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The map label for this gene is pdhB [H]

Identifier: 116494795

GI number: 116494795

Start: 1288334

End: 1289311

Strand: Direct

Name: pdhB [H]

Synonym: LSEI_1306

Alternate gene names: 116494795

Gene position: 1288334-1289311 (Clockwise)

Preceding gene: 116494794

Following gene: 116494796

Centisome position: 44.5

GC content: 49.8

Gene sequence:

>978_bases
ATGGCACAAAAAACAATGATCCAAGCCATCACGGATGCGCTTGATGTTGAGTTGGCGAACGACCCTAAGACCTTGGTATT
CGGCGAAGATGTCGGGAAAAACGGTGGTGTTTTCCGTGCAACTGATGGTTTGCAAGCAAAATACGGTGAGGATCGGGTTT
TCGATACCCCACTGGCGGAATCTGGCATCGGCGGTTTGTCGATTGGGTTGGCATTGACCGGTTGGCGGCCAATTCCTGAA
ATTCAGTTTTTCGGATTCGTTTTTGAAACGATGGACAGCATTGGTGGTCAGATGTCACGGATGCGTTACCGGATGGGCGG
CACTCGCTCAATGCCAATCACGATTCGGGCGCCTTTTGGCGGTGGTGTTCACACCCCGGAAATGCACAGTGACAACTTTG
AAGGGTTAATTGCGCAATTTCCTGGTATGCGTGTCGTTATTCCAAGCAATCCATATGATGCCAAAGGTTTGCTGATTAGT
TCGATCCGGAGCAATGATCCGGTATTGTTCCTTGAGCATATGAAACTATATCGTTCCTTCCGGCAAGATGTTCCAGAGGG
CACGTACACGGTACCGTTGGACAAAGCGGCGGTGACCCGCGAAGGTTCAGATGTATCGATCATCACGTATGGTGCGATGG
TTCGCGAAGCACTGAAAGCTGCTGATAATTTAGCCAAAGATGGGATTCAGGCTGAAATTGTTGACTTGCGGACAATTGCG
CCACTTGATGTCGAAACGATCATCCATTCGGTCAAAAAGACGCATAAGGTTGTTGTGGTGCAAGAAGCACAACGCATGGC
CGGTGTTGCATCAACGGTGATCAGTGAGATTTCCGAACGGGCGATTCTGTCGCTTGAGGCACCGATTGGTCGGGTTGCCG
CTCCGGATACCCCGTTCCCATTTGGCCAAGCTGAAAACATTTGGCTGCCAAATGCTAAGGATATTGAAGCTAAAGTCCGG
GAAACCGTTAATTTCTAG

Upstream 100 bases:

>100_bases
AGCAGACGGTATCCCGCTTCCTAAAGGACACGTACGAGACCGCACCGCAAAATGTTGCTGAACAGCTGGCAGAATTTCAA
GGAAAGGAGTCGAAGTAACC

Downstream 100 bases:

>100_bases
AAAGAAGAGGTGCCAACATGGCTTTTGAATTCAAACTGCCAGAACTTGGCGAAGGTTTGGCAGAAGGCGAAATCGTTAAG
TGGGACGTCAAACCTGGTGA

Product: acetoin dehydrogenase complex, E1 component, beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAQKTMIQAITDALDVELANDPKTLVFGEDVGKNGGVFRATDGLQAKYGEDRVFDTPLAESGIGGLSIGLALTGWRPIPE
IQFFGFVFETMDSIGGQMSRMRYRMGGTRSMPITIRAPFGGGVHTPEMHSDNFEGLIAQFPGMRVVIPSNPYDAKGLLIS
SIRSNDPVLFLEHMKLYRSFRQDVPEGTYTVPLDKAAVTREGSDVSIITYGAMVREALKAADNLAKDGIQAEIVDLRTIA
PLDVETIIHSVKKTHKVVVVQEAQRMAGVASTVISEISERAILSLEAPIGRVAAPDTPFPFGQAENIWLPNAKDIEAKVR
ETVNF

Sequences:

>Translated_325_residues
MAQKTMIQAITDALDVELANDPKTLVFGEDVGKNGGVFRATDGLQAKYGEDRVFDTPLAESGIGGLSIGLALTGWRPIPE
IQFFGFVFETMDSIGGQMSRMRYRMGGTRSMPITIRAPFGGGVHTPEMHSDNFEGLIAQFPGMRVVIPSNPYDAKGLLIS
SIRSNDPVLFLEHMKLYRSFRQDVPEGTYTVPLDKAAVTREGSDVSIITYGAMVREALKAADNLAKDGIQAEIVDLRTIA
PLDVETIIHSVKKTHKVVVVQEAQRMAGVASTVISEISERAILSLEAPIGRVAAPDTPFPFGQAENIWLPNAKDIEAKVR
ETVNF
>Mature_324_residues
AQKTMIQAITDALDVELANDPKTLVFGEDVGKNGGVFRATDGLQAKYGEDRVFDTPLAESGIGGLSIGLALTGWRPIPEI
QFFGFVFETMDSIGGQMSRMRYRMGGTRSMPITIRAPFGGGVHTPEMHSDNFEGLIAQFPGMRVVIPSNPYDAKGLLISS
IRSNDPVLFLEHMKLYRSFRQDVPEGTYTVPLDKAAVTREGSDVSIITYGAMVREALKAADNLAKDGIQAEIVDLRTIAP
LDVETIIHSVKKTHKVVVVQEAQRMAGVASTVISEISERAILSLEAPIGRVAAPDTPFPFGQAENIWLPNAKDIEAKVRE
TVNF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=326, Percent_Identity=42.638036809816, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI34101272, Length=326, Percent_Identity=42.638036809816, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=34.5565749235474, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI291084858, Length=327, Percent_Identity=32.7217125382263, Blast_Score=195, Evalue=6e-50,
Organism=Escherichia coli, GI1786622, Length=277, Percent_Identity=23.826714801444, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17506935, Length=324, Percent_Identity=38.8888888888889, Blast_Score=221, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17538422, Length=325, Percent_Identity=35.6923076923077, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=35.8895705521472, Blast_Score=209, Evalue=5e-55,
Organism=Drosophila melanogaster, GI160714828, Length=324, Percent_Identity=41.358024691358, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI160714832, Length=324, Percent_Identity=41.358024691358, Blast_Score=239, Evalue=1e-63,
Organism=Drosophila melanogaster, GI21358145, Length=324, Percent_Identity=36.7283950617284, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24650940, Length=324, Percent_Identity=36.7283950617284, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=38.8888888888889, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=38.8888888888889, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35379; Mature: 35248

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQKTMIQAITDALDVELANDPKTLVFGEDVGKNGGVFRATDGLQAKYGEDRVFDTPLAE
CCHHHHHHHHHHHHCEEECCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCHH
SGIGGLSIGLALTGWRPIPEIQFFGFVFETMDSIGGQMSRMRYRMGGTRSMPITIRAPFG
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEECCCC
GGVHTPEMHSDNFEGLIAQFPGMRVVIPSNPYDAKGLLISSIRSNDPVLFLEHMKLYRSF
CCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCCEEEHHHHHHHHHH
RQDVPEGTYTVPLDKAAVTREGSDVSIITYGAMVREALKAADNLAKDGIQAEIVDLRTIA
HHHCCCCCEEEECCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
PLDVETIIHSVKKTHKVVVVQEAQRMAGVASTVISEISERAILSLEAPIGRVAAPDTPFP
CCCHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCC
FGQAENIWLPNAKDIEAKVRETVNF
CCCCCCEECCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
AQKTMIQAITDALDVELANDPKTLVFGEDVGKNGGVFRATDGLQAKYGEDRVFDTPLAE
CHHHHHHHHHHHHCEEECCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCHH
SGIGGLSIGLALTGWRPIPEIQFFGFVFETMDSIGGQMSRMRYRMGGTRSMPITIRAPFG
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEECCCC
GGVHTPEMHSDNFEGLIAQFPGMRVVIPSNPYDAKGLLISSIRSNDPVLFLEHMKLYRSF
CCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCCEEEHHHHHHHHHH
RQDVPEGTYTVPLDKAAVTREGSDVSIITYGAMVREALKAADNLAKDGIQAEIVDLRTIA
HHHCCCCCEEEECCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
PLDVETIIHSVKKTHKVVVVQEAQRMAGVASTVISEISERAILSLEAPIGRVAAPDTPFP
CCCHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCC
FGQAENIWLPNAKDIEAKVRETVNF
CCCCCCEECCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]