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The map label for this gene is pdhA [H]

Identifier: 116494794

GI number: 116494794

Start: 1287219

End: 1288331

Strand: Direct

Name: pdhA [H]

Synonym: LSEI_1305

Alternate gene names: 116494794

Gene position: 1287219-1288331 (Clockwise)

Preceding gene: 116494792

Following gene: 116494795

Centisome position: 44.46

GC content: 48.61

Gene sequence:

>1113_bases
ATGGCAAAACAGCATGCTGCAGTTGATTTCAAGAAACTGTTGGAAAATCAAGATGCCGATTTTAAGCCGACCATCCAAAT
TCTGGATGAAGCGGGCAAGGTCGTCAATCCTGATATCATGCCCGATCTGAGTGATGATCAGTTGGTCGACTTGATGTCCA
AAATGGTTTGGCAGCGGGTTCTTGATCAACGAGCAACCGCGTTGAATCGGCAAGGACGATTAGGTTTTTATGCGCCAAGC
GCTGGTGAAGAGGCCAGCATGATTGGCAGCCATTCGGCCATGAAAACAACGGACTGGTTGTTACCTGCTTACCGTGACTT
GCCACAGTTGATTCAACATGGCTTGCCACTGGATAAAGCATTCTTATGGTCTCGTGGTCATGTTGCCGGTAATGAATACC
CAGAAGATTTTCACGCGTTACCGCCTCAGATTATTATTGGTGCGCAGTACGTCCAGACAGCCGGCGTTGCACTCGGCTTA
AAGAAGAATGGCAGCGATGAAGTAGCCTTCACGTATACCGGTGATGGTGGCACGTCACAAGGTGATTTCTACGAAGGTGT
CAACTTTGCTGGCCATTTCAAAGCCCCAGCAATCTTTATTGTGCAAGATAACGGCTTTGCGATTTCTGTACCGCGGGCCA
GTCAGACGGCTGCGAAGACTTTAGCGCAAAAAGCAGTTGCTGCTGGTATTCCAGGTGTGCAAGTTGACGGTATGGATGCC
CTAGCTGTCTATGAAGTGACAAAAGAAGCGCGGGCATGGACCGCCGCTGGTAATGGCCCTGTCTTGATTGAGACGCTGAC
CTATCGTTATGGGCCACATACGTTATCTGGCGATGATCCGACGCGTTATCGTTCCAAGGAGACAGATGAGTTATGGCAAA
AGCGCGATCCGTTAATTCGAATGCGGAACTACCTGACTGATAAGGGACTTTGGAACAAAGACAAGGAAGACGCCTTAATT
GATCAAGTTAAGGATGAAATTAAGGACGCAATTAACAAAGCTGATAAGGCACCACAGCAGACGGTATCCCGCTTCCTAAA
GGACACGTACGAGACCGCACCGCAAAATGTTGCTGAACAGCTGGCAGAATTTCAAGGAAAGGAGTCGAAGTAA

Upstream 100 bases:

>100_bases
TGCAAGGATAAAACCGCAATGTTACGCTTGGTTTGTAAAGATTTTCATTAGTACAGTTTTCCTGCGTTAATGACAACAGG
AATGGAAAGAGGTTCTGATT

Downstream 100 bases:

>100_bases
CCATGGCACAAAAAACAATGATCCAAGCCATCACGGATGCGCTTGATGTTGAGTTGGCGAACGACCCTAAGACCTTGGTA
TTCGGCGAAGATGTCGGGAA

Product: acetoin dehydrogenase complex, E1 component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MAKQHAAVDFKKLLENQDADFKPTIQILDEAGKVVNPDIMPDLSDDQLVDLMSKMVWQRVLDQRATALNRQGRLGFYAPS
AGEEASMIGSHSAMKTTDWLLPAYRDLPQLIQHGLPLDKAFLWSRGHVAGNEYPEDFHALPPQIIIGAQYVQTAGVALGL
KKNGSDEVAFTYTGDGGTSQGDFYEGVNFAGHFKAPAIFIVQDNGFAISVPRASQTAAKTLAQKAVAAGIPGVQVDGMDA
LAVYEVTKEARAWTAAGNGPVLIETLTYRYGPHTLSGDDPTRYRSKETDELWQKRDPLIRMRNYLTDKGLWNKDKEDALI
DQVKDEIKDAINKADKAPQQTVSRFLKDTYETAPQNVAEQLAEFQGKESK

Sequences:

>Translated_370_residues
MAKQHAAVDFKKLLENQDADFKPTIQILDEAGKVVNPDIMPDLSDDQLVDLMSKMVWQRVLDQRATALNRQGRLGFYAPS
AGEEASMIGSHSAMKTTDWLLPAYRDLPQLIQHGLPLDKAFLWSRGHVAGNEYPEDFHALPPQIIIGAQYVQTAGVALGL
KKNGSDEVAFTYTGDGGTSQGDFYEGVNFAGHFKAPAIFIVQDNGFAISVPRASQTAAKTLAQKAVAAGIPGVQVDGMDA
LAVYEVTKEARAWTAAGNGPVLIETLTYRYGPHTLSGDDPTRYRSKETDELWQKRDPLIRMRNYLTDKGLWNKDKEDALI
DQVKDEIKDAINKADKAPQQTVSRFLKDTYETAPQNVAEQLAEFQGKESK
>Mature_369_residues
AKQHAAVDFKKLLENQDADFKPTIQILDEAGKVVNPDIMPDLSDDQLVDLMSKMVWQRVLDQRATALNRQGRLGFYAPSA
GEEASMIGSHSAMKTTDWLLPAYRDLPQLIQHGLPLDKAFLWSRGHVAGNEYPEDFHALPPQIIIGAQYVQTAGVALGLK
KNGSDEVAFTYTGDGGTSQGDFYEGVNFAGHFKAPAIFIVQDNGFAISVPRASQTAAKTLAQKAVAAGIPGVQVDGMDAL
AVYEVTKEARAWTAAGNGPVLIETLTYRYGPHTLSGDDPTRYRSKETDELWQKRDPLIRMRNYLTDKGLWNKDKEDALID
QVKDEIKDAINKADKAPQQTVSRFLKDTYETAPQNVAEQLAEFQGKESK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=348, Percent_Identity=31.8965517241379, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI258645172, Length=348, Percent_Identity=31.8965517241379, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI4505685, Length=331, Percent_Identity=31.4199395770393, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI291084742, Length=331, Percent_Identity=31.4199395770393, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4885543, Length=338, Percent_Identity=29.2899408284024, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI291084744, Length=284, Percent_Identity=33.0985915492958, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI291084757, Length=324, Percent_Identity=29.320987654321, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI86563357, Length=374, Percent_Identity=31.283422459893, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI86563355, Length=374, Percent_Identity=31.283422459893, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17536047, Length=329, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI32564172, Length=329, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6321026, Length=325, Percent_Identity=29.8461538461538, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21355903, Length=365, Percent_Identity=28.2191780821918, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24639740, Length=323, Percent_Identity=29.7213622291022, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24639744, Length=323, Percent_Identity=29.7213622291022, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI28571106, Length=323, Percent_Identity=29.7213622291022, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24639746, Length=284, Percent_Identity=30.6338028169014, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24639748, Length=327, Percent_Identity=26.9113149847095, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40813; Mature: 40682

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQHAAVDFKKLLENQDADFKPTIQILDEAGKVVNPDIMPDLSDDQLVDLMSKMVWQRV
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LDQRATALNRQGRLGFYAPSAGEEASMIGSHSAMKTTDWLLPAYRDLPQLIQHGLPLDKA
HHHHHHHHCCCCCEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
FLWSRGHVAGNEYPEDFHALPPQIIIGAQYVQTAGVALGLKKNGSDEVAFTYTGDGGTSQ
HHHCCCCCCCCCCCHHHHCCCCCEEECHHHHHHHCEEEEECCCCCCCEEEEEECCCCCCC
GDFYEGVNFAGHFKAPAIFIVQDNGFAISVPRASQTAAKTLAQKAVAAGIPGVQVDGMDA
CCHHHCCCCCCCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCCH
LAVYEVTKEARAWTAAGNGPVLIETLTYRYGPHTLSGDDPTRYRSKETDELWQKRDPLIR
HHHHHHHHHHHHEECCCCCCEEEEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHCCHHHH
MRNYLTDKGLWNKDKEDALIDQVKDEIKDAINKADKAPQQTVSRFLKDTYETAPQNVAEQ
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LAEFQGKESK
HHHHCCCCCC
>Mature Secondary Structure 
AKQHAAVDFKKLLENQDADFKPTIQILDEAGKVVNPDIMPDLSDDQLVDLMSKMVWQRV
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LDQRATALNRQGRLGFYAPSAGEEASMIGSHSAMKTTDWLLPAYRDLPQLIQHGLPLDKA
HHHHHHHHCCCCCEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
FLWSRGHVAGNEYPEDFHALPPQIIIGAQYVQTAGVALGLKKNGSDEVAFTYTGDGGTSQ
HHHCCCCCCCCCCCHHHHCCCCCEEECHHHHHHHCEEEEECCCCCCCEEEEEECCCCCCC
GDFYEGVNFAGHFKAPAIFIVQDNGFAISVPRASQTAAKTLAQKAVAAGIPGVQVDGMDA
CCHHHCCCCCCCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCCH
LAVYEVTKEARAWTAAGNGPVLIETLTYRYGPHTLSGDDPTRYRSKETDELWQKRDPLIR
HHHHHHHHHHHHEECCCCCCEEEEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHCCHHHH
MRNYLTDKGLWNKDKEDALIDQVKDEIKDAINKADKAPQQTVSRFLKDTYETAPQNVAEQ
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LAEFQGKESK
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA