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The map label for this gene is clpP

Identifier: 116494470

GI number: 116494470

Start: 945573

End: 946163

Strand: Direct

Name: clpP

Synonym: LSEI_0963

Alternate gene names: 116494470

Gene position: 945573-946163 (Clockwise)

Preceding gene: 116494469

Following gene: 116494472

Centisome position: 32.66

GC content: 47.21

Gene sequence:

>591_bases
ATGCTAGTACCTACCGTCGTTGAACAAACTAGTCGTGGCGAACGTGCTTACGACATTTACTCACGTCTATTAAAAGACCG
AATCATTATGTTATCCGGTGAAGTCAATGATCAAATGGCCAATTCTGTCATCGCGCAACTGCTCTTCTTGGACGCGCAAG
ACTCTGAAAAGGATATCTATCTCTACATCAACAGTCCCGGTGGTGTTATCACCAGTGGCTTGGCGATGCTGGATACGATG
AACTTCATCAAGTCAGATGTGCAGACGATCGCTATCGGGATGGCTGCCTCAATGGCGTCCGTTTTGCTGGCTGGTGGGAC
GAAGGGGAAGCGGTTCGCATTGCCGAACTCAACCATCCTGATCCATCAACCTTCAGGCGGTGCCCAAGGTCAGCAGACCG
AAATTGAAATCGCTGCTGAAGAAATCTTGAAGACACGTCGCAAGATGAACCAAATTTTGGCTGACGCAACTGGTCAAACG
ATTGAGCAAATCAAGAAGGACACCGAGCGTGATCATTATATGAGCGCTCAGGAAGCCAAGGATTACGGCTTAATCGATGA
TATCTTGGTCAACAAAAATACGCAAAAATAA

Upstream 100 bases:

>100_bases
CAAAGATTTTTATCTAAATCTTTGACCTTATTTGACTTTAGTTGTATACTTAGCACTGTACTTTTAAGAGTGCTAATAAC
GATTATCAGGAGGTTAGGAC

Downstream 100 bases:

>100_bases
GCTGTAAAAGGAAAAGCGCGTTGCCGTATCGTGGCAACGCGCTTTTGTTTCCCCGAAAAGACTTGCAAAGCGAGGGCATA
TTGAGTAATATAATTAGGTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MLVPTVVEQTSRGERAYDIYSRLLKDRIIMLSGEVNDQMANSVIAQLLFLDAQDSEKDIYLYINSPGGVITSGLAMLDTM
NFIKSDVQTIAIGMAASMASVLLAGGTKGKRFALPNSTILIHQPSGGAQGQQTEIEIAAEEILKTRRKMNQILADATGQT
IEQIKKDTERDHYMSAQEAKDYGLIDDILVNKNTQK

Sequences:

>Translated_196_residues
MLVPTVVEQTSRGERAYDIYSRLLKDRIIMLSGEVNDQMANSVIAQLLFLDAQDSEKDIYLYINSPGGVITSGLAMLDTM
NFIKSDVQTIAIGMAASMASVLLAGGTKGKRFALPNSTILIHQPSGGAQGQQTEIEIAAEEILKTRRKMNQILADATGQT
IEQIKKDTERDHYMSAQEAKDYGLIDDILVNKNTQK
>Mature_196_residues
MLVPTVVEQTSRGERAYDIYSRLLKDRIIMLSGEVNDQMANSVIAQLLFLDAQDSEKDIYLYINSPGGVITSGLAMLDTM
NFIKSDVQTIAIGMAASMASVLLAGGTKGKRFALPNSTILIHQPSGGAQGQQTEIEIAAEEILKTRRKMNQILADATGQT
IEQIKKDTERDHYMSAQEAKDYGLIDDILVNKNTQK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=54.9738219895288, Blast_Score=231, Evalue=4e-61,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=63.5416666666667, Blast_Score=273, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=51.6129032258064, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=54.7872340425532, Blast_Score=228, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_LACC3 (Q03AL0)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806204.1
- ProteinModelPortal:   Q03AL0
- SMR:   Q03AL0
- STRING:   Q03AL0
- MEROPS:   S14.001
- GeneID:   4419204
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_0963
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   HANGEAS
- PhylomeDB:   Q03AL0
- ProtClustDB:   PRK00277
- BioCyc:   LCAS321967:LSEI_0963-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21525; Mature: 21525

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 97-97 ACT_SITE 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVPTVVEQTSRGERAYDIYSRLLKDRIIMLSGEVNDQMANSVIAQLLFLDAQDSEKDIY
CCCCHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVITSGLAMLDTMNFIKSDVQTIAIGMAASMASVLLAGGTKGKRFALPNSTIL
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEE
IHQPSGGAQGQQTEIEIAAEEILKTRRKMNQILADATGQTIEQIKKDTERDHYMSAQEAK
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHC
DYGLIDDILVNKNTQK
CCCCHHHHHCCCCCCC
>Mature Secondary Structure
MLVPTVVEQTSRGERAYDIYSRLLKDRIIMLSGEVNDQMANSVIAQLLFLDAQDSEKDIY
CCCCHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVITSGLAMLDTMNFIKSDVQTIAIGMAASMASVLLAGGTKGKRFALPNSTIL
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEE
IHQPSGGAQGQQTEIEIAAEEILKTRRKMNQILADATGQTIEQIKKDTERDHYMSAQEAK
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHC
DYGLIDDILVNKNTQK
CCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA