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The map label for this gene is mntH

Identifier: 116493604

GI number: 116493604

Start: 30423

End: 31799

Strand: Direct

Name: mntH

Synonym: LSEI_0030

Alternate gene names: 116493604

Gene position: 30423-31799 (Clockwise)

Preceding gene: 116493601

Following gene: 116493607

Centisome position: 1.05

GC content: 48.66

Gene sequence:

>1377_bases
ATGGCATCAGAAGATAAAAAATCAAAACGCGAACACATTATTCACTTCGAAGATACGGCAAGCAAAAGTCTTGATGAGGT
GAATGGCAGTGTTGAAGTACCGCACAATGCGGGCTTTTGGAAAACTTTAGCAGCTTATACTGGCCCAGGCATCCTAGTTG
CCGTTGGGTATATGGATCCTGGTAACTGGATCACCAGTATTGCCGGTGGCGCTTCATTTAAATATTCCTTGCTATCTGTC
ATTCTTATTTCCAGTCTGATTGCGATGCTGCTGCAAGCCATGGCGGCTCGTCTTGGTATTGTGACCGGCAGAGATTTAGC
GCAGATGACACGTGATCACACCAGCAAAGCGATGGGCGGTTTTCTTTGGGTCATTACAGAACTTGCGATTATGGCGACTG
ATATCGCCGAAATCATTGGCTCTGCCATTGCCTTGAAGTTACTGTTCAACATGCCGCTGATTGTCGGCATCATTATCACG
ACCGCCGATGTGCTGATCCTCTTACTGCTCATGCGCCTCGGTTTCCGTAAGATTGAGGCGGTTGTTGCGACCTTAGTGCT
GGTTATCTTATTGGTTTTCGCTTATGAAGTGATTCTCGCGCAACCAAATGTCCCGGAACTGCTGAAAGGCTATCTGCCAC
ACGCGGATATCGTGACCAACAAATCAATGCTCTATCTCTCTTTGGGGATTGTTGGTGCCACGGTGATGCCGCATGACCTG
TTCCTCGGCTCCTCGATTTCGCAAACACGAAAAATTGATCGCACGAAGCACGAAGAAGTCAAAAAGGCGATTAAGTTCTC
CACCATTGATTCCAACCTGCAACTGACCATGGCTTTCATTGTCAACTCACTACTGCTGATTCTTGGCGCAGCGCTGTTCT
TCGGCACCAGTAGCTCAGTTGGCCGCTTCGTTGATCTTTTCAACGCATTAAGCAACTCCCAGATTGTCGGTGCGATCGCC
AGCCCGATGCTTTCCATGTTGTTCGCGGTTGCGCTGCTCGCATCCGGCCAAAGCTCCACGATTACAGGAACACTTGCCGG
TCAGATTATCATGGAAGGCTTCATTCATTTGAAAATGCCGCTCTGGGCCCAACGACTTTTGACTCGGCTCATGTCCGTGA
CCCCAGTGCTCATCTTCGCGATTTACTACCATGGCAACGAAGCCAAAATCGAAAACCTGTTGACCTTCTCGCAGGTCTTC
CTCAGTATCGCATTACCATTCGCCGTCATCCCGCTAGTGCTCTACACTAGTGATAAAAAAATCATGGGTGAGTTCGCCAA
CCGTGCTTGGGTGAAGTGGACAGCATGGTTCATCAGTGGGGTCCTGATCATTTTGAACCTTTACCTGATTGCGCAGACGT
TAGGGTTTGTTAAATAA

Upstream 100 bases:

>100_bases
TGACCTGTATCCAAAAGGGTGTATATTTATGTCGGACGATGTTGAGTAAATACTCAAATTAGACCCAAATTTCAAGCCAA
TGGAAAGAGGGCTTCACACA

Downstream 100 bases:

>100_bases
GTCATTGTAGCAAGCAAAAGCCGCTCGATTCGCTGATCGAGCGGCTTTTAGTGTCGATTTATTTAAAAAGGGGACAGTTG
ACTCATCAAATTTCGGCGTA

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MASEDKKSKREHIIHFEDTASKSLDEVNGSVEVPHNAGFWKTLAAYTGPGILVAVGYMDPGNWITSIAGGASFKYSLLSV
ILISSLIAMLLQAMAARLGIVTGRDLAQMTRDHTSKAMGGFLWVITELAIMATDIAEIIGSAIALKLLFNMPLIVGIIIT
TADVLILLLLMRLGFRKIEAVVATLVLVILLVFAYEVILAQPNVPELLKGYLPHADIVTNKSMLYLSLGIVGATVMPHDL
FLGSSISQTRKIDRTKHEEVKKAIKFSTIDSNLQLTMAFIVNSLLLILGAALFFGTSSSVGRFVDLFNALSNSQIVGAIA
SPMLSMLFAVALLASGQSSTITGTLAGQIIMEGFIHLKMPLWAQRLLTRLMSVTPVLIFAIYYHGNEAKIENLLTFSQVF
LSIALPFAVIPLVLYTSDKKIMGEFANRAWVKWTAWFISGVLIILNLYLIAQTLGFVK

Sequences:

>Translated_458_residues
MASEDKKSKREHIIHFEDTASKSLDEVNGSVEVPHNAGFWKTLAAYTGPGILVAVGYMDPGNWITSIAGGASFKYSLLSV
ILISSLIAMLLQAMAARLGIVTGRDLAQMTRDHTSKAMGGFLWVITELAIMATDIAEIIGSAIALKLLFNMPLIVGIIIT
TADVLILLLLMRLGFRKIEAVVATLVLVILLVFAYEVILAQPNVPELLKGYLPHADIVTNKSMLYLSLGIVGATVMPHDL
FLGSSISQTRKIDRTKHEEVKKAIKFSTIDSNLQLTMAFIVNSLLLILGAALFFGTSSSVGRFVDLFNALSNSQIVGAIA
SPMLSMLFAVALLASGQSSTITGTLAGQIIMEGFIHLKMPLWAQRLLTRLMSVTPVLIFAIYYHGNEAKIENLLTFSQVF
LSIALPFAVIPLVLYTSDKKIMGEFANRAWVKWTAWFISGVLIILNLYLIAQTLGFVK
>Mature_457_residues
ASEDKKSKREHIIHFEDTASKSLDEVNGSVEVPHNAGFWKTLAAYTGPGILVAVGYMDPGNWITSIAGGASFKYSLLSVI
LISSLIAMLLQAMAARLGIVTGRDLAQMTRDHTSKAMGGFLWVITELAIMATDIAEIIGSAIALKLLFNMPLIVGIIITT
ADVLILLLLMRLGFRKIEAVVATLVLVILLVFAYEVILAQPNVPELLKGYLPHADIVTNKSMLYLSLGIVGATVMPHDLF
LGSSISQTRKIDRTKHEEVKKAIKFSTIDSNLQLTMAFIVNSLLLILGAALFFGTSSSVGRFVDLFNALSNSQIVGAIAS
PMLSMLFAVALLASGQSSTITGTLAGQIIMEGFIHLKMPLWAQRLLTRLMSVTPVLIFAIYYHGNEAKIENLLTFSQVFL
SIALPFAVIPLVLYTSDKKIMGEFANRAWVKWTAWFISGVLIILNLYLIAQTLGFVK

Specific function: H(+)-stimulated, highly selective, manganese uptake system

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI109255241, Length=436, Percent_Identity=34.1743119266055, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI295293167, Length=439, Percent_Identity=35.3075170842825, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI295293175, Length=439, Percent_Identity=35.3075170842825, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI295293173, Length=439, Percent_Identity=35.3075170842825, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI10835169, Length=439, Percent_Identity=35.3075170842825, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI295293178, Length=439, Percent_Identity=35.3075170842825, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI295293171, Length=439, Percent_Identity=35.3075170842825, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI295293169, Length=439, Percent_Identity=35.3075170842825, Blast_Score=238, Evalue=1e-62,
Organism=Escherichia coli, GI1788736, Length=434, Percent_Identity=37.0967741935484, Blast_Score=247, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17569473, Length=405, Percent_Identity=33.0864197530864, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI193210616, Length=459, Percent_Identity=32.244008714597, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71999499, Length=457, Percent_Identity=33.2603938730853, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71993856, Length=244, Percent_Identity=35.2459016393443, Blast_Score=156, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323062, Length=401, Percent_Identity=40.1496259351621, Blast_Score=259, Evalue=8e-70,
Organism=Saccharomyces cerevisiae, GI6324450, Length=420, Percent_Identity=35.2380952380952, Blast_Score=246, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6321841, Length=472, Percent_Identity=34.7457627118644, Blast_Score=236, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24648607, Length=445, Percent_Identity=34.8314606741573, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI281362176, Length=445, Percent_Identity=34.8314606741573, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24648609, Length=445, Percent_Identity=34.8314606741573, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI45553443, Length=422, Percent_Identity=35.3080568720379, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_LACC3 (Q03D26)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_805338.1
- STRING:   Q03D26
- GeneID:   4419294
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_0030
- eggNOG:   COG1914
- HOGENOM:   HBG312498
- OMA:   NWITSVV
- PhylomeDB:   Q03D26
- ProtClustDB:   PRK00701
- BioCyc:   LCAS321967:LSEI_0030-MONOMER
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447
- TIGRFAMs:   TIGR01197

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 49850; Mature: 49719

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x11b21cdc)-; HASH(0x1329d7dc)-; HASH(0xc319c2c)-; HASH(0x132b349c)-; HASH(0x1348dd60)-; HASH(0x1349b1a8)-; HASH(0x134946a4)-; HASH(0x133fb6f4)-; HASH(0x134a8d10)-; HASH(0x13498960)-; HASH(0x134ab230)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEDKKSKREHIIHFEDTASKSLDEVNGSVEVPHNAGFWKTLAAYTGPGILVAVGYMDP
CCCCCCCHHHHCEEEECCHHHHHHHHCCCCEECCCCCCHHHHHHHHCCCCEEEEEEECCC
GNWITSIAGGASFKYSLLSVILISSLIAMLLQAMAARLGIVTGRDLAQMTRDHTSKAMGG
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FLWVITELAIMATDIAEIIGSAIALKLLFNMPLIVGIIITTADVLILLLLMRLGFRKIEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
VVATLVLVILLVFAYEVILAQPNVPELLKGYLPHADIVTNKSMLYLSLGIVGATVMPHDL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHCCCCHHEEEHHHHHHHHCCHHH
FLGSSISQTRKIDRTKHEEVKKAIKFSTIDSNLQLTMAFIVNSLLLILGAALFFGTSSSV
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GRFVDLFNALSNSQIVGAIASPMLSMLFAVALLASGQSSTITGTLAGQIIMEGFIHLKMP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCH
LWAQRLLTRLMSVTPVLIFAIYYHGNEAKIENLLTFSQVFLSIALPFAVIPLVLYTSDKK
HHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IMGEFANRAWVKWTAWFISGVLIILNLYLIAQTLGFVK
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
ASEDKKSKREHIIHFEDTASKSLDEVNGSVEVPHNAGFWKTLAAYTGPGILVAVGYMDP
CCCCCCHHHHCEEEECCHHHHHHHHCCCCEECCCCCCHHHHHHHHCCCCEEEEEEECCC
GNWITSIAGGASFKYSLLSVILISSLIAMLLQAMAARLGIVTGRDLAQMTRDHTSKAMGG
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FLWVITELAIMATDIAEIIGSAIALKLLFNMPLIVGIIITTADVLILLLLMRLGFRKIEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
VVATLVLVILLVFAYEVILAQPNVPELLKGYLPHADIVTNKSMLYLSLGIVGATVMPHDL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHCCCCHHEEEHHHHHHHHCCHHH
FLGSSISQTRKIDRTKHEEVKKAIKFSTIDSNLQLTMAFIVNSLLLILGAALFFGTSSSV
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GRFVDLFNALSNSQIVGAIASPMLSMLFAVALLASGQSSTITGTLAGQIIMEGFIHLKMP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCH
LWAQRLLTRLMSVTPVLIFAIYYHGNEAKIENLLTFSQVFLSIALPFAVIPLVLYTSDKK
HHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IMGEFANRAWVKWTAWFISGVLIILNLYLIAQTLGFVK
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA