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The map label for this gene is guaD [H]

Identifier: 116494635

GI number: 116494635

Start: 1121540

End: 1122007

Strand: Direct

Name: guaD [H]

Synonym: LSEI_1136

Alternate gene names: 116494635

Gene position: 1121540-1122007 (Clockwise)

Preceding gene: 116494634

Following gene: 116494637

Centisome position: 38.74

GC content: 49.57

Gene sequence:

>468_bases
ATGTATCGAAAAGAATTTATGGCAATGGCCAATGAAGAAGCCAAGGCAAACGTCAATGGTAGCGATGGCGGTCCGTTTGG
TTGTGTGATCATCAAAGATGGTAAAGTTGTCAGCCGCGCGCATAATCAAGTGCTGGTCGATCACGACCCAACCGCCCATG
GCGAGATCACGGCGATTCGAAAAGCTGGCCAGGCACTTGGCACACATGACTTAACCGGCTGTGAACTCTACACATCTGCC
ATGCCATGTCCCATGTGTCTCAGCGCCATTATCTGGGCCAACATTAAGCAGGTATACTATGGCAACACAGCAGACGATGC
TGCGGCAATTGGCTTTCGCGATGCCGCTATCTATGATTTCATCAATGCCGGCTTGAAAGGCGACATGCTTGCTCTGACCC
AACATGATCGCGAGTTGACGATCGGGGCATTCAAAGACTATCAATCGGCTCAAAAGAAACTTTATTAG

Upstream 100 bases:

>100_bases
TTTGGGATATAAGGCATCTAATCATTCGGATGCCATCAAGAAAATGCTCGCTAGTGAATTTTTGGCGTGGTGAGTGCTGT
CTTTTTGGAGGGAATCGCTT

Downstream 100 bases:

>100_bases
CAACACGAGTGGCATCATCTATCATTAGCCAAAATGACTGACAGGAAAAAGCGAAAACCCGCATCAGTTGTCACCAAGTG
CTGTCAAAATGTATTTGACA

Product: cytosine/adenosine deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MYRKEFMAMANEEAKANVNGSDGGPFGCVIIKDGKVVSRAHNQVLVDHDPTAHGEITAIRKAGQALGTHDLTGCELYTSA
MPCPMCLSAIIWANIKQVYYGNTADDAAAIGFRDAAIYDFINAGLKGDMLALTQHDRELTIGAFKDYQSAQKKLY

Sequences:

>Translated_155_residues
MYRKEFMAMANEEAKANVNGSDGGPFGCVIIKDGKVVSRAHNQVLVDHDPTAHGEITAIRKAGQALGTHDLTGCELYTSA
MPCPMCLSAIIWANIKQVYYGNTADDAAAIGFRDAAIYDFINAGLKGDMLALTQHDRELTIGAFKDYQSAQKKLY
>Mature_155_residues
MYRKEFMAMANEEAKANVNGSDGGPFGCVIIKDGKVVSRAHNQVLVDHDPTAHGEITAIRKAGQALGTHDLTGCELYTSA
MPCPMCLSAIIWANIKQVYYGNTADDAAAIGFRDAAIYDFINAGLKGDMLALTQHDRELTIGAFKDYQSAQKKLY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=77, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554608, Length=152, Percent_Identity=46.0526315789474, Blast_Score=145, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17555996, Length=122, Percent_Identity=52.4590163934426, Blast_Score=129, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 16819; Mature: 16819

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRKEFMAMANEEAKANVNGSDGGPFGCVIIKDGKVVSRAHNQVLVDHDPTAHGEITAIR
CCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCCEEEEECCCCCCCHHHHHH
KAGQALGTHDLTGCELYTSAMPCPMCLSAIIWANIKQVYYGNTADDAAAIGFRDAAIYDF
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCHHHCCCCHHHHHHH
INAGLKGDMLALTQHDRELTIGAFKDYQSAQKKLY
HHCCCCCCEEEEECCCCEEEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MYRKEFMAMANEEAKANVNGSDGGPFGCVIIKDGKVVSRAHNQVLVDHDPTAHGEITAIR
CCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCCEEEEECCCCCCCHHHHHH
KAGQALGTHDLTGCELYTSAMPCPMCLSAIIWANIKQVYYGNTADDAAAIGFRDAAIYDF
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCHHHCCCCHHHHHHH
INAGLKGDMLALTQHDRELTIGAFKDYQSAQKKLY
HHCCCCCCEEEEECCCCEEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]