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The map label for this gene is trxA [H]

Identifier: 116619449

GI number: 116619449

Start: 407969

End: 408298

Strand: Direct

Name: trxA [H]

Synonym: Acid_0308

Alternate gene names: 116619449

Gene position: 407969-408298 (Clockwise)

Preceding gene: 116619448

Following gene: 116619457

Centisome position: 4.09

GC content: 59.09

Gene sequence:

>330_bases
ATGGCAGGTCAGAACACGTTAACCTTTTCCGATTCGACGTTCGACGAAGATGTGCTTCGGTCGGATGTCCCGGTCTTGGT
GGATTTTTGGGCCGAGTGGTGCGGCCCGTGCAGGCAGATGTCGCCCACGATCGATGTCGTGGCCGGCGAGTACGCTGGAA
AGGTGAAGGTCGGCAAACTCGATGTCGACGCCAATGGCGGCACCGCCATGCGGTACAACGTCCGCGGTATTCCGACCCTG
CTGCTCTTCAAGGGCGGCCAAGTGGTCGAACAGCGTGTCGGAGCCATCGGCAAGAGCGATGTGCTCAAAATGATCGACGC
ACACGTCTAA

Upstream 100 bases:

>100_bases
GACCTCCGCCGCTGCCTATTCGGAGCTTTACCGCCGGCTGTTGGGCCGCTGAATCCTTTTGTCCTTTTGGGATTCTAATA
GTTAGAGTTTAGGAGACGAA

Downstream 100 bases:

>100_bases
GTCAGTTTCAGCAAGTGAACTTCAGCGGGGCGGAACTCCGGTTCCGCCCACTATCATTTCAGCCCCCATCTCATCCTGGC
ATTTGACGCAGTATCGCGCC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MAGQNTLTFSDSTFDEDVLRSDVPVLVDFWAEWCGPCRQMSPTIDVVAGEYAGKVKVGKLDVDANGGTAMRYNVRGIPTL
LLFKGGQVVEQRVGAIGKSDVLKMIDAHV

Sequences:

>Translated_109_residues
MAGQNTLTFSDSTFDEDVLRSDVPVLVDFWAEWCGPCRQMSPTIDVVAGEYAGKVKVGKLDVDANGGTAMRYNVRGIPTL
LLFKGGQVVEQRVGAIGKSDVLKMIDAHV
>Mature_108_residues
AGQNTLTFSDSTFDEDVLRSDVPVLVDFWAEWCGPCRQMSPTIDVVAGEYAGKVKVGKLDVDANGGTAMRYNVRGIPTLL
LFKGGQVVEQRVGAIGKSDVLKMIDAHV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=81, Percent_Identity=40.7407407407407, Blast_Score=77, Evalue=3e-15,
Organism=Homo sapiens, GI5031973, Length=103, Percent_Identity=33.0097087378641, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI24308127, Length=80, Percent_Identity=35, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=51.4563106796116, Blast_Score=126, Evalue=3e-31,
Organism=Escherichia coli, GI1788936, Length=84, Percent_Identity=44.047619047619, Blast_Score=91, Evalue=2e-20,
Organism=Escherichia coli, GI87081747, Length=107, Percent_Identity=30.8411214953271, Blast_Score=68, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=76, Percent_Identity=42.1052631578947, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17556044, Length=80, Percent_Identity=40, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115532380, Length=72, Percent_Identity=44.4444444444444, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=44.4444444444444, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=72, Percent_Identity=44.4444444444444, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=94, Percent_Identity=35.1063829787234, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=94, Percent_Identity=35.1063829787234, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=94, Percent_Identity=35.1063829787234, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=83, Percent_Identity=36.144578313253, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=75, Percent_Identity=40, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=35.632183908046, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71998175, Length=78, Percent_Identity=42.3076923076923, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=44.047619047619, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=40.6976744186046, Blast_Score=70, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28573567, Length=81, Percent_Identity=40.7407407407407, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24639826, Length=92, Percent_Identity=41.304347826087, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19921434, Length=82, Percent_Identity=42.6829268292683, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358065, Length=85, Percent_Identity=40, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17648013, Length=81, Percent_Identity=41.9753086419753, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24583090, Length=81, Percent_Identity=41.9753086419753, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=40.2298850574713, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11775; Mature: 11643

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGQNTLTFSDSTFDEDVLRSDVPVLVDFWAEWCGPCRQMSPTIDVVAGEYAGKVKVGKL
CCCCCEEEECCCCCCHHHHHCCCCHHHHHHHHHCCHHHCCCCCEEEEECCCCCEEEEEEE
DVDANGGTAMRYNVRGIPTLLLFKGGQVVEQRVGAIGKSDVLKMIDAHV
EECCCCCEEEEEECCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
AGQNTLTFSDSTFDEDVLRSDVPVLVDFWAEWCGPCRQMSPTIDVVAGEYAGKVKVGKL
CCCCEEEECCCCCCHHHHHCCCCHHHHHHHHHCCHHHCCCCCEEEEECCCCCEEEEEEE
DVDANGGTAMRYNVRGIPTLLLFKGGQVVEQRVGAIGKSDVLKMIDAHV
EECCCCCEEEEEECCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]