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The map label for this gene is yfhQ [H]

Identifier: 116619437

GI number: 116619437

Start: 395646

End: 396659

Strand: Direct

Name: yfhQ [H]

Synonym: Acid_0296

Alternate gene names: 116619437

Gene position: 395646-396659 (Clockwise)

Preceding gene: 116619436

Following gene: 116619438

Centisome position: 3.97

GC content: 66.07

Gene sequence:

>1014_bases
GTGAGTGGCCCTTCGCTGAGCAGCCTGCTGTTGGCCTGGTATCGCGCGGCGCATCGCGACCTGCCGTGGCGGAGTTCGCG
CGATCCCTACCGCGTATGGATCAGCGAGATCATGCTGCAGCAGACGCGGGCGCAGGCGGTGATTCCCTACTACGAAAAGT
TTCTGGCGCGCTTCCCGTCGGTAGAATCGCTGGCTGCCGCGCCGGAGGAAGAAGTGCTCGCGTTGTGGAGCGGGCTGGGG
TACTACTCGCGGGCACGCAATTTGCGCAACGCGGCGCGCCAGATCACCGCCGCGGCTGGTTTCCCGCGCGAGTACGACGC
GATTCGCGCGCTGCCCGGCATCGGCGATTACACGGCGGCGGCGATCGCCAGCATCGCCTTCGGGCTGCCGCACGCCGTCC
TGGACGGGAACGTGCTGCGCGTGGTGGCGCGCGTGGAGAACGATGCCGCGGATATTGGCAGTTCCCGCACGCGCGAACGG
TTCCGCGCAATCGCGCAGCAATGGCTGGAGGCGAAGGAAGTCAAGCACGATCCGGGACATTTCAACCAGGCATTGATGGA
ATTGGGCGCCACGGTCTGCGTGCCGCGAAGACCTCTGTGCCTGGTCTGTCCGATCTCGGCGTGCTGCCGCGCGCGTCAGG
AAGGCACGGCGGCGCAGCTGCCAGTAAAGCTGCGCAAGCAGGAGCCGGTGCGGATTTCCGGCGTGCTGCTGGTGGTCCGG
CAGCGGGGCAGGATTCTGCTGCGGCGGCGTGAGGACTCTCAATCGCGGATGGCGGGATTCTGGGAGTTGCCCACGCCCGA
AGAACTTCCGGGGTCAGAGGTGGGCGAGCGTATCGGCGAGATCCGCCACACCATCACGCATCATCGTTACACCTTCGAAG
TACGCGCCGCCACCGCCGCGGTTCCGGCCACGGGCGGGTTTGCGTGGTTCACGATTGCGCAACTTGCGGAGATTCCCTTC
AGCACCACGGCGCGCAAGGCGCTGCAACTGGCAGGGTTCGTTTACAACTTGTGA

Upstream 100 bases:

>100_bases
ACGAAAATGTCCGGCTGGAACCGTTGAACCCCGAGTTCGAAGCCTGGGATGTGGAGCCCGAGGGCTTCGCCGTGGTTGCC
GAATGGCTGCGCGTCATCGA

Downstream 100 bases:

>100_bases
TAGTTTCGTAAAACTCTCACGATTAAGGACATTTCACCGAAAGCATCGAGTAGATTTGTGGATGCGAGGGTTAACGGGAT
AGATATGGAACGCCAGAGGA

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSGPSLSSLLLAWYRAAHRDLPWRSSRDPYRVWISEIMLQQTRAQAVIPYYEKFLARFPSVESLAAAPEEEVLALWSGLG
YYSRARNLRNAARQITAAAGFPREYDAIRALPGIGDYTAAAIASIAFGLPHAVLDGNVLRVVARVENDAADIGSSRTRER
FRAIAQQWLEAKEVKHDPGHFNQALMELGATVCVPRRPLCLVCPISACCRARQEGTAAQLPVKLRKQEPVRISGVLLVVR
QRGRILLRRREDSQSRMAGFWELPTPEELPGSEVGERIGEIRHTITHHRYTFEVRAATAAVPATGGFAWFTIAQLAEIPF
STTARKALQLAGFVYNL

Sequences:

>Translated_337_residues
MSGPSLSSLLLAWYRAAHRDLPWRSSRDPYRVWISEIMLQQTRAQAVIPYYEKFLARFPSVESLAAAPEEEVLALWSGLG
YYSRARNLRNAARQITAAAGFPREYDAIRALPGIGDYTAAAIASIAFGLPHAVLDGNVLRVVARVENDAADIGSSRTRER
FRAIAQQWLEAKEVKHDPGHFNQALMELGATVCVPRRPLCLVCPISACCRARQEGTAAQLPVKLRKQEPVRISGVLLVVR
QRGRILLRRREDSQSRMAGFWELPTPEELPGSEVGERIGEIRHTITHHRYTFEVRAATAAVPATGGFAWFTIAQLAEIPF
STTARKALQLAGFVYNL
>Mature_336_residues
SGPSLSSLLLAWYRAAHRDLPWRSSRDPYRVWISEIMLQQTRAQAVIPYYEKFLARFPSVESLAAAPEEEVLALWSGLGY
YSRARNLRNAARQITAAAGFPREYDAIRALPGIGDYTAAAIASIAFGLPHAVLDGNVLRVVARVENDAADIGSSRTRERF
RAIAQQWLEAKEVKHDPGHFNQALMELGATVCVPRRPLCLVCPISACCRARQEGTAAQLPVKLRKQEPVRISGVLLVVRQ
RGRILLRRREDSQSRMAGFWELPTPEELPGSEVGERIGEIRHTITHHRYTFEVRAATAAVPATGGFAWFTIAQLAEIPFS
TTARKALQLAGFVYNL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=403, Percent_Identity=35.4838709677419, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI115298652, Length=403, Percent_Identity=35.4838709677419, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI115298648, Length=403, Percent_Identity=35.4838709677419, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI115298650, Length=403, Percent_Identity=35.4838709677419, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI6912520, Length=403, Percent_Identity=35.4838709677419, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI190358497, Length=403, Percent_Identity=35.4838709677419, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI1789331, Length=351, Percent_Identity=34.7578347578348, Blast_Score=204, Evalue=7e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 37515; Mature: 37383

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPSLSSLLLAWYRAAHRDLPWRSSRDPYRVWISEIMLQQTRAQAVIPYYEKFLARFPS
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VESLAAAPEEEVLALWSGLGYYSRARNLRNAARQITAAAGFPREYDAIRALPGIGDYTAA
HHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHH
AIASIAFGLPHAVLDGNVLRVVARVENDAADIGSSRTRERFRAIAQQWLEAKEVKHDPGH
HHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
FNQALMELGATVCVPRRPLCLVCPISACCRARQEGTAAQLPVKLRKQEPVRISGVLLVVR
HHHHHHHCCCEEECCCCCEEEECCHHHHHHHHHCCCHHHCCHHHCCCCCCEEHHHHEEEH
QRGRILLRRREDSQSRMAGFWELPTPEELPGSEVGERIGEIRHTITHHRYTFEVRAATAA
HCCCEEEEECCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEEHHHEE
VPATGGFAWFTIAQLAEIPFSTTARKALQLAGFVYNL
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGPSLSSLLLAWYRAAHRDLPWRSSRDPYRVWISEIMLQQTRAQAVIPYYEKFLARFPS
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VESLAAAPEEEVLALWSGLGYYSRARNLRNAARQITAAAGFPREYDAIRALPGIGDYTAA
HHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHH
AIASIAFGLPHAVLDGNVLRVVARVENDAADIGSSRTRERFRAIAQQWLEAKEVKHDPGH
HHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
FNQALMELGATVCVPRRPLCLVCPISACCRARQEGTAAQLPVKLRKQEPVRISGVLLVVR
HHHHHHHCCCEEECCCCCEEEECCHHHHHHHHHCCCHHHCCHHHCCCCCCEEHHHHEEEH
QRGRILLRRREDSQSRMAGFWELPTPEELPGSEVGERIGEIRHTITHHRYTFEVRAATAA
HCCCEEEEECCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEEHHHEE
VPATGGFAWFTIAQLAEIPFSTTARKALQLAGFVYNL
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]