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The map label for this gene is 116494976

Identifier: 116494976

GI number: 116494976

Start: 1492637

End: 1493641

Strand: Direct

Name: 116494976

Synonym: LSEI_1492

Alternate gene names: NA

Gene position: 1492637-1493641 (Clockwise)

Preceding gene: 116494975

Following gene: 116494977

Centisome position: 51.55

GC content: 49.95

Gene sequence:

>1005_bases
ATGACGACTTATGCACGCGCGCACACAAATATTGCGCTGATTAAATATTGGGGAAAAGCCAATCGCAAGTTGATGCTGCC
AGCCACAAGCAGCATTTCTTTAACTTTAAATGACTTTTATACTGACACAGCAGTGACATTTGATCCTAGTCTAAATGATG
ATCGCTTCATGCTTAACGGTGAAGAACAAAACCCGGTTGCGGTCAGCCGCTTTTTGGATCGGGTTCGGCACTTAGGAAAA
ATTAGCACGTACGCCCAAGTCACTTCCTTGAATCACGTGCCGACTGCTGCCGGGCTGGCAAGTTCAGCCTCTGCTTTTGC
TGCCTTGGCCACTGCTGCCAGCCGCGCGGCAGGTCTAAACCTTTCTCCGACTGAACTATCAAGATTAGCGCGCCGCGGAT
CAGGTTCAGCAACGCGCTCTATCTTTGGTGGTGCCGTTATCTGGCATCGCGGCCATGACGACGCCTCTTCATTCGCTGAA
CCACTCGCGATTCAACCTAGTTTGCCATTACGAATGCTTGTGGTCACGGTATCTGCTGAAAAAAAGGCGGTCAGTTCACG
AAAAGGCATGGCCAACACAGTGGCCACAAGTCCCTACTATGATGCCTGGGTGGCCTCAAATGAAAGTTTAATTGAACCAA
TGATTACCGCGTTGGCTGAAGACGACTTAGCGCTGATCGGCAAATTGACAGAATTGTCCAGTATGCGCATGCATGCGGCG
ATTATGGCCGAGGAACCGCCATTCACCTACTTTCTGCCGGAAACATTACGGGCGTGGCAATTAGTGCAAGAACAACGGGC
TTTGGGTATTCCCGCGTTTGCCACGATGGATGCAGGACCAAATGTCAAAATTCTGACTACTGAACCTTACGTGGACATTT
TATTAACCGCCTTGCGCCCTGTGTTCGGTGATCGGATTTTGAGCACACGCCTTGGTCCGGATGCCAGCATCATCACAAAG
GAGCAATTTGATGACACAAAGTCAGCAATCGCATCGCAAGGATGA

Upstream 100 bases:

>100_bases
TTAGCAGCCAGTGATCAAGCGGTAGCGATTACCACGGCGCTTAAAGCTGCTAATGCGGCTAAAGTGTGGGAATACCATTT
TGAATCGAAATGAGGCTATT

Downstream 100 bases:

>100_bases
ACATGTTTTTCTAGCTGAAAAATACTTTCAATCTGTTGCTCATGCGGGTTTCGATCAGGTTCGTCTTTTGCATCGAGCTT
TGCCGGAAACAACCATGGCT

Product: mevalonate pyrophosphate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; GHMP Kinase Domain-Containing Protein; GHMP Kinase; Phosphomevalonate Kinase

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTTYARAHTNIALIKYWGKANRKLMLPATSSISLTLNDFYTDTAVTFDPSLNDDRFMLNGEEQNPVAVSRFLDRVRHLGK
ISTYAQVTSLNHVPTAAGLASSASAFAALATAASRAAGLNLSPTELSRLARRGSGSATRSIFGGAVIWHRGHDDASSFAE
PLAIQPSLPLRMLVVTVSAEKKAVSSRKGMANTVATSPYYDAWVASNESLIEPMITALAEDDLALIGKLTELSSMRMHAA
IMAEEPPFTYFLPETLRAWQLVQEQRALGIPAFATMDAGPNVKILTTEPYVDILLTALRPVFGDRILSTRLGPDASIITK
EQFDDTKSAIASQG

Sequences:

>Translated_334_residues
MTTYARAHTNIALIKYWGKANRKLMLPATSSISLTLNDFYTDTAVTFDPSLNDDRFMLNGEEQNPVAVSRFLDRVRHLGK
ISTYAQVTSLNHVPTAAGLASSASAFAALATAASRAAGLNLSPTELSRLARRGSGSATRSIFGGAVIWHRGHDDASSFAE
PLAIQPSLPLRMLVVTVSAEKKAVSSRKGMANTVATSPYYDAWVASNESLIEPMITALAEDDLALIGKLTELSSMRMHAA
IMAEEPPFTYFLPETLRAWQLVQEQRALGIPAFATMDAGPNVKILTTEPYVDILLTALRPVFGDRILSTRLGPDASIITK
EQFDDTKSAIASQG
>Mature_333_residues
TTYARAHTNIALIKYWGKANRKLMLPATSSISLTLNDFYTDTAVTFDPSLNDDRFMLNGEEQNPVAVSRFLDRVRHLGKI
STYAQVTSLNHVPTAAGLASSASAFAALATAASRAAGLNLSPTELSRLARRGSGSATRSIFGGAVIWHRGHDDASSFAEP
LAIQPSLPLRMLVVTVSAEKKAVSSRKGMANTVATSPYYDAWVASNESLIEPMITALAEDDLALIGKLTELSSMRMHAAI
MAEEPPFTYFLPETLRAWQLVQEQRALGIPAFATMDAGPNVKILTTEPYVDILLTALRPVFGDRILSTRLGPDASIITKE
QFDDTKSAIASQG

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=318, Percent_Identity=36.7924528301887, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17537201, Length=358, Percent_Identity=31.8435754189944, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17537203, Length=223, Percent_Identity=30.9417040358744, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324371, Length=332, Percent_Identity=36.7469879518072, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28571205, Length=315, Percent_Identity=34.6031746031746, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 36061; Mature: 35930

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTYARAHTNIALIKYWGKANRKLMLPATSSISLTLNDFYTDTAVTFDPSLNDDRFMLNG
CCCCCCCCCCEEEEEEECCCCCEEEEECCCCEEEEEECEECCCEEEECCCCCCCEEEECC
EEQNPVAVSRFLDRVRHLGKISTYAQVTSLNHVPTAAGLASSASAFAALATAASRAAGLN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LSPTELSRLARRGSGSATRSIFGGAVIWHRGHDDASSFAEPLAIQPSLPLRMLVVTVSAE
CCHHHHHHHHHCCCCCHHHHHHCCEEEEECCCCCHHHHHCCEEECCCCCEEEEEEEECCH
KKAVSSRKGMANTVATSPYYDAWVASNESLIEPMITALAEDDLALIGKLTELSSMRMHAA
HHHHHHHCCCCHHCCCCCCCHHEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHE
IMAEEPPFTYFLPETLRAWQLVQEQRALGIPAFATMDAGPNVKILTTEPYVDILLTALRP
EEECCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECHHHHHHHHHHHH
VFGDRILSTRLGPDASIITKEQFDDTKSAIASQG
HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTYARAHTNIALIKYWGKANRKLMLPATSSISLTLNDFYTDTAVTFDPSLNDDRFMLNG
CCCCCCCCCEEEEEEECCCCCEEEEECCCCEEEEEECEECCCEEEECCCCCCCEEEECC
EEQNPVAVSRFLDRVRHLGKISTYAQVTSLNHVPTAAGLASSASAFAALATAASRAAGLN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LSPTELSRLARRGSGSATRSIFGGAVIWHRGHDDASSFAEPLAIQPSLPLRMLVVTVSAE
CCHHHHHHHHHCCCCCHHHHHHCCEEEEECCCCCHHHHHCCEEECCCCCEEEEEEEECCH
KKAVSSRKGMANTVATSPYYDAWVASNESLIEPMITALAEDDLALIGKLTELSSMRMHAA
HHHHHHHCCCCHHCCCCCCCHHEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHE
IMAEEPPFTYFLPETLRAWQLVQEQRALGIPAFATMDAGPNVKILTTEPYVDILLTALRP
EEECCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECHHHHHHHHHHHH
VFGDRILSTRLGPDASIITKEQFDDTKSAIASQG
HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA