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The map label for this gene is hslU [H]

Identifier: 116494891

GI number: 116494891

Start: 1392727

End: 1394136

Strand: Direct

Name: hslU [H]

Synonym: LSEI_1405

Alternate gene names: 116494891

Gene position: 1392727-1394136 (Clockwise)

Preceding gene: 116494890

Following gene: 116494892

Centisome position: 48.1

GC content: 46.1

Gene sequence:

>1410_bases
ATGGCAGAAGTACAAACCCCAAAACAGATCGTTGAAAAACTCGATCAATATGTCATTGGACAAGATGATGCAAAACGGGC
CGTCGCGGTTGCCTTGTATAACCGTTATCGGCGAATGCAATTATCGCCAAAAATGCAAGAAGAGATTACCCCGAAAAACT
TACTGATGATCGGACCAACCGGTGTCGGGAAAACCGAAATTGCACGACGACTGGCGAAAATAGTTGAGGCGCCATTTGTG
AAGGTGGAAGCGACTAAGTTTACGGAAGTTGGCTACGTTGGCCGTGATGTCGAATCCATGGTCCGAGATCTTGCCGAAAC
TGCCGTTGCCATGGAAGAAGAGAAGCAATTTTCAAAGGTTCGCATACGTGCCGAAAAAGAAGCCAACAAGCGTTTGGTTA
AAATTTTAGTGCCGGCCATTCGTAAGGAAAAGAATACCAATCCGATGGCCGAGATGATGAGCATGTTGCAAGGGATGCAA
AATGGCAAAATGCCAGCTGGCGATGATGCAGATGCAGGCGGCGAAGTGACCGATGATATTCGCAATAAGCGTTTGAGCGT
GGCAGAGCAACTGGAAAAAGGATTACTTGAAGATCATGAAATCACCGTTGCTGTCAATGATGAGAAAAAAGGCGGTGGCA
TGGGTGACATGTACGGTCAGATGGGCATTGATCTAAGCGACACTATTGGCGCTTTAATGCCTAAGAAAAAGGTTGAGCGG
ACCATGACCGTCAAAGAAGCTCGCGAAATCTTCATCAAAGAGGAATCTGACAAACTGGTCAATCATGCCGACATTTATCA
CGACGCCATTCCAAGTGCCGAGAATAACGGGATCATTTTCATCGATGAAATCGATAAAATTGCTGCAGGAAACAAGCATA
ATAGCGGCGAAGTTTCGCGTGAAGGTGTGCAGCGAGATATTTTACCGATTGTAGAAGGATCGCAGATTAACACTAAGTAT
GGTCCTATCAATACGGATCACATCTTGTTCATTGGCTCAGGTGCGTTTGCCGAGGCTAAGCCTAGTGATTTGATTGCTGA
ACTTCAAGGGCGTTTTCCAATTCGGGTTGAATTGAAGGACTTAACCGAAAAAGACTTTGTGCGGATCTTGACCGAGCCAG
ACAATGCTTTGATCAAGCAGTATATCGCCTTGATTGGTGCAGATGGCGTGAAGATTACCTTCACGAAGGAAGCGGTTGAT
CGAATTGCAGAGATTGCGACTCAGGTCAACCACGACACTGATAATATTGGAGCGCGGCGACTGGCAACCATTCTTGAAAA
ACTGCTTGAAGACGTACTTTATGAAGGTCCAGATATGGCGATGGGCAGTGTGACCGTCACCCAGCAATATGTGGATGACA
AGATTGGCCATATTGCGGCTGATTCAAACATGACGCGGTATATTTTGTAG

Upstream 100 bases:

>100_bases
ATCGCAGGGAATATCGATATTTTCACAAACCACAATGTTATTGTCGAAAGCTTTTAGTTTGTAACCGTCGGCAATTACAT
TGACCTACAGGAGGCTTATG

Downstream 100 bases:

>100_bases
TTAACAATAATGTTGTAGGTAAAGGATGAGGATGTATGGTAACGATTGCAAATGACTTTTTGACAGTTAAAATCAGTCGG
CATGGTGCTGAACTGACCAG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MAEVQTPKQIVEKLDQYVIGQDDAKRAVAVALYNRYRRMQLSPKMQEEITPKNLLMIGPTGVGKTEIARRLAKIVEAPFV
KVEATKFTEVGYVGRDVESMVRDLAETAVAMEEEKQFSKVRIRAEKEANKRLVKILVPAIRKEKNTNPMAEMMSMLQGMQ
NGKMPAGDDADAGGEVTDDIRNKRLSVAEQLEKGLLEDHEITVAVNDEKKGGGMGDMYGQMGIDLSDTIGALMPKKKVER
TMTVKEAREIFIKEESDKLVNHADIYHDAIPSAENNGIIFIDEIDKIAAGNKHNSGEVSREGVQRDILPIVEGSQINTKY
GPINTDHILFIGSGAFAEAKPSDLIAELQGRFPIRVELKDLTEKDFVRILTEPDNALIKQYIALIGADGVKITFTKEAVD
RIAEIATQVNHDTDNIGARRLATILEKLLEDVLYEGPDMAMGSVTVTQQYVDDKIGHIAADSNMTRYIL

Sequences:

>Translated_469_residues
MAEVQTPKQIVEKLDQYVIGQDDAKRAVAVALYNRYRRMQLSPKMQEEITPKNLLMIGPTGVGKTEIARRLAKIVEAPFV
KVEATKFTEVGYVGRDVESMVRDLAETAVAMEEEKQFSKVRIRAEKEANKRLVKILVPAIRKEKNTNPMAEMMSMLQGMQ
NGKMPAGDDADAGGEVTDDIRNKRLSVAEQLEKGLLEDHEITVAVNDEKKGGGMGDMYGQMGIDLSDTIGALMPKKKVER
TMTVKEAREIFIKEESDKLVNHADIYHDAIPSAENNGIIFIDEIDKIAAGNKHNSGEVSREGVQRDILPIVEGSQINTKY
GPINTDHILFIGSGAFAEAKPSDLIAELQGRFPIRVELKDLTEKDFVRILTEPDNALIKQYIALIGADGVKITFTKEAVD
RIAEIATQVNHDTDNIGARRLATILEKLLEDVLYEGPDMAMGSVTVTQQYVDDKIGHIAADSNMTRYIL
>Mature_468_residues
AEVQTPKQIVEKLDQYVIGQDDAKRAVAVALYNRYRRMQLSPKMQEEITPKNLLMIGPTGVGKTEIARRLAKIVEAPFVK
VEATKFTEVGYVGRDVESMVRDLAETAVAMEEEKQFSKVRIRAEKEANKRLVKILVPAIRKEKNTNPMAEMMSMLQGMQN
GKMPAGDDADAGGEVTDDIRNKRLSVAEQLEKGLLEDHEITVAVNDEKKGGGMGDMYGQMGIDLSDTIGALMPKKKVERT
MTVKEAREIFIKEESDKLVNHADIYHDAIPSAENNGIIFIDEIDKIAAGNKHNSGEVSREGVQRDILPIVEGSQINTKYG
PINTDHILFIGSGAFAEAKPSDLIAELQGRFPIRVELKDLTEKDFVRILTEPDNALIKQYIALIGADGVKITFTKEAVDR
IAEIATQVNHDTDNIGARRLATILEKLLEDVLYEGPDMAMGSVTVTQQYVDDKIGHIAADSNMTRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=39.6396396396396, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790366, Length=475, Percent_Identity=46.7368421052632, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1786642, Length=104, Percent_Identity=45.1923076923077, Blast_Score=98, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71982908, Length=240, Percent_Identity=30.8333333333333, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71982905, Length=238, Percent_Identity=31.0924369747899, Blast_Score=98, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6319704, Length=117, Percent_Identity=35.042735042735, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648291, Length=241, Percent_Identity=31.9502074688797, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24648289, Length=241, Percent_Identity=31.9502074688797, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 52025; Mature: 51894

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVQTPKQIVEKLDQYVIGQDDAKRAVAVALYNRYRRMQLSPKMQEEITPKNLLMIGPT
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEECCC
GVGKTEIARRLAKIVEAPFVKVEATKFTEVGYVGRDVESMVRDLAETAVAMEEEKQFSKV
CCCHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RIRAEKEANKRLVKILVPAIRKEKNTNPMAEMMSMLQGMQNGKMPAGDDADAGGEVTDDI
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
RNKRLSVAEQLEKGLLEDHEITVAVNDEKKGGGMGDMYGQMGIDLSDTIGALMPKKKVER
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHCCCCHHHHHHHHCCHHHHHH
TMTVKEAREIFIKEESDKLVNHADIYHDAIPSAENNGIIFIDEIDKIAAGNKHNSGEVSR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHCCCCCCCCCHHH
EGVQRDILPIVEGSQINTKYGPINTDHILFIGSGAFAEAKPSDLIAELQGRFPIRVELKD
HHHHHHCHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEEHHH
LTEKDFVRILTEPDNALIKQYIALIGADGVKITFTKEAVDRIAEIATQVNHDTDNIGARR
CCCCHHHEEECCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCHHHHH
LATILEKLLEDVLYEGPDMAMGSVTVTQQYVDDKIGHIAADSNMTRYIL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCEECCCCCCCCCC
>Mature Secondary Structure 
AEVQTPKQIVEKLDQYVIGQDDAKRAVAVALYNRYRRMQLSPKMQEEITPKNLLMIGPT
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEECCC
GVGKTEIARRLAKIVEAPFVKVEATKFTEVGYVGRDVESMVRDLAETAVAMEEEKQFSKV
CCCHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RIRAEKEANKRLVKILVPAIRKEKNTNPMAEMMSMLQGMQNGKMPAGDDADAGGEVTDDI
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
RNKRLSVAEQLEKGLLEDHEITVAVNDEKKGGGMGDMYGQMGIDLSDTIGALMPKKKVER
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHCCCCHHHHHHHHCCHHHHHH
TMTVKEAREIFIKEESDKLVNHADIYHDAIPSAENNGIIFIDEIDKIAAGNKHNSGEVSR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHCCCCCCCCCHHH
EGVQRDILPIVEGSQINTKYGPINTDHILFIGSGAFAEAKPSDLIAELQGRFPIRVELKD
HHHHHHCHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEEHHH
LTEKDFVRILTEPDNALIKQYIALIGADGVKITFTKEAVDRIAEIATQVNHDTDNIGARR
CCCCHHHEEECCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCHHHHH
LATILEKLLEDVLYEGPDMAMGSVTVTQQYVDDKIGHIAADSNMTRYIL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA