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The map label for this gene is trxA [H]

Identifier: 116493829

GI number: 116493829

Start: 264629

End: 264943

Strand: Direct

Name: trxA [H]

Synonym: LSEI_0261

Alternate gene names: 116493829

Gene position: 264629-264943 (Clockwise)

Preceding gene: 116493827

Following gene: 116493830

Centisome position: 9.14

GC content: 46.03

Gene sequence:

>315_bases
ATGGCAATTGAGGCAACGAAAGATAACTTGAAGGCATTGACAGCTGAAGGCACGGTTGTCGTTGATTTTTGGGCACCGTG
GTGCGGCCCTTGTAAAGTGCTTGATCCGATGTTAACGGCCCTAGAGCAAGAACTGCCAGCGCTTAAGGTGGTTCGTTATA
ATGTTGAAAAAGATCATACGTTGCCGAGCACTATGGGCATTATGTCAGTACCCACCTTAGTCATTTATCAGCAAGGAGAG
GCGCGCGAAAAAGTGACAGGTGTTTACCCTAAAGACAAACTTAAACGGTATTTTGAACAGAAACTTGAGGCGTAG

Upstream 100 bases:

>100_bases
AAGTTAGGATCTGGTCATTGACCGGATCTTTTTTTATACCTTGATAAGTAAGTGGCAGTCGTGCTAAATTGCAAGAGCAA
GCATGGAAGGGGATCACATC

Downstream 100 bases:

>100_bases
GTATGACACATTCAGTTGAGCGTCAGGATACAGCAATCCAAAATCAAGTATTGGCAACATGCTTGCTTGCTGGACGCATT
ATGATTGAAGGCGGTTCGGA

Product: Thiol-disulfide isomerase and thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAIEATKDNLKALTAEGTVVVDFWAPWCGPCKVLDPMLTALEQELPALKVVRYNVEKDHTLPSTMGIMSVPTLVIYQQGE
AREKVTGVYPKDKLKRYFEQKLEA

Sequences:

>Translated_104_residues
MAIEATKDNLKALTAEGTVVVDFWAPWCGPCKVLDPMLTALEQELPALKVVRYNVEKDHTLPSTMGIMSVPTLVIYQQGE
AREKVTGVYPKDKLKRYFEQKLEA
>Mature_103_residues
AIEATKDNLKALTAEGTVVVDFWAPWCGPCKVLDPMLTALEQELPALKVVRYNVEKDHTLPSTMGIMSVPTLVIYQQGEA
REKVTGVYPKDKLKRYFEQKLEA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=102, Percent_Identity=36.2745098039216, Blast_Score=78, Evalue=1e-16,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=33.9805825242718, Blast_Score=75, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=79, Percent_Identity=31.6455696202532, Blast_Score=61, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=72, Percent_Identity=34.7222222222222, Blast_Score=60, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 11697; Mature: 11566

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEATKDNLKALTAEGTVVVDFWAPWCGPCKVLDPMLTALEQELPALKVVRYNVEKDHT
CCCCCCCCCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
LPSTMGIMSVPTLVIYQQGEAREKVTGVYPKDKLKRYFEQKLEA
CCCHHHHHHCCEEEEECCCCCCHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIEATKDNLKALTAEGTVVVDFWAPWCGPCKVLDPMLTALEQELPALKVVRYNVEKDHT
CCCCCCCCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
LPSTMGIMSVPTLVIYQQGEAREKVTGVYPKDKLKRYFEQKLEA
CCCHHHHHHCCEEEEECCCCCCHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]