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The map label for this gene is typA [H]

Identifier: 116494802

GI number: 116494802

Start: 1296454

End: 1298298

Strand: Direct

Name: typA [H]

Synonym: LSEI_1313

Alternate gene names: 116494802

Gene position: 1296454-1298298 (Clockwise)

Preceding gene: 116494801

Following gene: 116494803

Centisome position: 44.78

GC content: 47.64

Gene sequence:

>1845_bases
GTGAAAACACGTGACGATATTCGCAACATTGCGATCATTGCCCACGTTGACCATGGTAAGACCACATTGGTTAACGAAAT
GCTTAAACAATCAGATACACTTGATCAACACATTCAATTACAGGATCGGGCAATGGATACCAACGCCATTGAAAAAGAAC
GTGGGATCACCATCCTGAGTAAAAACACGGCAGTTAAGTTCGGCGATACGACCATCAACATCCTCGATACCCCGGGGCAT
GCTGACTTTGGTGGTGAAGTGGAACGAGTTATGAAGATGGTTGACGGCGTTTTGCTTGTCGTTGACGCTTTTGAAGGCCC
AATGCCGCAAACGCGGTTTGTCTTGAAAAAGGCGCTTGAACAGCATTTGACACCGATCGTTGTCATCAACAAGGTCGATC
GTCCAGGTGCGCGCCCTGAAGAAGTCGTTGATGAAGTTCTCGAATTGTTCATTGAATTGGGCGCTGATGATGCACAACTG
GAATTCCCGGTTGTCTATGCTTCCGCTGTCAATGGCACTTCCAGCATGGATTCCGATTTGTCAACGCAAAAGCACACCAT
GACCCCGTTGTTTGAGACCATCGTCAAAACCATTCCGGCACCCATCGACAACAGTGACGAACCTTTGCAGTTCCAAGTTG
CGATGCTTGATTACAACGATTACGTTGGTCGAATTGGGATTGGTCGGATTTTCCGCGGCAAGATTAAAATCGGCGACAAT
GTTACCGTTATGAAGCTGGATGGTTCTCAAAAGAACTTCCGCGTGACAAAACTCTTTGGTTTCTTTGGCTTGACCCGAAC
CGAAATCAACTCTGCTAAAGCCGGCGATTTGATCGCGGTTTCTGGGATGGATGACATCTTCGTTGGTGAAACGGTGACGG
CAGCTGATACGCCGGAAGCTTTGCCGATTTTGCGGATTGATGAACCAACTTTGCAGATGATGTTTGTTGCGAATGACAGT
CCATTTGCAGGTCGTGAAGGTAAAAATGTGACTGCTCGTAAACTTGAGGAGCGTCTGAAGTCGCAATTGCAGACAGATGT
GTCGCTGCGCGTTGACGACACTGATCAGGCAGGTGCCTGGATGGTTTCCGGTCGTGGCGAATTGCATCTTTCAATTTTGG
TTGAAGAGATGCGGCGCGAAGGTTTTGAATTGCAATTAGGTCGTCCTGAAGTTATCTATCGTGACATTGATGGTGTCATG
ATGGAACCGTTCGAAAGCGTCCAAATTGACACTCCTGAACAATATACTGGGACAGTCATTGATGCGATGAGCCAACGTAA
AGGCGAAATGCAGAACATGGAGAACGAAGGCAACGGTCAAACCCGTTTGACATTCTTGGCGCCTTCTCGTGGTCTGATCG
GGTACTCAACCGAATTTCTCTCTGCTACTGGCGGTTACGGCATCATGAACCATACCTTCGAAAAATACGCTCCGGTTATC
AAGAATTGGGAACCAGGCCGTACACAAGGTGCTTTGGTTTCCATCAACGCTGGTTCAGCAACGACGTACAGTCTGCAATC
CGTTGAAGACCGTGGCCAGTTGTTTATCAATGCCGGCACCGAGGTTTATGAAGGCATGATTGTTGGTCAAAACTCGCGTG
AAAATGACATTGCAGTCAATGTCACCAAAGGTAAGAACTTGACCAACACCCGTGCAGCCGGGAAAGACCACGCAGCAGCC
ATCAAGACGCCAAAAGATATGACGCTTGAAGAATCCATTGAATTCTTGAATGATGACGAATACTGCGAAGTTACCCCTAA
GAACATTCGCTTGCGTAAGAAGATCCTTAACACAGGCGAACGTCAAAAAGCGGCTAAGCGCAAGAAAATTGCCGCATCCA
AGTAA

Upstream 100 bases:

>100_bases
ATTGTGTGTTATAATTTCAAATCGTATAACTGTGTCAGTTGCTGGCACTTTTTTAATGCGGTAGGCGGCCAGTAGTGCCA
GCAGAAAGGAAGTATAAATC

Downstream 100 bases:

>100_bases
ATAAGTTGGTCAAAAAGTCGTCTGTAAAAGGCGGCTTTTTTGATGTCTTGATCACAATAATTGTGATTGTTAGACAAGGC
TTAACTTGTCGACTGAGCGG

Product: stress response membrane GTPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MKTRDDIRNIAIIAHVDHGKTTLVNEMLKQSDTLDQHIQLQDRAMDTNAIEKERGITILSKNTAVKFGDTTINILDTPGH
ADFGGEVERVMKMVDGVLLVVDAFEGPMPQTRFVLKKALEQHLTPIVVINKVDRPGARPEEVVDEVLELFIELGADDAQL
EFPVVYASAVNGTSSMDSDLSTQKHTMTPLFETIVKTIPAPIDNSDEPLQFQVAMLDYNDYVGRIGIGRIFRGKIKIGDN
VTVMKLDGSQKNFRVTKLFGFFGLTRTEINSAKAGDLIAVSGMDDIFVGETVTAADTPEALPILRIDEPTLQMMFVANDS
PFAGREGKNVTARKLEERLKSQLQTDVSLRVDDTDQAGAWMVSGRGELHLSILVEEMRREGFELQLGRPEVIYRDIDGVM
MEPFESVQIDTPEQYTGTVIDAMSQRKGEMQNMENEGNGQTRLTFLAPSRGLIGYSTEFLSATGGYGIMNHTFEKYAPVI
KNWEPGRTQGALVSINAGSATTYSLQSVEDRGQLFINAGTEVYEGMIVGQNSRENDIAVNVTKGKNLTNTRAAGKDHAAA
IKTPKDMTLEESIEFLNDDEYCEVTPKNIRLRKKILNTGERQKAAKRKKIAASK

Sequences:

>Translated_614_residues
MKTRDDIRNIAIIAHVDHGKTTLVNEMLKQSDTLDQHIQLQDRAMDTNAIEKERGITILSKNTAVKFGDTTINILDTPGH
ADFGGEVERVMKMVDGVLLVVDAFEGPMPQTRFVLKKALEQHLTPIVVINKVDRPGARPEEVVDEVLELFIELGADDAQL
EFPVVYASAVNGTSSMDSDLSTQKHTMTPLFETIVKTIPAPIDNSDEPLQFQVAMLDYNDYVGRIGIGRIFRGKIKIGDN
VTVMKLDGSQKNFRVTKLFGFFGLTRTEINSAKAGDLIAVSGMDDIFVGETVTAADTPEALPILRIDEPTLQMMFVANDS
PFAGREGKNVTARKLEERLKSQLQTDVSLRVDDTDQAGAWMVSGRGELHLSILVEEMRREGFELQLGRPEVIYRDIDGVM
MEPFESVQIDTPEQYTGTVIDAMSQRKGEMQNMENEGNGQTRLTFLAPSRGLIGYSTEFLSATGGYGIMNHTFEKYAPVI
KNWEPGRTQGALVSINAGSATTYSLQSVEDRGQLFINAGTEVYEGMIVGQNSRENDIAVNVTKGKNLTNTRAAGKDHAAA
IKTPKDMTLEESIEFLNDDEYCEVTPKNIRLRKKILNTGERQKAAKRKKIAASK
>Mature_614_residues
MKTRDDIRNIAIIAHVDHGKTTLVNEMLKQSDTLDQHIQLQDRAMDTNAIEKERGITILSKNTAVKFGDTTINILDTPGH
ADFGGEVERVMKMVDGVLLVVDAFEGPMPQTRFVLKKALEQHLTPIVVINKVDRPGARPEEVVDEVLELFIELGADDAQL
EFPVVYASAVNGTSSMDSDLSTQKHTMTPLFETIVKTIPAPIDNSDEPLQFQVAMLDYNDYVGRIGIGRIFRGKIKIGDN
VTVMKLDGSQKNFRVTKLFGFFGLTRTEINSAKAGDLIAVSGMDDIFVGETVTAADTPEALPILRIDEPTLQMMFVANDS
PFAGREGKNVTARKLEERLKSQLQTDVSLRVDDTDQAGAWMVSGRGELHLSILVEEMRREGFELQLGRPEVIYRDIDGVM
MEPFESVQIDTPEQYTGTVIDAMSQRKGEMQNMENEGNGQTRLTFLAPSRGLIGYSTEFLSATGGYGIMNHTFEKYAPVI
KNWEPGRTQGALVSINAGSATTYSLQSVEDRGQLFINAGTEVYEGMIVGQNSRENDIAVNVTKGKNLTNTRAAGKDHAAA
IKTPKDMTLEESIEFLNDDEYCEVTPKNIRLRKKILNTGERQKAAKRKKIAASK

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=507, Percent_Identity=26.0355029585799, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI94966754, Length=137, Percent_Identity=40.1459854014599, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=37.4149659863946, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI4503483, Length=152, Percent_Identity=34.8684210526316, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI310132016, Length=115, Percent_Identity=38.2608695652174, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI310110807, Length=115, Percent_Identity=38.2608695652174, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI310123363, Length=115, Percent_Identity=38.2608695652174, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI25306283, Length=168, Percent_Identity=36.3095238095238, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI19923640, Length=168, Percent_Identity=36.3095238095238, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI25306287, Length=168, Percent_Identity=36.3095238095238, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI217272892, Length=140, Percent_Identity=37.1428571428571, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI217272894, Length=140, Percent_Identity=37.1428571428571, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI34147630, Length=275, Percent_Identity=30.1818181818182, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI94966752, Length=105, Percent_Identity=40, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI53729339, Length=167, Percent_Identity=33.5329341317365, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI53729337, Length=167, Percent_Identity=33.5329341317365, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=53.5655058043118, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=577, Percent_Identity=27.9029462738302, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789738, Length=166, Percent_Identity=37.9518072289157, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790835, Length=178, Percent_Identity=30.3370786516854, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789737, Length=255, Percent_Identity=29.8039215686275, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790412, Length=255, Percent_Identity=29.8039215686275, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17557151, Length=551, Percent_Identity=24.1379310344828, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17533571, Length=172, Percent_Identity=37.7906976744186, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17556745, Length=160, Percent_Identity=36.875, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71988811, Length=133, Percent_Identity=35.3383458646617, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71988819, Length=133, Percent_Identity=35.3383458646617, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17506493, Length=164, Percent_Identity=32.9268292682927, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17552882, Length=136, Percent_Identity=35.2941176470588, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=279, Percent_Identity=29.0322580645161, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323320, Length=514, Percent_Identity=26.4591439688716, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324707, Length=147, Percent_Identity=40.1360544217687, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=147, Percent_Identity=40.1360544217687, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324761, Length=274, Percent_Identity=30.2919708029197, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323098, Length=177, Percent_Identity=32.7683615819209, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=36.6197183098592, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=38.255033557047, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI78706572, Length=515, Percent_Identity=24.8543689320388, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574573, Length=142, Percent_Identity=39.4366197183099, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24582462, Length=171, Percent_Identity=35.672514619883, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585711, Length=154, Percent_Identity=34.4155844155844, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585713, Length=154, Percent_Identity=34.4155844155844, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585709, Length=154, Percent_Identity=34.4155844155844, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357743, Length=197, Percent_Identity=35.0253807106599, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281363316, Length=235, Percent_Identity=33.1914893617021, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17864358, Length=235, Percent_Identity=33.1914893617021, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221458488, Length=161, Percent_Identity=38.5093167701863, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921738, Length=233, Percent_Identity=30.9012875536481, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28572034, Length=196, Percent_Identity=32.6530612244898, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19922690, Length=291, Percent_Identity=27.1477663230241, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67944; Mature: 67944

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRDDIRNIAIIAHVDHGKTTLVNEMLKQSDTLDQHIQLQDRAMDTNAIEKERGITILS
CCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHCCEEEEE
KNTAVKFGDTTINILDTPGHADFGGEVERVMKMVDGVLLVVDAFEGPMPQTRFVLKKALE
CCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
QHLTPIVVINKVDRPGARPEEVVDEVLELFIELGADDAQLEFPVVYASAVNGTSSMDSDL
HHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCC
STQKHTMTPLFETIVKTIPAPIDNSDEPLQFQVAMLDYNDYVGRIGIGRIFRGKIKIGDN
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCEEECEEEEEEEEECCC
VTVMKLDGSQKNFRVTKLFGFFGLTRTEINSAKAGDLIAVSGMDDIFVGETVTAADTPEA
EEEEEECCCCCCEEEEEEHHHHCCCHHHCCCCCCCCEEEECCCCCEEECCEEECCCCCCC
LPILRIDEPTLQMMFVANDSPFAGREGKNVTARKLEERLKSQLQTDVSLRVDDTDQAGAW
CEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCEE
MVSGRGELHLSILVEEMRREGFELQLGRPEVIYRDIDGVMMEPFESVQIDTPEQYTGTVI
EEECCCCEEHHHHHHHHHHCCCEEECCCCEEEEECCCCHHCCCCHHCCCCCCCHHHHHHH
DAMSQRKGEMQNMENEGNGQTRLTFLAPSRGLIGYSTEFLSATGGYGIMNHTFEKYAPVI
HHHHHHCCHHHCCCCCCCCCEEEEEECCCCCCEEECHHHHHCCCCCCHHHHHHHHHHHHH
KNWEPGRTQGALVSINAGSATTYSLQSVEDRGQLFINAGTEVYEGMIVGQNSRENDIAVN
CCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEECCCHHHCCEEECCCCCCCCEEEE
VTKGKNLTNTRAAGKDHAAAIKTPKDMTLEESIEFLNDDEYCEVTPKNIRLRKKILNTGE
EECCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCH
RQKAAKRKKIAASK
HHHHHHHHHHCCCC
>Mature Secondary Structure
MKTRDDIRNIAIIAHVDHGKTTLVNEMLKQSDTLDQHIQLQDRAMDTNAIEKERGITILS
CCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHCCEEEEE
KNTAVKFGDTTINILDTPGHADFGGEVERVMKMVDGVLLVVDAFEGPMPQTRFVLKKALE
CCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
QHLTPIVVINKVDRPGARPEEVVDEVLELFIELGADDAQLEFPVVYASAVNGTSSMDSDL
HHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCC
STQKHTMTPLFETIVKTIPAPIDNSDEPLQFQVAMLDYNDYVGRIGIGRIFRGKIKIGDN
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCEEECEEEEEEEEECCC
VTVMKLDGSQKNFRVTKLFGFFGLTRTEINSAKAGDLIAVSGMDDIFVGETVTAADTPEA
EEEEEECCCCCCEEEEEEHHHHCCCHHHCCCCCCCCEEEECCCCCEEECCEEECCCCCCC
LPILRIDEPTLQMMFVANDSPFAGREGKNVTARKLEERLKSQLQTDVSLRVDDTDQAGAW
CEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCEE
MVSGRGELHLSILVEEMRREGFELQLGRPEVIYRDIDGVMMEPFESVQIDTPEQYTGTVI
EEECCCCEEHHHHHHHHHHCCCEEECCCCEEEEECCCCHHCCCCHHCCCCCCCHHHHHHH
DAMSQRKGEMQNMENEGNGQTRLTFLAPSRGLIGYSTEFLSATGGYGIMNHTFEKYAPVI
HHHHHHCCHHHCCCCCCCCCEEEEEECCCCCCEEECHHHHHCCCCCCHHHHHHHHHHHHH
KNWEPGRTQGALVSINAGSATTYSLQSVEDRGQLFINAGTEVYEGMIVGQNSRENDIAVN
CCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEECCCHHHCCEEECCCCCCCCEEEE
VTKGKNLTNTRAAGKDHAAAIKTPKDMTLEESIEFLNDDEYCEVTPKNIRLRKKILNTGE
EECCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCH
RQKAAKRKKIAASK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]