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The map label for this gene is kdpD [H]

Identifier: 116619215

GI number: 116619215

Start: 100678

End: 102174

Strand: Direct

Name: kdpD [H]

Synonym: Acid_0070

Alternate gene names: 116619215

Gene position: 100678-102174 (Clockwise)

Preceding gene: 116619214

Following gene: 116619216

Centisome position: 1.01

GC content: 63.79

Gene sequence:

>1497_bases
GTGGGGCAGACAATCCTGGCTGCCGCCGGCTTTCAGCCGGCGCGCCCCCTACCGGAGCCAATCCCTGTGCGCCTGAAGCT
CCTCCACTTTCTTACCTCCCTACTCGCCGTCGCTGGAGTGCTCGCGCTCTACCTGTTCCTCCTCCCGGTCAACAACACCA
CGGTCGCCCTGTCCCTCCTGCTGGTGATCCTCGCGATATCGGCGCGTTGGGGCCTGGCGGAGGCGACGCTCGCCTCGGTG
ATCGCCGTTCTCGGGTTGAACTACTACTTCCTCCCGCCCGTGCGCACCTTCACCATCCAGGATCCCCAGAATTGGGTGGC
GCTGGTTGCCTTCCTGGTAACGGCTGTCACCGCTAGCCAGTTATCGGCCCGTGTGCGCCGCCGCGCGGCGGAGGCCGAAG
CGCGCCGCCTTGAGATCGAACGTCTCTATGCGCTCGTACAGGCCATGATCCTAAGCGGCAATGCGCGGCGCACCCTGCGC
GAGTTCGTGCAGACCGTTGTCAAAGTCTTCGCCTGCGACGCGGCCGCTTTCTACTACCAGCCCGGCGGCGAGTTCTTCCG
GTCGGGACCGGAAAGCAGTCCGATCACCGACCACGATCTGCTGGCTGCGGCCGAGGTGGACCACGTCTCATTCGATCCCG
AAAAACACATTGCGACCGCACCCGTACGTCTCGGCGGCCGTCCCTTGGGAAGCATGGCGCTGCTTGGCGAACTGCCTTCG
GAACAGACCATGAGCGCCATCGTCAACCTAGTCGCCATTTCCGTGGAGAAGGCGCGCGCGCTCGAGGATGCCAGCCATGC
CGAGGCCGCCCGACAAAGTGAGGTATTGAAATCGGCCCTGCTGGATTCGCTCGCGCACGATATCAAAACGCCGCTCACCT
CCATCAAAGCCGCGGTCACAAGTCTGTTGAGCAACTCCGCCGCGGCCGACCAGGAACTGCTCACCATCATCAATGAGGAG
GCCGATCGGCTCAACCAGTTGGCCGCCGAAGTTATCGCGATGGCTCGCGTGGAGGCCGGCAAACTCCATCTGGAGAAACG
GCCCGTGAATGTCGCGGAGCTTATCGAAGGCGCGCTCGGCGAACTGGGCGCGCGCAGTGGCCATGCCGTCACGGTCAACC
TGTCCCCGCGGCTTCCGCGCGCCTCGTGCGATCCCGAGTTCGTGCAACAGGTAGTCAAGCAGTTGCTGGAGAACGCACTG
AAGTATTCGCCGGAGGGAGCGGAGGTCACCGTCTCGGCGGAGCGCAAAGGTGCGAAAATCGTGGTCGGTGTCGCCGACCG
CGGCCCGGGCATCGACGAAGAGGAGCGCGCGCGCGTCTTCGACAAATTCTTCCGGGGCAAACGGCACCGCTTCGAAACCA
AGGGGACCGGCATGGGACTGGCGATTGCAAAGGGCATCATTGAAGCTCACGGCGAAAAGATCTGGGTGGAGAGCGAGCCC
GAGCACGGTTCGGCCTTCTATTTCTCTTTGCCGCTAGCCGAAGGCAGGGACGCTTGA

Upstream 100 bases:

>100_bases
TAATTTGCCGTTTTAACGGGCCGATCTCCCGAGATTACCGACCGCTCCTTAACAGTCGCGGCTCGCATGGCGATGTTGCC
CCTTCGGGTCCATTACGGAT

Downstream 100 bases:

>100_bases
GCATCGCAAAAATCCTGGTCGTGGACGACGATCCGCAGATCCGCCGCGTCATGAAAGCGACGCTGGTGGGACACAGCTAT
GAGGTGATCGAGGCGCGCAC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MGQTILAAAGFQPARPLPEPIPVRLKLLHFLTSLLAVAGVLALYLFLLPVNNTTVALSLLLVILAISARWGLAEATLASV
IAVLGLNYYFLPPVRTFTIQDPQNWVALVAFLVTAVTASQLSARVRRRAAEAEARRLEIERLYALVQAMILSGNARRTLR
EFVQTVVKVFACDAAAFYYQPGGEFFRSGPESSPITDHDLLAAAEVDHVSFDPEKHIATAPVRLGGRPLGSMALLGELPS
EQTMSAIVNLVAISVEKARALEDASHAEAARQSEVLKSALLDSLAHDIKTPLTSIKAAVTSLLSNSAAADQELLTIINEE
ADRLNQLAAEVIAMARVEAGKLHLEKRPVNVAELIEGALGELGARSGHAVTVNLSPRLPRASCDPEFVQQVVKQLLENAL
KYSPEGAEVTVSAERKGAKIVVGVADRGPGIDEEERARVFDKFFRGKRHRFETKGTGMGLAIAKGIIEAHGEKIWVESEP
EHGSAFYFSLPLAEGRDA

Sequences:

>Translated_498_residues
MGQTILAAAGFQPARPLPEPIPVRLKLLHFLTSLLAVAGVLALYLFLLPVNNTTVALSLLLVILAISARWGLAEATLASV
IAVLGLNYYFLPPVRTFTIQDPQNWVALVAFLVTAVTASQLSARVRRRAAEAEARRLEIERLYALVQAMILSGNARRTLR
EFVQTVVKVFACDAAAFYYQPGGEFFRSGPESSPITDHDLLAAAEVDHVSFDPEKHIATAPVRLGGRPLGSMALLGELPS
EQTMSAIVNLVAISVEKARALEDASHAEAARQSEVLKSALLDSLAHDIKTPLTSIKAAVTSLLSNSAAADQELLTIINEE
ADRLNQLAAEVIAMARVEAGKLHLEKRPVNVAELIEGALGELGARSGHAVTVNLSPRLPRASCDPEFVQQVVKQLLENAL
KYSPEGAEVTVSAERKGAKIVVGVADRGPGIDEEERARVFDKFFRGKRHRFETKGTGMGLAIAKGIIEAHGEKIWVESEP
EHGSAFYFSLPLAEGRDA
>Mature_497_residues
GQTILAAAGFQPARPLPEPIPVRLKLLHFLTSLLAVAGVLALYLFLLPVNNTTVALSLLLVILAISARWGLAEATLASVI
AVLGLNYYFLPPVRTFTIQDPQNWVALVAFLVTAVTASQLSARVRRRAAEAEARRLEIERLYALVQAMILSGNARRTLRE
FVQTVVKVFACDAAAFYYQPGGEFFRSGPESSPITDHDLLAAAEVDHVSFDPEKHIATAPVRLGGRPLGSMALLGELPSE
QTMSAIVNLVAISVEKARALEDASHAEAARQSEVLKSALLDSLAHDIKTPLTSIKAAVTSLLSNSAAADQELLTIINEEA
DRLNQLAAEVIAMARVEAGKLHLEKRPVNVAELIEGALGELGARSGHAVTVNLSPRLPRASCDPEFVQQVVKQLLENALK
YSPEGAEVTVSAERKGAKIVVGVADRGPGIDEEERARVFDKFFRGKRHRFETKGTGMGLAIAKGIIEAHGEKIWVESEPE
HGSAFYFSLPLAEGRDA

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=482, Percent_Identity=24.896265560166, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI145693157, Length=257, Percent_Identity=30.7392996108949, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=27.7777777777778, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=29.7674418604651, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=25.974025974026, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789149, Length=257, Percent_Identity=28.4046692607004, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=31.2236286919831, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1790346, Length=220, Percent_Identity=30.4545454545455, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786600, Length=239, Percent_Identity=25.1046025104602, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=291, Percent_Identity=27.4914089347079, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788549, Length=248, Percent_Identity=28.2258064516129, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786783, Length=214, Percent_Identity=28.0373831775701, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI48994928, Length=238, Percent_Identity=27.3109243697479, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787894, Length=224, Percent_Identity=29.0178571428571, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787374, Length=198, Percent_Identity=31.3131313131313, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790300, Length=264, Percent_Identity=27.6515151515151, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789808, Length=197, Percent_Identity=29.4416243654822, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788279, Length=217, Percent_Identity=24.4239631336406, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789403, Length=227, Percent_Identity=24.6696035242291, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=186, Percent_Identity=26.8817204301075, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR014729
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53669; Mature: 53538

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQTILAAAGFQPARPLPEPIPVRLKLLHFLTSLLAVAGVLALYLFLLPVNNTTVALSLL
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LVILAISARWGLAEATLASVIAVLGLNYYFLPPVRTFTIQDPQNWVALVAFLVTAVTASQ
HHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEECCHHHHHHHHHHHHHHHHHHH
LSARVRRRAAEAEARRLEIERLYALVQAMILSGNARRTLREFVQTVVKVFACDAAAFYYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEC
PGGEFFRSGPESSPITDHDLLAAAEVDHVSFDPEKHIATAPVRLGGRPLGSMALLGELPS
CCHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHEECCHHCCCCCCCHHHHHHCCCC
EQTMSAIVNLVAISVEKARALEDASHAEAARQSEVLKSALLDSLAHDIKTPLTSIKAAVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLLSNSAAADQELLTIINEEADRLNQLAAEVIAMARVEAGKLHLEKRPVNVAELIEGALG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
ELGARSGHAVTVNLSPRLPRASCDPEFVQQVVKQLLENALKYSPEGAEVTVSAERKGAKI
HHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEE
VVGVADRGPGIDEEERARVFDKFFRGKRHRFETKGTGMGLAIAKGIIEAHGEKIWVESEP
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCC
EHGSAFYFSLPLAEGRDA
CCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
GQTILAAAGFQPARPLPEPIPVRLKLLHFLTSLLAVAGVLALYLFLLPVNNTTVALSLL
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LVILAISARWGLAEATLASVIAVLGLNYYFLPPVRTFTIQDPQNWVALVAFLVTAVTASQ
HHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEECCHHHHHHHHHHHHHHHHHHH
LSARVRRRAAEAEARRLEIERLYALVQAMILSGNARRTLREFVQTVVKVFACDAAAFYYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEC
PGGEFFRSGPESSPITDHDLLAAAEVDHVSFDPEKHIATAPVRLGGRPLGSMALLGELPS
CCHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHEECCHHCCCCCCCHHHHHHCCCC
EQTMSAIVNLVAISVEKARALEDASHAEAARQSEVLKSALLDSLAHDIKTPLTSIKAAVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLLSNSAAADQELLTIINEEADRLNQLAAEVIAMARVEAGKLHLEKRPVNVAELIEGALG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
ELGARSGHAVTVNLSPRLPRASCDPEFVQQVVKQLLENALKYSPEGAEVTVSAERKGAKI
HHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEE
VVGVADRGPGIDEEERARVFDKFFRGKRHRFETKGTGMGLAIAKGIIEAHGEKIWVESEP
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCC
EHGSAFYFSLPLAEGRDA
CCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9226259; 11466286 [H]