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The map label for this gene is uvrC

Identifier: 116494833

GI number: 116494833

Start: 1329652

End: 1331460

Strand: Direct

Name: uvrC

Synonym: LSEI_1346

Alternate gene names: 116494833

Gene position: 1329652-1331460 (Clockwise)

Preceding gene: 116494832

Following gene: 116494837

Centisome position: 45.93

GC content: 45.33

Gene sequence:

>1809_bases
ATGGCCTCAGCACACATTGAACACAAGTTATCGTTGCTGCCAGATCTGCCTGGCAGTTATCAAATGAAGGATATCAACGG
CAAAATTATTTATGTCGGCAAGGCCAAAAACCTGAAAAATCGGGTGCGGTCTTATTTCAAGAGTTCACACGACGGTAAAG
TTGCGGCGATGGTGTCACAGGTAGCGGATTTTGATTTCATTGTGACTTCAACTGACAAAGAAGCCTTTTTGCTCGAAATT
ACGCTGATTCAAAAATATCAGCCGTATTACAACATTAAGTTGAAAAAAGGGACTGGCTATCCGTACATTAAAATTACTCA
TGAACGCGATCCGAAGATTGAAATCACTGGTACTATCCGTAAAGATGGCGGTTATTACTTTGGGCCATACCCAAATGTCT
ATGCAGCGCAAGAAACCATGCATTTTATCCAGAAGGTTTATCCATTGCGGCGCTGTAACGGCTATCAAGGCAGACCGTGC
TTGTATTATCACATGGGTCAGTGTCTGGGTGCCTGCTTCCGGACTGTTCCGGAAAAGGAATACACGGACCAAATTGAACG
TATTAAGCGCTTCTTGAATGGGAACGTTGGCAAGGCTAAAGCCAGTTTGACGGCTAAAATGGAGCGGGCTGCGAAAAATC
TTCAATTTGAGCGAGCCGCAGAAATTCGAGATCAACTGCATTATATTGAACAGACGTTGGAGAAGCAAAAAATTATTTCA
CACGACAATACAACGCGTGATTTGTTCAATTTTTATATGGATAAGGGCTGGATCAGTATCCAGGTCTTCTTTATTCGTCA
AGCACGTTTAATGAAACGTGAGTCACGACTTTTTCCAGTGGTGAATACTGCCAAAGAAGAATTCGAATCATTTATTTTAC
AGTTTTACAGCCGCAGGAATAATGTGAAACCACGCGAAGTTCTCGTACCTGCTGGGCTTGATAATAAAGTACTGGCAGAT
ATCTTAGAGATTCCAGTTAGAACGCCACAGCGCGGTGAAAAACGGGACTTGATGGCCTTGGCTGCTAAGAACAGTCAAAT
TAAGCTTGAAGACAAATTCCGTCTGATGGAATTGGATAATCGTACCACGATTGGCGCGATGAAAGAGCTGATGGCCGCTT
TGAACTTGCCAATGGGGCATGTGGCTGAGGCATTCGACCACAGTCACATTCAAGGAGCTGATCCGGTGTCGGCGATGGTG
CAGTTTGTGGATGGCCAGCCAGCTAAGAACAATTATCGAAAGTACAAGTTGGATGCTGACAAAACGCATAATGGCGCAGA
TGAGGCGGCTAATACGCGCGAAGTCATTCGCCGGCGCTATACCCGGTTGTTAAAGGAGCGTGCACCGTTACCAGATTTGA
TCTTGATGGATGGCGGCGAGATTGAAATGAACGCAGCCAAGGATGTTTTGGAAAACGAACTCAACCTTGATATTCCTGTG
GCAGGGATGGTCAAAAATAATAAGCATAAAACGGCAGCATTGTTATTTGGCAATGCTGATCAGCTGATTAATCTTGATCC
TAAGTCGCAAGGCTTTTACCTGCTTGAACGGATTCAGGATGAGGTGCATCGTTTTGCGATTACCTTCCATCGGCAGCTGC
ACGCCAAGAACTCGTTGGCCTCTCGATTAGAAGGTATCAAGGGGGTCGGACCCAAGACGCGGCTGAAGCTGTTACGGAAA
TTCAAGACGATCAATAAGATTAAAGAAGCTCCCCTTGAAGATATTCAGGAGCTAGGTATTTCTAAAAAAGTTGCGCAGGC
ATTGAAGCTGTCGCTGACGGCAGAGCCGACACCAGCGCGGCGGGTTTAA

Upstream 100 bases:

>100_bases
TGGGGGCAGTCATGCCATCACTGATCAAAGCCGCTTGCTTGCAATCTATTTTTAGAATCTTTATAATGTTAGCGAACATT
TGTTTTATAAGGAGATTACG

Downstream 100 bases:

>100_bases
TCAAATCGTAGGAGCGTTTAGGACATCGTTCATAACCATCAGTAAGAACAAACAATCTTGAGATTTAAAGATCTAGTGCC
AAGGCGAAGCAATCGTAGGC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MASAHIEHKLSLLPDLPGSYQMKDINGKIIYVGKAKNLKNRVRSYFKSSHDGKVAAMVSQVADFDFIVTSTDKEAFLLEI
TLIQKYQPYYNIKLKKGTGYPYIKITHERDPKIEITGTIRKDGGYYFGPYPNVYAAQETMHFIQKVYPLRRCNGYQGRPC
LYYHMGQCLGACFRTVPEKEYTDQIERIKRFLNGNVGKAKASLTAKMERAAKNLQFERAAEIRDQLHYIEQTLEKQKIIS
HDNTTRDLFNFYMDKGWISIQVFFIRQARLMKRESRLFPVVNTAKEEFESFILQFYSRRNNVKPREVLVPAGLDNKVLAD
ILEIPVRTPQRGEKRDLMALAAKNSQIKLEDKFRLMELDNRTTIGAMKELMAALNLPMGHVAEAFDHSHIQGADPVSAMV
QFVDGQPAKNNYRKYKLDADKTHNGADEAANTREVIRRRYTRLLKERAPLPDLILMDGGEIEMNAAKDVLENELNLDIPV
AGMVKNNKHKTAALLFGNADQLINLDPKSQGFYLLERIQDEVHRFAITFHRQLHAKNSLASRLEGIKGVGPKTRLKLLRK
FKTINKIKEAPLEDIQELGISKKVAQALKLSLTAEPTPARRV

Sequences:

>Translated_602_residues
MASAHIEHKLSLLPDLPGSYQMKDINGKIIYVGKAKNLKNRVRSYFKSSHDGKVAAMVSQVADFDFIVTSTDKEAFLLEI
TLIQKYQPYYNIKLKKGTGYPYIKITHERDPKIEITGTIRKDGGYYFGPYPNVYAAQETMHFIQKVYPLRRCNGYQGRPC
LYYHMGQCLGACFRTVPEKEYTDQIERIKRFLNGNVGKAKASLTAKMERAAKNLQFERAAEIRDQLHYIEQTLEKQKIIS
HDNTTRDLFNFYMDKGWISIQVFFIRQARLMKRESRLFPVVNTAKEEFESFILQFYSRRNNVKPREVLVPAGLDNKVLAD
ILEIPVRTPQRGEKRDLMALAAKNSQIKLEDKFRLMELDNRTTIGAMKELMAALNLPMGHVAEAFDHSHIQGADPVSAMV
QFVDGQPAKNNYRKYKLDADKTHNGADEAANTREVIRRRYTRLLKERAPLPDLILMDGGEIEMNAAKDVLENELNLDIPV
AGMVKNNKHKTAALLFGNADQLINLDPKSQGFYLLERIQDEVHRFAITFHRQLHAKNSLASRLEGIKGVGPKTRLKLLRK
FKTINKIKEAPLEDIQELGISKKVAQALKLSLTAEPTPARRV
>Mature_601_residues
ASAHIEHKLSLLPDLPGSYQMKDINGKIIYVGKAKNLKNRVRSYFKSSHDGKVAAMVSQVADFDFIVTSTDKEAFLLEIT
LIQKYQPYYNIKLKKGTGYPYIKITHERDPKIEITGTIRKDGGYYFGPYPNVYAAQETMHFIQKVYPLRRCNGYQGRPCL
YYHMGQCLGACFRTVPEKEYTDQIERIKRFLNGNVGKAKASLTAKMERAAKNLQFERAAEIRDQLHYIEQTLEKQKIISH
DNTTRDLFNFYMDKGWISIQVFFIRQARLMKRESRLFPVVNTAKEEFESFILQFYSRRNNVKPREVLVPAGLDNKVLADI
LEIPVRTPQRGEKRDLMALAAKNSQIKLEDKFRLMELDNRTTIGAMKELMAALNLPMGHVAEAFDHSHIQGADPVSAMVQ
FVDGQPAKNNYRKYKLDADKTHNGADEAANTREVIRRRYTRLLKERAPLPDLILMDGGEIEMNAAKDVLENELNLDIPVA
GMVKNNKHKTAALLFGNADQLINLDPKSQGFYLLERIQDEVHRFAITFHRQLHAKNSLASRLEGIKGVGPKTRLKLLRKF
KTINKIKEAPLEDIQELGISKKVAQALKLSLTAEPTPARRV

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=602, Percent_Identity=35.0498338870432, Blast_Score=332, Evalue=3e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_LACC3 (Q039J7)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806567.1
- ProteinModelPortal:   Q039J7
- STRING:   Q039J7
- GeneID:   4419434
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_1346
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q039J7
- ProtClustDB:   PRK00558
- BioCyc:   LCAS321967:LSEI_1346-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68903; Mature: 68772

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASAHIEHKLSLLPDLPGSYQMKDINGKIIYVGKAKNLKNRVRSYFKSSHDGKVAAMVSQ
CCCCCHHHHHHHCCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHH
VADFDFIVTSTDKEAFLLEITLIQKYQPYYNIKLKKGTGYPYIKITHERDPKIEITGTIR
HCCCEEEEECCCCCEEEEEEEEHHHCCCEEEEEEECCCCCCEEEEECCCCCCEEEEEEEE
KDGGYYFGPYPNVYAAQETMHFIQKVYPLRRCNGYQGRPCLYYHMGQCLGACFRTVPEKE
ECCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHH
YTDQIERIKRFLNGNVGKAKASLTAKMERAAKNLQFERAAEIRDQLHYIEQTLEKQKIIS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
HDNTTRDLFNFYMDKGWISIQVFFIRQARLMKRESRLFPVVNTAKEEFESFILQFYSRRN
CCCCHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
NVKPREVLVPAGLDNKVLADILEIPVRTPQRGEKRDLMALAAKNSQIKLEDKFRLMELDN
CCCCHHEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHEECCCEEEECCCEEEEECCC
RTTIGAMKELMAALNLPMGHVAEAFDHSHIQGADPVSAMVQFVDGQPAKNNYRKYKLDAD
CCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCC
KTHNGADEAANTREVIRRRYTRLLKERAPLPDLILMDGGEIEMNAAKDVLENELNLDIPV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHCCCCCCCCE
AGMVKNNKHKTAALLFGNADQLINLDPKSQGFYLLERIQDEVHRFAITFHRQLHAKNSLA
ECCEECCCCCEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRLEGIKGVGPKTRLKLLRKFKTINKIKEAPLEDIQELGISKKVAQALKLSLTAEPTPAR
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHEEECCCCCCC
RV
CC
>Mature Secondary Structure 
ASAHIEHKLSLLPDLPGSYQMKDINGKIIYVGKAKNLKNRVRSYFKSSHDGKVAAMVSQ
CCCCHHHHHHHCCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHH
VADFDFIVTSTDKEAFLLEITLIQKYQPYYNIKLKKGTGYPYIKITHERDPKIEITGTIR
HCCCEEEEECCCCCEEEEEEEEHHHCCCEEEEEEECCCCCCEEEEECCCCCCEEEEEEEE
KDGGYYFGPYPNVYAAQETMHFIQKVYPLRRCNGYQGRPCLYYHMGQCLGACFRTVPEKE
ECCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHH
YTDQIERIKRFLNGNVGKAKASLTAKMERAAKNLQFERAAEIRDQLHYIEQTLEKQKIIS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
HDNTTRDLFNFYMDKGWISIQVFFIRQARLMKRESRLFPVVNTAKEEFESFILQFYSRRN
CCCCHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
NVKPREVLVPAGLDNKVLADILEIPVRTPQRGEKRDLMALAAKNSQIKLEDKFRLMELDN
CCCCHHEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHEECCCEEEECCCEEEEECCC
RTTIGAMKELMAALNLPMGHVAEAFDHSHIQGADPVSAMVQFVDGQPAKNNYRKYKLDAD
CCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCC
KTHNGADEAANTREVIRRRYTRLLKERAPLPDLILMDGGEIEMNAAKDVLENELNLDIPV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHCCCCCCCCE
AGMVKNNKHKTAALLFGNADQLINLDPKSQGFYLLERIQDEVHRFAITFHRQLHAKNSLA
ECCEECCCCCEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRLEGIKGVGPKTRLKLLRKFKTINKIKEAPLEDIQELGISKKVAQALKLSLTAEPTPAR
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHEEECCCCCCC
RV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA