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The map label for this gene is rnz

Identifier: 116494840

GI number: 116494840

Start: 1340914

End: 1341876

Strand: Direct

Name: rnz

Synonym: LSEI_1353

Alternate gene names: 116494840

Gene position: 1340914-1341876 (Clockwise)

Preceding gene: 116494839

Following gene: 116494841

Centisome position: 46.31

GC content: 46.83

Gene sequence:

>963_bases
ATGGAAATTCAATTTTTGGGCACAGGCGCAGGGTCGCCTTCCAAGTCTCGGAATGTTAGCAGTTTAGCCTTAAAATTACT
TGATGAGCGTAATGAGGTTTGGTTGTTTGATGCCGGGGAAGGCACACAACATCAGATTTTACAAACCGCTATTCGACCAC
GAAAAATTGCCAAAGTATTTATTACTCACTTGCATGGGGACCATATTTTTGGCTTGCCAGGGTTTTTGGCCAGTCGCTCC
AACCAAGGCGGCACAGATCCGTTGACGATTTACGGGCCTTCTGGCATTGAGGATTTTGTAAAAACCAGTTTGAAGGTTTC
TCAAAGTCATCTCAGTTACCCGTTAAAATTTGTTTTATTACAGCATCCAGGCGTGGCTTTTGAAGATCAAACTTTCAAAG
TCACTTTTGATCGCTTGGATCATCGAATTACGAGCTTTGGTTTTCGGATCGAAGAAAAACCGCATCCTGGCGAGTTGTTG
ATTGATAAGGTACGTGCCGCTAAAATTCCTTCTGGACCGGTTTATGCGGCTTTGAAGGCCGGCGAAACTGTAACCTTGCC
AGATGGCCGGATTTTTGACGGCCACGATTTCATTGGCCCTGCGCAACCTGGCAGAACGGTTGCCATTTTCGGGGATACCC
GCATGTGCAATCGCGCGCTGCCTTTAGCAGCAGGCGCTGATGTGTTGGTTCACGAAAGTACCTTTGGACCGGATGAAAGC
CAATTAGCTAAGCAGTATTATCATGCGACCAATGTACAAGCAGCGGCGTTGGCTAAACGTGCAGGTGTCGGGCGGCTCTT
GCTGAACCATATTTCGGCACGATATCTGAGTCCCGGGGTAGCGATGTTGGAAAAAACGGCGCGGCAGATTTTTCCAAATA
CGCATGTTGTCAAAGACTTCGAGGAAATTAACATTCCATTTCGGAGTGAACAATCGGAACCTGCTGTCACAGTTAAATCA
TAA

Upstream 100 bases:

>100_bases
AAACCTTGCAAATCTCGGCTTACCAACATTGAAACCGCGAAAATGGCGAGGAACTTGTGGTAGACTACAAAGTGAAGTTC
GACAGAATAGGAAGTATGGT

Downstream 100 bases:

>100_bases
AGCTCAGCGGTAGCAAGTGAATATCAAAACAGAGGAGGAAATCATGATGAACCAACATCCGACGGTGGTTATTTCTGGAG
GATCGTCAGGCTTAGGCAAG

Product: beta-lactamase superfamily hydrolase

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MEIQFLGTGAGSPSKSRNVSSLALKLLDERNEVWLFDAGEGTQHQILQTAIRPRKIAKVFITHLHGDHIFGLPGFLASRS
NQGGTDPLTIYGPSGIEDFVKTSLKVSQSHLSYPLKFVLLQHPGVAFEDQTFKVTFDRLDHRITSFGFRIEEKPHPGELL
IDKVRAAKIPSGPVYAALKAGETVTLPDGRIFDGHDFIGPAQPGRTVAIFGDTRMCNRALPLAAGADVLVHESTFGPDES
QLAKQYYHATNVQAAALAKRAGVGRLLLNHISARYLSPGVAMLEKTARQIFPNTHVVKDFEEINIPFRSEQSEPAVTVKS

Sequences:

>Translated_320_residues
MEIQFLGTGAGSPSKSRNVSSLALKLLDERNEVWLFDAGEGTQHQILQTAIRPRKIAKVFITHLHGDHIFGLPGFLASRS
NQGGTDPLTIYGPSGIEDFVKTSLKVSQSHLSYPLKFVLLQHPGVAFEDQTFKVTFDRLDHRITSFGFRIEEKPHPGELL
IDKVRAAKIPSGPVYAALKAGETVTLPDGRIFDGHDFIGPAQPGRTVAIFGDTRMCNRALPLAAGADVLVHESTFGPDES
QLAKQYYHATNVQAAALAKRAGVGRLLLNHISARYLSPGVAMLEKTARQIFPNTHVVKDFEEINIPFRSEQSEPAVTVKS
>Mature_320_residues
MEIQFLGTGAGSPSKSRNVSSLALKLLDERNEVWLFDAGEGTQHQILQTAIRPRKIAKVFITHLHGDHIFGLPGFLASRS
NQGGTDPLTIYGPSGIEDFVKTSLKVSQSHLSYPLKFVLLQHPGVAFEDQTFKVTFDRLDHRITSFGFRIEEKPHPGELL
IDKVRAAKIPSGPVYAALKAGETVTLPDGRIFDGHDFIGPAQPGRTVAIFGDTRMCNRALPLAAGADVLVHESTFGPDES
QLAKQYYHATNVQAAALAKRAGVGRLLLNHISARYLSPGVAMLEKTARQIFPNTHVVKDFEEINIPFRSEQSEPAVTVKS

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=363, Percent_Identity=33.8842975206612, Blast_Score=198, Evalue=5e-51,
Organism=Escherichia coli, GI87082078, Length=306, Percent_Identity=47.7124183006536, Blast_Score=290, Evalue=6e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_LACC3 (Q039J0)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806574.1
- ProteinModelPortal:   Q039J0
- SMR:   Q039J0
- STRING:   Q039J0
- GeneID:   4419441
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_1353
- eggNOG:   COG1234
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- PhylomeDB:   Q039J0
- ProtClustDB:   CLSK2317996
- BioCyc:   LCAS321967:LSEI_1353-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 35026; Mature: 35026

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIQFLGTGAGSPSKSRNVSSLALKLLDERNEVWLFDAGEGTQHQILQTAIRPRKIAKVF
CEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCHHHHHHHH
ITHLHGDHIFGLPGFLASRSNQGGTDPLTIYGPSGIEDFVKTSLKVSQSHLSYPLKFVLL
HHHHCCCEEECCCHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEE
QHPGVAFEDQTFKVTFDRLDHRITSFGFRIEEKPHPGELLIDKVRAAKIPSGPVYAALKA
ECCCCEECCCEEEEEHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEC
GETVTLPDGRIFDGHDFIGPAQPGRTVAIFGDTRMCNRALPLAAGADVLVHESTFGPDES
CCEEECCCCEEECCCCCCCCCCCCCEEEEECCCHHHHCCCCCCCCCEEEEECCCCCCCHH
QLAKQYYHATNVQAAALAKRAGVGRLLLNHISARYLSPGVAMLEKTARQIFPNTHVVKDF
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHH
EEINIPFRSEQSEPAVTVKS
HHCCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MEIQFLGTGAGSPSKSRNVSSLALKLLDERNEVWLFDAGEGTQHQILQTAIRPRKIAKVF
CEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCHHHHHHHH
ITHLHGDHIFGLPGFLASRSNQGGTDPLTIYGPSGIEDFVKTSLKVSQSHLSYPLKFVLL
HHHHCCCEEECCCHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEE
QHPGVAFEDQTFKVTFDRLDHRITSFGFRIEEKPHPGELLIDKVRAAKIPSGPVYAALKA
ECCCCEECCCEEEEEHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEC
GETVTLPDGRIFDGHDFIGPAQPGRTVAIFGDTRMCNRALPLAAGADVLVHESTFGPDES
CCEEECCCCEEECCCCCCCCCCCCCEEEEECCCHHHHCCCCCCCCCEEEEECCCCCCCHH
QLAKQYYHATNVQAAALAKRAGVGRLLLNHISARYLSPGVAMLEKTARQIFPNTHVVKDF
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHH
EEINIPFRSEQSEPAVTVKS
HHCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA