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The map label for this gene is pyrDA [H]

Identifier: 116495212

GI number: 116495212

Start: 1725529

End: 1726467

Strand: Direct

Name: pyrDA [H]

Synonym: LSEI_1732

Alternate gene names: 116495212

Gene position: 1725529-1726467 (Clockwise)

Preceding gene: 116495211

Following gene: 116495213

Centisome position: 59.6

GC content: 48.88

Gene sequence:

>939_bases
ATGACTGACCTGCAAACAAGTATTGGCGACTTTCAATTTGATAATGTGTTCATGAACGCAAGCGGTGTACGCTGCTACAC
CGAGGAAGACTTAGATGCGTTGGCACAAAGTGATGCTGGGACCTTTGTCACTAAAAGTGCTACCCAAGCAAAACGCCTCG
GCAATCCCAGCCCGCGCTATGCTCGACTAGAACTCGGCTCTATCAATTCGATGGGCTTACCTAATGAGGGCCTCGATTAC
TATCTCAACTACGCCTTGAAGTTTCAGGAAAAGCATCCAGGTCAATGGATTTTTCTGTCAGTTGCCGGCTTGACAATGGA
AGAAAATCTCGCCATGGCACACACTATCGAAGACTCCGATTTTAATGGCTTGGTCGAGTTTAACCTGAGCTGCCCAAATG
TTCCGGGTAAACCCCAAACCGGTTACGATTTTGACCGAACCAAGGAAGTGCTTACCAACCTCTTCACGTTCTTTACCAAA
CCAGCAGGCGTTAAATTGCCACCTTATTTTGACCTCGCGCAATTCGACCAAATGGCTGCCATCTTAAATCAGTTCCCGTT
GCAATTTGTGAATTCTATTAACAGTCTCGGCAACGGCCTCATGATCGATCCCGAAACTGACACAGCGTTAATTAAGCCAA
AAGGCGGCTTTGGCGGTATTGGCGGCGCCTATGCGAAACCAATCGCACTAGCCAATGTCCGTGCCTTTTCACAGCGGCTG
GACCCGAAGATTCAGCTTATCGGCACTGGTGGTGTGACCAATGGCCGTGATGCCTATGATCTCATCCTCGCCGGTGCGAG
TTTGGTTCAAGTTGGCACCTTGCTTCAAGAAGAAAGACCGGCCGTATTCACCCGCCTGAGCCGTGAACTTCAGGCTGTCA
TGCAGACCAAGGGATATACCAACCTTAGCGACTTTAAAGGACAATTGAAAACCCAATGA

Upstream 100 bases:

>100_bases
CCGGTTTCTAAACGCCTCAGCTCACGCTCTGAGGCGTTGACTGGTTTCTATTGTATTTCTATGCTTAAATAGGAACAGCA
AATAATGAAGGAGTGGGCTT

Downstream 100 bases:

>100_bases
CGAACGAAAAAATGAAGGTTTGGGCATACTTTAAACACAACGCTGGCGACTTTAGCCGGCATTGGGGCGCGTATATCATG
CTCATCAGCGTCACTAATCT

Product: dihydroorotate dehydrogenase 1A

Products: NA

Alternate protein names: DHOdehase A; DHOD A; DHODase A; Dihydroorotate oxidase A [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTDLQTSIGDFQFDNVFMNASGVRCYTEEDLDALAQSDAGTFVTKSATQAKRLGNPSPRYARLELGSINSMGLPNEGLDY
YLNYALKFQEKHPGQWIFLSVAGLTMEENLAMAHTIEDSDFNGLVEFNLSCPNVPGKPQTGYDFDRTKEVLTNLFTFFTK
PAGVKLPPYFDLAQFDQMAAILNQFPLQFVNSINSLGNGLMIDPETDTALIKPKGGFGGIGGAYAKPIALANVRAFSQRL
DPKIQLIGTGGVTNGRDAYDLILAGASLVQVGTLLQEERPAVFTRLSRELQAVMQTKGYTNLSDFKGQLKTQ

Sequences:

>Translated_312_residues
MTDLQTSIGDFQFDNVFMNASGVRCYTEEDLDALAQSDAGTFVTKSATQAKRLGNPSPRYARLELGSINSMGLPNEGLDY
YLNYALKFQEKHPGQWIFLSVAGLTMEENLAMAHTIEDSDFNGLVEFNLSCPNVPGKPQTGYDFDRTKEVLTNLFTFFTK
PAGVKLPPYFDLAQFDQMAAILNQFPLQFVNSINSLGNGLMIDPETDTALIKPKGGFGGIGGAYAKPIALANVRAFSQRL
DPKIQLIGTGGVTNGRDAYDLILAGASLVQVGTLLQEERPAVFTRLSRELQAVMQTKGYTNLSDFKGQLKTQ
>Mature_311_residues
TDLQTSIGDFQFDNVFMNASGVRCYTEEDLDALAQSDAGTFVTKSATQAKRLGNPSPRYARLELGSINSMGLPNEGLDYY
LNYALKFQEKHPGQWIFLSVAGLTMEENLAMAHTIEDSDFNGLVEFNLSCPNVPGKPQTGYDFDRTKEVLTNLFTFFTKP
AGVKLPPYFDLAQFDQMAAILNQFPLQFVNSINSLGNGLMIDPETDTALIKPKGGFGGIGGAYAKPIALANVRAFSQRLD
PKIQLIGTGGVTNGRDAYDLILAGASLVQVGTLLQEERPAVFTRLSRELQAVMQTKGYTNLSDFKGQLKTQ

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=331, Percent_Identity=25.3776435045317, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17509475, Length=320, Percent_Identity=26.25, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322633, Length=309, Percent_Identity=58.8996763754045, Blast_Score=392, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281361352, Length=299, Percent_Identity=27.7591973244147, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137316, Length=299, Percent_Identity=27.7591973244147, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 34139; Mature: 34008

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLQTSIGDFQFDNVFMNASGVRCYTEEDLDALAQSDAGTFVTKSATQAKRLGNPSPRY
CCCCCCCCCCEEECCEEECCCCCEEECHHHHHHHHHCCCCCEEECCHHHHHHCCCCCCCE
ARLELGSINSMGLPNEGLDYYLNYALKFQEKHPGQWIFLSVAGLTMEENLAMAHTIEDSD
EEEEECCCCCCCCCCCCHHHHEEEEEEECCCCCCCEEEEEEECCEEECCEEEEEEECCCC
FNGLVEFNLSCPNVPGKPQTGYDFDRTKEVLTNLFTFFTKPAGVKLPPYFDLAQFDQMAA
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ILNQFPLQFVNSINSLGNGLMIDPETDTALIKPKGGFGGIGGAYAKPIALANVRAFSQRL
HHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHC
DPKIQLIGTGGVTNGRDAYDLILAGASLVQVGTLLQEERPAVFTRLSRELQAVMQTKGYT
CCEEEEEECCCCCCCCCHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
NLSDFKGQLKTQ
CHHHHCCCCCCC
>Mature Secondary Structure 
TDLQTSIGDFQFDNVFMNASGVRCYTEEDLDALAQSDAGTFVTKSATQAKRLGNPSPRY
CCCCCCCCCEEECCEEECCCCCEEECHHHHHHHHHCCCCCEEECCHHHHHHCCCCCCCE
ARLELGSINSMGLPNEGLDYYLNYALKFQEKHPGQWIFLSVAGLTMEENLAMAHTIEDSD
EEEEECCCCCCCCCCCCHHHHEEEEEEECCCCCCCEEEEEEECCEEECCEEEEEEECCCC
FNGLVEFNLSCPNVPGKPQTGYDFDRTKEVLTNLFTFFTKPAGVKLPPYFDLAQFDQMAA
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ILNQFPLQFVNSINSLGNGLMIDPETDTALIKPKGGFGGIGGAYAKPIALANVRAFSQRL
HHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHC
DPKIQLIGTGGVTNGRDAYDLILAGASLVQVGTLLQEERPAVFTRLSRELQAVMQTKGYT
CCEEEEEECCCCCCCCCHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
NLSDFKGQLKTQ
CHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]