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The map label for this gene is rnr [H]

Identifier: 116494482

GI number: 116494482

Start: 958484

End: 960853

Strand: Direct

Name: rnr [H]

Synonym: LSEI_0976

Alternate gene names: 116494482

Gene position: 958484-960853 (Clockwise)

Preceding gene: 116494481

Following gene: 116494483

Centisome position: 33.11

GC content: 45.65

Gene sequence:

>2370_bases
ATGACCACAGTTGGCCATATTCGTAATGAACTTTTAGCAACATTTCGTAAAAATCCGAAGATTGATTATTCGGTCCAGAC
GCTGAGCCGTGCCTTGAAATTAAACGAAGGCACTGATTTTAAAACGCTGGTTCAAGCCTTAACTGGTATGGAAAATGACA
ATTTAATCCATCCCATTAGTGAAGGCCGTTATGCTTGGGGCGGCACGCCTAAAGTGTTGACAGGTATTTTCCATGGCAAT
GAAAAAGGGTTTGGTTTCGTTGCGATCGAAGATCAGGACAATGATGTTTATGTGCCGTCAACGAGCACTGATTTTGCTTT
GGACGGTGATACCGTTGAAGTCCGTATCGTCCGTGAAGCACGTCCAAACGATACGCGTGGACCAGAAGGCGAAATCACTA
AGGTTGTTGAACGCAGCCTAACGACACTTGTAGGCGAATTCAAACCATTTTCCGACAAAGATCGGGCCAAGTCTGGTTTT
ATTGGTATGGTTGTCAGCCACGAGAAGAAACTGAAGAATTTTCCGGTTTATGTCAAAGACACTGGTACCATGCCGCAATT
AGGCGACATGACGGTTACCGAGATTACGGAATTTCCTAATGAACACCATCCGAAGCTGATGTATGGCATGGTGGTTGAAA
CATTGGGAAATAAGAATGATCCCGGTGTGGATATTATGTCATTAGTGATGCAAAACCATATCAAGACTGAGTTTCCTGAT
GAGGTAATGACTCAAACTAATGATATCCCGGATCATGTCACCCCAGAAGAACGGGTGAACCGTAAAGATATCACCGATCA
AGCCGTTGTGACGATTGACGGCGACGACAGTAAAGACTTCGATGATGCCGTTGTCGTTTGGAAATTGCCAAACGGAAACT
TCCATCTTGGTGTGCATATTGCAGACGTGTCGCACTATGTTACAGAAGGCTCAGCCTTGGACAAAGAAGCGTTTGATCGC
GGGACTAGTACGTATCTGGTCGACCGTGTCATTCCGATGCTGCCATTCCGGCTGTCTAATGGCATTTGTTCGTTGAATCC
TGGCGTTGATCGCTTGGCAATGTCTTGTGATATGGAAATTGATCAAGATGGTCACGTGGTTAATCACGAGATTTATCAAA
GCATCATCAAGAGCCATGCGCGGATGACTTATAACAACGTCAACAAGATTGTGACTGACCATGATCCAGAAGTGATGGCC
GAGTATCAGGAACTTGTGCCGATGTTTGAAGACATGGTTCAGCTGCATCAAATTCTTTACAAGATGCGGCATGCTCGAGG
TGCTATTGACTTCGAAGAAAACGAAGCCAAGATCATTGTTGATGATATGGGTCACCCAACAGACATTGTTCTGCGTGAGC
GTGGTGTGTCAGAACGAATGATTGAATCCTTCATGCTGGCCGCTAACGAAACCGTCGCTGAACATTACAACAAGCAACAT
TTACCATTCTTATACCGGGTTCACGAAACACCAGATGCCGACCGTATTAAAGAATTCATGGAATTCATTGCTAGTTTTGG
TATCACCGTGCCGATGAAAAAAGGCAAAGAAATCACCCCAAAGCAACTTCAGGATGTTGTGACAGATGTCACTGGCACGC
CTGAAGAAGCAATGGTGAGCGTTAAAATGTTGCGGAGTTTAAAACAGGCTCGGTATTCACCAGATCCACTTGGACATTTT
GGCTTGGCAGCAAAGTATTACTGCCACTTTACCAGTCCAATTCGGCGTTATCCTGACTTGGTCGCTCATCGCTTGATTCG
TGATTATGCGGTTGAAGGCACTGGCGACGATATCAAGGCAAGCTGGAATAAGAAATTACCAGATATTGCAGCTCAGGCAT
CCATGGCGGAACGGCGGAGCATTGACGCTGAGCGTGCAGTTGACGATCTTAAGAAGGCTGAATTTATGGCTGATAAGGTC
GGCGAAGAATTTGATGCTGTTGTTAGCGGCGTGACGAGCTTTGGGATGTTTGTGGCTTTGCCGAACACCGTAGAAGGGCT
TGTTCATATCACGCGGATGACCGATGATTATTATTCATTCATCGATAGTCAGATGGCTTTAGTTGGCGAACGCACCAAGC
GCACGTACCGAATTGGCCAGTCTTTGCGAGTTAAACTTGATAATGTTGATATTGATCAGCGACAGGTAGACTTTTCATTG
ATTCCTGATGAAAATACGCCAACAAGTGATCTGGGCAAGTTCGTCAAAAAAGAAGACCGGCGTGAACGTCGGCCAAATGG
CAACAAGCCTGGTTTTGGCAATAATAACCATGGTGGGCCAAATCGTAATCAACACAACAATCGACCACGCAAACCAGCTG
GTGCGCCACATCAAGGCAAGCACTATAATGCCAAGCGCGGCACTAAATAA

Upstream 100 bases:

>100_bases
TGGTATGACAATGCCAAGCATGTGATCACCGTGAATTCGGCGCATCACGCACTACAACAAGACGTTATCGCATTTATGCA
ACAAGAAAACGAGGGATAGC

Downstream 100 bases:

>100_bases
CGCTGGCAACTTTTGAAAGGGGGATGGTTCAATGGCGAAGAAACATCGACAAAAACCTGACAACCTGCTCGCCCAGAATA
AAAAGGCTGGTCATGATTAC

Product: exoribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 789; Mature: 788

Protein sequence:

>789_residues
MTTVGHIRNELLATFRKNPKIDYSVQTLSRALKLNEGTDFKTLVQALTGMENDNLIHPISEGRYAWGGTPKVLTGIFHGN
EKGFGFVAIEDQDNDVYVPSTSTDFALDGDTVEVRIVREARPNDTRGPEGEITKVVERSLTTLVGEFKPFSDKDRAKSGF
IGMVVSHEKKLKNFPVYVKDTGTMPQLGDMTVTEITEFPNEHHPKLMYGMVVETLGNKNDPGVDIMSLVMQNHIKTEFPD
EVMTQTNDIPDHVTPEERVNRKDITDQAVVTIDGDDSKDFDDAVVVWKLPNGNFHLGVHIADVSHYVTEGSALDKEAFDR
GTSTYLVDRVIPMLPFRLSNGICSLNPGVDRLAMSCDMEIDQDGHVVNHEIYQSIIKSHARMTYNNVNKIVTDHDPEVMA
EYQELVPMFEDMVQLHQILYKMRHARGAIDFEENEAKIIVDDMGHPTDIVLRERGVSERMIESFMLAANETVAEHYNKQH
LPFLYRVHETPDADRIKEFMEFIASFGITVPMKKGKEITPKQLQDVVTDVTGTPEEAMVSVKMLRSLKQARYSPDPLGHF
GLAAKYYCHFTSPIRRYPDLVAHRLIRDYAVEGTGDDIKASWNKKLPDIAAQASMAERRSIDAERAVDDLKKAEFMADKV
GEEFDAVVSGVTSFGMFVALPNTVEGLVHITRMTDDYYSFIDSQMALVGERTKRTYRIGQSLRVKLDNVDIDQRQVDFSL
IPDENTPTSDLGKFVKKEDRRERRPNGNKPGFGNNNHGGPNRNQHNNRPRKPAGAPHQGKHYNAKRGTK

Sequences:

>Translated_789_residues
MTTVGHIRNELLATFRKNPKIDYSVQTLSRALKLNEGTDFKTLVQALTGMENDNLIHPISEGRYAWGGTPKVLTGIFHGN
EKGFGFVAIEDQDNDVYVPSTSTDFALDGDTVEVRIVREARPNDTRGPEGEITKVVERSLTTLVGEFKPFSDKDRAKSGF
IGMVVSHEKKLKNFPVYVKDTGTMPQLGDMTVTEITEFPNEHHPKLMYGMVVETLGNKNDPGVDIMSLVMQNHIKTEFPD
EVMTQTNDIPDHVTPEERVNRKDITDQAVVTIDGDDSKDFDDAVVVWKLPNGNFHLGVHIADVSHYVTEGSALDKEAFDR
GTSTYLVDRVIPMLPFRLSNGICSLNPGVDRLAMSCDMEIDQDGHVVNHEIYQSIIKSHARMTYNNVNKIVTDHDPEVMA
EYQELVPMFEDMVQLHQILYKMRHARGAIDFEENEAKIIVDDMGHPTDIVLRERGVSERMIESFMLAANETVAEHYNKQH
LPFLYRVHETPDADRIKEFMEFIASFGITVPMKKGKEITPKQLQDVVTDVTGTPEEAMVSVKMLRSLKQARYSPDPLGHF
GLAAKYYCHFTSPIRRYPDLVAHRLIRDYAVEGTGDDIKASWNKKLPDIAAQASMAERRSIDAERAVDDLKKAEFMADKV
GEEFDAVVSGVTSFGMFVALPNTVEGLVHITRMTDDYYSFIDSQMALVGERTKRTYRIGQSLRVKLDNVDIDQRQVDFSL
IPDENTPTSDLGKFVKKEDRRERRPNGNKPGFGNNNHGGPNRNQHNNRPRKPAGAPHQGKHYNAKRGTK
>Mature_788_residues
TTVGHIRNELLATFRKNPKIDYSVQTLSRALKLNEGTDFKTLVQALTGMENDNLIHPISEGRYAWGGTPKVLTGIFHGNE
KGFGFVAIEDQDNDVYVPSTSTDFALDGDTVEVRIVREARPNDTRGPEGEITKVVERSLTTLVGEFKPFSDKDRAKSGFI
GMVVSHEKKLKNFPVYVKDTGTMPQLGDMTVTEITEFPNEHHPKLMYGMVVETLGNKNDPGVDIMSLVMQNHIKTEFPDE
VMTQTNDIPDHVTPEERVNRKDITDQAVVTIDGDDSKDFDDAVVVWKLPNGNFHLGVHIADVSHYVTEGSALDKEAFDRG
TSTYLVDRVIPMLPFRLSNGICSLNPGVDRLAMSCDMEIDQDGHVVNHEIYQSIIKSHARMTYNNVNKIVTDHDPEVMAE
YQELVPMFEDMVQLHQILYKMRHARGAIDFEENEAKIIVDDMGHPTDIVLRERGVSERMIESFMLAANETVAEHYNKQHL
PFLYRVHETPDADRIKEFMEFIASFGITVPMKKGKEITPKQLQDVVTDVTGTPEEAMVSVKMLRSLKQARYSPDPLGHFG
LAAKYYCHFTSPIRRYPDLVAHRLIRDYAVEGTGDDIKASWNKKLPDIAAQASMAERRSIDAERAVDDLKKAEFMADKVG
EEFDAVVSGVTSFGMFVALPNTVEGLVHITRMTDDYYSFIDSQMALVGERTKRTYRIGQSLRVKLDNVDIDQRQVDFSLI
PDENTPTSDLGKFVKKEDRRERRPNGNKPGFGNNNHGGPNRNQHNNRPRKPAGAPHQGKHYNAKRGTK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=566, Percent_Identity=26.678445229682, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI190014625, Length=634, Percent_Identity=26.1829652996845, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI134288890, Length=469, Percent_Identity=30.0639658848614, Blast_Score=186, Evalue=7e-47,
Organism=Homo sapiens, GI19115966, Length=494, Percent_Identity=28.7449392712551, Blast_Score=165, Evalue=2e-40,
Organism=Homo sapiens, GI219521928, Length=494, Percent_Identity=28.7449392712551, Blast_Score=164, Evalue=3e-40,
Organism=Escherichia coli, GI87082383, Length=720, Percent_Identity=34.1666666666667, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1787542, Length=604, Percent_Identity=27.317880794702, Blast_Score=177, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI212645896, Length=424, Percent_Identity=30.188679245283, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17553506, Length=422, Percent_Identity=30.3317535545024, Blast_Score=161, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324552, Length=575, Percent_Identity=28, Blast_Score=191, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6320499, Length=419, Percent_Identity=24.582338902148, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323943, Length=359, Percent_Identity=25.6267409470752, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24649634, Length=479, Percent_Identity=31.7327766179541, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24654592, Length=428, Percent_Identity=28.5046728971963, Blast_Score=153, Evalue=5e-37,
Organism=Drosophila melanogaster, GI19922976, Length=428, Percent_Identity=28.5046728971963, Blast_Score=153, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24654597, Length=428, Percent_Identity=28.5046728971963, Blast_Score=153, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 88982; Mature: 88850

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVGHIRNELLATFRKNPKIDYSVQTLSRALKLNEGTDFKTLVQALTGMENDNLIHPIS
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEECCCC
EGRYAWGGTPKVLTGIFHGNEKGFGFVAIEDQDNDVYVPSTSTDFALDGDTVEVRIVREA
CCCCCCCCCHHHHEEEEECCCCCEEEEEEECCCCCEECCCCCCCEEECCCEEEEEEEECC
RPNDTRGPEGEITKVVERSLTTLVGEFKPFSDKDRAKSGFIGMVVSHEKKLKNFPVYVKD
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEECCHHHHCCCCEEEEC
TGTMPQLGDMTVTEITEFPNEHHPKLMYGMVVETLGNKNDPGVDIMSLVMQNHIKTEFPD
CCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCH
EVMTQTNDIPDHVTPEERVNRKDITDQAVVTIDGDDSKDFDDAVVVWKLPNGNFHLGVHI
HHHHCCCCCCCCCCCHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEEE
ADVSHYVTEGSALDKEAFDRGTSTYLVDRVIPMLPFRLSNGICSLNPGVDRLAMSCDMEI
ECHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCHHHCCCEEECCCCHHHHHHHCCCEE
DQDGHVVNHEIYQSIIKSHARMTYNNVNKIVTDHDPEVMAEYQELVPMFEDMVQLHQILY
CCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KMRHARGAIDFEENEAKIIVDDMGHPTDIVLRERGVSERMIESFMLAANETVAEHYNKQH
HHHHHCCCCCCCCCCCEEEEECCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
LPFLYRVHETPDADRIKEFMEFIASFGITVPMKKGKEITPKQLQDVVTDVTGTPEEAMVS
CCEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHH
VKMLRSLKQARYSPDPLGHFGLAAKYYCHFTSPIRRYPDLVAHRLIRDYAVEGTGDDIKA
HHHHHHHHHHCCCCCCCCHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SWNKKLPDIAAQASMAERRSIDAERAVDDLKKAEFMADKVGEEFDAVVSGVTSFGMFVAL
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
PNTVEGLVHITRMTDDYYSFIDSQMALVGERTKRTYRIGQSLRVKLDNVDIDQRQVDFSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEECEEE
IPDENTPTSDLGKFVKKEDRRERRPNGNKPGFGNNNHGGPNRNQHNNRPRKPAGAPHQGK
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HYNAKRGTK
CCCCCCCCC
>Mature Secondary Structure 
TTVGHIRNELLATFRKNPKIDYSVQTLSRALKLNEGTDFKTLVQALTGMENDNLIHPIS
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEECCCC
EGRYAWGGTPKVLTGIFHGNEKGFGFVAIEDQDNDVYVPSTSTDFALDGDTVEVRIVREA
CCCCCCCCCHHHHEEEEECCCCCEEEEEEECCCCCEECCCCCCCEEECCCEEEEEEEECC
RPNDTRGPEGEITKVVERSLTTLVGEFKPFSDKDRAKSGFIGMVVSHEKKLKNFPVYVKD
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEECCHHHHCCCCEEEEC
TGTMPQLGDMTVTEITEFPNEHHPKLMYGMVVETLGNKNDPGVDIMSLVMQNHIKTEFPD
CCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCH
EVMTQTNDIPDHVTPEERVNRKDITDQAVVTIDGDDSKDFDDAVVVWKLPNGNFHLGVHI
HHHHCCCCCCCCCCCHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEEE
ADVSHYVTEGSALDKEAFDRGTSTYLVDRVIPMLPFRLSNGICSLNPGVDRLAMSCDMEI
ECHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCHHHCCCEEECCCCHHHHHHHCCCEE
DQDGHVVNHEIYQSIIKSHARMTYNNVNKIVTDHDPEVMAEYQELVPMFEDMVQLHQILY
CCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KMRHARGAIDFEENEAKIIVDDMGHPTDIVLRERGVSERMIESFMLAANETVAEHYNKQH
HHHHHCCCCCCCCCCCEEEEECCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
LPFLYRVHETPDADRIKEFMEFIASFGITVPMKKGKEITPKQLQDVVTDVTGTPEEAMVS
CCEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHH
VKMLRSLKQARYSPDPLGHFGLAAKYYCHFTSPIRRYPDLVAHRLIRDYAVEGTGDDIKA
HHHHHHHHHHCCCCCCCCHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SWNKKLPDIAAQASMAERRSIDAERAVDDLKKAEFMADKVGEEFDAVVSGVTSFGMFVAL
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
PNTVEGLVHITRMTDDYYSFIDSQMALVGERTKRTYRIGQSLRVKLDNVDIDQRQVDFSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEECEEE
IPDENTPTSDLGKFVKKEDRRERRPNGNKPGFGNNNHGGPNRNQHNNRPRKPAGAPHQGK
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HYNAKRGTK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]