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The map label for this gene is pgcA [H]

Identifier: 116494456

GI number: 116494456

Start: 927511

End: 929238

Strand: Direct

Name: pgcA [H]

Synonym: LSEI_0949

Alternate gene names: 116494456

Gene position: 927511-929238 (Clockwise)

Preceding gene: 116494455

Following gene: 116494457

Centisome position: 32.04

GC content: 47.74

Gene sequence:

>1728_bases
GTGAGTTATCGTGATACGTATCAACAATGGGTCGACGAACCGACCCTTGATCCGGAGCTGAAAGCTGATCTTAAGAATAT
GGCTGATGATGAGACGACTAAGGAACAGGCATTTGCTGCTCCTATGGCGTTTGGCACGGCAGGCATGCGTGGTGTTCTTG
GTGCCGGGATTGGTCGGATGAATATTTACACGGTTCGGCAAGCCACTGAAGGTTTGGCCCGGTTTATGGACACACTGTCG
GATGAAACTAAGGCCCGGGGGGTTGCGATTAGTTACGACTCCCGTTACATGAGTCAAGAGTTTGCTTATGAAAGTGCCGG
GGTCTTGGGTGCTCATGGTATTAAGAGCTATGTTTTTGATCAGTTGCGGCCAACACCGGAATTAAGTTTTGCGGTGCGTC
ATTTAAAGACCTATGCAGGCATTATGATCACTGCTAGTCATAACCCTAAGCAGTACAATGGGTATAAGATTTACGGTCCA
GATGGCGGGCAGATGCCACCGGAAGAATCCGACAAAATCACCAAATATGCTCGTTCAGCAGCGGATCTTTTTGCTATCAA
GTCTCTGAACATCCATGTGCTACGCGCCAAAAAGTTGATGCAACCGATTGGTGAAGATGTTGATGAAGCTTACTATGCTG
AAGTGGCCACGGTCACCATCAACCATGATTTGATTAACAAAGTCGGCAAGAACATGTCGTTGGTTTATAGCCCACTGCAC
GGGACTGGACGGATTCCAGCGCAAATGGTTTTGCGTAATGCTGGTTTCGAAAACTTCCGGTTGGTACCTGAGCAAAGTAT
TGCTGATCCAGAATTTGCAACTACCCCATTCCCGAACCCAGAGTTCGCTCAAGTCTTTGATTTGCCAATTGCATTAGGCA
AAAAAATCGGCGCTGATGTCTTAATCGCGACTGATCCCGATGCTGATCGGCTGGGCACAGCAGTTAAAGTCGGCGACCAT
TATCAGTTGTTGACTGGTAACCAAATCGCTTCAGTCTTATTGCATTATATTCTGGAAGCGCGCAAGCAAGCTGGCACACT
GCCGAAGAATGGCGCGGTTGTGAAGTCAATCGTGTCGACGGAATTGGCAACCGCCATTGCGAAGGATTATGGCGTGGACA
TGATCAATGTGCTGACTGGTTTCAAGTTTATCGGTGATCAGATCAAGCATTTTCAAGCTACTGGCGAGCACGAATTTCTG
TTTGGCTTTGAGGAAAGTTACGGCTATCTGATCAAGCCATTCGTGCGCGACAAGGATGCGATTCAGTCAACAGTGCTGCT
GGCTGAAGTTGCCGCCTACTATCAGTCACAAGGCAAAACGCTTTGGGACGGCGTTCAGGAACTGTACAAGAAGTATGGTT
ACTATGCTGAAAAGACCGTTGGTGTTGACTTTGAAGGGGTTGACGGTCAGAAGCAAATGGCTAACTTGATGACCAAGTTC
CGCGAAGAACAGCCTGCTGATTTTGCGGGTGTCAAGATTACGAAGGTTGAAGACTTCCTGAGTCAGGAAGCTAAATCCGC
TGATGGCACTGTTGAAAAACTGACCATGCCATCAAGCAACGTTCTGAAGTATATTTTGGCAGACGGTACTTGGATTGCTA
TCCGGCCATCCGGCACCGAACCGAAAGTTAAGTTCTATGTCGGTACCAAAGCAGACACAGAAGCTAAGGCCCAAGAAAAA
TTGGATGCCTTCGAAAAGGCGCTCAATGATTTTCGTGAAGAAGCTTAG

Upstream 100 bases:

>100_bases
GAGCGCGTTTTCAACCCAGCACTCGTCCACTTATAGTATGATTGGGACGGGAAGGGTATTGCCCGAAATTATTAATTATA
GACAGATGGGAGCTGATCAC

Downstream 100 bases:

>100_bases
TTTGTTTTAAACGAATCAATGTGTGAATCCTGACGATTAAGCAGGTGAAGCAAGATAGCGGCGAACGCCTTGTCCCAAAT
TTGGGACAAGGCGTTCGCCG

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MSYRDTYQQWVDEPTLDPELKADLKNMADDETTKEQAFAAPMAFGTAGMRGVLGAGIGRMNIYTVRQATEGLARFMDTLS
DETKARGVAISYDSRYMSQEFAYESAGVLGAHGIKSYVFDQLRPTPELSFAVRHLKTYAGIMITASHNPKQYNGYKIYGP
DGGQMPPEESDKITKYARSAADLFAIKSLNIHVLRAKKLMQPIGEDVDEAYYAEVATVTINHDLINKVGKNMSLVYSPLH
GTGRIPAQMVLRNAGFENFRLVPEQSIADPEFATTPFPNPEFAQVFDLPIALGKKIGADVLIATDPDADRLGTAVKVGDH
YQLLTGNQIASVLLHYILEARKQAGTLPKNGAVVKSIVSTELATAIAKDYGVDMINVLTGFKFIGDQIKHFQATGEHEFL
FGFEESYGYLIKPFVRDKDAIQSTVLLAEVAAYYQSQGKTLWDGVQELYKKYGYYAEKTVGVDFEGVDGQKQMANLMTKF
REEQPADFAGVKITKVEDFLSQEAKSADGTVEKLTMPSSNVLKYILADGTWIAIRPSGTEPKVKFYVGTKADTEAKAQEK
LDAFEKALNDFREEA

Sequences:

>Translated_575_residues
MSYRDTYQQWVDEPTLDPELKADLKNMADDETTKEQAFAAPMAFGTAGMRGVLGAGIGRMNIYTVRQATEGLARFMDTLS
DETKARGVAISYDSRYMSQEFAYESAGVLGAHGIKSYVFDQLRPTPELSFAVRHLKTYAGIMITASHNPKQYNGYKIYGP
DGGQMPPEESDKITKYARSAADLFAIKSLNIHVLRAKKLMQPIGEDVDEAYYAEVATVTINHDLINKVGKNMSLVYSPLH
GTGRIPAQMVLRNAGFENFRLVPEQSIADPEFATTPFPNPEFAQVFDLPIALGKKIGADVLIATDPDADRLGTAVKVGDH
YQLLTGNQIASVLLHYILEARKQAGTLPKNGAVVKSIVSTELATAIAKDYGVDMINVLTGFKFIGDQIKHFQATGEHEFL
FGFEESYGYLIKPFVRDKDAIQSTVLLAEVAAYYQSQGKTLWDGVQELYKKYGYYAEKTVGVDFEGVDGQKQMANLMTKF
REEQPADFAGVKITKVEDFLSQEAKSADGTVEKLTMPSSNVLKYILADGTWIAIRPSGTEPKVKFYVGTKADTEAKAQEK
LDAFEKALNDFREEA
>Mature_574_residues
SYRDTYQQWVDEPTLDPELKADLKNMADDETTKEQAFAAPMAFGTAGMRGVLGAGIGRMNIYTVRQATEGLARFMDTLSD
ETKARGVAISYDSRYMSQEFAYESAGVLGAHGIKSYVFDQLRPTPELSFAVRHLKTYAGIMITASHNPKQYNGYKIYGPD
GGQMPPEESDKITKYARSAADLFAIKSLNIHVLRAKKLMQPIGEDVDEAYYAEVATVTINHDLINKVGKNMSLVYSPLHG
TGRIPAQMVLRNAGFENFRLVPEQSIADPEFATTPFPNPEFAQVFDLPIALGKKIGADVLIATDPDADRLGTAVKVGDHY
QLLTGNQIASVLLHYILEARKQAGTLPKNGAVVKSIVSTELATAIAKDYGVDMINVLTGFKFIGDQIKHFQATGEHEFLF
GFEESYGYLIKPFVRDKDAIQSTVLLAEVAAYYQSQGKTLWDGVQELYKKYGYYAEKTVGVDFEGVDGQKQMANLMTKFR
EEQPADFAGVKITKVEDFLSQEAKSADGTVEKLTMPSSNVLKYILADGTWIAIRPSGTEPKVKFYVGTKADTEAKAQEKL
DAFEKALNDFREEA

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=552, Percent_Identity=31.7028985507246, Blast_Score=266, Evalue=5e-71,
Organism=Homo sapiens, GI31377548, Length=550, Percent_Identity=31.8181818181818, Blast_Score=261, Evalue=9e-70,
Organism=Escherichia coli, GI1786904, Length=598, Percent_Identity=25.0836120401338, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71993870, Length=582, Percent_Identity=30.7560137457045, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71993878, Length=316, Percent_Identity=34.1772151898734, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323934, Length=563, Percent_Identity=30.550621669627, Blast_Score=203, Evalue=8e-53,
Organism=Drosophila melanogaster, GI20129809, Length=550, Percent_Identity=29.0909090909091, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24651977, Length=437, Percent_Identity=31.350114416476, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24653722, Length=549, Percent_Identity=25.3187613843352, Blast_Score=178, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 63567; Mature: 63436

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYRDTYQQWVDEPTLDPELKADLKNMADDETTKEQAFAAPMAFGTAGMRGVLGAGIGRM
CCCHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NIYTVRQATEGLARFMDTLSDETKARGVAISYDSRYMSQEFAYESAGVLGAHGIKSYVFD
EEEEHHHHHHHHHHHHHHHCCHHHHCCEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHH
QLRPTPELSFAVRHLKTYAGIMITASHNPKQYNGYKIYGPDGGQMPPEESDKITKYARSA
HCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
ADLFAIKSLNIHVLRAKKLMQPIGEDVDEAYYAEVATVTINHDLINKVGKNMSLVYSPLH
HHHHHEECCCEEEEHHHHHHHHHCCCHHHHHHHEEEEEEECHHHHHHCCCCCEEEEECCC
GTGRIPAQMVLRNAGFENFRLVPEQSIADPEFATTPFPNPEFAQVFDLPIALGKKIGADV
CCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
LIATDPDADRLGTAVKVGDHYQLLTGNQIASVLLHYILEARKQAGTLPKNGAVVKSIVST
EEEECCCHHHHCCEEEECCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ELATAIAKDYGVDMINVLTGFKFIGDQIKHFQATGEHEFLFGFEESYGYLIKPFVRDKDA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHCCHHH
IQSTVLLAEVAAYYQSQGKTLWDGVQELYKKYGYYAEKTVGVDFEGVDGQKQMANLMTKF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHH
REEQPADFAGVKITKVEDFLSQEAKSADGTVEKLTMPSSNVLKYILADGTWIAIRPSGTE
HHCCCCCCCCEEEEHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHCCCCEEEEEECCCCC
PKVKFYVGTKADTEAKAQEKLDAFEKALNDFREEA
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SYRDTYQQWVDEPTLDPELKADLKNMADDETTKEQAFAAPMAFGTAGMRGVLGAGIGRM
CCHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NIYTVRQATEGLARFMDTLSDETKARGVAISYDSRYMSQEFAYESAGVLGAHGIKSYVFD
EEEEHHHHHHHHHHHHHHHCCHHHHCCEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHH
QLRPTPELSFAVRHLKTYAGIMITASHNPKQYNGYKIYGPDGGQMPPEESDKITKYARSA
HCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
ADLFAIKSLNIHVLRAKKLMQPIGEDVDEAYYAEVATVTINHDLINKVGKNMSLVYSPLH
HHHHHEECCCEEEEHHHHHHHHHCCCHHHHHHHEEEEEEECHHHHHHCCCCCEEEEECCC
GTGRIPAQMVLRNAGFENFRLVPEQSIADPEFATTPFPNPEFAQVFDLPIALGKKIGADV
CCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
LIATDPDADRLGTAVKVGDHYQLLTGNQIASVLLHYILEARKQAGTLPKNGAVVKSIVST
EEEECCCHHHHCCEEEECCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ELATAIAKDYGVDMINVLTGFKFIGDQIKHFQATGEHEFLFGFEESYGYLIKPFVRDKDA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHCCHHH
IQSTVLLAEVAAYYQSQGKTLWDGVQELYKKYGYYAEKTVGVDFEGVDGQKQMANLMTKF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHH
REEQPADFAGVKITKVEDFLSQEAKSADGTVEKLTMPSSNVLKYILADGTWIAIRPSGTE
HHCCCCCCCCEEEEHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHCCCCEEEEEECCCCC
PKVKFYVGTKADTEAKAQEKLDAFEKALNDFREEA
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]