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The map label for this gene is trxB [H]

Identifier: 116494455

GI number: 116494455

Start: 926332

End: 927279

Strand: Direct

Name: trxB [H]

Synonym: LSEI_0948

Alternate gene names: 116494455

Gene position: 926332-927279 (Clockwise)

Preceding gene: 116494454

Following gene: 116494456

Centisome position: 31.99

GC content: 50.0

Gene sequence:

>948_bases
ATGGCAAAAAAATATGATGTAATCGTGATCGGTGCCGGCCCAGGTGGTATGACGGCTGCACTTTATGCATCGCGTGCCAA
TTTATCTGTGCTGATGCTGGATCGCGGCGTCTATGGCGGGCAGATGAACAACACCGCTGAAGTTGAAAACTATCCGGGTT
TCAAGTCAATCCTCGGGCCAGATCTTGGTCAGAAAATGTATGATGGTGCCACCCAATTTGGTGCTGAGTATGCCTATGGC
AATGTCGTTAGCGTTCAAAACCGCGGTGCCGTCAAGCTAGTGAAAACTGACGAGGATGAGTACGAGGCTAAAGCGATTGT
CATTGCGACAGGCGCAGAGCATAAGAAGTTGGGCGTACCGGGCGAAGAAGCCTACAGCGGCCGTGGCGTTTCATACTGTG
CTGTCTGCGATGGCGCCTTCTTTAAAGATCGCGAGTTGGCCGTTATTGGCGGTGGCGATTCCGCGATTGAAGAAGGCCTT
TACCTGACACAAATGGCCAAGAAGGTCACAGTTATTCATCGCCGTGATCAATTGCGTGCTCAGCAGATTATCCAGAAGCG
AGCATTTGCCAATGATAAGATGCATTTCGTTTGGAATGCTCAGGTTCAGGAAATCCAAGGTGACGATATGAAAGTCACCG
GCGTGAAGTACCGTGATAAGGAAACTGGCGAGGAACATGTTTTGCCAGTCGCCGGGGTTTTCATTTATGTTGGCATTATG
CCGATGACTGAAGCCTTCCAAGATTTAGGTGTTCTGGATGAGCATGGTTGGATTCCAACCGACGAGCATATGCGGACAAA
GGTTCCAGGCGTTTTCGCGATCGGCGATGTTCGCGCCAAGGACCTGCGGCAGATTACCACAGCTGTTGGTGAAGGTGGCA
CAGCTGGACAAGGCGTCTTCAACTATATCCAGAGTTTGAATGATACGAATATTGAGATTAAGGCGTAA

Upstream 100 bases:

>100_bases
TCGATTTTGACAATGCGAGTTTACAAAAACCATAAAACCATGTATATTAAACAGTATAGCTTACTAATTGTAAGCAATAT
GGGAAAAGGAGAGACTGCCC

Downstream 100 bases:

>100_bases
TTTTGTTCGAGACCAGCGATGCGAGTCGCTGGTTTTTTTGTGTCTGTGAGCAGAAACGCTTAGAAACAAGCAGTCTTGGA
AACTTGTTTTAGCTAGCACG

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MAKKYDVIVIGAGPGGMTAALYASRANLSVLMLDRGVYGGQMNNTAEVENYPGFKSILGPDLGQKMYDGATQFGAEYAYG
NVVSVQNRGAVKLVKTDEDEYEAKAIVIATGAEHKKLGVPGEEAYSGRGVSYCAVCDGAFFKDRELAVIGGGDSAIEEGL
YLTQMAKKVTVIHRRDQLRAQQIIQKRAFANDKMHFVWNAQVQEIQGDDMKVTGVKYRDKETGEEHVLPVAGVFIYVGIM
PMTEAFQDLGVLDEHGWIPTDEHMRTKVPGVFAIGDVRAKDLRQITTAVGEGGTAGQGVFNYIQSLNDTNIEIKA

Sequences:

>Translated_315_residues
MAKKYDVIVIGAGPGGMTAALYASRANLSVLMLDRGVYGGQMNNTAEVENYPGFKSILGPDLGQKMYDGATQFGAEYAYG
NVVSVQNRGAVKLVKTDEDEYEAKAIVIATGAEHKKLGVPGEEAYSGRGVSYCAVCDGAFFKDRELAVIGGGDSAIEEGL
YLTQMAKKVTVIHRRDQLRAQQIIQKRAFANDKMHFVWNAQVQEIQGDDMKVTGVKYRDKETGEEHVLPVAGVFIYVGIM
PMTEAFQDLGVLDEHGWIPTDEHMRTKVPGVFAIGDVRAKDLRQITTAVGEGGTAGQGVFNYIQSLNDTNIEIKA
>Mature_314_residues
AKKYDVIVIGAGPGGMTAALYASRANLSVLMLDRGVYGGQMNNTAEVENYPGFKSILGPDLGQKMYDGATQFGAEYAYGN
VVSVQNRGAVKLVKTDEDEYEAKAIVIATGAEHKKLGVPGEEAYSGRGVSYCAVCDGAFFKDRELAVIGGGDSAIEEGLY
LTQMAKKVTVIHRRDQLRAQQIIQKRAFANDKMHFVWNAQVQEIQGDDMKVTGVKYRDKETGEEHVLPVAGVFIYVGIMP
MTEAFQDLGVLDEHGWIPTDEHMRTKVPGVFAIGDVRAKDLRQITTAVGEGGTAGQGVFNYIQSLNDTNIEIKA

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=285, Percent_Identity=23.859649122807, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI65787454, Length=285, Percent_Identity=23.859649122807, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI226437568, Length=285, Percent_Identity=23.859649122807, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787114, Length=319, Percent_Identity=41.692789968652, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87081763, Length=305, Percent_Identity=32.4590163934426, Blast_Score=168, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6320560, Length=313, Percent_Identity=38.9776357827476, Blast_Score=205, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6321898, Length=314, Percent_Identity=35.3503184713376, Blast_Score=180, Evalue=3e-46,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 34212; Mature: 34081

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKYDVIVIGAGPGGMTAALYASRANLSVLMLDRGVYGGQMNNTAEVENYPGFKSILGP
CCCEEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHCC
DLGQKMYDGATQFGAEYAYGNVVSVQNRGAVKLVKTDEDEYEAKAIVIATGAEHKKLGVP
HHHHHHHHCHHHHCCHHCCCCEEEECCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCC
GEEAYSGRGVSYCAVCDGAFFKDRELAVIGGGDSAIEEGLYLTQMAKKVTVIHRRDQLRA
CHHHCCCCCCEEEEEECCCEECCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHH
QQIIQKRAFANDKMHFVWNAQVQEIQGDDMKVTGVKYRDKETGEEHVLPVAGVFIYVGIM
HHHHHHHHHCCCCEEEEECCEEEECCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
PMTEAFQDLGVLDEHGWIPTDEHMRTKVPGVFAIGDVRAKDLRQITTAVGEGGTAGQGVF
HHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCHHHH
NYIQSLNDTNIEIKA
HHHHCCCCCCEEEEC
>Mature Secondary Structure 
AKKYDVIVIGAGPGGMTAALYASRANLSVLMLDRGVYGGQMNNTAEVENYPGFKSILGP
CCEEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHCC
DLGQKMYDGATQFGAEYAYGNVVSVQNRGAVKLVKTDEDEYEAKAIVIATGAEHKKLGVP
HHHHHHHHCHHHHCCHHCCCCEEEECCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCC
GEEAYSGRGVSYCAVCDGAFFKDRELAVIGGGDSAIEEGLYLTQMAKKVTVIHRRDQLRA
CHHHCCCCCCEEEEEECCCEECCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHH
QQIIQKRAFANDKMHFVWNAQVQEIQGDDMKVTGVKYRDKETGEEHVLPVAGVFIYVGIM
HHHHHHHHHCCCCEEEEECCEEEECCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
PMTEAFQDLGVLDEHGWIPTDEHMRTKVPGVFAIGDVRAKDLRQITTAVGEGGTAGQGVF
HHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCHHHH
NYIQSLNDTNIEIKA
HHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]