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The map label for this gene is iscS1 [H]

Identifier: 116494780

GI number: 116494780

Start: 1267629

End: 1268792

Strand: Direct

Name: iscS1 [H]

Synonym: LSEI_1289

Alternate gene names: 116494780

Gene position: 1267629-1268792 (Clockwise)

Preceding gene: 116494779

Following gene: 116494781

Centisome position: 43.78

GC content: 48.2

Gene sequence:

>1164_bases
ATGCAACATGTTTATCTTGATAACGCGGCGACCACACCCATGGCCCCAGAAGTGATTCAGACCATGATGGACCAAATGGA
GCACGATTTTGGTAATGCCAGTTCGACTCATTGGTTTGGCCGAACAGCTCATACTGTCATGGACAAGAGTCGCAAAATTT
TGGCCGATGCAATCCATGCACAGCCCGGGAATATGGTGATCACCAGCGGCGCAACAGAAAGTAACAATACGGCGATCACT
CAAACGGCGCATACGCGTGCTAGTTTGGGGAAGCACATCATTACAACGGCTATTGAACATCCTTCCGTTTTGCAGCCGCT
AAAAGCCTTGGAAAAGGAAGGCTTTCGGGTGACCTATCTGCCAGTCGACGAAAATGGCCGAATCAGTTTAGCTGATTTTG
ACGCGGCTTTGGACGATGACACTATCTTAGTGACCATCATGATGGGCAATAATGAGGTTGGCAGTCGGATGCCAATCAGT
GAAATTGGTGCGCGACTAGTCGATCATCAAGCTTGGTTTCATACAGATGCAACCCAGGCTTTTGGCTTACTAGACATCGA
TGTTCAAGCGCAACACATTGATATGTTAAGTGTTTCGGCGCACAAAATTAACGGACCCAAAGGCATCGGTTTTCTTTACC
GCGATCCTAAGGTTCAGTTCCCGTCTTTGTTGAAAGGTGGCGAGCAGGAGTTGAAACGTCGTGCTGGTACAGAAAACATT
GCTGGCATTGCCGGGTTTGCAACGGCGGTTAGTCTGATCACTTCTGATGAGAAGGCTAAGCGGCAGTCAAAGTATCTTGG
TTTTAAGCAGCAGATTATGGGTGCATTGGATGATGCGGAGATTCCCTATGCAGTTAATGGTGATATTCGGCCAGATAATG
TCAATCACGTTTTCAATATCTGGTTGAAGGGGATCTCAACATACGCTTTGCAGACCAACCTTGATTTGGCTGGCATTGCA
GTTTCTGGTGGTTCTGCCTGCACAGCTGGTTCACTTGAGCCTTCACACGTTTTAACTGCCATGTTTGGCGCTGATAGCCC
GCGGCTTGGCGAGTCGATTCGTTTGTCATTTGGCGCGCAAACAACCAAAGCAGACATTCAGGCCTTTATTGATGCCCTGT
TACCAATCGTGCAACGGCTTCAGGCAAAACAATCGGCGCGATAA

Upstream 100 bases:

>100_bases
CAAATTTGTGATCAAGGCGGGTGAACAAAGTGCCGCGATGCTTCTTAGCTTTTTTGCTCACCTACAGGCATCACCTCAGT
CTTAGGAGTTGATTGTTAAT

Downstream 100 bases:

>100_bases
GTTTGGTTTGCGAGTGACCCGTTACCATGCGTCTCAACAGTTAAAAAGCTCAAGATTGTCCTTCACCACCTAATAATCCT
TATCAACCTCCCCAGTGTTG

Product: cysteine sulfinate desulfinase/cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MQHVYLDNAATTPMAPEVIQTMMDQMEHDFGNASSTHWFGRTAHTVMDKSRKILADAIHAQPGNMVITSGATESNNTAIT
QTAHTRASLGKHIITTAIEHPSVLQPLKALEKEGFRVTYLPVDENGRISLADFDAALDDDTILVTIMMGNNEVGSRMPIS
EIGARLVDHQAWFHTDATQAFGLLDIDVQAQHIDMLSVSAHKINGPKGIGFLYRDPKVQFPSLLKGGEQELKRRAGTENI
AGIAGFATAVSLITSDEKAKRQSKYLGFKQQIMGALDDAEIPYAVNGDIRPDNVNHVFNIWLKGISTYALQTNLDLAGIA
VSGGSACTAGSLEPSHVLTAMFGADSPRLGESIRLSFGAQTTKADIQAFIDALLPIVQRLQAKQSAR

Sequences:

>Translated_387_residues
MQHVYLDNAATTPMAPEVIQTMMDQMEHDFGNASSTHWFGRTAHTVMDKSRKILADAIHAQPGNMVITSGATESNNTAIT
QTAHTRASLGKHIITTAIEHPSVLQPLKALEKEGFRVTYLPVDENGRISLADFDAALDDDTILVTIMMGNNEVGSRMPIS
EIGARLVDHQAWFHTDATQAFGLLDIDVQAQHIDMLSVSAHKINGPKGIGFLYRDPKVQFPSLLKGGEQELKRRAGTENI
AGIAGFATAVSLITSDEKAKRQSKYLGFKQQIMGALDDAEIPYAVNGDIRPDNVNHVFNIWLKGISTYALQTNLDLAGIA
VSGGSACTAGSLEPSHVLTAMFGADSPRLGESIRLSFGAQTTKADIQAFIDALLPIVQRLQAKQSAR
>Mature_387_residues
MQHVYLDNAATTPMAPEVIQTMMDQMEHDFGNASSTHWFGRTAHTVMDKSRKILADAIHAQPGNMVITSGATESNNTAIT
QTAHTRASLGKHIITTAIEHPSVLQPLKALEKEGFRVTYLPVDENGRISLADFDAALDDDTILVTIMMGNNEVGSRMPIS
EIGARLVDHQAWFHTDATQAFGLLDIDVQAQHIDMLSVSAHKINGPKGIGFLYRDPKVQFPSLLKGGEQELKRRAGTENI
AGIAGFATAVSLITSDEKAKRQSKYLGFKQQIMGALDDAEIPYAVNGDIRPDNVNHVFNIWLKGISTYALQTNLDLAGIA
VSGGSACTAGSLEPSHVLTAMFGADSPRLGESIRLSFGAQTTKADIQAFIDALLPIVQRLQAKQSAR

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=390, Percent_Identity=39.2307692307692, Blast_Score=252, Evalue=3e-67,
Organism=Homo sapiens, GI156713448, Length=421, Percent_Identity=33.2541567695962, Blast_Score=163, Evalue=2e-40,
Organism=Escherichia coli, GI48994898, Length=386, Percent_Identity=41.4507772020725, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1787970, Length=346, Percent_Identity=24.5664739884393, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1789175, Length=399, Percent_Identity=23.5588972431078, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25143064, Length=388, Percent_Identity=40.4639175257732, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17533177, Length=322, Percent_Identity=31.055900621118, Blast_Score=138, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6319831, Length=384, Percent_Identity=40.625, Blast_Score=243, Evalue=5e-65,
Organism=Drosophila melanogaster, GI20129463, Length=382, Percent_Identity=38.7434554973822, Blast_Score=248, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41857; Mature: 41857

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHVYLDNAATTPMAPEVIQTMMDQMEHDFGNASSTHWFGRTAHTVMDKSRKILADAIHA
CCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
QPGNMVITSGATESNNTAITQTAHTRASLGKHIITTAIEHPSVLQPLKALEKEGFRVTYL
CCCCEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEE
PVDENGRISLADFDAALDDDTILVTIMMGNNEVGSRMPISEIGARLVDHQAWFHTDATQA
EECCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
FGLLDIDVQAQHIDMLSVSAHKINGPKGIGFLYRDPKVQFPSLLKGGEQELKRRAGTENI
CEEEEEECCHHHEEEEEECHHCCCCCCCCEEEEECCCCCCHHHHCCCHHHHHHHCCCCCH
AGIAGFATAVSLITSDEKAKRQSKYLGFKQQIMGALDDAEIPYAVNGDIRPDNVNHVFNI
HHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHH
WLKGISTYALQTNLDLAGIAVSGGSACTAGSLEPSHVLTAMFGADSPRLGESIRLSFGAQ
HHHHHHEEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCC
TTKADIQAFIDALLPIVQRLQAKQSAR
CHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQHVYLDNAATTPMAPEVIQTMMDQMEHDFGNASSTHWFGRTAHTVMDKSRKILADAIHA
CCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
QPGNMVITSGATESNNTAITQTAHTRASLGKHIITTAIEHPSVLQPLKALEKEGFRVTYL
CCCCEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEE
PVDENGRISLADFDAALDDDTILVTIMMGNNEVGSRMPISEIGARLVDHQAWFHTDATQA
EECCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
FGLLDIDVQAQHIDMLSVSAHKINGPKGIGFLYRDPKVQFPSLLKGGEQELKRRAGTENI
CEEEEEECCHHHEEEEEECHHCCCCCCCCEEEEECCCCCCHHHHCCCHHHHHHHCCCCCH
AGIAGFATAVSLITSDEKAKRQSKYLGFKQQIMGALDDAEIPYAVNGDIRPDNVNHVFNI
HHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHH
WLKGISTYALQTNLDLAGIAVSGGSACTAGSLEPSHVLTAMFGADSPRLGESIRLSFGAQ
HHHHHHEEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCC
TTKADIQAFIDALLPIVQRLQAKQSAR
CHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]