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The map label for this gene is parC [H]

Identifier: 116494895

GI number: 116494895

Start: 1398337

End: 1400781

Strand: Direct

Name: parC [H]

Synonym: LSEI_1409

Alternate gene names: 116494895

Gene position: 1398337-1400781 (Clockwise)

Preceding gene: 116494894

Following gene: 116494896

Centisome position: 48.3

GC content: 49.0

Gene sequence:

>2445_bases
TTGGCCAATCAGATTCAAGAACTGACCTTAGAAGAGGTCATGGGCGACCGGTTTGGCCGGTACTCGAAATACATTATTCA
AGAACGGGCGCTGCCTGATGTGCGTGACGGCCTCAAACCGGTTCAGCGTCGCATTTTATTTGCGATGAACCAAGATGGCA
ATACGTATGATAAGGGCTTCCGCAAGTCGGCTAAAAGTGTCGGGAATGTCATGGGTAATTATCATCCCCACGGCGACAGC
TCCATTTATGAAGCGATGGTTCGGCTAAGCCAGGATTGGAAGTTACGGGCCCCACTGATTCAGATGCACGGGAATAACGG
TTCCATGGATGGTGATCCGCCAGCTGCAATGCGATACACGGAAGCGCGTTTAAGCAAAATCAGCAAGGAAATGCTGGCCG
ACATCGATAAGGAAACCGTCGATATGGTGTTGAACTTTGATGACACGGCACAGGAACCGACTGTGCTGCCAGCTGGGTTT
CCAAATTTGCTGGTGAACGGTGCCACCGGTATTTCTGCCGGTTATGCAACCGAAATTCCGCCGCACAATCTGCGGGAAGT
TATTGCTGCCGTCTTATACTTGCTGAAGCATCCCACTGCTGATTTAGATACTTTAATGCAATACGTCAAGGGTCCCGATT
TTCCAACAGGTGGGATTATTCAAGGGCTTGATGGCATCAAGCAAGCTTACGAAACCGGCCGCGGTAAAATCGTGGTTCGT
TCTCGGACACACATCGAAACCATTCGTGGCGGTCGTGAGAAGATCGTGGTCACTGAGATCCCGTATGATGTCAATAAAGC
GCAGATGATTAAAAAAATCGATGAATTACGCATCAACAAAAAAGTGGACGGTATCGCCGAAGTCCGTGACGAAAGCGACC
GTTTTGGGCTTAGCGTTGTCATCGAATTAAAAAAAGAAGCCGATGCACATGGCATCTTAAACTATTTATTTAAAAATACC
GATCTACAAATTGCATACAACTTTAACATGGTCGCTATTGCCGACATGCAGCCGAAGTTGCTAGGACTTAAGGCCATGTT
GGAAGCATACGTCGAACATCGACGCGATGTGGTCACTCGGCGAACGCGTTTTGACCTCAACAAGGCCGCTGCTCGACAGC
ACATTGTCGAAGGCTTGATCAAAATGCTATCGATTTTGGATCAGGTCATCGCCGCGATTCGTGCTTCCAAGGATAAAGGG
GATGCTAAGCGTAACTTAGTCAAGAAGTTTGATTTTTCGGAAGCTCAGGCGGAAGCGATTGTTTCCTTGCAGCTGTATCG
ATTGACCAATACCGATATCACGGCTTTACAGAAAGAAGCAGCACAATTGGCGAAAGCAATCGCCGAGTATCAAGATATTT
TGGCCCGCCCCGCTGCCCGCGATCGGGTGATTGAAGGCGAGTTGAAGCGGATTGCCAAGGAGTACGGGGATGATCGTCGC
AGCAGCATTCAAGCCAAAATTGAAACACTTGAAGTGGCGACAACGGTGACGGTGGCTGATGAAACCGTCATGGTGCAGGT
TTCTCGTGATGGGTACGTTAAACGCAGTTCACTGCGCAGTTATCAGGCGGTTGATCCGGCCGACAATGGTTTGAAGGCCA
ATGATCTTGCCATTTTCACTGGCGAACTGAGTACGTTGCAGCATCTTTACATCGTGACAAATGCCGGAAATGTCATTTAT
CGACCAGTGCATGAAATTAGTGATGCGCGTTGGAAAGACACCGGCGAACACTTAAGCCAAACAGTTGGCCTTGGCACTGA
CGAAAAAGTCTTGGCAGTGTTTGCTTTTGATCAACTCGATGGCGCTGGCAGTTTTGTGTTAGGGTCAAGTGACGGGTACA
TCAAACAAACTGCCTTAAGTGATTTGCAGCCGCAACGGACGTACAAGAGTAAGCCGATGATGGCGATGAAGCTGAAAGAC
CCAGCCGCGATTGTCACCAATGCATACTTCACGACTGATCAGCAACAGGATGTCTTTGTGGTCAGCCGCCACGCTTACGG
ACTGACATTCCCGTTAAGCGATGTGTCAACTGTCGGTGCCCGGGCAACCGGCGTTAAAAGTATGGATCTAAAGCCAGACG
ATGAGGTTGTCAATTTCATTCTAGTGAAGGATCCAACTACGGCTAAGGTCGGTATTTTGACCCAACGTGGCGCCTTCAAA
AAGATGGCCTTAAGCGAAGTCGGGGAAATGAGTCGTGCCCGTCGTGGTTTACTGGTCTTGCGTGAGCTTAAGCGTGATCC
GCATCGGATTGTCGCGATGATGTCAGTCGATGACGCTACCCGCCTGAATGTTTTGACCGATACGGGTAAGGTAACGACCC
TTAATCCGGCACAACATCCAGCAGGTGACCGCTATTCGAATGGTTCGTTTGTCATTGACACTGATGTCCTTGGCAAGCCA
GTTTTTGTTCAAACCAAAGAAGAACCAGCAGATCAAGTCGAATAA

Upstream 100 bases:

>100_bases
CGGCAGTATTTTGGAAACCCCGACTGCTAATCACGAAAAATTACAGTTTGGTGCCAAGCAAATCGTCAAACAACTGGACA
AGAAAGGAAAGTAAAAGCCA

Downstream 100 bases:

>100_bases
ATGGTGATCATTGACACCGCCGTCTGTACTAATACAGATGGTGGCGTTTTTGATTATTATAGGACAGACCAGTTGTGCAC
AATTTAACAAAATGCCGAAA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 814; Mature: 813

Protein sequence:

>814_residues
MANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNQDGNTYDKGFRKSAKSVGNVMGNYHPHGDS
SIYEAMVRLSQDWKLRAPLIQMHGNNGSMDGDPPAAMRYTEARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGF
PNLLVNGATGISAGYATEIPPHNLREVIAAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQGLDGIKQAYETGRGKIVVR
SRTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRINKKVDGIAEVRDESDRFGLSVVIELKKEADAHGILNYLFKNT
DLQIAYNFNMVAIADMQPKLLGLKAMLEAYVEHRRDVVTRRTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDKG
DAKRNLVKKFDFSEAQAEAIVSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPAARDRVIEGELKRIAKEYGDDRR
SSIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSSLRSYQAVDPADNGLKANDLAIFTGELSTLQHLYIVTNAGNVIY
RPVHEISDARWKDTGEHLSQTVGLGTDEKVLAVFAFDQLDGAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMAMKLKD
PAAIVTNAYFTTDQQQDVFVVSRHAYGLTFPLSDVSTVGARATGVKSMDLKPDDEVVNFILVKDPTTAKVGILTQRGAFK
KMALSEVGEMSRARRGLLVLRELKRDPHRIVAMMSVDDATRLNVLTDTGKVTTLNPAQHPAGDRYSNGSFVIDTDVLGKP
VFVQTKEEPADQVE

Sequences:

>Translated_814_residues
MANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNQDGNTYDKGFRKSAKSVGNVMGNYHPHGDS
SIYEAMVRLSQDWKLRAPLIQMHGNNGSMDGDPPAAMRYTEARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGF
PNLLVNGATGISAGYATEIPPHNLREVIAAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQGLDGIKQAYETGRGKIVVR
SRTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRINKKVDGIAEVRDESDRFGLSVVIELKKEADAHGILNYLFKNT
DLQIAYNFNMVAIADMQPKLLGLKAMLEAYVEHRRDVVTRRTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDKG
DAKRNLVKKFDFSEAQAEAIVSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPAARDRVIEGELKRIAKEYGDDRR
SSIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSSLRSYQAVDPADNGLKANDLAIFTGELSTLQHLYIVTNAGNVIY
RPVHEISDARWKDTGEHLSQTVGLGTDEKVLAVFAFDQLDGAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMAMKLKD
PAAIVTNAYFTTDQQQDVFVVSRHAYGLTFPLSDVSTVGARATGVKSMDLKPDDEVVNFILVKDPTTAKVGILTQRGAFK
KMALSEVGEMSRARRGLLVLRELKRDPHRIVAMMSVDDATRLNVLTDTGKVTTLNPAQHPAGDRYSNGSFVIDTDVLGKP
VFVQTKEEPADQVE
>Mature_813_residues
ANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNQDGNTYDKGFRKSAKSVGNVMGNYHPHGDSS
IYEAMVRLSQDWKLRAPLIQMHGNNGSMDGDPPAAMRYTEARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGFP
NLLVNGATGISAGYATEIPPHNLREVIAAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQGLDGIKQAYETGRGKIVVRS
RTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRINKKVDGIAEVRDESDRFGLSVVIELKKEADAHGILNYLFKNTD
LQIAYNFNMVAIADMQPKLLGLKAMLEAYVEHRRDVVTRRTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDKGD
AKRNLVKKFDFSEAQAEAIVSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPAARDRVIEGELKRIAKEYGDDRRS
SIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSSLRSYQAVDPADNGLKANDLAIFTGELSTLQHLYIVTNAGNVIYR
PVHEISDARWKDTGEHLSQTVGLGTDEKVLAVFAFDQLDGAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMAMKLKDP
AAIVTNAYFTTDQQQDVFVVSRHAYGLTFPLSDVSTVGARATGVKSMDLKPDDEVVNFILVKDPTTAKVGILTQRGAFKK
MALSEVGEMSRARRGLLVLRELKRDPHRIVAMMSVDDATRLNVLTDTGKVTTLNPAQHPAGDRYSNGSFVIDTDVLGKPV
FVQTKEEPADQVE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm. Note=Bipolarly localized [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=181, Percent_Identity=30.939226519337, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI19913408, Length=250, Percent_Identity=29.2, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1788562, Length=852, Percent_Identity=36.2676056338028, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1789396, Length=521, Percent_Identity=39.7312859884837, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17535065, Length=177, Percent_Identity=31.0734463276836, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115534553, Length=173, Percent_Identity=32.3699421965318, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=177, Percent_Identity=31.0734463276836, Blast_Score=73, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=491, Percent_Identity=22.4032586558045, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=197, Percent_Identity=27.9187817258883, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136538, Length=212, Percent_Identity=29.7169811320755, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 90291; Mature: 90160

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNQDGNTYDKGF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCCCHHHHHH
RKSAKSVGNVMGNYHPHGDSSIYEAMVRLSQDWKLRAPLIQMHGNNGSMDGDPPAAMRYT
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEECCCEEEEECCCCCCCCCCCHHHHHH
EARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGFPNLLVNGATGISAGYATEIP
HHHHHHHHHHHHHHCCHHHHHEEECCCCCCCCCEECCCCCHHHEEECCCCCCCCCCCCCC
PHNLREVIAAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQGLDGIKQAYETGRGKIVVR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEE
SRTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRINKKVDGIAEVRDESDRFGLSVV
CCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEE
IELKKEADAHGILNYLFKNTDLQIAYNFNMVAIADMQPKLLGLKAMLEAYVEHRRDVVTR
EEECCCCCHHHHHHHHHCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
RTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDKGDAKRNLVKKFDFSEAQAEAI
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHH
VSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPAARDRVIEGELKRIAKEYGDDRR
HEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHH
SSIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSSLRSYQAVDPADNGLKANDLAIFT
HHHHHHHHEEEEEEEEEEECCEEEEEECCCCCEEHHHCCCCCCCCCCCCCCCCCCEEEEE
GELSTLQHLYIVTNAGNVIYRPVHEISDARWKDTGEHLSQTVGLGTDEKVLAVFAFDQLD
CCHHCEEEEEEEEECCCEEECCHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCC
GAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMAMKLKDPAAIVTNAYFTTDQQQDVFV
CCCCEEEECCCCCCHHHHHHCCCCHHHHCCCCEEEEEECCCCEEEEEEEEECCCCCCEEE
VSRHAYGLTFPLSDVSTVGARATGVKSMDLKPDDEVVNFILVKDPTTAKVGILTQRGAFK
EEECCCEEEECCCHHHHHCCHHCCCCCCCCCCCHHHEEEEEEECCCCCEEEEEECCCHHH
KMALSEVGEMSRARRGLLVLRELKRDPHRIVAMMSVDDATRLNVLTDTGKVTTLNPAQHP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCEEEECCCCCC
AGDRYSNGSFVIDTDVLGKPVFVQTKEEPADQVE
CCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure 
ANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNQDGNTYDKGF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCCCHHHHHH
RKSAKSVGNVMGNYHPHGDSSIYEAMVRLSQDWKLRAPLIQMHGNNGSMDGDPPAAMRYT
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEECCCEEEEECCCCCCCCCCCHHHHHH
EARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGFPNLLVNGATGISAGYATEIP
HHHHHHHHHHHHHHCCHHHHHEEECCCCCCCCCEECCCCCHHHEEECCCCCCCCCCCCCC
PHNLREVIAAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQGLDGIKQAYETGRGKIVVR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEE
SRTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRINKKVDGIAEVRDESDRFGLSVV
CCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEE
IELKKEADAHGILNYLFKNTDLQIAYNFNMVAIADMQPKLLGLKAMLEAYVEHRRDVVTR
EEECCCCCHHHHHHHHHCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
RTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDKGDAKRNLVKKFDFSEAQAEAI
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHH
VSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPAARDRVIEGELKRIAKEYGDDRR
HEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHH
SSIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSSLRSYQAVDPADNGLKANDLAIFT
HHHHHHHHEEEEEEEEEEECCEEEEEECCCCCEEHHHCCCCCCCCCCCCCCCCCCEEEEE
GELSTLQHLYIVTNAGNVIYRPVHEISDARWKDTGEHLSQTVGLGTDEKVLAVFAFDQLD
CCHHCEEEEEEEEECCCEEECCHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCC
GAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMAMKLKDPAAIVTNAYFTTDQQQDVFV
CCCCEEEECCCCCCHHHHHHCCCCHHHHCCCCEEEEEECCCCEEEEEEEEECCCCCCEEE
VSRHAYGLTFPLSDVSTVGARATGVKSMDLKPDDEVVNFILVKDPTTAKVGILTQRGAFK
EEECCCEEEECCCHHHHHCCHHCCCCCCCCCCCHHHEEEEEEECCCCCEEEEEECCCHHH
KMALSEVGEMSRARRGLLVLRELKRDPHRIVAMMSVDDATRLNVLTDTGKVTTLNPAQHP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCEEEECCCCCC
AGDRYSNGSFVIDTDVLGKPVFVQTKEEPADQVE
CCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]