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The map label for this gene is mvk [H]

Identifier: 116494975

GI number: 116494975

Start: 1491694

End: 1492629

Strand: Direct

Name: mvk [H]

Synonym: LSEI_1491

Alternate gene names: 116494975

Gene position: 1491694-1492629 (Clockwise)

Preceding gene: 116494966

Following gene: 116494976

Centisome position: 51.52

GC content: 50.0

Gene sequence:

>936_bases
ATGGAAATCGGGACGGGAAAAAGTTATGCAAAAATTATTCTGCTTGGCGAACACGCGGTCGTGTATGGGGAACCGGCCAT
TGCACTGCCAGTGAAGAGTGTCGGCTTGTCAGCTCGCGTCACGCCTCAGCCGGATGGCAGACAAACTGTGACGTCTTCTT
TTTTCACAGGAAATTTAAATGCTGGTCAATTGACCAATTTTGCCGGTATTGCCATGCTTATTCGACGTTTATTGATCTTC
TTTAACGCCAAGAATCAAGGATTTCATTTAACCATCACGAGTGCTTTGCCTTCCGAGCGCGGTATGGGCTCATCTGCCGC
AACCGCTGTGGCAGTTGTTCGCGCTTTTTACGATGCATTTCAAACATCGCTATCACACGACACATTACTGAACTGGGCCG
CTGTCTCTGAAAAAGCTTTGCATGGCAATCCAAGCGGTCTTGATGCTGCCACGGCTAGCGCTGAGCGGCCGCAATGGTTC
GTCCGTGGTAAGGCGCCGCGCTCGATCATGATGCCACGAAACGGTGTGTTGCTAATTGCCGATACTGGCGTTGCCGGACA
AACTAAAATTGCAGTTGGAGCAGTGGCAGATCGTTTAAAGCAGAATCCCAAAATGTACCGGCCGCTCATCAAGGATATCG
GTGACACCGTTCGCCAGGCAGCATTGGCGTTGGCGCAAGATGATATTATTACCTTAGGCCAACTGTTCAATCGCGATCAG
GCCGATCTGTCTGCACTTGGCGTTAGCAGTCCTGACCTTGACCGTCTCATTAACGTGGCGATTGATAACGGTGCTTATGG
CGCTAAATTAACAGGCTCAGGGATGGGTGGTTGCATGATTGCTTTAGCAGCCAGTGATCAAGCGGTAGCGATTACCACGG
CGCTTAAAGCTGCTAATGCGGCTAAAGTGTGGGAATACCATTTTGAATCGAAATGA

Upstream 100 bases:

>100_bases
GCTCACGCTCTGTTACATTATGCTTTAGTCTAGCATATCTAAGTAGTGCCTGACGGGCGTTTGCGCTATCATTAATAAAG
AATATTGACGAGGTGTTTAT

Downstream 100 bases:

>100_bases
GGCTATTATGACGACTTATGCACGCGCGCACACAAATATTGCGCTGATTAAATATTGGGGAAAAGCCAATCGCAAGTTGA
TGCTGCCAGCCACAAGCAGC

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MEIGTGKSYAKIILLGEHAVVYGEPAIALPVKSVGLSARVTPQPDGRQTVTSSFFTGNLNAGQLTNFAGIAMLIRRLLIF
FNAKNQGFHLTITSALPSERGMGSSAATAVAVVRAFYDAFQTSLSHDTLLNWAAVSEKALHGNPSGLDAATASAERPQWF
VRGKAPRSIMMPRNGVLLIADTGVAGQTKIAVGAVADRLKQNPKMYRPLIKDIGDTVRQAALALAQDDIITLGQLFNRDQ
ADLSALGVSSPDLDRLINVAIDNGAYGAKLTGSGMGGCMIALAASDQAVAITTALKAANAAKVWEYHFESK

Sequences:

>Translated_311_residues
MEIGTGKSYAKIILLGEHAVVYGEPAIALPVKSVGLSARVTPQPDGRQTVTSSFFTGNLNAGQLTNFAGIAMLIRRLLIF
FNAKNQGFHLTITSALPSERGMGSSAATAVAVVRAFYDAFQTSLSHDTLLNWAAVSEKALHGNPSGLDAATASAERPQWF
VRGKAPRSIMMPRNGVLLIADTGVAGQTKIAVGAVADRLKQNPKMYRPLIKDIGDTVRQAALALAQDDIITLGQLFNRDQ
ADLSALGVSSPDLDRLINVAIDNGAYGAKLTGSGMGGCMIALAASDQAVAITTALKAANAAKVWEYHFESK
>Mature_311_residues
MEIGTGKSYAKIILLGEHAVVYGEPAIALPVKSVGLSARVTPQPDGRQTVTSSFFTGNLNAGQLTNFAGIAMLIRRLLIF
FNAKNQGFHLTITSALPSERGMGSSAATAVAVVRAFYDAFQTSLSHDTLLNWAAVSEKALHGNPSGLDAATASAERPQWF
VRGKAPRSIMMPRNGVLLIADTGVAGQTKIAVGAVADRLKQNPKMYRPLIKDIGDTVRQAALALAQDDIITLGQLFNRDQ
ADLSALGVSSPDLDRLINVAIDNGAYGAKLTGSGMGGCMIALAASDQAVAITTALKAANAAKVWEYHFESK

Specific function: Galactose metabolism; first step. [C]

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI167001643, Length=325, Percent_Identity=27.0769230769231, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4557769, Length=325, Percent_Identity=27.0769230769231, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78707210, Length=212, Percent_Identity=28.3018867924528, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 32739; Mature: 32739

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIGTGKSYAKIILLGEHAVVYGEPAIALPVKSVGLSARVTPQPDGRQTVTSSFFTGNLN
CCCCCCCCEEEEEEEECEEEEECCCEEEEEHHHCCCEEEECCCCCCCHHHHHHEEECCCC
AGQLTNFAGIAMLIRRLLIFFNAKNQGFHLTITSALPSERGMGSSAATAVAVVRAFYDAF
CCCHHHHHHHHHHHHHHHHEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
QTSLSHDTLLNWAAVSEKALHGNPSGLDAATASAERPQWFVRGKAPRSIMMPRNGVLLIA
HHHCCHHHHHHHHHHCCHHHCCCCCCCCHHCCCCCCCEEEEECCCCCEEECCCCCEEEEE
DTGVAGQTKIAVGAVADRLKQNPKMYRPLIKDIGDTVRQAALALAQDDIITLGQLFNRDQ
ECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
ADLSALGVSSPDLDRLINVAIDNGAYGAKLTGSGMGGCMIALAASDQAVAITTALKAANA
HHHHHCCCCCCCHHHHEEEEECCCCCCCEEECCCCCCEEEEEECCCCEEEEEHHHHHCCC
AKVWEYHFESK
HHHEEEECCCC
>Mature Secondary Structure
MEIGTGKSYAKIILLGEHAVVYGEPAIALPVKSVGLSARVTPQPDGRQTVTSSFFTGNLN
CCCCCCCCEEEEEEEECEEEEECCCEEEEEHHHCCCEEEECCCCCCCHHHHHHEEECCCC
AGQLTNFAGIAMLIRRLLIFFNAKNQGFHLTITSALPSERGMGSSAATAVAVVRAFYDAF
CCCHHHHHHHHHHHHHHHHEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
QTSLSHDTLLNWAAVSEKALHGNPSGLDAATASAERPQWFVRGKAPRSIMMPRNGVLLIA
HHHCCHHHHHHHHHHCCHHHCCCCCCCCHHCCCCCCCEEEEECCCCCEEECCCCCEEEEE
DTGVAGQTKIAVGAVADRLKQNPKMYRPLIKDIGDTVRQAALALAQDDIITLGQLFNRDQ
ECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
ADLSALGVSSPDLDRLINVAIDNGAYGAKLTGSGMGGCMIALAASDQAVAITTALKAANA
HHHHHCCCCCCCHHHHEEEEECCCCCCCEEECCCCCCEEEEEECCCCEEEEEHHHHHCCC
AKVWEYHFESK
HHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]