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The map label for this gene is ald1 [H]

Identifier: 116495637

GI number: 116495637

Start: 2172566

End: 2173687

Strand: Direct

Name: ald1 [H]

Synonym: LSEI_2182

Alternate gene names: 116495637

Gene position: 2172566-2173687 (Clockwise)

Preceding gene: 116495636

Following gene: 116495638

Centisome position: 75.04

GC content: 50.98

Gene sequence:

>1122_bases
GTGAAAGTTGGCGTTGTGAAAGAGCAAAAAGCTGGCGAAGGTCGTGTGGCTGTCACACCAGAAAATGTTAAAAAGCTGGT
TGATGTAGGAGCGACTGTTTTGGTTGAAAAATCAGCCGGAGTCGGTGCAGGTTTTCCTGATGCAGATTACGCTGCGGCTG
GCGGCACTATCGTCAGTCACGCTCAGAGTTGGGATAGTGATCTCGTTGTCAAAGTCAAAGAACCTGACGAGGAAGAATAT
CAGTATTTCAAGCCAGGTCAGGTCGTCTGGGGATTCCAACATTTGGCCTCCTCACCTGCCACTGTGAAAGCCATGCAAGC
TGCCGGCACGACAGCGATCGGCGGAGAAACCATCGTTGAAAATGGCGAGTTGGCATTGCTAAAACCGATGAGCGCTATCG
CAGGTCGCCGGTCCGTCATCATGGGCGCTTATTATCTTGAAGCACAGCATGGCGGTGAAGGCATTTTATTGCCAGGCACA
CCGGAAGTTGCTTCAGGCACGGTTGTTATTTTCGGTGGTGGGAACGCTGCTTTTAACGCCGCCAGTTTGGCATTAGCCAT
GGGCTGTCGCGTCACAATCATCGAACTTAAAAAGGACCGCCGTGACTGGTTAGCGAAGCAGTTTACAGGTGAAGCCTTGA
CGCTCCTGCCATCGACGCCCGAGAATCTCGCCGCGGCTATCAAGACCGCCGATGTCTTCATCTCAACCATTCTGATTCCG
GGCGCAAAGCCGCCGAAGTTAGTCACAACAGCGATGGTACAGTCGATGAAACCGGGCAGTGTCCTTGTAGATGTAGCCAT
TGATCAAGGCGGCACGGTTGAAACTATTGATGCACCAACCTCTATTGATGATCCGGTTTTCACCAAATACGGCGTCATCC
ATTATGCCGTGCCAAATCAACCAGGCGCGGTACCGCGCACAGCGACGATGGCACTGGCAGTTGGCAACATCAAATATCTT
TTGGCAATCGCAAAATCTGGGATTGATGGCGCCATTAAAAATGATCCTGCGCTGGCTTCTGGCGTCAATCTTTATCACGG
CCAAATCACCAATAAGGGCCTTGCCGAATCATTAAACTTACCGGTTGTTTCATTAGAAACAGCGCTCAAAACGCAACATT
AG

Upstream 100 bases:

>100_bases
GTAAGCGGATACATTTTATATGTGAGAAATATCACACAGTTGTTGTGCTACTTGTTGTGAAGGCCTTAACATTGCTGGTG
GAAAGAAAGGACTGATTGTT

Downstream 100 bases:

>100_bases
GAGGTGGATAAGATGATGACCGCAACGCAAACCGTGAGTATAAAAGATGTTCAAGAGGCTAGCCATCTCATTCATGAGGT
TGGCCGAGTCACACCGCTCA

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MKVGVVKEQKAGEGRVAVTPENVKKLVDVGATVLVEKSAGVGAGFPDADYAAAGGTIVSHAQSWDSDLVVKVKEPDEEEY
QYFKPGQVVWGFQHLASSPATVKAMQAAGTTAIGGETIVENGELALLKPMSAIAGRRSVIMGAYYLEAQHGGEGILLPGT
PEVASGTVVIFGGGNAAFNAASLALAMGCRVTIIELKKDRRDWLAKQFTGEALTLLPSTPENLAAAIKTADVFISTILIP
GAKPPKLVTTAMVQSMKPGSVLVDVAIDQGGTVETIDAPTSIDDPVFTKYGVIHYAVPNQPGAVPRTATMALAVGNIKYL
LAIAKSGIDGAIKNDPALASGVNLYHGQITNKGLAESLNLPVVSLETALKTQH

Sequences:

>Translated_373_residues
MKVGVVKEQKAGEGRVAVTPENVKKLVDVGATVLVEKSAGVGAGFPDADYAAAGGTIVSHAQSWDSDLVVKVKEPDEEEY
QYFKPGQVVWGFQHLASSPATVKAMQAAGTTAIGGETIVENGELALLKPMSAIAGRRSVIMGAYYLEAQHGGEGILLPGT
PEVASGTVVIFGGGNAAFNAASLALAMGCRVTIIELKKDRRDWLAKQFTGEALTLLPSTPENLAAAIKTADVFISTILIP
GAKPPKLVTTAMVQSMKPGSVLVDVAIDQGGTVETIDAPTSIDDPVFTKYGVIHYAVPNQPGAVPRTATMALAVGNIKYL
LAIAKSGIDGAIKNDPALASGVNLYHGQITNKGLAESLNLPVVSLETALKTQH
>Mature_373_residues
MKVGVVKEQKAGEGRVAVTPENVKKLVDVGATVLVEKSAGVGAGFPDADYAAAGGTIVSHAQSWDSDLVVKVKEPDEEEY
QYFKPGQVVWGFQHLASSPATVKAMQAAGTTAIGGETIVENGELALLKPMSAIAGRRSVIMGAYYLEAQHGGEGILLPGT
PEVASGTVVIFGGGNAAFNAASLALAMGCRVTIIELKKDRRDWLAKQFTGEALTLLPSTPENLAAAIKTADVFISTILIP
GAKPPKLVTTAMVQSMKPGSVLVDVAIDQGGTVETIDAPTSIDDPVFTKYGVIHYAVPNQPGAVPRTATMALAVGNIKYL
LAIAKSGIDGAIKNDPALASGVNLYHGQITNKGLAESLNLPVVSLETALKTQH

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=355, Percent_Identity=29.8591549295775, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI122939153, Length=355, Percent_Identity=29.8591549295775, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1787887, Length=358, Percent_Identity=29.0502793296089, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17550456, Length=348, Percent_Identity=29.8850574712644, Blast_Score=134, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38678; Mature: 38678

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGVVKEQKAGEGRVAVTPENVKKLVDVGATVLVEKSAGVGAGFPDADYAAAGGTIVSH
CCCCCCCCCCCCCCEEEECHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHCCCCHHHHH
AQSWDSDLVVKVKEPDEEEYQYFKPGQVVWGFQHLASSPATVKAMQAAGTTAIGGETIVE
CCCCCCEEEEEEECCCHHHHHEECCCCEEEEHHHHCCCCCCEEHHHHCCCEECCCCEEEE
NGELALLKPMSAIAGRRSVIMGAYYLEAQHGGEGILLPGTPEVASGTVVIFGGGNAAFNA
CCCEEEECCHHHHCCCCEEEEEEEEEEEECCCCEEECCCCCCCCCCEEEEEECCCCHHHH
ASLALAMGCRVTIIELKKDRRDWLAKQFTGEALTLLPSTPENLAAAIKTADVFISTILIP
HHHHHHHCCEEEEEEECCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHEEEHEEEC
GAKPPKLVTTAMVQSMKPGSVLVDVAIDQGGTVETIDAPTSIDDPVFTKYGVIHYAVPNQ
CCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCHHCCEEEEECCCC
PGAVPRTATMALAVGNIKYLLAIAKSGIDGAIKNDPALASGVNLYHGQITNKGLAESLNL
CCCCCCCEEEEEEECCHHEEEEEHHCCCCCCCCCCCCHHCCCEEEECCCCCCCHHHHCCC
PVVSLETALKTQH
CEEEEHHHHCCCC
>Mature Secondary Structure
MKVGVVKEQKAGEGRVAVTPENVKKLVDVGATVLVEKSAGVGAGFPDADYAAAGGTIVSH
CCCCCCCCCCCCCCEEEECHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHCCCCHHHHH
AQSWDSDLVVKVKEPDEEEYQYFKPGQVVWGFQHLASSPATVKAMQAAGTTAIGGETIVE
CCCCCCEEEEEEECCCHHHHHEECCCCEEEEHHHHCCCCCCEEHHHHCCCEECCCCEEEE
NGELALLKPMSAIAGRRSVIMGAYYLEAQHGGEGILLPGTPEVASGTVVIFGGGNAAFNA
CCCEEEECCHHHHCCCCEEEEEEEEEEEECCCCEEECCCCCCCCCCEEEEEECCCCHHHH
ASLALAMGCRVTIIELKKDRRDWLAKQFTGEALTLLPSTPENLAAAIKTADVFISTILIP
HHHHHHHCCEEEEEEECCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHEEEHEEEC
GAKPPKLVTTAMVQSMKPGSVLVDVAIDQGGTVETIDAPTSIDDPVFTKYGVIHYAVPNQ
CCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCHHCCEEEEECCCC
PGAVPRTATMALAVGNIKYLLAIAKSGIDGAIKNDPALASGVNLYHGQITNKGLAESLNL
CCCCCCCEEEEEEECCHHEEEEEHHCCCCCCCCCCCCHHCCCEEEECCCCCCCHHHHCCC
PVVSLETALKTQH
CEEEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA