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The map label for this gene is tdcB [H]

Identifier: 116495638

GI number: 116495638

Start: 2173700

End: 2174719

Strand: Direct

Name: tdcB [H]

Synonym: LSEI_2183

Alternate gene names: 116495638

Gene position: 2173700-2174719 (Clockwise)

Preceding gene: 116495637

Following gene: 116495639

Centisome position: 75.08

GC content: 49.61

Gene sequence:

>1020_bases
ATGATGACCGCAACGCAAACCGTGAGTATAAAAGATGTTCAAGAGGCTAGCCATCTCATTCATGAGGTTGGCCGAGTCAC
ACCGCTCATTCAATCCATGTTTCTTAGTCGCACCGTTACCCATGGTGATGTGTATCTCAAACTGGAAAACATGCAGCTCA
CAGGTTCATTTAAGTTTCGCGGTGCTTATAACAAAATCCGCCATCTCAGTGACGCCGAAAAAGCTCGTGGTGTCATCACG
GCCAGTGCTGGCAATCATGCCCAAGGCGTTGCATTGACGGCTCACTTACTCGACATTGATGCGACAGTTGTGATGCCTAA
AACAGCGCCATTAGCCAAACAACAAGCCACGAGCGGCTATGGTGCAAAAGTTGTCCTTGCCGGTGATACTTTTGACGAAT
CTCGTGCCTTCATGGAACAAAAGGCCAAGGAAGATGGCCTAACCATCGTTGACCCCTACAATGATCCATTGGTCATTGCC
GGACAAGGCTCCATCGGCTTAGAGATTTTAGATCAGCTGTGGGATGTTGATACCGTCATCGTACCAGTTGGCGGTGGTGG
CCTGATTACGGGGATTGCCACCGTTCTGAAACATTTTAATCCCTATATTCACATCGTTGGTGTCCAATCAGAAAATGTCC
ACGGTATGACGGCCTCGTTGCAAGCAGGCAAGTTGACCCGACAATGTACTGGCCCAACCCTAGCTGACGGCACAGCGGTC
GCCATGCCCGGCGATATCACCTTTGGCCTAGCTGAGGAATTAGTCGATGAGATGGTACTCGTCTCAGAAGAAGAAATTGC
TGAAGCGATGAAAGACCTTCTCCAACGCACCAAAACCGTGGCAGAAGGCGCCGGTGCATTACCAACAGCAGCCCTCGAGG
CTCACAAAATCGCACCGCAATGGCTAGTAGGCAAGAAAGTTGTTGCACTTGTCTCTGGTGGCAACGTCGATTTGGAACGG
GTAGCAGATAACATTGATCATTTCTTTAAAAGTGATCCGACTGGGCACTTCATCGGATAA

Upstream 100 bases:

>100_bases
TCACGGCCAAATCACCAATAAGGGCCTTGCCGAATCATTAAACTTACCGGTTGTTTCATTAGAAACAGCGCTCAAAACGC
AACATTAGGAGGTGGATAAG

Downstream 100 bases:

>100_bases
AAACAGAGCGTGAGCTAGCGCGGTTTCTGAACTAGCTCATGCTCTCACCATAACGCGCTCGCCAGCGCTTAAACCCGCGC
TGGCTCGCGCTCACTTTCAA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MMTATQTVSIKDVQEASHLIHEVGRVTPLIQSMFLSRTVTHGDVYLKLENMQLTGSFKFRGAYNKIRHLSDAEKARGVIT
ASAGNHAQGVALTAHLLDIDATVVMPKTAPLAKQQATSGYGAKVVLAGDTFDESRAFMEQKAKEDGLTIVDPYNDPLVIA
GQGSIGLEILDQLWDVDTVIVPVGGGGLITGIATVLKHFNPYIHIVGVQSENVHGMTASLQAGKLTRQCTGPTLADGTAV
AMPGDITFGLAEELVDEMVLVSEEEIAEAMKDLLQRTKTVAEGAGALPTAALEAHKIAPQWLVGKKVVALVSGGNVDLER
VADNIDHFFKSDPTGHFIG

Sequences:

>Translated_339_residues
MMTATQTVSIKDVQEASHLIHEVGRVTPLIQSMFLSRTVTHGDVYLKLENMQLTGSFKFRGAYNKIRHLSDAEKARGVIT
ASAGNHAQGVALTAHLLDIDATVVMPKTAPLAKQQATSGYGAKVVLAGDTFDESRAFMEQKAKEDGLTIVDPYNDPLVIA
GQGSIGLEILDQLWDVDTVIVPVGGGGLITGIATVLKHFNPYIHIVGVQSENVHGMTASLQAGKLTRQCTGPTLADGTAV
AMPGDITFGLAEELVDEMVLVSEEEIAEAMKDLLQRTKTVAEGAGALPTAALEAHKIAPQWLVGKKVVALVSGGNVDLER
VADNIDHFFKSDPTGHFIG
>Mature_339_residues
MMTATQTVSIKDVQEASHLIHEVGRVTPLIQSMFLSRTVTHGDVYLKLENMQLTGSFKFRGAYNKIRHLSDAEKARGVIT
ASAGNHAQGVALTAHLLDIDATVVMPKTAPLAKQQATSGYGAKVVLAGDTFDESRAFMEQKAKEDGLTIVDPYNDPLVIA
GQGSIGLEILDQLWDVDTVIVPVGGGGLITGIATVLKHFNPYIHIVGVQSENVHGMTASLQAGKLTRQCTGPTLADGTAV
AMPGDITFGLAEELVDEMVLVSEEEIAEAMKDLLQRTKTVAEGAGALPTAALEAHKIAPQWLVGKKVVALVSGGNVDLER
VADNIDHFFKSDPTGHFIG

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=325, Percent_Identity=37.5384615384615, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI19923959, Length=306, Percent_Identity=30.718954248366, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=28.2958199356913, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=52.0504731861199, Blast_Score=284, Evalue=5e-78,
Organism=Escherichia coli, GI1790207, Length=299, Percent_Identity=39.7993311036789, Blast_Score=187, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI71991565, Length=312, Percent_Identity=42.3076923076923, Blast_Score=200, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17537387, Length=306, Percent_Identity=39.5424836601307, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17508781, Length=313, Percent_Identity=31.3099041533546, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320930, Length=308, Percent_Identity=41.8831168831169, Blast_Score=205, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6322631, Length=313, Percent_Identity=39.6166134185303, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319788, Length=278, Percent_Identity=26.6187050359712, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355833, Length=312, Percent_Identity=42.3076923076923, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24645328, Length=213, Percent_Identity=43.1924882629108, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 36027; Mature: 36027

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTATQTVSIKDVQEASHLIHEVGRVTPLIQSMFLSRTVTHGDVYLKLENMQLTGSFKFR
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCEEEEEEECEEEEEEEEEC
GAYNKIRHLSDAEKARGVITASAGNHAQGVALTAHLLDIDATVVMPKTAPLAKQQATSGY
CHHHHHHHCCHHHHHCEEEEECCCCCCCCEEEEEEEEECCEEEEECCCCCCHHHHCCCCC
GAKVVLAGDTFDESRAFMEQKAKEDGLTIVDPYNDPLVIAGQGSIGLEILDQLWDVDTVI
CEEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCHHHHHHHHCCCCEEE
VPVGGGGLITGIATVLKHFNPYIHIVGVQSENVHGMTASLQAGKLTRQCTGPTLADGTAV
EEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCCCHHHCCCCCCCCCEEE
AMPGDITFGLAEELVDEMVLVSEEEIAEAMKDLLQRTKTVAEGAGALPTAALEAHKIAPQ
EECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCH
WLVGKKVVALVSGGNVDLERVADNIDHFFKSDPTGHFIG
HHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MMTATQTVSIKDVQEASHLIHEVGRVTPLIQSMFLSRTVTHGDVYLKLENMQLTGSFKFR
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCEEEEEEECEEEEEEEEEC
GAYNKIRHLSDAEKARGVITASAGNHAQGVALTAHLLDIDATVVMPKTAPLAKQQATSGY
CHHHHHHHCCHHHHHCEEEEECCCCCCCCEEEEEEEEECCEEEEECCCCCCHHHHCCCCC
GAKVVLAGDTFDESRAFMEQKAKEDGLTIVDPYNDPLVIAGQGSIGLEILDQLWDVDTVI
CEEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCHHHHHHHHCCCCEEE
VPVGGGGLITGIATVLKHFNPYIHIVGVQSENVHGMTASLQAGKLTRQCTGPTLADGTAV
EEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCCCHHHCCCCCCCCCEEE
AMPGDITFGLAEELVDEMVLVSEEEIAEAMKDLLQRTKTVAEGAGALPTAALEAHKIAPQ
EECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCH
WLVGKKVVALVSGGNVDLERVADNIDHFFKSDPTGHFIG
HHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA