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The map label for this gene is malL [H]

Identifier: 116493970

GI number: 116493970

Start: 408172

End: 409857

Strand: Direct

Name: malL [H]

Synonym: LSEI_0406

Alternate gene names: 116493970

Gene position: 408172-409857 (Clockwise)

Preceding gene: 116493969

Following gene: 116493973

Centisome position: 14.1

GC content: 45.49

Gene sequence:

>1686_bases
ATGAATGAAATACCATGGTGGAAAAAGAGCGTTGTCTATCAGGTTTATCCGAAAAGCTTCAATGATAGTAACGGTGATGG
CGTCGGGGACTTAAATGGTATCAGTGAAAAATTGGATTATTTAGCCGATTTGGGCGTAGATGTGCTCTGGCTGAATCCGA
TTTACCGATCGCCACAGGTTGATAACGGCTACGATATTTCGAATTATCGCGATGTTGAACCACAATTAGGGACAATGGCC
GATTTTGAACACTTGTTGCAGGCAGCACATGATCGACATCTAAAGATTATCTTGGACTTGGTTGTGAATCACACGTCTGA
TCAACATCCGTGGTTCAAAGCCGCCAAATCATCAGTGAGCGATCCGCATCACGATTACTACATCTGGAAGAAGCCAGTTG
ACGATCATGAGCCTAATAATTGGGGCTCAAGCTTTGGTGGTTCAGCTTGGGAATACAAAAAAGATCTGGGCGAGTATTAC
CTGCATCTTTTTGCCAAGCAACAACCGGATCTCAACTGGGAAAATCCTAAGGTACGCCAAGAAGTTTATGATCTCATGCG
CTTTTGGCTAGATAAGGGAGTTGATGGCTTCCGGATGGATGTCATATCACTGATTTCTAAAGATCCGGCTTATCCAGATG
GCCCGCTCATTCAAGGCAAGGCATACGGTAGTTATTATGCCGGAGCGGCAAATGGCCCTAAGGTTCATGATTACTTGCAG
GAAATGCACGAGCAAGTGTTGTCGCACTACAATATCATGACGGTCGGCGAGACGCCCCATACAACGGCACAGCAGGCGCA
ATTATACACGGCGGCAGATCGTCACGAGTTGGATATGGTTTTTCATTTTGACCATATGCATCTTGACTATGGCCAATATG
GCAAGTTCTCGACAAATCGATTTAAATTAGTTGATCTCAAAGAAGTCTTGGCACGTTGGGAGAACACATTAGCGCAAGTC
GATGGCTGGAACAGCCTTTACTGGAGCAACCACGATCAGCCACGGCCTGTGACACGATTTGGAGATGAAGGCCAGTATCG
AATTCGATCAGCCAAAATGCTGGGGACTGTGCTGCACATGTTGCAGGGAACGCCTTATATTTTTGAGGGAGAAGAACTCG
GTCTGAAGAATGTTCATTTTGATCAATTAAGCGATTATAACGATCTTGAGACCAAGAACATTTTCAAAGAACTCACCCAA
CAGCATCATGAAAGTCCTGAGGCGGCCATGAAGGCCATTTATCTGCATTCGCGCGATAATGCTCGTACGCCGATGCCTTG
GGATGGCAGTGAAAAAGGTGGTTTCACCACCGGACAACCATGGCTGGGACTAAATCCAGATCACAAAGACATTAATGCAG
CTGAAGACTTGGCAGATAGTGACGGTGTTTACCACTATTATCAACACCTGATTAAATTACGACATGAAGAGCCATTGATT
ACCACTGGTGTATTTGAGCTACTTGCTCCTGATGATCCGAACTTGTTTATTTACCTGCGCAAAGGGGAACATGAGACCTT
GCTGGTGGCAGGTAACTTCTCAAGTGAGGAACGCACATGGTCAGTGCCGGATGACTTGCAAGCTAAGGATGTGGATGTGT
TGATTCGGAATAGTGAAATTTCCGATTCACTAGAGAAAACACTGACATTACCACCATTTGGCGCAGTGGTGTACAAGCTT
CAATAG

Upstream 100 bases:

>100_bases
GATCAGTATATTAGCGATGCTCGAATTGATGCGCTGATTCAAGAGGCCAAAGATGCAATCGTCAATGTCAACGAGATTCA
AGTTGAGGAAGATGACGATG

Downstream 100 bases:

>100_bases
CAATACGAGTGAGTTCGAATTCACGAAAAATGCTCATCTTCTAGTTTGGCTTAGAAGATGAGCATTTTTGTGTTATATCG
TGTCTTTGCCAGAAAAATTC

Product: trehalose-6-phosphate hydrolase

Products: NA

Alternate protein names: Dextrin 6-alpha-D-glucanohydrolase; Oligosaccharide alpha-1,6-glucosidase; Sucrase-isomaltase; Isomaltase [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MNEIPWWKKSVVYQVYPKSFNDSNGDGVGDLNGISEKLDYLADLGVDVLWLNPIYRSPQVDNGYDISNYRDVEPQLGTMA
DFEHLLQAAHDRHLKIILDLVVNHTSDQHPWFKAAKSSVSDPHHDYYIWKKPVDDHEPNNWGSSFGGSAWEYKKDLGEYY
LHLFAKQQPDLNWENPKVRQEVYDLMRFWLDKGVDGFRMDVISLISKDPAYPDGPLIQGKAYGSYYAGAANGPKVHDYLQ
EMHEQVLSHYNIMTVGETPHTTAQQAQLYTAADRHELDMVFHFDHMHLDYGQYGKFSTNRFKLVDLKEVLARWENTLAQV
DGWNSLYWSNHDQPRPVTRFGDEGQYRIRSAKMLGTVLHMLQGTPYIFEGEELGLKNVHFDQLSDYNDLETKNIFKELTQ
QHHESPEAAMKAIYLHSRDNARTPMPWDGSEKGGFTTGQPWLGLNPDHKDINAAEDLADSDGVYHYYQHLIKLRHEEPLI
TTGVFELLAPDDPNLFIYLRKGEHETLLVAGNFSSEERTWSVPDDLQAKDVDVLIRNSEISDSLEKTLTLPPFGAVVYKL
Q

Sequences:

>Translated_561_residues
MNEIPWWKKSVVYQVYPKSFNDSNGDGVGDLNGISEKLDYLADLGVDVLWLNPIYRSPQVDNGYDISNYRDVEPQLGTMA
DFEHLLQAAHDRHLKIILDLVVNHTSDQHPWFKAAKSSVSDPHHDYYIWKKPVDDHEPNNWGSSFGGSAWEYKKDLGEYY
LHLFAKQQPDLNWENPKVRQEVYDLMRFWLDKGVDGFRMDVISLISKDPAYPDGPLIQGKAYGSYYAGAANGPKVHDYLQ
EMHEQVLSHYNIMTVGETPHTTAQQAQLYTAADRHELDMVFHFDHMHLDYGQYGKFSTNRFKLVDLKEVLARWENTLAQV
DGWNSLYWSNHDQPRPVTRFGDEGQYRIRSAKMLGTVLHMLQGTPYIFEGEELGLKNVHFDQLSDYNDLETKNIFKELTQ
QHHESPEAAMKAIYLHSRDNARTPMPWDGSEKGGFTTGQPWLGLNPDHKDINAAEDLADSDGVYHYYQHLIKLRHEEPLI
TTGVFELLAPDDPNLFIYLRKGEHETLLVAGNFSSEERTWSVPDDLQAKDVDVLIRNSEISDSLEKTLTLPPFGAVVYKL
Q
>Mature_561_residues
MNEIPWWKKSVVYQVYPKSFNDSNGDGVGDLNGISEKLDYLADLGVDVLWLNPIYRSPQVDNGYDISNYRDVEPQLGTMA
DFEHLLQAAHDRHLKIILDLVVNHTSDQHPWFKAAKSSVSDPHHDYYIWKKPVDDHEPNNWGSSFGGSAWEYKKDLGEYY
LHLFAKQQPDLNWENPKVRQEVYDLMRFWLDKGVDGFRMDVISLISKDPAYPDGPLIQGKAYGSYYAGAANGPKVHDYLQ
EMHEQVLSHYNIMTVGETPHTTAQQAQLYTAADRHELDMVFHFDHMHLDYGQYGKFSTNRFKLVDLKEVLARWENTLAQV
DGWNSLYWSNHDQPRPVTRFGDEGQYRIRSAKMLGTVLHMLQGTPYIFEGEELGLKNVHFDQLSDYNDLETKNIFKELTQ
QHHESPEAAMKAIYLHSRDNARTPMPWDGSEKGGFTTGQPWLGLNPDHKDINAAEDLADSDGVYHYYQHLIKLRHEEPLI
TTGVFELLAPDDPNLFIYLRKGEHETLLVAGNFSSEERTWSVPDDLQAKDVDVLIRNSEISDSLEKTLTLPPFGAVVYKL
Q

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=527, Percent_Identity=30.3605313092979, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1790687, Length=557, Percent_Identity=44.3447037701975, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1786604, Length=189, Percent_Identity=30.6878306878307, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI32565753, Length=205, Percent_Identity=32.1951219512195, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25147709, Length=507, Percent_Identity=24.2603550295858, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6321726, Length=545, Percent_Identity=40.1834862385321, Blast_Score=409, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6322245, Length=579, Percent_Identity=38.3419689119171, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6324416, Length=580, Percent_Identity=39.1379310344828, Blast_Score=398, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322241, Length=580, Percent_Identity=39.1379310344828, Blast_Score=398, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322021, Length=580, Percent_Identity=39.1379310344828, Blast_Score=398, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6319776, Length=582, Percent_Identity=37.9725085910653, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6321731, Length=582, Percent_Identity=37.8006872852234, Blast_Score=383, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24583747, Length=533, Percent_Identity=34.3339587242026, Blast_Score=278, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24583749, Length=533, Percent_Identity=34.3339587242026, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24583745, Length=587, Percent_Identity=33.0494037478705, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI24586593, Length=530, Percent_Identity=32.8301886792453, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI221330053, Length=593, Percent_Identity=30.8600337268128, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24586599, Length=593, Percent_Identity=30.5227655986509, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI45549022, Length=545, Percent_Identity=31.9266055045872, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24586591, Length=523, Percent_Identity=34.4168260038241, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24586597, Length=539, Percent_Identity=30.6122448979592, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24586587, Length=511, Percent_Identity=29.7455968688845, Blast_Score=242, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24586589, Length=526, Percent_Identity=31.3688212927757, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI281360393, Length=473, Percent_Identity=29.8097251585624, Blast_Score=189, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.10 [H]

Molecular weight: Translated: 64563; Mature: 64563

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIPWWKKSVVYQVYPKSFNDSNGDGVGDLNGISEKLDYLADLGVDVLWLNPIYRSPQV
CCCCCCCHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
DNGYDISNYRDVEPQLGTMADFEHLLQAAHDRHLKIILDLVVNHTSDQHPWFKAAKSSVS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCC
DPHHDYYIWKKPVDDHEPNNWGSSFGGSAWEYKKDLGEYYLHLFAKQQPDLNWENPKVRQ
CCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
EVYDLMRFWLDKGVDGFRMDVISLISKDPAYPDGPLIQGKAYGSYYAGAANGPKVHDYLQ
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCEECCCCCCCHHHHHHH
EMHEQVLSHYNIMTVGETPHTTAQQAQLYTAADRHELDMVFHFDHMHLDYGQYGKFSTNR
HHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCEECCCCCCCCCCCCC
FKLVDLKEVLARWENTLAQVDGWNSLYWSNHDQPRPVTRFGDEGQYRIRSAKMLGTVLHM
EEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHH
LQGTPYIFEGEELGLKNVHFDQLSDYNDLETKNIFKELTQQHHESPEAAMKAIYLHSRDN
HCCCCEEECCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHEEECCCC
ARTPMPWDGSEKGGFTTGQPWLGLNPDHKDINAAEDLADSDGVYHYYQHLIKLRHEEPLI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCC
TTGVFELLAPDDPNLFIYLRKGEHETLLVAGNFSSEERTWSVPDDLQAKDVDVLIRNSEI
HHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCCCEECCCCCCCCCCEEEEEECCCH
SDSLEKTLTLPPFGAVVYKLQ
HHHHHHHCCCCCCCCEEEEEC
>Mature Secondary Structure
MNEIPWWKKSVVYQVYPKSFNDSNGDGVGDLNGISEKLDYLADLGVDVLWLNPIYRSPQV
CCCCCCCHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
DNGYDISNYRDVEPQLGTMADFEHLLQAAHDRHLKIILDLVVNHTSDQHPWFKAAKSSVS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCC
DPHHDYYIWKKPVDDHEPNNWGSSFGGSAWEYKKDLGEYYLHLFAKQQPDLNWENPKVRQ
CCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
EVYDLMRFWLDKGVDGFRMDVISLISKDPAYPDGPLIQGKAYGSYYAGAANGPKVHDYLQ
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCEECCCCCCCHHHHHHH
EMHEQVLSHYNIMTVGETPHTTAQQAQLYTAADRHELDMVFHFDHMHLDYGQYGKFSTNR
HHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCEECCCCCCCCCCCCC
FKLVDLKEVLARWENTLAQVDGWNSLYWSNHDQPRPVTRFGDEGQYRIRSAKMLGTVLHM
EEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHH
LQGTPYIFEGEELGLKNVHFDQLSDYNDLETKNIFKELTQQHHESPEAAMKAIYLHSRDN
HCCCCEEECCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHEEECCCC
ARTPMPWDGSEKGGFTTGQPWLGLNPDHKDINAAEDLADSDGVYHYYQHLIKLRHEEPLI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCC
TTGVFELLAPDDPNLFIYLRKGEHETLLVAGNFSSEERTWSVPDDLQAKDVDVLIRNSEI
HHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCCCEECCCCCCCCCCEEEEEECCCH
SDSLEKTLTLPPFGAVVYKLQ
HHHHHHHCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1761534 [H]