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The map label for this gene is parE [H]

Identifier: 116494894

GI number: 116494894

Start: 1396318

End: 1398330

Strand: Direct

Name: parE [H]

Synonym: LSEI_1408

Alternate gene names: 116494894

Gene position: 1396318-1398330 (Clockwise)

Preceding gene: 116494892

Following gene: 116494895

Centisome position: 48.23

GC content: 48.53

Gene sequence:

>2013_bases
ATGGATAAAGCAACGCAAGCATATAATGATTCATCCATTCAGGTGCTGCATGGCTTGGAAGCTGTGCGGAAGCGTCCGGG
GATGTATATTGGTTCCACCGATGGCCGCGGTTTGCATCACTTGGTCTATGAAATCGTGGACAACTCTGTCGATGAAGCGC
TCGCGGGGTTTGGGGATGAGATCAATGTGACGATTCACGCCGATAACTCTGTGACCGTACAGGATCATGGTCGAGGGATG
CCAACGGGGATGCACCCGAGTGGTAAACCGACGATTGAAGTCATTTTAACCGTGCTACATGCCGGCGGAAAATTTAACCA
AAATAGTTACAAAACTTCTGGTGGTTTGCATGGGGTTGGCTCAAGCGTCGTCAATGCCCTATCGGAGTCATTGACTGTGC
GAGTTGTGCGGGATAAACACGCATTTGAGGAGCATTTTATCAATGGCGGTCATCCTGATGGCAGTTTGCAGAAGTTGGGC
AAAGTTAATGAACCTAATGGCACGACCATCACATTCAAGCCGGACCCGACTATTTTTCAAACCACCGTCTTCAGTTATGA
TACCTTGGCCGAACGCTTGCGCGAATCAGCCTTTCTACTGAAAAATATTACGATTAATCTGACGGATGAACGCACCGGTA
AGCACGACAGTTATCACTATCCTGATGGCTTGGTCAGTTTTGTTAAATACCTTAATGAAGGCAAAGACGCATTGTCACAG
GTGATCAATTTTGAAGGCAAAAAGGACGGTATCGTGGTTGATTTTGCCGGCCAATATAACGATGGCTATTCTGAAAACCT
GATTTCGTTTGTTAATAACGTTCGCACTGGTGATGGCGGGACGCATGAAATTGGCTTGCGCAGCGGCATGACGCGAGCAT
TCAATGAATTTGCCCGAAAAGTCGGCTTGCTGAGGGAACGCGACAAGAACCTTGAAGGCAGTGATGTGCGTGAAGGTTTT
GCAGGTATTTTAAGTGTCCGCATTCCAGAAGAAATTTTGCAATTTGAGGGCCAGACAAAGGGCAAGCTAGGTACGCCGCA
AGCCCGCACTGTGGTCGATGGGATTGTCTATGACAAGCTGTCAACTTTTTTGATGGAAAACGGTGAAGAGTCGCAAGAGT
TGGTTCGTAAAGCCGTCAAAGCCCGTGATGCGCGGGAAGCGGCTCGAAAAGCGCGCGACGATAGCCGGACGGGACGCAAG
CGCAAGAAGGACCAAGGTTTGCTTTCCGGTAAATTGACCCCGGCGCAAACCAAGAACCCTAAGCGTAACGAATTGTATCT
CGTCGAAGGGGATTCTGCCGGTGGTTCAGCTAAACAAGGCCGAGACCGAAAGTTTCAGGCGATCTTGCCATTGCGAGGGA
AAGTACTGAATACCCAGAAGGCCAAGTTACAGGACATCGTTAAAAACGAAGAAATCAATACGATGATTTACACCATCGGC
GCTGGTGTCGGTGCGGATTTTGATCTGCAGCAGGCCAACTACGACAAAATCATTATTATGACTGATGCGGATACTGATGG
CGCGCATATTCAGATTTTGCTACTAACCTTCTTTTATCGCTACATGCGGCCGCTGATTGACGCAGGCCGAATTTACATTG
CTTTGCCACCATTGTATCGGCTGCAAAAAGGCGCTGGTGCTAAAACCAAGATCAGTTATGCTTGGACCGATGAAGAGTTG
GCCAAAGAGACCAAGGCCATGGGCAAGGGTTACACATTGACCCGATTTAAAGGACTTGGGGAAATGAATGCCGACCAGCT
TTGGGAAACGACTATGAATCCTGAGACGCGGACTTTGATCCGGGTTCGGATTGACGATGCTCAGCTGGCGGAACGACGCG
TGACCACTTTGATGGGTGATCGCGTTGAGCCGCGTCGTGAATGGATTGAGCATAACGTCAAGTTTGATATGGATGACGAC
GGCAGTATTTTGGAAACCCCGACTGCTAATCACGAAAAATTACAGTTTGGTGCCAAGCAAATCGTCAAACAACTGGACAA
GAAAGGAAAGTAA

Upstream 100 bases:

>100_bases
CGGTTTCTAATCGGGCTGGCTCGCGCTCTTATTTTTTATTTCTGAAATCTCAACGCGTGGTGTATTCTATAACTTAGTTG
TTCAAAAAAGGGAGTTTATT

Downstream 100 bases:

>100_bases
AAGCCATTGGCCAATCAGATTCAAGAACTGACCTTAGAAGAGGTCATGGGCGACCGGTTTGGCCGGTACTCGAAATACAT
TATTCAAGAACGGGCGCTGC

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 670; Mature: 670

Protein sequence:

>670_residues
MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEIVDNSVDEALAGFGDEINVTIHADNSVTVQDHGRGM
PTGMHPSGKPTIEVILTVLHAGGKFNQNSYKTSGGLHGVGSSVVNALSESLTVRVVRDKHAFEEHFINGGHPDGSLQKLG
KVNEPNGTTITFKPDPTIFQTTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPDGLVSFVKYLNEGKDALSQ
VINFEGKKDGIVVDFAGQYNDGYSENLISFVNNVRTGDGGTHEIGLRSGMTRAFNEFARKVGLLRERDKNLEGSDVREGF
AGILSVRIPEEILQFEGQTKGKLGTPQARTVVDGIVYDKLSTFLMENGEESQELVRKAVKARDAREAARKARDDSRTGRK
RKKDQGLLSGKLTPAQTKNPKRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTQKAKLQDIVKNEEINTMIYTIG
AGVGADFDLQQANYDKIIIMTDADTDGAHIQILLLTFFYRYMRPLIDAGRIYIALPPLYRLQKGAGAKTKISYAWTDEEL
AKETKAMGKGYTLTRFKGLGEMNADQLWETTMNPETRTLIRVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKFDMDDD
GSILETPTANHEKLQFGAKQIVKQLDKKGK

Sequences:

>Translated_670_residues
MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEIVDNSVDEALAGFGDEINVTIHADNSVTVQDHGRGM
PTGMHPSGKPTIEVILTVLHAGGKFNQNSYKTSGGLHGVGSSVVNALSESLTVRVVRDKHAFEEHFINGGHPDGSLQKLG
KVNEPNGTTITFKPDPTIFQTTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPDGLVSFVKYLNEGKDALSQ
VINFEGKKDGIVVDFAGQYNDGYSENLISFVNNVRTGDGGTHEIGLRSGMTRAFNEFARKVGLLRERDKNLEGSDVREGF
AGILSVRIPEEILQFEGQTKGKLGTPQARTVVDGIVYDKLSTFLMENGEESQELVRKAVKARDAREAARKARDDSRTGRK
RKKDQGLLSGKLTPAQTKNPKRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTQKAKLQDIVKNEEINTMIYTIG
AGVGADFDLQQANYDKIIIMTDADTDGAHIQILLLTFFYRYMRPLIDAGRIYIALPPLYRLQKGAGAKTKISYAWTDEEL
AKETKAMGKGYTLTRFKGLGEMNADQLWETTMNPETRTLIRVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKFDMDDD
GSILETPTANHEKLQFGAKQIVKQLDKKGK
>Mature_670_residues
MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEIVDNSVDEALAGFGDEINVTIHADNSVTVQDHGRGM
PTGMHPSGKPTIEVILTVLHAGGKFNQNSYKTSGGLHGVGSSVVNALSESLTVRVVRDKHAFEEHFINGGHPDGSLQKLG
KVNEPNGTTITFKPDPTIFQTTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPDGLVSFVKYLNEGKDALSQ
VINFEGKKDGIVVDFAGQYNDGYSENLISFVNNVRTGDGGTHEIGLRSGMTRAFNEFARKVGLLRERDKNLEGSDVREGF
AGILSVRIPEEILQFEGQTKGKLGTPQARTVVDGIVYDKLSTFLMENGEESQELVRKAVKARDAREAARKARDDSRTGRK
RKKDQGLLSGKLTPAQTKNPKRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTQKAKLQDIVKNEEINTMIYTIG
AGVGADFDLQQANYDKIIIMTDADTDGAHIQILLLTFFYRYMRPLIDAGRIYIALPPLYRLQKGAGAKTKISYAWTDEEL
AKETKAMGKGYTLTRFKGLGEMNADQLWETTMNPETRTLIRVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKFDMDDD
GSILETPTANHEKLQFGAKQIVKQLDKKGK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=217, Percent_Identity=31.7972350230415, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI19913406, Length=227, Percent_Identity=28.1938325991189, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI48994957, Length=545, Percent_Identity=49.5412844036697, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1789408, Length=641, Percent_Identity=40.8736349453978, Blast_Score=422, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17535065, Length=662, Percent_Identity=25.0755287009063, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI212645845, Length=545, Percent_Identity=23.4862385321101, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI212645657, Length=182, Percent_Identity=28.021978021978, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=639, Percent_Identity=24.8826291079812, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17136538, Length=663, Percent_Identity=25.3393665158371, Blast_Score=123, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 74467; Mature: 74467

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEIVDNSVDEALAGFGDE
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCE
INVTIHADNSVTVQDHGRGMPTGMHPSGKPTIEVILTVLHAGGKFNQNSYKTSGGLHGVG
EEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
SSVVNALSESLTVRVVRDKHAFEEHFINGGHPDGSLQKLGKVNEPNGTTITFKPDPTIFQ
HHHHHHHHHHEEEEEEHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCEEE
TTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPDGLVSFVKYLNEGKDALSQ
EEHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHH
VINFEGKKDGIVVDFAGQYNDGYSENLISFVNNVRTGDGGTHEIGLRSGMTRAFNEFARK
HHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEHHHHHCHHHHHHHHHHH
VGLLRERDKNLEGSDVREGFAGILSVRIPEEILQFEGQTKGKLGTPQARTVVDGIVYDKL
HHHHHHHCCCCCCCHHHHHHHHHHEECCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
STFLMENGEESQELVRKAVKARDAREAARKARDDSRTGRKRKKDQGLLSGKLTPAQTKNP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
KRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTQKAKLQDIVKNEEINTMIYTIG
CCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEC
AGVGADFDLQQANYDKIIIMTDADTDGAHIQILLLTFFYRYMRPLIDAGRIYIALPPLYR
CCCCCCCCCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHCCEEEEECCCHHH
LQKGAGAKTKISYAWTDEELAKETKAMGKGYTLTRFKGLGEMNADQLWETTMNPETRTLI
HHCCCCCCEEEEEEECCHHHHHHHHHHCCCCEEHHCCCCCCCCHHHHHHHCCCCCCEEEE
RVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKFDMDDDGSILETPTANHEKLQFGAKQ
EEEECHHHHHHHHHHHHHCCCCCHHHHHHHCCCEECCCCCCCEEECCCCCHHHHHHHHHH
IVKQLDKKGK
HHHHHHHCCC
>Mature Secondary Structure
MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEIVDNSVDEALAGFGDE
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCE
INVTIHADNSVTVQDHGRGMPTGMHPSGKPTIEVILTVLHAGGKFNQNSYKTSGGLHGVG
EEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
SSVVNALSESLTVRVVRDKHAFEEHFINGGHPDGSLQKLGKVNEPNGTTITFKPDPTIFQ
HHHHHHHHHHEEEEEEHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCEEE
TTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPDGLVSFVKYLNEGKDALSQ
EEHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHH
VINFEGKKDGIVVDFAGQYNDGYSENLISFVNNVRTGDGGTHEIGLRSGMTRAFNEFARK
HHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEHHHHHCHHHHHHHHHHH
VGLLRERDKNLEGSDVREGFAGILSVRIPEEILQFEGQTKGKLGTPQARTVVDGIVYDKL
HHHHHHHCCCCCCCHHHHHHHHHHEECCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
STFLMENGEESQELVRKAVKARDAREAARKARDDSRTGRKRKKDQGLLSGKLTPAQTKNP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
KRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTQKAKLQDIVKNEEINTMIYTIG
CCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEC
AGVGADFDLQQANYDKIIIMTDADTDGAHIQILLLTFFYRYMRPLIDAGRIYIALPPLYR
CCCCCCCCCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHCCEEEEECCCHHH
LQKGAGAKTKISYAWTDEELAKETKAMGKGYTLTRFKGLGEMNADQLWETTMNPETRTLI
HHCCCCCCEEEEEEECCHHHHHHHHHHCCCCEEHHCCCCCCCCHHHHHHHCCCCCCEEEE
RVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKFDMDDDGSILETPTANHEKLQFGAKQ
EEEECHHHHHHHHHHHHHCCCCCHHHHHHHCCCEECCCCCCCEEECCCCCHHHHHHHHHH
IVKQLDKKGK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]