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The map label for this gene is czcS [H]

Identifier: 116494458

GI number: 116494458

Start: 930114

End: 931124

Strand: Direct

Name: czcS [H]

Synonym: LSEI_0951

Alternate gene names: 116494458

Gene position: 930114-931124 (Clockwise)

Preceding gene: 116494457

Following gene: 116494459

Centisome position: 32.13

GC content: 47.87

Gene sequence:

>1011_bases
ATGGTTAAGCATGATTATTGGGCTATGCCGGAAACCAAAAGTGTGCTGAGATTGACAGTGTGGTTGATAGTTATTTTGTG
GGCCGCTTTACTCACGGTGATGGTGCTTGTGCCAGTCACTCGGCTTTGGCTAGTTGTTATTGGCCTTGGCAGCACACTGG
CCAGTAGTTGGGTCGTGTTGCGGTGGGCAGTCAAGTTTAGTCAGCGTTTTGACTTGGCGCTGCGACAACTAGATCTGACA
AAGGCAGGTGCAAGCAACTATGCGATTGATCGGAATGATGAAGGACTGTTTTCCGATCTCAACAATCGACTTTATCAATA
TGCCCGCCAAATGCAGGCTGAACGCACGGCGGTGAAGCGTGATCGCGATCAGCTGAGTGTTGCTATTACCGATATTGCGC
ATCAGTTGCGAACACCTTTAGCGGCGAATAATAATTTGCTTGAAATGATGACCGCGGCTAATTGGGAGGTCACCCGTCAG
GAGCTTTTAGCGCAGCACACGCGTCAAGCAGAGTTAGTTGAGCAGCTCATTTTATTAGCTAAGGTGGATACACATACGCT
GAGCCAAACTAGACAAGATGTGAGCGTAGCGGCGCTGGGGAAAGAGGCATTGAAGCCACTGCTGCGAATGGTTGCTGATA
ATCAGTTGACGATTGATTGGCAGGTATCACCAGACCTAATGCTTCATGTGAACCCGGCATTGGTCAAAGAAGCGTTGGTC
AATGTCTTGAAAAATGCGGTTGAACATACTGCTTTTGGCGGTCAAATTCAGATTATTGGGATTGCTGATCCTATTCGCGT
CCGCCTGAAGATTATCAATACAGGCTCACCAATTGCTGAAGCAGATATGCCGCATTTATTTGAGCGTTTTTTCCGTGGTC
AATATGCCACTGCCAATAACGTGGGCATTGGGTTAGCGATCGCTGCTGGCATTACGCGTGAAAACGATGGCCGCTTATCT
GCTGAAAATACCGCGGAAGGCGTACAATTCACGTTTGAATTTTTTCGTTGA

Upstream 100 bases:

>100_bases
ACTTTAACCGTGACCATCAAACGTCTGCGGGAAAAGCTTGAGGATGATCCGGCACATACGACCTTAATTCGGACTGTGCG
GGGAATGGGGTATTTTATTG

Downstream 100 bases:

>100_bases
GCGTTTTTTGTCACTTACTTGTCACTTACCATTGATAGGCTGAGAGTATCATAAGAAAGCCAACACAGATTGATGTGTCA
GGCGCGAGGAGGGGTACTAG

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MVKHDYWAMPETKSVLRLTVWLIVILWAALLTVMVLVPVTRLWLVVIGLGSTLASSWVVLRWAVKFSQRFDLALRQLDLT
KAGASNYAIDRNDEGLFSDLNNRLYQYARQMQAERTAVKRDRDQLSVAITDIAHQLRTPLAANNNLLEMMTAANWEVTRQ
ELLAQHTRQAELVEQLILLAKVDTHTLSQTRQDVSVAALGKEALKPLLRMVADNQLTIDWQVSPDLMLHVNPALVKEALV
NVLKNAVEHTAFGGQIQIIGIADPIRVRLKIINTGSPIAEADMPHLFERFFRGQYATANNVGIGLAIAAGITRENDGRLS
AENTAEGVQFTFEFFR

Sequences:

>Translated_336_residues
MVKHDYWAMPETKSVLRLTVWLIVILWAALLTVMVLVPVTRLWLVVIGLGSTLASSWVVLRWAVKFSQRFDLALRQLDLT
KAGASNYAIDRNDEGLFSDLNNRLYQYARQMQAERTAVKRDRDQLSVAITDIAHQLRTPLAANNNLLEMMTAANWEVTRQ
ELLAQHTRQAELVEQLILLAKVDTHTLSQTRQDVSVAALGKEALKPLLRMVADNQLTIDWQVSPDLMLHVNPALVKEALV
NVLKNAVEHTAFGGQIQIIGIADPIRVRLKIINTGSPIAEADMPHLFERFFRGQYATANNVGIGLAIAAGITRENDGRLS
AENTAEGVQFTFEFFR
>Mature_336_residues
MVKHDYWAMPETKSVLRLTVWLIVILWAALLTVMVLVPVTRLWLVVIGLGSTLASSWVVLRWAVKFSQRFDLALRQLDLT
KAGASNYAIDRNDEGLFSDLNNRLYQYARQMQAERTAVKRDRDQLSVAITDIAHQLRTPLAANNNLLEMMTAANWEVTRQ
ELLAQHTRQAELVEQLILLAKVDTHTLSQTRQDVSVAALGKEALKPLLRMVADNQLTIDWQVSPDLMLHVNPALVKEALV
NVLKNAVEHTAFGGQIQIIGIADPIRVRLKIINTGSPIAEADMPHLFERFFRGQYATANNVGIGLAIAAGITRENDGRLS
AENTAEGVQFTFEFFR

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=28.4403669724771, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790861, Length=238, Percent_Identity=27.3109243697479, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786783, Length=220, Percent_Identity=30, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788393, Length=212, Percent_Identity=25.9433962264151, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37686; Mature: 37686

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKHDYWAMPETKSVLRLTVWLIVILWAALLTVMVLVPVTRLWLVVIGLGSTLASSWVVL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RWAVKFSQRFDLALRQLDLTKAGASNYAIDRNDEGLFSDLNNRLYQYARQMQAERTAVKR
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DRDQLSVAITDIAHQLRTPLAANNNLLEMMTAANWEVTRQELLAQHTRQAELVEQLILLA
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KVDTHTLSQTRQDVSVAALGKEALKPLLRMVADNQLTIDWQVSPDLMLHVNPALVKEALV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECHHHHHHHHH
NVLKNAVEHTAFGGQIQIIGIADPIRVRLKIINTGSPIAEADMPHLFERFFRGQYATANN
HHHHHHHHHHCCCCEEEEEEECCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCC
VGIGLAIAAGITRENDGRLSAENTAEGVQFTFEFFR
CCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MVKHDYWAMPETKSVLRLTVWLIVILWAALLTVMVLVPVTRLWLVVIGLGSTLASSWVVL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RWAVKFSQRFDLALRQLDLTKAGASNYAIDRNDEGLFSDLNNRLYQYARQMQAERTAVKR
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DRDQLSVAITDIAHQLRTPLAANNNLLEMMTAANWEVTRQELLAQHTRQAELVEQLILLA
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KVDTHTLSQTRQDVSVAALGKEALKPLLRMVADNQLTIDWQVSPDLMLHVNPALVKEALV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECHHHHHHHHH
NVLKNAVEHTAFGGQIQIIGIADPIRVRLKIINTGSPIAEADMPHLFERFFRGQYATANN
HHHHHHHHHHCCCCEEEEEEECCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCC
VGIGLAIAAGITRENDGRLSAENTAEGVQFTFEFFR
CCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]