCAGGCCATCGGTCGCAAGGACCCGCGCGGCATCGCCGTCGCCGGTTGGACCGCCCTTCTC
CTTGCCGCCCTCTTCATGGGTTCCGCCGGCCTCGGCTTCTCCATCGCCCCACGCTGGATAGCGCGCCTCTATACCCCCGA
CGTCGCGGTCATCGCCGCCAGCGTCACTCTCCTGAGAATCGCCGCCCTCTTCCAGATCTTCGATGGCCTCCAGGTGGTCG
CCACCGGAGCTCTCCGCGGCCTTGGTGACACCCGCACCCCCGCCTACGCTCACCTGGTGGGATATTGGATTTTCGGAATG
CCCGTCGCCGGGCTCCTCTGCTTCCACTACGGATGGGGCGTCAGCGGCATCTGGGTCGGCCTCACCATCGCTTTGATCAT
GATCGGCCTCATTCTCATTTTCGTCTGGCGCAGAGCCCTGCTGGATCGGCTGCTTTGA

Upstream 100 bases:

>100_bases
CACGCCCGCCTCTCCACCACGCAAAAATACACCCAGGTATCTTTGACCGACCTGATGGCGGTCTACGACAAGGCGCATCC
CAAGGCATGATCGCGCGTAT

Downstream 100 bases:

>100_bases
CAGTCTTTTCTTCTTGGCGTTACTATGCGGCTCGGCGTCGTTGCGAGAAAAATGCCCTGCTCGCTGGGGCAGAACCGTCT
CTCGCCCGAGCACTCCAACA

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MIPGFRKEIRPMLRLGVPLALAELGWMAMGFVDTVMAGRLGAAAIGAGALGGMLFFPIAVCGTGLLLGMDTLVSQAFGAG
DDDACRRTFINGLWIALLVAPAVAVLLALTIPALRVTGTNPEVLSLLAPFVHALLWGVLPLLFYTAFRRYLQAQNIVRPI
TFAVISANLVNFAGNWLLMYGHWGLPRMGLEGSGISTSFSRLYIALVLLIAVLRHERLHRNRLFHMDWRPEFPCIRGLLA
LGFPSAMQILFEGAVFAVVTVLASHLDEFSLAAHGIAVNVISITYMVPLGISSAAAVRVGQAIGRKDPRGIAVAGWTALL
LAALFMGSAGLGFSIAPRWIARLYTPDVAVIAASVTLLRIAALFQIFDGLQVVATGALRGLGDTRTPAYAHLVGYWIFGM
PVAGLLCFHYGWGVSGIWVGLTIALIMIGLILIFVWRRALLDRLL

Sequences:

>Translated_445_residues
MIPGFRKEIRPMLRLGVPLALAELGWMAMGFVDTVMAGRLGAAAIGAGALGGMLFFPIAVCGTGLLLGMDTLVSQAFGAG
DDDACRRTFINGLWIALLVAPAVAVLLALTIPALRVTGTNPEVLSLLAPFVHALLWGVLPLLFYTAFRRYLQAQNIVRPI
TFAVISANLVNFAGNWLLMYGHWGLPRMGLEGSGISTSFSRLYIALVLLIAVLRHERLHRNRLFHMDWRPEFPCIRGLLA
LGFPSAMQILFEGAVFAVVTVLASHLDEFSLAAHGIAVNVISITYMVPLGISSAAAVRVGQAIGRKDPRGIAVAGWTALL
LAALFMGSAGLGFSIAPRWIARLYTPDVAVIAASVTLLRIAALFQIFDGLQVVATGALRGLGDTRTPAYAHLVGYWIFGM
PVAGLLCFHYGWGVSGIWVGLTIALIMIGLILIFVWRRALLDRLL
>Mature_445_residues
MIPGFRKEIRPMLRLGVPLALAELGWMAMGFVDTVMAGRLGAAAIGAGALGGMLFFPIAVCGTGLLLGMDTLVSQAFGAG
DDDACRRTFINGLWIALLVAPAVAVLLALTIPALRVTGTNPEVLSLLAPFVHALLWGVLPLLFYTAFRRYLQAQNIVRPI
TFAVISANLVNFAGNWLLMYGHWGLPRMGLEGSGISTSFSRLYIALVLLIAVLRHERLHRNRLFHMDWRPEFPCIRGLLA
LGFPSAMQILFEGAVFAVVTVLASHLDEFSLAAHGIAVNVISITYMVPLGISSAAAVRVGQAIGRKDPRGIAVAGWTALL
LAALFMGSAGLGFSIAPRWIARLYTPDVAVIAASVTLLRIAALFQIFDGLQVVATGALRGLGDTRTPAYAHLVGYWIFGM
PVAGLLCFHYGWGVSGIWVGLTIALIMIGLILIFVWRRALLDRLL

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=447, Percent_Identity=27.2930648769575, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI153792564, Length=432, Percent_Identity=27.5462962962963, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI38261960, Length=468, Percent_Identity=25.4273504273504, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI48994890, Length=448, Percent_Identity=30.3571428571429, Blast_Score=184, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6320545, Length=443, Percent_Identity=23.2505643340858, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321821, Length=398, Percent_Identity=25.1256281407035, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47809; Mature: 47809

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]