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The map label for this gene is nhaK [H]

Identifier: 116493536

GI number: 116493536

Start: 1788363

End: 1790462

Strand: Direct

Name: nhaK [H]

Synonym: PEPE_1810

Alternate gene names: 116493536

Gene position: 1788363-1790462 (Clockwise)

Preceding gene: 116493535

Following gene: 116493537

Centisome position: 97.6

GC content: 38.67

Gene sequence:

>2100_bases
TTGCAAACATTTTACACAATTGCACTACTTTTAACAGGTGTAATCTTATCTAATATTATTAAACAACTTGTGCCTCGAAT
TCCCGAAGCATTTATTTTAATTATCGTTGGAGTAATCCTATCATTTACCCCAGCATTTCATAATTTTGAATTAAGACCAG
AATTTTTTATGTTAGTGGTTATTGCACCTATCATGTTTATAGATGGTCAAAAACAATCCTTCAATCGAATTCGCCAACGT
TTTCGCGTGGTATTTTTTCTGTCGGTAGTTTTAGCTGGCGCCAGCGCTTTAGTTGTTGGAATCTTAACTAATAATTTTGA
AACCAAATGGACGCTACCAGTGGCCATTGCCCTAGCAGCCATCGTTACTCCCACCGATGCGGTTGCTGTTAAATCGATGA
CCAGCGGAACTGCCATGCCCGAAAATGTTAATGAAGCTTTAGAACTAGAATCCTTATTTAACGATGCCACTGGACTGGTA
ATCCTTGATTTAGCTTTATCTGTTTTACAAAATGGAACTTTTTCAGCAATTACCGGAGTCGAACATTTTATTTTTGTCGC
GCTTGGTGGCGTAATCATTGGAATTATTGCCGGCTTTTTAATTGTTTCTCTTCGCGTTAATTTAAACATGCGCGCTAATA
ATCCGGAAACTATCATCATTCCGATTAGTCTGTTGACCCCTTTTCTCGTCTATCTTTTAGCTGAACATTTGGGAACTTCT
GGCATTCTAGCCGTCGTTGCTACTGGAATGGTTCATAATTGGGAATCTGAACGCCTCCGTTTAACTTCAACTCGAGTTCA
GCTTACCTCAGCAACCGTCTGGAATACTATCTCAAGTTTCCTAAATAGCGTCGTTTTCTTATTCCTTGGAGTGACTTTAC
CGATGGTTTGGAAAGATTTTATCCAGATGGGAACGATGACGATTGCTCAATTAATTGGTATTAGTTTACTGATTTATCTA
TCAATGCTAGCTATCCGTTACTGGTGGTCTGTTCATGAAAATCCAGACAATCCTGACCATTTCTTAGGCCCACATGACAA
ATCCGTGCATCAGCTATGGTCAAGGATATTTGCAATTAGTGGTGTGCATGGGACCGTGACTTTGGCGATGGCCTTTTCAC
TTCCTACTAGAATCGGTGGTCATCCCTTCCCTTATCGTGAAGAATTAATTGTGATTGCCACGCTAGTAATTTTAATTAGT
ATGTTAGTCAGTGCTATCAGTCTTCCGCTGATGCTTCCTGTCAAAACGACGGAATATTCACTCGCTGATATCGATCATGT
TCGTAATAAGATGGTGGATTATGCTACTTTACAACTACGTGATACCATCGATGATCACGCGGTTCGTGAGGCTTTAACGG
AACAGTTGCAGTCCCAAAAAGGGGCATTGAATGGCCAAATTATTGATTTTGATGAATATCAGGAGTTAATGTTTGAAACC
AAAGACTTCATTGTCACTTACATTCATGGACCTTCAATTTCAGCTAAATATAGTTTAGAAGTTGTTAATATCTATGAAAA
AATTCTAAATAATTTTGTAGCTCCTAACTTTAATCCTCGGGAGCACTTTGCTAACCGAGTACATTATATATTTAAAAAGA
ACTTTAAAAAGGTATCAGGTCTTTGCAAACACGCCCTCTGGCACGTCAAAAATGGGCAAATTACCAAACATCAACGTACC
GTTGCTCGTCAAAAATGGTTGGCTGCTCAACCTTCGGATACATTCCAACAACGTCTGGACGTTCGGGATGCTCTTTTGGA
ACTCAACAATGAAGTGATCGACTCTACTGATAAATACTTAGACGATGTTTTGCGTGGTCGCTTATTACGTAAACAAAGTA
ATAACCAATATATTAACCTCGTTCGTAGATCTATCAATCGATACTGCTCAATGGTTCGTCATGATTATAATAAACAGGCA
GTCTTTGTAAGTAGCGATTTATACATTCAAGCCTTTCAGCAAGAATATAACTTTATTCAACGTGGAGTAAGCCGTGGGGT
TATTACCCCAGAAATGGCAACTGTGCTCTATGATGAGATTAATCAAGCTCAATCACTACAATTACAACGTACTCAACAGC
TTCAAATTATTACATCTTAA

Upstream 100 bases:

>100_bases
ATATCACATGCTGTAGTAAAATGAGACGATGAAGTCATCATCTCATTTTTTGTTATAATGACTTCTATAAATTTTATTCA
TAGGAGATTAGGTAGTAACC

Downstream 100 bases:

>100_bases
GCATTTTAAAAACACCTCTTGCGCGTTACTTATTTATAAGTAGCACATAGGAGGTGTTTTAGTTCGAATTAAATTAATTT
AAACAAATTTTGAACTTCAT

Product: NhaP-type Na+/H+ and K+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 699

Protein sequence:

>699_residues
MQTFYTIALLLTGVILSNIIKQLVPRIPEAFILIIVGVILSFTPAFHNFELRPEFFMLVVIAPIMFIDGQKQSFNRIRQR
FRVVFFLSVVLAGASALVVGILTNNFETKWTLPVAIALAAIVTPTDAVAVKSMTSGTAMPENVNEALELESLFNDATGLV
ILDLALSVLQNGTFSAITGVEHFIFVALGGVIIGIIAGFLIVSLRVNLNMRANNPETIIIPISLLTPFLVYLLAEHLGTS
GILAVVATGMVHNWESERLRLTSTRVQLTSATVWNTISSFLNSVVFLFLGVTLPMVWKDFIQMGTMTIAQLIGISLLIYL
SMLAIRYWWSVHENPDNPDHFLGPHDKSVHQLWSRIFAISGVHGTVTLAMAFSLPTRIGGHPFPYREELIVIATLVILIS
MLVSAISLPLMLPVKTTEYSLADIDHVRNKMVDYATLQLRDTIDDHAVREALTEQLQSQKGALNGQIIDFDEYQELMFET
KDFIVTYIHGPSISAKYSLEVVNIYEKILNNFVAPNFNPREHFANRVHYIFKKNFKKVSGLCKHALWHVKNGQITKHQRT
VARQKWLAAQPSDTFQQRLDVRDALLELNNEVIDSTDKYLDDVLRGRLLRKQSNNQYINLVRRSINRYCSMVRHDYNKQA
VFVSSDLYIQAFQQEYNFIQRGVSRGVITPEMATVLYDEINQAQSLQLQRTQQLQIITS

Sequences:

>Translated_699_residues
MQTFYTIALLLTGVILSNIIKQLVPRIPEAFILIIVGVILSFTPAFHNFELRPEFFMLVVIAPIMFIDGQKQSFNRIRQR
FRVVFFLSVVLAGASALVVGILTNNFETKWTLPVAIALAAIVTPTDAVAVKSMTSGTAMPENVNEALELESLFNDATGLV
ILDLALSVLQNGTFSAITGVEHFIFVALGGVIIGIIAGFLIVSLRVNLNMRANNPETIIIPISLLTPFLVYLLAEHLGTS
GILAVVATGMVHNWESERLRLTSTRVQLTSATVWNTISSFLNSVVFLFLGVTLPMVWKDFIQMGTMTIAQLIGISLLIYL
SMLAIRYWWSVHENPDNPDHFLGPHDKSVHQLWSRIFAISGVHGTVTLAMAFSLPTRIGGHPFPYREELIVIATLVILIS
MLVSAISLPLMLPVKTTEYSLADIDHVRNKMVDYATLQLRDTIDDHAVREALTEQLQSQKGALNGQIIDFDEYQELMFET
KDFIVTYIHGPSISAKYSLEVVNIYEKILNNFVAPNFNPREHFANRVHYIFKKNFKKVSGLCKHALWHVKNGQITKHQRT
VARQKWLAAQPSDTFQQRLDVRDALLELNNEVIDSTDKYLDDVLRGRLLRKQSNNQYINLVRRSINRYCSMVRHDYNKQA
VFVSSDLYIQAFQQEYNFIQRGVSRGVITPEMATVLYDEINQAQSLQLQRTQQLQIITS
>Mature_699_residues
MQTFYTIALLLTGVILSNIIKQLVPRIPEAFILIIVGVILSFTPAFHNFELRPEFFMLVVIAPIMFIDGQKQSFNRIRQR
FRVVFFLSVVLAGASALVVGILTNNFETKWTLPVAIALAAIVTPTDAVAVKSMTSGTAMPENVNEALELESLFNDATGLV
ILDLALSVLQNGTFSAITGVEHFIFVALGGVIIGIIAGFLIVSLRVNLNMRANNPETIIIPISLLTPFLVYLLAEHLGTS
GILAVVATGMVHNWESERLRLTSTRVQLTSATVWNTISSFLNSVVFLFLGVTLPMVWKDFIQMGTMTIAQLIGISLLIYL
SMLAIRYWWSVHENPDNPDHFLGPHDKSVHQLWSRIFAISGVHGTVTLAMAFSLPTRIGGHPFPYREELIVIATLVILIS
MLVSAISLPLMLPVKTTEYSLADIDHVRNKMVDYATLQLRDTIDDHAVREALTEQLQSQKGALNGQIIDFDEYQELMFET
KDFIVTYIHGPSISAKYSLEVVNIYEKILNNFVAPNFNPREHFANRVHYIFKKNFKKVSGLCKHALWHVKNGQITKHQRT
VARQKWLAAQPSDTFQQRLDVRDALLELNNEVIDSTDKYLDDVLRGRLLRKQSNNQYINLVRRSINRYCSMVRHDYNKQA
VFVSSDLYIQAFQQEYNFIQRGVSRGVITPEMATVLYDEINQAQSLQLQRTQQLQIITS

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=498, Percent_Identity=24.4979919678715, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI148727259, Length=361, Percent_Identity=25.4847645429363, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790501, Length=428, Percent_Identity=31.3084112149533, Blast_Score=171, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71999819, Length=469, Percent_Identity=22.8144989339019, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71999817, Length=469, Percent_Identity=22.8144989339019, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980847, Length=478, Percent_Identity=24.0585774058577, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 78867; Mature: 78867

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTFYTIALLLTGVILSNIIKQLVPRIPEAFILIIVGVILSFTPAFHNFELRPEFFMLVV
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
IAPIMFIDGQKQSFNRIRQRFRVVFFLSVVLAGASALVVGILTNNFETKWTLPVAIALAA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHEEHHHHCCCCCEEHHHHHHHHHH
IVTPTDAVAVKSMTSGTAMPENVNEALELESLFNDATGLVILDLALSVLQNGTFSAITGV
HHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHH
EHFIFVALGGVIIGIIAGFLIVSLRVNLNMRANNPETIIIPISLLTPFLVYLLAEHLGTS
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHCCC
GILAVVATGMVHNWESERLRLTSTRVQLTSATVWNTISSFLNSVVFLFLGVTLPMVWKDF
HHHHHHHHHHHCCCCCCCEEEEHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQMGTMTIAQLIGISLLIYLSMLAIRYWWSVHENPDNPDHFLGPHDKSVHQLWSRIFAIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GVHGTVTLAMAFSLPTRIGGHPFPYREELIVIATLVILISMLVSAISLPLMLPVKTTEYS
CCCHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
LADIDHVRNKMVDYATLQLRDTIDDHAVREALTEQLQSQKGALNGQIIDFDEYQELMFET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHH
KDFIVTYIHGPSISAKYSLEVVNIYEKILNNFVAPNFNPREHFANRVHYIFKKNFKKVSG
HHHEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LCKHALWHVKNGQITKHQRTVARQKWLAAQPSDTFQQRLDVRDALLELNNEVIDSTDKYL
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHCCHHHHH
DDVLRGRLLRKQSNNQYINLVRRSINRYCSMVRHDYNKQAVFVSSDLYIQAFQQEYNFIQ
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHH
RGVSRGVITPEMATVLYDEINQAQSLQLQRTQQLQIITS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
>Mature Secondary Structure
MQTFYTIALLLTGVILSNIIKQLVPRIPEAFILIIVGVILSFTPAFHNFELRPEFFMLVV
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
IAPIMFIDGQKQSFNRIRQRFRVVFFLSVVLAGASALVVGILTNNFETKWTLPVAIALAA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHEEHHHHCCCCCEEHHHHHHHHHH
IVTPTDAVAVKSMTSGTAMPENVNEALELESLFNDATGLVILDLALSVLQNGTFSAITGV
HHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHH
EHFIFVALGGVIIGIIAGFLIVSLRVNLNMRANNPETIIIPISLLTPFLVYLLAEHLGTS
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHCCC
GILAVVATGMVHNWESERLRLTSTRVQLTSATVWNTISSFLNSVVFLFLGVTLPMVWKDF
HHHHHHHHHHHCCCCCCCEEEEHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQMGTMTIAQLIGISLLIYLSMLAIRYWWSVHENPDNPDHFLGPHDKSVHQLWSRIFAIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GVHGTVTLAMAFSLPTRIGGHPFPYREELIVIATLVILISMLVSAISLPLMLPVKTTEYS
CCCHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
LADIDHVRNKMVDYATLQLRDTIDDHAVREALTEQLQSQKGALNGQIIDFDEYQELMFET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHH
KDFIVTYIHGPSISAKYSLEVVNIYEKILNNFVAPNFNPREHFANRVHYIFKKNFKKVSG
HHHEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LCKHALWHVKNGQITKHQRTVARQKWLAAQPSDTFQQRLDVRDALLELNNEVIDSTDKYL
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHCCHHHHH
DDVLRGRLLRKQSNNQYINLVRRSINRYCSMVRHDYNKQAVFVSSDLYIQAFQQEYNFIQ
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHH
RGVSRGVITPEMATVLYDEINQAQSLQLQRTQQLQIITS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]