Click here to switch to the map view.

The map label for this gene is obgE

Identifier: 116494837

GI number: 116494837

Start: 1335724

End: 1337010

Strand: Direct

Name: obgE

Synonym: LSEI_1350

Alternate gene names: 116494837

Gene position: 1335724-1337010 (Clockwise)

Preceding gene: 116494833

Following gene: 116494838

Centisome position: 46.13

GC content: 50.51

Gene sequence:

>1287_bases
ATGTTTGTCGATCAGGTTCAAGTAGAGGTTCAGGCGGGCAAAGGCGGCGACGGTATGGTCGCGTTCCGGCGCGAGAAATT
TGTACCGTTTGGCGGCCCGGCCGGCGGTGACGGCGGTCATGGCGGCAGCATCATCTTATACGTTGATGAAGGTTTGCGCA
CGTTAATGGATTTCCGTTATCAACGGCATTTTAAAGCGTCAGCTGGTGGCAATGGCCAAGGCAAGCAAATGTATGGCCGC
GCTGCTGAAGATCGGCGGATTGCAGTGCCGGCTGGTACGACAGTTACCGATGCTGACACAGGCGAGGTTTTAGGCGATTT
AACTGAGCCGGGTCAAACTTTGGTTGTTGCTAAAGGTGGCCGCGGTGGTCGCGGTAATATGCACTTTGTTTCGCCCAAAA
ATACGGCGCCGGAAATTTCCGAAAATGGCGAACCGGGCGAGCATCGTTTCATCAAATTGGAACTGAAGGTGCTTGCGGAT
GTTGGGTTGGTTGGTTTTCCTTCTGTCGGTAAATCGACACTGTTATCAGTTGTAACCCAAGCCAAGCCAAAAATTGCGGC
TTATCAATTTACGACGTTAGTACCCAATCTTGGTATGGTTCAATTAGATGATGGTACCGATTTTGTGATGGCTGATTTGC
CCGGTTTGATTGAAGGGGCTTCACAAGGTGTCGGTCTTGGCATCCAGTTCTTGCGGCATGTTGAACGCACTCGTGTGCTA
CTGCACCTAGTTGAGATGGATCCTGATAATGGACGCGAGCCGCTTGATGATTACGATCAAATTCGTAAAGAATTAGGGGC
TTATGACGATAACATTTTGAAGCGGCCTGAACTCGTGGTCGCGACCAAGATGGACTTGCCCGGCGCGGCTGAACGATTTG
CTGATTTTAAGGCAGCGTTACTTGCTCGTGGCGTCGCGGCGGATCATATCTTTGAAATTTCTAGTCTGACGCATCGTGGC
GTGACGCCACTCATGCACAAGACAGCCGAAGTACTCAAAACAGCACCGCATTTTGAGCCGAAACAAGCGGCGGTTAAAAC
GGCTGATTATAAGTATCAACCAGAGCCGGCTTTGAAAGTAACCCGCGATAGTGACGGGACGTTTGTGCTCACTGGTGACA
AGATTGAGCGGGCGTTTAAAATGGCCAATCTTGATCATGAAGATGGCGCGATGCGCTTTGCTCGGCAATTACGCAGCATG
GGGGTTGATGATGCTTTGCGTGATGCTGGTGCTGAAAGCGGCGATTTAGTCGCCATTGATGATTTTACATTTGAGTTCGT
TGAATGA

Upstream 100 bases:

>100_bases
CTTGGGACGTGTTAAAATAGTTGAGGTATGCGTTACGCTGTACTGAAATATAAACATCGCGTATAATCAAATGACATGTT
TTTCTGAAAGGAGATCGCCA

Downstream 100 bases:

>100_bases
TCTTCGGCTGAACGGCTGGGGAAGTTATTTTTAGACAGAATGGTGGGGCCGCAATTGAAACAGACGCGTGGACGAAAGCG
CCGGTACATTCATGGATTTG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MFVDQVQVEVQAGKGGDGMVAFRREKFVPFGGPAGGDGGHGGSIILYVDEGLRTLMDFRYQRHFKASAGGNGQGKQMYGR
AAEDRRIAVPAGTTVTDADTGEVLGDLTEPGQTLVVAKGGRGGRGNMHFVSPKNTAPEISENGEPGEHRFIKLELKVLAD
VGLVGFPSVGKSTLLSVVTQAKPKIAAYQFTTLVPNLGMVQLDDGTDFVMADLPGLIEGASQGVGLGIQFLRHVERTRVL
LHLVEMDPDNGREPLDDYDQIRKELGAYDDNILKRPELVVATKMDLPGAAERFADFKAALLARGVAADHIFEISSLTHRG
VTPLMHKTAEVLKTAPHFEPKQAAVKTADYKYQPEPALKVTRDSDGTFVLTGDKIERAFKMANLDHEDGAMRFARQLRSM
GVDDALRDAGAESGDLVAIDDFTFEFVE

Sequences:

>Translated_428_residues
MFVDQVQVEVQAGKGGDGMVAFRREKFVPFGGPAGGDGGHGGSIILYVDEGLRTLMDFRYQRHFKASAGGNGQGKQMYGR
AAEDRRIAVPAGTTVTDADTGEVLGDLTEPGQTLVVAKGGRGGRGNMHFVSPKNTAPEISENGEPGEHRFIKLELKVLAD
VGLVGFPSVGKSTLLSVVTQAKPKIAAYQFTTLVPNLGMVQLDDGTDFVMADLPGLIEGASQGVGLGIQFLRHVERTRVL
LHLVEMDPDNGREPLDDYDQIRKELGAYDDNILKRPELVVATKMDLPGAAERFADFKAALLARGVAADHIFEISSLTHRG
VTPLMHKTAEVLKTAPHFEPKQAAVKTADYKYQPEPALKVTRDSDGTFVLTGDKIERAFKMANLDHEDGAMRFARQLRSM
GVDDALRDAGAESGDLVAIDDFTFEFVE
>Mature_428_residues
MFVDQVQVEVQAGKGGDGMVAFRREKFVPFGGPAGGDGGHGGSIILYVDEGLRTLMDFRYQRHFKASAGGNGQGKQMYGR
AAEDRRIAVPAGTTVTDADTGEVLGDLTEPGQTLVVAKGGRGGRGNMHFVSPKNTAPEISENGEPGEHRFIKLELKVLAD
VGLVGFPSVGKSTLLSVVTQAKPKIAAYQFTTLVPNLGMVQLDDGTDFVMADLPGLIEGASQGVGLGIQFLRHVERTRVL
LHLVEMDPDNGREPLDDYDQIRKELGAYDDNILKRPELVVATKMDLPGAAERFADFKAALLARGVAADHIFEISSLTHRG
VTPLMHKTAEVLKTAPHFEPKQAAVKTADYKYQPEPALKVTRDSDGTFVLTGDKIERAFKMANLDHEDGAMRFARQLRSM
GVDDALRDAGAESGDLVAIDDFTFEFVE

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=298, Percent_Identity=41.2751677852349, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI111955139, Length=294, Percent_Identity=37.0748299319728, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI111955063, Length=180, Percent_Identity=39.4444444444444, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4557537, Length=121, Percent_Identity=34.7107438016529, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4758796, Length=86, Percent_Identity=47.6744186046512, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789574, Length=343, Percent_Identity=45.7725947521866, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI1787454, Length=138, Percent_Identity=34.7826086956522, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17508313, Length=329, Percent_Identity=37.6899696048632, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17552324, Length=303, Percent_Identity=29.042904290429, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71981008, Length=118, Percent_Identity=38.135593220339, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=32.3741007194245, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555344, Length=86, Percent_Identity=46.5116279069767, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=174, Percent_Identity=39.6551724137931, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319281, Length=108, Percent_Identity=46.2962962962963, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321612, Length=73, Percent_Identity=49.3150684931507, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI20129375, Length=300, Percent_Identity=41.6666666666667, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24585318, Length=304, Percent_Identity=38.4868421052632, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21356473, Length=100, Percent_Identity=46, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17981711, Length=127, Percent_Identity=38.5826771653543, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24640873, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640877, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640875, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_LACC3 (Q039J3)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806571.1
- ProteinModelPortal:   Q039J3
- SMR:   Q039J3
- STRING:   Q039J3
- GeneID:   4419438
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_1350
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   HFTTLVP
- PhylomeDB:   Q039J3
- ProtClustDB:   PRK12297
- BioCyc:   LCAS321967:LSEI_1350-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 46268; Mature: 46268

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDQVQVEVQAGKGGDGMVAFRREKFVPFGGPAGGDGGHGGSIILYVDEGLRTLMDFRY
CCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHH
QRHFKASAGGNGQGKQMYGRAAEDRRIAVPAGTTVTDADTGEVLGDLTEPGQTLVVAKGG
HHHEECCCCCCCCCHHHHCCCCCCCEEEECCCCEECCCCCHHHHHCCCCCCCEEEEECCC
RGGRGNMHFVSPKNTAPEISENGEPGEHRFIKLELKVLADVGLVGFPSVGKSTLLSVVTQ
CCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEHHCCCCCCCCCCHHHHHHHHHH
AKPKIAAYQFTTLVPNLGMVQLDDGTDFVMADLPGLIEGASQGVGLGIQFLRHVERTRVL
CCCCEEEEEHHHHCCCCCEEEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHH
LHLVEMDPDNGREPLDDYDQIRKELGAYDDNILKRPELVVATKMDLPGAAERFADFKAAL
HHHEECCCCCCCCCCHHHHHHHHHHCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
LARGVAADHIFEISSLTHRGVTPLMHKTAEVLKTAPHFEPKQAAVKTADYKYQPEPALKV
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCEEE
TRDSDGTFVLTGDKIERAFKMANLDHEDGAMRFARQLRSMGVDDALRDAGAESGDLVAID
EECCCCEEEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEE
DFTFEFVE
CCEEEECC
>Mature Secondary Structure
MFVDQVQVEVQAGKGGDGMVAFRREKFVPFGGPAGGDGGHGGSIILYVDEGLRTLMDFRY
CCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHH
QRHFKASAGGNGQGKQMYGRAAEDRRIAVPAGTTVTDADTGEVLGDLTEPGQTLVVAKGG
HHHEECCCCCCCCCHHHHCCCCCCCEEEECCCCEECCCCCHHHHHCCCCCCCEEEEECCC
RGGRGNMHFVSPKNTAPEISENGEPGEHRFIKLELKVLADVGLVGFPSVGKSTLLSVVTQ
CCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEHHCCCCCCCCCCHHHHHHHHHH
AKPKIAAYQFTTLVPNLGMVQLDDGTDFVMADLPGLIEGASQGVGLGIQFLRHVERTRVL
CCCCEEEEEHHHHCCCCCEEEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHH
LHLVEMDPDNGREPLDDYDQIRKELGAYDDNILKRPELVVATKMDLPGAAERFADFKAAL
HHHEECCCCCCCCCCHHHHHHHHHHCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
LARGVAADHIFEISSLTHRGVTPLMHKTAEVLKTAPHFEPKQAAVKTADYKYQPEPALKV
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCEEE
TRDSDGTFVLTGDKIERAFKMANLDHEDGAMRFARQLRSMGVDDALRDAGAESGDLVAID
EECCCCEEEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEE
DFTFEFVE
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA