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The map label for this gene is fucA [H]

Identifier: 116619461

GI number: 116619461

Start: 416081

End: 416926

Strand: Direct

Name: fucA [H]

Synonym: Acid_0320

Alternate gene names: 116619461

Gene position: 416081-416926 (Clockwise)

Preceding gene: 116619457

Following gene: 116619462

Centisome position: 4.18

GC content: 62.41

Gene sequence:

>846_bases
ATGCATTCTGCTACAATCGGGAATTCCGTAATGGTCAAAACCGAGCGCGAGTACCGAGACGATATCTGTCAGATTGGCCG
CCTGGTCTTTCAAAAAGGCTGGGTCGCCGCCAACGACGGCAATATCACCATCCGGCTCGACGCGGAACGGATTCTGGCAA
CTCCCACCGGCGTCTGCAAGGGCATGATGCACCCCGACGACCTCATCATCGTCGATATGAAAGGCAATAAAATTTCGGGA
CGCGCGCAGGGCACCAGCGAGATCGCCATGCACACCACCGTGTATGGGCTGCGCCCCGACGTGAAAGCGGTCGTCCACGC
CCATCCCCCGGTCGCCACCGGTTACGCCACCGCCGGCCGCGAACTCAACCTCGCGCTGCTGCCGGAGGTCGTGATCGGGC
TGGGCTGCGTGCCGCTGGCCGATTACGGTCTGCCCGGCACCCCCGCTCTGACTGAGCCGATGCTGCCCCTGATTCCCAAG
TACGACGCGCTGATGATGGCCAATCACGGCGCCGTCTGCTACGGCGAGGATGTTTTTAAGGCCTATTTCAAGATGGAAAC
CCTCGAGCATTTCGCGCGCATCCAACTGGTCGCCGAGTTGTTGGGGGGTCCCAAGGTGCTGCCGCGGACGGAAGTGGATA
AGCTCCTGGATTCGCGGACGCGCTATGGCGTCAAGGCCAAGAGCGCGGGCGAACCTAATTGTCCGGTGGCCGCGGAGGAA
GTAGGGCGCAGCAGCTGCGGGGCCGCCGGCGCCGCCCCGCGCGCCGATGAAGAACATTTTTACGTGTCGCGCTCGGAGCT
GGTGTCCATTGTCGAGGAAGCGCTCAAGGCGCGCGGTATAGCTTAA

Upstream 100 bases:

>100_bases
CGATCTTTGGTGGTGATGAAGGCCCGGCAATGCGGGCACATCCGGCGAGGATCCATTAGCTCCATCATACGCTGAGCGCT
CCAAGCAACCGGAGATCCGC

Downstream 100 bases:

>100_bases
GACGATTTCTTGGAGAATTAACCGATGGGTGAAGCGTTAGGAATGATCGAAACGCGTGGTCTGATTGCAATGATCGAGGC
CGCCGACGCGATGGTGAAGG

Product: class II aldolase/adducin family protein

Products: NA

Alternate protein names: L-fuculose-1-phosphate aldolase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MHSATIGNSVMVKTEREYRDDICQIGRLVFQKGWVAANDGNITIRLDAERILATPTGVCKGMMHPDDLIIVDMKGNKISG
RAQGTSEIAMHTTVYGLRPDVKAVVHAHPPVATGYATAGRELNLALLPEVVIGLGCVPLADYGLPGTPALTEPMLPLIPK
YDALMMANHGAVCYGEDVFKAYFKMETLEHFARIQLVAELLGGPKVLPRTEVDKLLDSRTRYGVKAKSAGEPNCPVAAEE
VGRSSCGAAGAAPRADEEHFYVSRSELVSIVEEALKARGIA

Sequences:

>Translated_281_residues
MHSATIGNSVMVKTEREYRDDICQIGRLVFQKGWVAANDGNITIRLDAERILATPTGVCKGMMHPDDLIIVDMKGNKISG
RAQGTSEIAMHTTVYGLRPDVKAVVHAHPPVATGYATAGRELNLALLPEVVIGLGCVPLADYGLPGTPALTEPMLPLIPK
YDALMMANHGAVCYGEDVFKAYFKMETLEHFARIQLVAELLGGPKVLPRTEVDKLLDSRTRYGVKAKSAGEPNCPVAAEE
VGRSSCGAAGAAPRADEEHFYVSRSELVSIVEEALKARGIA
>Mature_281_residues
MHSATIGNSVMVKTEREYRDDICQIGRLVFQKGWVAANDGNITIRLDAERILATPTGVCKGMMHPDDLIIVDMKGNKISG
RAQGTSEIAMHTTVYGLRPDVKAVVHAHPPVATGYATAGRELNLALLPEVVIGLGCVPLADYGLPGTPALTEPMLPLIPK
YDALMMANHGAVCYGEDVFKAYFKMETLEHFARIQLVAELLGGPKVLPRTEVDKLLDSRTRYGVKAKSAGEPNCPVAAEE
VGRSSCGAAGAAPRADEEHFYVSRSELVSIVEEALKARGIA

Specific function: Catalyzes the reversible aldol cleavage of L-fuculose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. The substrate preference order is glyceraldehyde > DL- lactaldehyde, glycolaldehyde > acrolein > formaldehyde, methylglyoxal > acet

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family. AraD/FucA subfamily [H]

Homologues:

Organism=Homo sapiens, GI9257190, Length=208, Percent_Identity=28.3653846153846, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI89276787, Length=208, Percent_Identity=28.3653846153846, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI297307160, Length=208, Percent_Identity=28.3653846153846, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI297307158, Length=208, Percent_Identity=28.3653846153846, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI9257192, Length=208, Percent_Identity=28.3653846153846, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI29826325, Length=233, Percent_Identity=27.4678111587983, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI29826323, Length=236, Percent_Identity=27.5423728813559, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI29826321, Length=236, Percent_Identity=27.5423728813559, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI29826319, Length=236, Percent_Identity=27.5423728813559, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789094, Length=193, Percent_Identity=31.6062176165803, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789164, Length=214, Percent_Identity=25.2336448598131, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: =4.1.2.17 [H]

Molecular weight: Translated: 30194; Mature: 30194

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSATIGNSVMVKTEREYRDDICQIGRLVFQKGWVAANDGNITIRLDAERILATPTGVCK
CCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEEHHHHHCCCHHHHH
GMMHPDDLIIVDMKGNKISGRAQGTSEIAMHTTVYGLRPDVKAVVHAHPPVATGYATAGR
CCCCCCCEEEEEECCCEECCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCC
ELNLALLPEVVIGLGCVPLADYGLPGTPALTEPMLPLIPKYDALMMANHGAVCYGEDVFK
CCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECHHHHH
AYFKMETLEHFARIQLVAELLGGPKVLPRTEVDKLLDSRTRYGVKAKSAGEPNCPVAAEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHH
VGRSSCGAAGAAPRADEEHFYVSRSELVSIVEEALKARGIA
CCCHHCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHSATIGNSVMVKTEREYRDDICQIGRLVFQKGWVAANDGNITIRLDAERILATPTGVCK
CCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEEHHHHHCCCHHHHH
GMMHPDDLIIVDMKGNKISGRAQGTSEIAMHTTVYGLRPDVKAVVHAHPPVATGYATAGR
CCCCCCCEEEEEECCCEECCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCC
ELNLALLPEVVIGLGCVPLADYGLPGTPALTEPMLPLIPKYDALMMANHGAVCYGEDVFK
CCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECHHHHH
AYFKMETLEHFARIQLVAELLGGPKVLPRTEVDKLLDSRTRYGVKAKSAGEPNCPVAAEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHH
VGRSSCGAAGAAPRADEEHFYVSRSELVSIVEEALKARGIA
CCCHHCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]