Click here to switch to the map view.

The map label for this gene is metA

Identifier: 116516883

GI number: 116516883

Start: 1425127

End: 1426071

Strand: Reverse

Name: metA

Synonym: SPD_1406

Alternate gene names: 116516883

Gene position: 1426071-1425127 (Counterclockwise)

Preceding gene: 116516257

Following gene: 116516031

Centisome position: 69.7

GC content: 41.48

Gene sequence:

>945_bases
ATGCCGATTCGAATTGATAAAAAATTGCCAGCTGTTGAGATTTTACGGACAGAGAATATCTTTGTCATGGATGATCAACG
TGCTGCCCACCAAGATATCCGTCCTTTGAAGATTTTAATTTTAAATCTCATGCCACAGAAAATGGTCACAGAGACCCAGT
TGTTGCGCCACTTGGCTAATACACCCCTACAACTGGATATTGATTTTCTCTATATGGAGAGCCACCGTTCTAAAACAACT
CGTTCAGAGCACATGGAGACCTTCTATAAAACTTTTCCTGAAGTCAAGGATGAGTATTTTGATGGGATGATCATCACGGG
TGCTCCAGTTGAGCATTTACCATTTGAGGAAGTGGACTATTGGGAGGAATTTAGACAGATGCTTGAGTGGTCTAAGACTC
ATGTCTATTCGACCCTTCATATCTGTTGGGGGGCTCAGGCTGGGCTTTATCTGCGCTATGGTGTAGAAAAATACCAGATG
GACAGTAAGCTATCAGGTATTTATCCTCAGGACACCCTAAAAGAGGGTCACCTTCTATTTAGAGGCTTTGATGATAGCTA
TGTATCCCCTCATTCACGGCACACGGAGATTTCTAAGGAAGAGGTCTTAAACAAGACCAATCTCGAGATTTTATCAGAAG
GACCTCAGGTTGGGGTTTCTATTTTGGCCAGTCGTGATTTACGAGAAATTTATAGTTTTGGTCATTTGGAGTATGACCGT
GATACCTTGGCAAAAGAGTATTTTCGAGATCGTGATGCAGGTTTCGACCCACATATTCCAGAAAATTACTTTAAAGATGA
TGATGTTAATCAGGTACCTTGTCTTTGTTGGTCTTCATCTGCAGCCCTCTTTTTCAGTAATTGGGTAAACCATGCGGTCT
ATCAGGAGACGCCTTTTGATTGGAGAAAGATAGAAGATGATGCATCTGCATATGGGTATTTATAA

Upstream 100 bases:

>100_bases
AAACTATATCTTCTTGCAGTATAATAAAAGGACTAAGTGTTTGAGATTTGTCTTCAAACATATGCAATTATTCCTGAAAG
AGTACAGTTAGGAGAGGGTT

Downstream 100 bases:

>100_bases
GAGGAATTATGACATATTTAGACGCTTTTAAATCAGGTACCTTGGTTTTACCGAGTGCCCTGCTCTTGCATTTTAAGGAA
CTCTTTCCTTCTAGCGACGA

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MPIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLMPQKMVTETQLLRHLANTPLQLDIDFLYMESHRSKTT
RSEHMETFYKTFPEVKDEYFDGMIITGAPVEHLPFEEVDYWEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQM
DSKLSGIYPQDTLKEGHLLFRGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVGVSILASRDLREIYSFGHLEYDR
DTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLCWSSSAALFFSNWVNHAVYQETPFDWRKIEDDASAYGYL

Sequences:

>Translated_314_residues
MPIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLMPQKMVTETQLLRHLANTPLQLDIDFLYMESHRSKTT
RSEHMETFYKTFPEVKDEYFDGMIITGAPVEHLPFEEVDYWEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQM
DSKLSGIYPQDTLKEGHLLFRGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVGVSILASRDLREIYSFGHLEYDR
DTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLCWSSSAALFFSNWVNHAVYQETPFDWRKIEDDASAYGYL
>Mature_313_residues
PIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLMPQKMVTETQLLRHLANTPLQLDIDFLYMESHRSKTTR
SEHMETFYKTFPEVKDEYFDGMIITGAPVEHLPFEEVDYWEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQMD
SKLSGIYPQDTLKEGHLLFRGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVGVSILASRDLREIYSFGHLEYDRD
TLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLCWSSSAALFFSNWVNHAVYQETPFDWRKIEDDASAYGYL

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=304, Percent_Identity=48.6842105263158, Blast_Score=313, Evalue=8e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_STRP2 (Q04JH2)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816866.1
- ProteinModelPortal:   Q04JH2
- SMR:   Q04JH2
- STRING:   Q04JH2
- EnsemblBacteria:   EBSTRT00000019836
- GeneID:   4442126
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1406
- eggNOG:   COG1897
- GeneTree:   EBGT00050000029445
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- ProtClustDB:   PRK05368
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 36926; Mature: 36795

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLMPQKMVTETQLLRHLAN
CCEECCCCCCCEEEEECCCEEEEECCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHC
TPLQLDIDFLYMESHRSKTTRSEHMETFYKTFPEVKDEYFDGMIITGAPVEHLPFEEVDY
CCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHH
WEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQMDSKLSGIYPQDTLKEGHLLF
HHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCHHHHHHHHHCCCCCHHHHCCCCEEE
RGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVGVSILASRDLREIYSFGHLEYDR
EECCCCCCCCCCCCCCCCHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
DTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLCWSSSAALFFSNWVNHAVYQETPFD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCC
WRKIEDDASAYGYL
HHHCCCCCHHCCCC
>Mature Secondary Structure 
PIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLMPQKMVTETQLLRHLAN
CEECCCCCCCEEEEECCCEEEEECCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHC
TPLQLDIDFLYMESHRSKTTRSEHMETFYKTFPEVKDEYFDGMIITGAPVEHLPFEEVDY
CCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHH
WEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQMDSKLSGIYPQDTLKEGHLLF
HHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCHHHHHHHHHCCCCCHHHHCCCCEEE
RGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVGVSILASRDLREIYSFGHLEYDR
EECCCCCCCCCCCCCCCCHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
DTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLCWSSSAALFFSNWVNHAVYQETPFD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCC
WRKIEDDASAYGYL
HHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA