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The map label for this gene is hepT [H]

Identifier: 116495626

GI number: 116495626

Start: 2161694

End: 2162662

Strand: Direct

Name: hepT [H]

Synonym: LSEI_2171

Alternate gene names: 116495626

Gene position: 2161694-2162662 (Clockwise)

Preceding gene: 116495621

Following gene: 116495627

Centisome position: 74.66

GC content: 50.57

Gene sequence:

>969_bases
ATGATTCATCCACTGTGGCACCGATTCCCCATGGTCTATCAACAACTCGAACAGATTCAGCAACGGCTTGAACACGTCGC
TGTTTTGCGTGAGCCGCAAGTCCACGCATTGATCCAGCAACAGATCAACGCTGGCGGCAAAATGCTGCGCAGCGGGCTAA
TGCTTATGCTAGCGCGTTTAGGCAACCCTGACAACGACGATCTCATAACCGCCGGCGCTGCCATTGAGGCCTTACATCTC
GCGACCTTGGTTCACGATGATGTACTTGACCACGCCGACCTGCGCCGCGGTTCCGATACCGTCTCAGCCAAGTCAGGCAA
TCGTGAGGCAATCTATGCTGGCGATTTCCTCTTTGCCATCTATTTTCAATTATTAAGCGAACAAAATCCAGCAACAACCG
ATTTAGCGACCAATGCGCGCGTCATGAAGCACATCTTTATGGGAGAAGTTGACCAAAATGGTCCCAGCGCGCCACTCATT
CCAAGTGTTTCCGAATACTTGAAAGCCATAGCCGGCAAAACGGCAGCACTTTTTGCTTTGGCAACTTACACTGGTGCGAC
AATCGGTCAACTAGACTTTACCGAAAAAAAAGCCGCGTATCGTTTTGGCCGCCAACTAGGCATGGCCTTTCAGATGATTG
ATGACTTGTTGGATTACACCCAAACAACTGCTACGCTGAATAAACCGGTGCTCGAAGATTTACATAACGGCATTGTCACA
CTTCCATTAATTTATGCCTATCAAAACGTCCCCGAACAACTCGCCCCAATGGTCGGGACCGCAGCAAAAATCGCTGCCAA
CAGCGACCGAATTGCGGCAATTGTGAGTGAACACGGCTTGCCCCAAGCCCGTCAACTCGCCACTCGCTACACTGATAAGG
CTATCAACGCCCTCGCGCCATTGCCTGATGCGCGCATTAAGCAAGAACTACGCAAGCTCACTCAGCAATTATTGCAACGA
GATCATTGA

Upstream 100 bases:

>100_bases
ACTCAAGAAAAACAGATAAAGACATGACAACCTCCAACAATTGACTTTTAAGAATCACATACAGTAGAGTGAATATGTCT
ATAGGAAAGAGAGAAAATGC

Downstream 100 bases:

>100_bases
TCGTCTGGACTTCATATATGCCTATCCTTTTTGACAGAAAAATAAGTACCGACGGATAAAGTTCGGCTAACAATAGAACC
AGCATATCTAGACTCAGTCG

Product: geranylgeranyl pyrophosphate synthase

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MIHPLWHRFPMVYQQLEQIQQRLEHVAVLREPQVHALIQQQINAGGKMLRSGLMLMLARLGNPDNDDLITAGAAIEALHL
ATLVHDDVLDHADLRRGSDTVSAKSGNREAIYAGDFLFAIYFQLLSEQNPATTDLATNARVMKHIFMGEVDQNGPSAPLI
PSVSEYLKAIAGKTAALFALATYTGATIGQLDFTEKKAAYRFGRQLGMAFQMIDDLLDYTQTTATLNKPVLEDLHNGIVT
LPLIYAYQNVPEQLAPMVGTAAKIAANSDRIAAIVSEHGLPQARQLATRYTDKAINALAPLPDARIKQELRKLTQQLLQR
DH

Sequences:

>Translated_322_residues
MIHPLWHRFPMVYQQLEQIQQRLEHVAVLREPQVHALIQQQINAGGKMLRSGLMLMLARLGNPDNDDLITAGAAIEALHL
ATLVHDDVLDHADLRRGSDTVSAKSGNREAIYAGDFLFAIYFQLLSEQNPATTDLATNARVMKHIFMGEVDQNGPSAPLI
PSVSEYLKAIAGKTAALFALATYTGATIGQLDFTEKKAAYRFGRQLGMAFQMIDDLLDYTQTTATLNKPVLEDLHNGIVT
LPLIYAYQNVPEQLAPMVGTAAKIAANSDRIAAIVSEHGLPQARQLATRYTDKAINALAPLPDARIKQELRKLTQQLLQR
DH
>Mature_322_residues
MIHPLWHRFPMVYQQLEQIQQRLEHVAVLREPQVHALIQQQINAGGKMLRSGLMLMLARLGNPDNDDLITAGAAIEALHL
ATLVHDDVLDHADLRRGSDTVSAKSGNREAIYAGDFLFAIYFQLLSEQNPATTDLATNARVMKHIFMGEVDQNGPSAPLI
PSVSEYLKAIAGKTAALFALATYTGATIGQLDFTEKKAAYRFGRQLGMAFQMIDDLLDYTQTTATLNKPVLEDLHNGIVT
LPLIYAYQNVPEQLAPMVGTAAKIAANSDRIAAIVSEHGLPQARQLATRYTDKAINALAPLPDARIKQELRKLTQQLLQR
DH

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=321, Percent_Identity=27.4143302180685, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI1789578, Length=291, Percent_Identity=35.3951890034364, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17505681, Length=300, Percent_Identity=30.3333333333333, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319475, Length=291, Percent_Identity=29.8969072164948, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24651612, Length=299, Percent_Identity=28.4280936454849, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 35535; Mature: 35535

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHPLWHRFPMVYQQLEQIQQRLEHVAVLREPQVHALIQQQINAGGKMLRSGLMLMLARL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GNPDNDDLITAGAAIEALHLATLVHDDVLDHADLRRGSDTVSAKSGNREAIYAGDFLFAI
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHH
YFQLLSEQNPATTDLATNARVMKHIFMGEVDQNGPSAPLIPSVSEYLKAIAGKTAALFAL
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
ATYTGATIGQLDFTEKKAAYRFGRQLGMAFQMIDDLLDYTQTTATLNKPVLEDLHNGIVT
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LPLIYAYQNVPEQLAPMVGTAAKIAANSDRIAAIVSEHGLPQARQLATRYTDKAINALAP
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
LPDARIKQELRKLTQQLLQRDH
CCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIHPLWHRFPMVYQQLEQIQQRLEHVAVLREPQVHALIQQQINAGGKMLRSGLMLMLARL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GNPDNDDLITAGAAIEALHLATLVHDDVLDHADLRRGSDTVSAKSGNREAIYAGDFLFAI
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHH
YFQLLSEQNPATTDLATNARVMKHIFMGEVDQNGPSAPLIPSVSEYLKAIAGKTAALFAL
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
ATYTGATIGQLDFTEKKAAYRFGRQLGMAFQMIDDLLDYTQTTATLNKPVLEDLHNGIVT
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LPLIYAYQNVPEQLAPMVGTAAKIAANSDRIAAIVSEHGLPQARQLATRYTDKAINALAP
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
LPDARIKQELRKLTQQLLQRDH
CCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]